Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
REVERSED-PHASE LIQUID CHROMATOGRAPHY WITH MASS DETECTION AND NMR CHARACTERIZATION OF SITAGLIPTIN DEGRADATION RELATED IMPURITIES
The current work on impurity profiling of Sitagliptin in its bulk drugs, included development of a stability- indicating reverse-phased liquid chromatographic method and its validation for the estimation of degradation related impurities (DRIs). Sitagliptin was subjected to acid and alkaline hydrolysis, H2O2 oxidation, thermal degradation and photolysis. Acid hydrolysis and H2O2 oxidation yielded ...
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MOLECULAR MARKERS FOR CAPECITABINE THERAPY: A REVIEW
Capecitabine an oral prodrug of 5- fluorouracil is widely used for the treatment of variety of solid tumors, particularly colorectal cancer. However it is not devoid of toxicities and may limit therapy. A little is known about predictors of toxicity, response and survival in patients treated with capecitabine. The pharmacogenetic testing methods can identify such variants and thus indicate those p...
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SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEW PYRAZOLE DERIVATIVES
The synthesis of a novel of pyrazole derivatives was achieved by condensation of acetyl furan with phenyl hydrazine to give hydrazone (1) On the other hand, cyclization of α, β-unsaturated ketone. Using Vilsmeier reagent by DMF (dimethylformamid) and POCl3 Phosphorusoxychloride) to give compound (2). The chemical structures of allnew compounds were established by IR, ¹HNMR, and mass spectra dat...
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EVALUATION OF ANTI-DIABETIC AND HEAPATOPROTECTIVITY OF CORIANDRUM SATIVUM IN ALLOXAN INDUCED EXPERIMENTAL ANIMALS: A HISTOPATHOLOGY STUDY
Objective: Diabetes mellitus is metabolic disorder and day by day number of people increased across the world. The aim of the present study was to evaluate the antidiabetic and heapatoprotectivity of ethanolic extracts of Coriandrum sativum in alloxan induced diabetic rat and find out the harmonious activity of the extract. Methods: The alloxan (150 mg/kg, i.p) used for induction of diabetes after...
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DEVELOPMENT OF VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF IRBESARTAN IN BULK AND PHARMACEUTICAL DOSAGE FORMS
A stability indicating RP-HPLC method was developed and validated for the determination of Irbesartan in bulk and dosage forms using Telmisartan (10 μg/ml) as the internal standard. An Inert ODS C-18, 5μm column having 250 x 4.6mm internal diameter in isocratic mode with mobile phase containing methanol: water (90:10) and the pH was adjusted to 3 with 1 % GAA. The flow rate was 1 ml/min and effl...
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STUDY OF ORAL HYPOGLYCEMIC ACTIVITY OF RHIZOMES OF HEMIDESMUS INDICUS R. Br. IN ALBINO WISTAR RATS
The present study was carried out to evaluate oral hypoglycemic activity of rhizome of Hemidesmus indicus R.Br. in Albino wistar rats. Hemidesmus indicus (Family: Asclepiadaceae) is a commonly known Indian Medicinal Plant. It contains various phytoconstituents like hemidesminine, hemidine, hemidesmin-1 and hemidesmin-2 and other chemical constituents like glycosides, flavonoids, tannins, sterols a...
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SCREENING OF PHYTOCHEMICAL AND IN-VITRO ANTIOXIDANT PROPERTY OF A POLYHERBAL FORMULATION
Herbal plants produce a diverse range of bioactive molecules, making them a rich source of different types of medicines. Thus, a proper scientific evidence or assessment has become the criteria for acceptance of herbal health claims. As such developing a polyherbal formulation will definitely produce synergistic effect as needed comparable to standard drugs that are available in market all over th...
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EFFECT OF MEDICINAL PLANT EXTRACTS ON THE ANTIMICROBIAL ACTIVITY OF AMOXYCLAVE AND ERYTHROMYCIN AGAINST E. COLI AND S. AUREUS
Development of microbial resistance leads new drug discovery, modification of antibiotics, administration of two or more antibiotics, use of traditional medicinal plants and their combinations with antibiotics. In the present study, 72 medicinal plants extracts were screened to potentiate the antimicrobial with erythromycin and amoxyclave. Among all the medicinal plant, Colebrookea oppositifolia w...
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COMPARATIVE STUDY OF THE ESTIMATION OF LDL CHOLESTEROL BY THE DIRECT METHOD AND FRIEDEWALD EQUATION IN SECONDARY HYPERLIPIDEMIA
The objective of the study is to measure the difference between the levels of LDL by Direct method versus Friedewald equation. The study includes 30 patients and 30 controls in the age of 25 – 75 years of both sexes. Fasting blood samples were collected and estimated Total Cholesterol (TC), Triglycerides (TG), Low Density Lipoprotein (LDL-C) cholesterol and High density lipoprotein (HDL) cholest...
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ANTI OBESITY ACTIVITY AND BENEFICIAL EFFECTS OF METHANOLIC EXTRACT OF DESMOSTACHYA BIPINNATA IN HFD AND PROGESTERONE INDUCED OBESITY IN RATS AND MICE
Obesity is very serious and concerned problem these days. From the first human civilization, research is going to find the drugs to treat obesity and its complications. Despite availability of many drugs in market to treat obesity, no single drug is ideal for treating all sorts of problems caused by obesity. So the research is going on finding perfect drug. Prior going to evaluating drugs on hum...
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