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A COMPARATIVE RETROSPECTIVE AND PROSPECTIVE ANALYSIS OF EMERGING RESISTANCE IN EMPIRICAL ANTIBIOTIC TREATMENT AMONG LIVER CIRRHOSIS PATIENTS WITH SPONTANEOUS BACTERIAL PERITONITIS: AN INTERVENTIONAL STUDY IN A TERTIARY CARE HOSPITAL
Background: Previous hospitalization, nosocomial infection and specific risk factors like prolonged quinolone use for Spontaneous Bacterial Peritonitis prophylaxis can be related to drug-resistant bacterial infections and high mortality in liver cirrhosis. Aim and Objectives: To study the prescription pattern of antibiotics used in SBP, compare the efficacy and emerging resistance of antibiotics, ...
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FORMULATION DEVELOPMENT AND IN-VIVO RADIOGRAPHIC STUDIES OF DILTIAZEM HYDROCHLORIDE LOADED FLOATING CAPSULES PREPARED BY MODIFIED PULSINCAP TECHNOLOGY
Oral extended release formulation with site-specific drug delivery formulations has been of greater importance in the field of drug delivery system to achieve adequate therapeutic results. The concept of novel gastro-retentive drug delivery system aroused due to site specificity behavior of the drug concerning drug absorption and solubility. The objective of the research work is to develop and eva...
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DESIGN AND CHARACTERIZATION OF CHRONOPHARMACEUTICAL DRUG DELIVERY OF PROPRANOLOL HYDROCHLORIDE
Objectives: In the present study, an effort was made to develop a novel pulsatile dosage form for the treatment of hypertension using Propranolol hydrochloride as a model drug. A time-delayed capsule was prepared by sealing the pellets inside the insoluble hard gelatin capsule body with an erodible hydrogel plug. Methods: The pellets were prepared by the Fluidized Bed Wurster (bottom spray) techni...
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ANALGESIC ACTIVITY AND PHYTOCHEMICAL PROFILE OF AQUEOUS, ETHANOL AND DICHLOROMETHANE EXTRACTS OF PERSEA SCHIEDEANA LEAVES
Traditionally Persea schiedeana is used for headache relief, as anti-hypertensive, nervous relaxant, dermal diseases, among others. In this study, this plant from Salvadorian flora acute toxicity was evaluated in-vivo at 500 mg/kg, and the analgesic activity was tested by acetic acid, formalin, and tail flick tests in NIH Swiss mice at doses of 100, 250, and 500 mg/kg body weight, using as a posit...
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ADVERSE DRUG REACTION MONITORING AMONGST DIABETIC PATIENTS OF TERTIARY CARE CENTRE OF NORTHERN INDIA RELATED TO ANTI-DIABETIC DRUGS
Diabetes mellitus caused by inherited and/or acquired deficiency in insulin production or by the development of insulin resistance. This is chronic as well as moderately increasing day by day in developing countries as well as globally and has reached about to the epidemic ratio, and now it is a matter of worry for the populations. This deficiency results in increased blood glucose concentrations,...
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ANTIOXIDANT AND ANTI-DIABETIC POTENTIAL OF OPERCULINA TURPETHUM (L.) SILVA MANSO LEAF
‘Natural curing agents for diabetes’ is a matter of world research. Diabetes, the gift of altered life pattern, affected considerably larger proportion of world population. Ancient Indian literature has the treasure of knowledge regarding natural curing agents. The plant Operculina turpethum (Convolvulaceae) is one among them. The plant root is used in many Ayurvedic formulations to treat vari...
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MICROWAVE INDUCED SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG SIMVASTATIN USING POLOXAMER 188 BY MICROWAVE IRRADIATION METHOD
To increase the solubility of poorly water-soluble drug simvastatin using hydrophilic carrier poloxamer 188 using solid dispersion techniques by microwave irradiation method. The microwave irradiation technique was used to prepare solid dispersions in minimum time interval in different drug carrier ratios, i.e. 1:2, 1:5, 1:8 and was subjected to microwave for different times, i.e. 3 min, 5 min, an...
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IN-VIVO EFFECT OF WITHACOAGULIN AND COAGULIN C ISOLATED FROM WITHANIA COAGULANS DUNAL FRUITS ON BLOOD PRESSURE OF ALBINO RATS
The present study was designed to evaluate the in vivo effect of withacoagulin and coagulin C isolated from Withania coagulans Dunal fruits on blood pressure of albino rats. DOCA (10 mg/kg; i.p.) along with diet high in sodium chloride salt was used to induce hypertension in rats. Comparative effects of withacoagulin and coagulin C isolated from Withania coagulans Dunal fruits were observed. Femal...
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ATTENUATION OF QUORUM SENSING ASSOCIATED VIRULENCE FACTORS AND BIOFILM FORMATION IN PSEUDOMONAS AERUGINOSA PAO1 BY PHOMA MULTI-ROSTRATA PUTY3, A SAPROPHYTIC FUNGUS, ISOLATED FROM CARICA PAPAYA
Pseudomonas aeruginosa is one of the most emerging multidrug-resistant opportunistic pathogens, which poses a threat to immunocompromised patients. Treatment of P. aeruginosa in the affected patients has become difficult because of its ability to develop resistant strains against most of the conventional therapeutic antibiotics. Quorum sensing plays a crucial role in the virulence nature of P. aer...
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PREFORMULATION, FORMULATION DEVELOPMENT AND DRUG RELEASE STUDIES OF CLOPIDOGREL BISULPHATE FLOATING MICROBALLOONS
Multi particulate systems are of greater importance than the single unit dosage forms in oral drug delivery. Floating micro balloons are among the best methods to increase gastric retention among all the multi particulate drug delivery systems. They offer more reproducible drug absorption, reduce the risk of local irritation and improve the bioavailability of the drug. In the current research work...
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