Nanosized ﬂuorescent carbon particles, carbon dots (CDs), are a kind of ﬂuorescent material that has many applications in recent years. They have biological application like delivery of therapeutic payloads for cancer therapy mainly due to their biocompatibility and unique optical properties. Fluorescent carbon dots overcome the short comings of high toxicity of traditional nano materials. Mor...
DEVELOPMENT AND VALIDATIONRP-HPLC METHOD FOR THE SIMULTANEOUS DETERMINETION OF LOPERAMIDE HYDROCHLORIDE AND NORFLOXACIN IN PHARMACEUTICAL FORMULATION
A reverse-phase liquid chromatographic (RP-HPLC) method was developed for the determinations of loperamide hydrochloride and norfloxacin in their marketed formulation and bulk. The separation was carried out using mobile phase of triethylamine and acetonitrile (50:50%) with pH 4.The pH adjusted with orthophosphoric acid. The column used was Capcell pack C18 Column (250mn x 4.6mm, 5mm) and flow rat...
IDENTIFICATION OF POTENT VIRTUAL LEADS AS TOPOISOMERASE-II INHIBITORS USING PHARMACOPHORE MODELLING, MOLECULAR DOCKING AND ADME STUDIES
Topoisomerase enzymes are highly expressed in cells which undergo rapid multiplication. Inhibition of this enzyme represents a potential therapeutic approach for diseases such as cancer. In order to understand the structure activity correlation of 2, 4, 6 pyridine based topoisomerase inhibitor, we have carried out a combined pharmacophore modelling, 3D-QSAR studies, molecular docking and virtual s...
The present study was carried out to evaluate anti-tussive activity of ethyl acetate and methanolic extract of leaves of Adhatoda vasica Nees. As cough is a natural reflex expulsive defense mechanism of the body, it is the most common symptom of respiratory disease. Ammonium hydroxide and Sulphur dioxide induced cough models in mice were used for evaluation of antitussive activity of ethyl acetate...
Pharmacokinetic modeling is the representation of the logarithmic mathematical equations in order to measure the physiologic response of the body to the drug. Absorption, distribution, metabolism and excretion follow drug kinetic principles according to specific reaction mechanisms in which concentration of the drug may either be dependent or independent of drug-body interactions. Michaelis-Menten...
Aim: To compare the immunomodulatory effect of Ocimum sanctum and Ocimum basilicum in mice. Methods: Acute oral toxicity test was performed as per OECD -23 guidelines. Maximum dose level of 2000 mg/kg was selected for toxicological evaluation. Delayed type hypersensitivity reaction were carried out for assessment of cell mediated immune functions Result: Administration of Ocimum sanctum and ...
EVALUATION OF ANTI-NOCICEPTIVE AND ANTI-PYRETIC ACTIVITY OF AERVA PSEUDOTOMENTOSA LEAVES AQUEOUS EXTRACT
Aerva pseudotomentosa Blatt. & Hallb. (Amaranthaceae) is arid region plant commonly known as Bui. It is used in ethno medicinal practices for the treatment of pain and inflammatory hyperalgesic disorders such as rheumatic pain, fever, inflammation, wounds and urinary disorders. This study was conducted to evaluate the anti-nociceptive, antipyretic effects of A. pseudotomentosa leaves aqueous e...
ADHATODA VASICA: EFFECT OF ADMINISTERING ETHANOLIC EXTRACT OF ADHATODA VASICA ON BLOOD COUNT AND SOD ENZYME ACTIVITY AGAINST EXPOSURE TO γ – RADIATIONS
In the present studies, antibacterial studies and medicinal effects of the ethanolic extract of Adhatoda vasica on the physiological variations including blood countvariations w.r.t. RBC, WBC, Hb and enzyme SOD activity of the subjects under study, Swiss Albino mice, on exposure to gamma radiations, have been evaluated. Phyto-chemical analysis of A. vasica showed the presence of alkaloids, sapon...
Serum markers reflect a bone cell activity that regulate bone remodeling, bone alkaline phosphatase (PAO), Total Intact Procollagen Type I N-terminal propeptide (TP1NP) for training and tartrate-resistant acid phosphatase (TRAPB5), carboxy-terminal collagen crosslinks (Cross Laps) for bone resorption. These markers are sensitive and early tools, Elevated serum levels of these markers is a very goo...
Introduction: Measurement of glycated hemoglobin (HbA1c) and fructosamine has a growing role in the assessment of glycemic control but their use for screening purpose is questionable. Material and methods: The study was carried out on 50 controls and 50 patients suffering from hyperthyroidism from October 2014 to March 2015 at Geetanjali Medical College & Hospital, Udaipur (Rajasthan). Results...