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DEVELOPMENT OF TOPICAL NAIL LACQUER FORMULATION FOR THE MANAGEMENT OF ONYCHOMYCOSIS
Nail plate being a formidable barrier, drug permeation through this layer is limited. Taking this as a challenging task, the present study focuses on the formulation of an antifungal topical nail lacquer using Oxiconazole nitrate. The novelty of the studies can be stated as the use of a combination of permeation enhancers like salicylic acid, thioglycolic acid, and urea for effective therapeutic t...
2985
1935
ANALGESIC ACTIVITY AND PHYTOCHEMICAL PROFILE OF AQUEOUS, ETHANOL AND DICHLOROMETHANE EXTRACTS OF PERSEA SCHIEDEANA LEAVES
Traditionally Persea schiedeana is used for headache relief, as anti-hypertensive, nervous relaxant, dermal diseases, among others. In this study, this plant from Salvadorian flora acute toxicity was evaluated in-vivo at 500 mg/kg, and the analgesic activity was tested by acetic acid, formalin, and tail flick tests in NIH Swiss mice at doses of 100, 250, and 500 mg/kg body weight, using as a posit...
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1298
IN-VITRO ANTI-CANCER ACTIVITY OF TWO BRITTLE STAR SPECIES: OPHIOCOMA ERINACEUS AND OPHIOMASTRIX ANNULOSA
Marine organisms are excellent sources of structurally diverse molecules that are potentially valuable as drugs. The brittle starfish was shown to contain the bioactive components which exhibit various biological activities including cytotoxicity effects. Hence, the present study was carried out to determine the cytotoxicity of the extracts of two different starfish species like Ophiocoma erinaceu...
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1347
CYANOBACTERIA ASSISTED BIO-REDUCTION OF SILVER NANOPARTICLE CONJUGATES AND STUDY ON THEIR CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY AGAINST PATHOGENIC BACTERIA
Green nanotechnology has recently emerged as an area of research involving more eco-friendly and energy-efficient approaches for the synthesis of inorganic nanoparticles. The point of the present investigation is to evaluate the capacity of selected strains of freshwater Cyanobacteria (Microalgae) for their capability to biosynthesize silver nanoparticles by utilizing both live biomass of microalg...
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1397
IN-VIVO EFFECT OF WITHACOAGULIN AND COAGULIN C ISOLATED FROM WITHANIA COAGULANS DUNAL FRUITS ON BLOOD PRESSURE OF ALBINO RATS
The present study was designed to evaluate the in vivo effect of withacoagulin and coagulin C isolated from Withania coagulans Dunal fruits on blood pressure of albino rats. DOCA (10 mg/kg; i.p.) along with diet high in sodium chloride salt was used to induce hypertension in rats. Comparative effects of withacoagulin and coagulin C isolated from Withania coagulans Dunal fruits were observed. Femal...
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1295
A BRIEF REVIEW ON SLEEP PARALYSIS: MANAGEMENT AND TREATMENT
The brain alternates between wakefulness, nonrapid eye movement (NREM) sleep and rapid eye movement (REM) sleep during sleep. Sleepwalking, sleep terrors, sleepwalking and sleep paralysis are common examples of the behavioral manifestations linked with parasomnias or partial arousals from sleep. Sleep Paralysis is a condition in which someone lying supine position, about drop off to sleep or just ...
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1197
A COMPREHENSIVE INSIGHT INTO ARTIFICIAL BLOOD
In hospitals, blood transfusions are a common occurrence. Because blood-related products are limited and have a range of adverse side effects, researchers have worked on artificial blood components for nearly 40 years. It is crucial to develop effective and selective alternatives for natural blood products. Artificial blood is a useful idea in transfusion medicine wherein clearly defined compounds...
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1507
DEVELOPMENT OF OSMOTIC CONTROLLED RELEASE FORMULATION OF AN ANTIDIABETIC DRUG METFORMIN HYDROCHLORIDE
Osmotic tablets have emerged as a new technology for the delivery of drugs whose release rate is to be controlled. These tablets offer controlled drug release with the help of certain osmogens and also provide zero-order rate kinetics. In the present study, we have developed an osmotic tablet of Metformin Hydrochloride (HCL) to enhance its oral bioavailability. Metformin HCL is a biguanide derivat...
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1671
EVALUATION OF TRIDAX PROCUMBENS LEAF EXTRACT LOADED PVA FILM FOR WOUND HEALING APPLICATION
Wounds are a severe health problem. The development of pharmaceutical dosage forms to ensure patient comfort and safety and optimize treatment effectiveness is of great interest to the pharmaceutical and biomaterials industries. Tridax procumbens (T. procumbens) leaf is a medicinal herb used for treating wounds since ancient times. In this work, a biomaterial film was developed by using PVA with T...
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1546
FORMULATION DEVELOPMENT AND IN-VIVO RADIOGRAPHIC STUDIES OF DILTIAZEM HYDROCHLORIDE LOADED FLOATING CAPSULES PREPARED BY MODIFIED PULSINCAP TECHNOLOGY
Oral extended release formulation with site-specific drug delivery formulations has been of greater importance in the field of drug delivery system to achieve adequate therapeutic results. The concept of novel gastro-retentive drug delivery system aroused due to site specificity behavior of the drug concerning drug absorption and solubility. The objective of the research work is to develop and eva...
2980
1931