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SCREENING OF TERATOGENICITY OF THE MARINE ALGA SYMPHYOCLADIA LATIUSCULA
Objective: To explore the Teratogenicity of isolated Polyphenols of Symphyocladia latiuscula (PSL) on pregnant female rats. Experimental Design: The marine alga Symphyocladia latiuscula were the preparation of methanolic extract followed by isolation of Polyphenols. The Teratogenic study was performed according to the OECD guidelines, no 415. And the test drug; PSL 100, 200 and 1000 mg/kg and posi...
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FORMULATION AND EVALUATION OF LANSOPRAZOLE AND DOMPERIDONE MOUTH DISSOLVING TABLETS
Lansoprazole and Domperidone, used as Proton pump inhibitor and antiemetic agents, especially for disease related to gastric ulcer. The purpose of the research was to improve aqueous solubility of drugs by β-CD using a different method, and perform phase solubility study of both drugs using β-CD and calculate Ks, and ∆Gt. Prepare Complex of LAN and DOM with β-CD using different methods like p...
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AN UPDATE ON BIOLEACHING TECHNOLOGY: IRON BACTERIA AS A SOURCE OF OXIDIZING IRON TRACES FROM WATER SAMPLES
The removal of metals by the use of microbes is known as bioleaching in terms of oxidation or degradation of metal from complex raw materials or depots. Such microbial oxidation or bio-removal occurs in terms of sulphur degradation and oxidation (for example, sulphur oxidation, iron oxidation etc.). This process is thus known as bioleaching, which is related to the all metal oxidation processes li...
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IN-VIVO PHARMACOKINETIC EVALUATION OF PIOGLITAZONE – HPMC K 15 M FLOATING TABLETS
The objective of the study is to make a pharmacokinetic evaluation of Pioglitazone floating tablets formulated employing HPMC K 15 M in comparison to Pioglitazone pure drug in rabbits. The two products were tested in a crossover RBD in healthy rabbits of either sex (n=6). The plasma concentrations of Pioglitazone were determined by a validated HPLC method. From the time versus plasma concentration...
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PHARMACOLOGICAL EVALUATION OF THE IN-VIVO ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF THE ESSENTIAL OIL FROM CYMBOPOGON OLIVIERI (BOISS.) BOR.
Cymbopogon olivieri (Poaceae) is a native plant to the south of Iran and is used for the treatment of some inflammative based disorders and as a pain killer. Regarding the presence of volatile terpenoids in the aerial parts, we were prompted to investigate the analgesic and anti-inflammatory activities of the essential oil from C. olivieri in animal models. The oil was also analyzed by GC and GCâ€...
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STUDY OF EFFECT OF INSULIN ON COGNITIVE FUNCTION IN DIABETES MELLITUS IN A TERTIARY CARE HOSPITAL
Diabetes Mellitus is a major lifestyle metabolic disorder and doubtlessly a challenging public health problem of the 21st century. Diabetes is associated with reduced performance on various domains of cognitive function, this study was aimed to access the effect of insulin on cognitive function in patients of Diabetes Mellitus. It was a prospective, observational and non-interventional study. 60 c...
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STEADY SHEAR AND DYNAMIC SHEAR RHEOLOGICAL PROPERTIES OF CARBOXYMETHYL LOCUST BEAN GUM INFLUENCING EROSION OF THE POLYSACCHARIDE COAT OF COMPRESSION COATED TABLETS
Pulsatile drug delivery is one such system thereby delivering drug at the right time, right place and in right amounts and holds good promises and provides benefit to the patients suffering from chronic problems like arthritis, asthma, hypertension, etc. The present study investigated that optimization of quinapril hydrochloride was successfully done and batch A8 was given satisfactory results. Ta...
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IN-VITRO EVALUATION OF ANTIOXIDANT ACTIVITIES OF OLDENLANDIA CORYMBOSA L. (SYN. HEDYOTIS CORYMBOSA) FRACTIONATED EXTRACTS IN VARIOUS SOLVENTS
Antioxidants are the substance having the potential to quench free radicals and significantly delay or inhibit oxidation of the substrate, thus protect biological systems against potentially harmful effects of free radicals; in low concentrations. The present study was aimed to evaluate the in-vitro antioxidant activity of Oldenlandia corymbosa L., a locally available medicinal plant of Assam, use...
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AN ACUTE ORAL TOXICITY STUDY OF T-AYU-HM PREMIUM TABLET IN RATS: AN INITIATIVE FOR SICKLE CELL ANEMIA MANAGEMENT
Sickle cell anemia is a major life-threatening hemoglobin disorder in the world. This hemoglobin disorder is an autosomal recessive type, therefore considered as a major health problem in the world. The pain symptoms and complications of sickle cell anemia can be life-threatening many times. Management of sickle cell anemia demands drugs to be safe, well-tolerated, lesser side effects, and effecti...
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FORMULATION, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY EVALUATION OF COLLAGEN BASED SILVER NANOPARTICLE
Nanoparticles are widely used in different technological fields, one of which is medicine. Collagen is used in several types of wound dressing. A silver nanoparticle is used as an antimicrobial agent to reduce microbial infection. In this research work, we have synthesized silver nanoparticles with collagen and studied for antibacterial activity against aureus (S. aureus), Escherichia coli (E. col...
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