DUAL ROLE OF ARJUNOLIC ACID AND B12 IN MITIGATING SODIUM ARSENITE INDUCED MALFUNCTION OF FEMALE REPRODUCTIVE ORGANS
The present study was proposed to delineate the curative role of arjunolic acid and vitamin B12 alone or in combination against arsenic induced oxidative stress and female reproductive dysfunction. The Wistar strain adult female rats were treated with sodium arsenite at the dose of 1.0 mg/100 gm body weight orally for first eight days. Next eight days rats were treated with arjunolic acid (1.0 mg/...
ETHNOMEDICINAL PLANTS AND THEIR CONTRIBUTION TO CURE VARIOUS AILMENTS AS HOUSEHOLD REMEDIES IN GARHWAL HIMALAYA, INDIA
The present investigation was carried out in five villages of the marginalized hill area block of Dewal in Chamoli district, regarding the uses of mild and native ethno-medicinal plants, by locals in their traditional health care system. The people residing in this area have been in isolation for centuries and possess good knowledge of phytotherapy. A total of 51 species of medicinal plants (both ...
SYNTHESIS AND ANTIBACTERIAL SCREENING OF SCHIFF BASES DERIVED FROM 3-(5-BROMOTHIOPHEN-2-YL)-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
A series of new Schiff bases were synthesized by condensation of 3-(5-bromothiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde with different aromatic aldehydes. The 3-(5-bromothiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde was prepared from 1-(1-(5-bromothiophen-2-yl)ethylidene)-2-(4-chlorophenyl)hydrazine by the Vilsmeier Haack reaction. The 1-(1-(5-bromothiophen-2-yl)ethyl...
EFFICIENT GENOMIC DNA EXTRACTION AND MOLECULAR ANALYSIS OF MEDICINALLY RICH VALERIANA JATAMANSI DRY ROOTS
One of the major problems faced by the pharmaceutical industry is to maintain the quality and efficacy of herbal drugs due to the lack of purity of herbal raw materials. Furthermore, using traditional identification methods to identify the correct plant part needed for the preparation of herbal medicine can be difficult. Creating a novel system to assess the quality of a medicinal herb and to disc...
To evaluate phytochemical constituents and antioxidant potential of aqueous and hydroalcoholic extracts of root of Mentha arvensis L from Kashmir region. The antioxidant activity of aqueous and hydroalcoholic extracts of Mentha arvensis L was evaluated by using 1, 1-diphenyl, 2-picrylhydrazyl (DPPH) scavenging, reducing power, metal chelating, hydrogen peroxide scavenging and nitrous oxide scave...
ASSESSMENT OF PHARMACEUTICAL QUALITY CONTROL AND IN VITRO EQUIVALENCE OF VARIOUS BRANDS OF ATENOLOL (100MG) TABLETS AVAILABLE IN SUDANESE MARKET UNDER BIOWAIVER CONDITIONS.
As Atenolol is one of the first choice medications in the management of hypertension in Sudan, it was very important to carry out post authorization safety studies on some of the brands commercially available on the market. The pharmaceutical equivalence of three Atenolol 100 mg tablets was evaluated using official and non-official standards according to US Pharmacopoeia including weight variation...
STABILITY INDICATING GREEN ANALYTICAL GAS CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF DIPHENHYDRAMINE IN PURE AND MARKETED FORMULATIONS
The current work defines development of a simple, rapid and precise method based on gas chromatography coupled with Flame Ionization Detector (GC-FID) for the quantitative estimation of diphenhydramine (DPH) present in the marketed formulations following the principles of green analytical chemistry. The analysis was performed using Zebron Phase: ZB-DRUG-1 column with Nitrogen as a carrier gas havi...
Background: Oleogel is a thermo-reversible, viscoelastic, semi-solid self-assembled preparation in which an apolar phase gets immobilized within a 3-D networked structure formed via physical or chemical interaction with different organogelators. Objective: The objective of the present investigation was to develop drug-loaded (paracetamol) Span 40 / Tween 80-based soybean oleogels for topical appli...
EARLY PREDICTION OF CISPLATIN NEPHROTOXICITY IN HEAD AND NECK CANCER PATIENTS – AN EVALUATION WITH URINARY BIOMARKERS
Background: Nephrotoxic Acute Kidney Injury (AKI) is a common condition associated with considerable morbidity and mortality. Acute exposure to potentially nephrotoxic drugs requires early appraisal of the extent of renal injury to determine the need for specific interventions. Hence this study was designed to evaluate two urinary biomarkers for the early diagnosis of AKI due to cisplatin chemothe...
AN ANALYTICAL STUDY ON THE CLINICAL EFFICACY OF PEENISA PUGAI TOWARDS THE MANAGEMENT OF PEENISAM (SINUSITIS)
Pugai (fumigation) is one among the external medicines in treating a variety of diseases with the fumes of herbs or aromatic substance. Peenisa pugai is an external therapeutic measure that has been indicated in Siddha literature for the effective management of Peenisam that can be symptomatically correlated with that of Sinusitis. The aim of the present Pilot study was to compare the efficacy of ...