Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
6-OXA-3-THIAOCTANOIC ACID HAS POTENTIAL INHIBITORS AGAINST THYROID CANCER- IN-SILICO ANALYSIS
Cancer is an uncontrollable incurable disease with abnormal growth and proliferation of cells. Thyroid cancer is caused due to the thyroid hormone effects on growth, development and homeostasis in mammals. Thyroid cancer is the most common endocrine malignancy. Thyroid hormone is encoded by two types of thyroid receptors that are TRα and TRβ. TRα is functionally divided in two types TRα1 and T...
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DEVELOPMENT AND VALIDATION OF NEW RP-HPLC METHOD FOR ESTIMATION OF MEPHENESIN AND IBUPROFEN
A new RP-HPLC method was developed for Mephenesin (MEP) and Ibuprofen (IBU) and validated as per ICH guidelines. Good chromatographic separation of Mephenesin and Ibuprofen was achieved by using Agilent C18 column (150mm×4.6mm, 3.2µ p.s). The system was operated at ambient temperature using a mobile phase consisting of Acetonitrile, 0.01M potassium dihydrogen phosphate pH 3.0 (60:40 v/v) isocrat...
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ENHANCED BIOAVAILABILITY OF GLIMEPIRIDE THROUGH MICROEMULSION BASED TRANSDERMAL GELS
The objective of the present research work was to conduct in vivo pharmacokinetic study of microemulsion based transdermal gel of glimepiride for evaluating the enhanced bioavailability. Saturation solubility studies of the drug were conducted in various solvents and oils. Labrafil M 1944 CS, Tween 80 and Transcutol P were used as oil phase, surfactant and cosurfactants respectively for the prep...
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CLINICAL AND RADIOGRAPHIC EVALUATION OF PULPAL AND PERIRADICULAR TISSUE
Objective: The aim of the present study was to evaluate the clinical and radiographic aspects of pulpal and periradicular tissue for patient undergoes endodontic treatment. Patient and method: The present study was limited to patients who treated endodontically by postgraduate students of Conservative Department, School of Dentistry/Faculty of Medical Sciences between January 2014 to February 2015...
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SYNTHESIS AND CHARACTERIZATION OF SITE SPECIFIC SUPERPOROUS HYDROGEL HYBRIDS OF LORATADINE
The aim of present study is to formulate and optimize the site specific controlled release formulation for release of loratadine in upper gastrointestinal tract. Superposrous hydrogel hybrids (SPHH) were prepared by using ferric chloride as crosslinking agent and sodium carboxymethyl cellulose as composite agent. The Superporous Hydrogels were evaluated for swelling ratio, mechanical strength, den...
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SCREENING OF MARINE SOILS FROM BAY OF BENGAL NEAR CHIRALA COAST OF ANDHRA PRADESH FOR ISOLATION OF LIPOLYTIC ACTINOBACTERIA AND CHARACTERIZATION OF THE MOST POTENT ISOLATES
Three marine soil samples collected at various seashores of the Bay of Bengal near Chirala Coast of Andhra Pradesh were screened for the isolation of lipolytic Actinobacteria by tributyrin agar clearing method. The isolates were cultured under submerged fermentation conditions and assayed for their extra cellular lipase producing capabilities using olive oil as substrate. Enzyme profiling of the s...
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SIMULTANEOUS ESTIMATION OF HYDROCHLOROTHIAZIDE, AMLODIPINE BESYLATE AND TELMISARTAN IN COMBINED TABLET DOSAGE FORM BY USING RP- HPLC METHOD
A simple, selective, rapid, precise reverse phase high pressure liquid chromatographic method has been developed for the simultaneous estimation of Hydrochlorothiazide, Amlodipine besylate and Telmisartan in tablet dosage form as per ICH guidelines. The wavelength selected for the analysis was 239 nm for amlodipine besylate, telmisartan and hydrochlorothiazide. The solvents used were methanol and ...
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ANTIMICROBIAL ACTIVITIES OF PHARMACOLOGICAL AND ANTIOXIDANT COMPOUNDS OF SOME EDIBLE MUSHROOMS AGAINST BRUCELLA SPP.
Although there are numerous studies on antimicrobial activities of mushrooms against many common pathogenic microorganisms, there is hardly any study against Brucella spp., responsible for brucellosis in animals and human beings throughout the globe. The present study was aimed to evaluate the in vitro antimicrobial activities of ethanol extracts of five edible mushrooms namely, Pleurotus ostreatu...
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VIRTUAL SCREENING, SYNTHESIS OF NEWER HETEROCYCLES AS PPAR γ AGONISTS WITH ANTIDIABETIC ACTIVITY
Recent decades have experienced a sharp increase in the incidence and prevalence of diabetes mellitus. The major therapeutic approach is to diabetes is to reduce gastrointestinal glucose production and absorption through the inhibition of carbohydrate digesting enzymes such as α-amylase and α-glucosidase. The agonists of PPAR γ is of great interest to the pharmaceutical industry since they regu...
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EXPERIMENTAL DESIGN BASED OPTIMIZATION OF HPLC METHOD FOR DETERMINATION OF BLONANSERIN IN IN-VITRO HUMAN SERUM SAMPLE, FORCED DEGRADED SAMPLE AND PHARMACEUTICAL FORMULATIONS
Paper presents a novel high performance liquid chromatography method development, optimization, validation and application of determining blonanserin in bulk drug, its formulation, human serum and in the presence of its degradation products. Selection of important factors which may influence separation were concluded: percentage of acetonitrile in the mobile phase, the percentage of orthophosphori...
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