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CANAGLIFLOZIN SILICA LIPID HYBRID PARTICLES FOR IMPROVED SOLUBILITY AND DISSOLUTION
Silica lipid-hybrid formulations have gained an increased interest in recent times as a means to enhance the solubility as well as dissolution of poorly water-soluble lipophilic drugs. The objective of the present investigation was to design and optimize silica lipid hybrid particles of Canagliflozin to improve its solubility. Canagliflozin is an antidiabetic drug used to improve glycaemic control...
2938
2044
ANALYSIS OF BIOACTIVE COMPOUNDS PRESENT IN METHANOLIC EXTRACT OF PHYMATOSORUS SCOLOPENDRIA (BURM. F.) PIC. SERM. THROUGH GAS CHROMATOGRAPHY AND MASS SPECTROSCOPY
Phymatosorus scolopendria (Burm. F.) Pic. Serm. belongs to the family Polypodiaceae which is commonly known as musk-fern or wart-fern. Medicinally, the experimental plant possesses insect repellent, anti-inflammatory and bronchodilator activity and hence used ethnomedicinally by tribal people, but was not explored for its bioactive compounds. Hence, the objective of this study was to determine the...
2936
1996
IN-VITRO ANTI-CANCER ACTIVITY OF TWO BRITTLE STAR SPECIES: OPHIOCOMA ERINACEUS AND OPHIOMASTRIX ANNULOSA
Marine organisms are excellent sources of structurally diverse molecules that are potentially valuable as drugs. The brittle starfish was shown to contain the bioactive components which exhibit various biological activities including cytotoxicity effects. Hence, the present study was carried out to determine the cytotoxicity of the extracts of two different starfish species like Ophiocoma erinaceu...
2934
1320
NANOEMULSION: A SNAPSHOT ON DEVELOPMENT, CHARACTERIZATION, APPLICATIONS, PATENTS AND CLINICAL TRIALS
Nanoemulsionis a special case of emulsion. It is nano-sized emulsion used as a carrier. It has the ability to deliver the drug to the target site. It is a good vehicle for the controlled delivery of the drug. It is prepared by the high energy and low energy emulsification method. Emulsifier plays an important role in stabilizing the nanoemulsion. It is anisotropic and thermo-dynamically stable sys...
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1632
SYNTHESIS AND CHARACTERIZATION OF 6 – HYDROXY – 3, 4 -DIHYDROQUINOLINONE CILOSTAZOL IMPURITY-A AS PER INDIAN PHARMACOPOEIA
Impurity profile study is critical for getting market approval of finished dosage forms from regulatory authorities. There are many manufacturing firms (small and medium scale) in India that they cannot afford the high priced USP reference standards for analysis. So, the availability of cheaper affordable IP reference standards will help them adhere to quality guidelines for active pharmaceutical ...
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2538
RECENT ADVANCEMENT IN THE DEVELOPMENT OF THERAPEUTIC PEPTIDES
Peptides are naturally occurring biologics, which provide essential functions as hormones, growth factors, biological messengers, anti-infective, neurotransmitters, and antimicrobials. Peptide hormones such as insulin, vasopressin, oxytocin, and gonadotropin-releasing hormone have significantly accelerated advances in modern drug development fields, including biology, chemistry, pharmacology, and ...
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12791
PHARMACOLOGICAL EFFECTS OF VITIS VINIFERA SUBSP. VINIFERA: A REVIEW
Grapes are one of the most widely grown fruits and have been used for winemaking since the ancient Greek and Roman civilizations. Grapes are rich in proanthocyanidins which have been shown to possess potent free radical scavenging activity. Grape seeds are a complex matrix containing 40% fiber, 16% oil, 11% proteins, and 7% complex phenols such as tannins, in addition to abundant quantities of gal...
2932
1397
EVALUATION OF EFFECT OF AYURVEDIC PREPARATIONS ON NEPHROPATHY IN DIABETIC WISTAR RATS
Introduction: Type 2 diabetes, which is the most common type, is often a result of excess body weight and physical inactivity in genetically predisposed individuals. Over due course of time diabetes can cause blindness, kidney damage, neurological problems, and coronary artery disease. Improvement in glycemic control is important factors in delaying the onset and progression of diabetes-related co...
2932
1250
A REPRODUCTIVE AND DEVELOPMENTAL STUDY FOLLOWING 28 DAYS REPEATED ORAL EXPOSURE OF LEAVES OF PTEROSPERMUM ACERIFOLIUM (L.) WILLD IN WISTAR ALBINO RATS
The present study was aimed to evaluate the effects of repeated administration of methanolic leaf extract of Pterospermum acerifolium Linn. Willd. (MEPA) on the reproductive system of male and female Wistar albino rats and its developmental effects on subsequent generation. MEPA was administered to Wistar albino rats by gavage for 28 days repeatedly at doses of 250, 500 and 1000 mg/kg body weight,...
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1351
DEVELOPMENT OF TOPICAL NAIL LACQUER FORMULATION FOR THE MANAGEMENT OF ONYCHOMYCOSIS
Nail plate being a formidable barrier, drug permeation through this layer is limited. Taking this as a challenging task, the present study focuses on the formulation of an antifungal topical nail lacquer using Oxiconazole nitrate. The novelty of the studies can be stated as the use of a combination of permeation enhancers like salicylic acid, thioglycolic acid, and urea for effective therapeutic t...
2931
1898