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SYNTHESIS OF NOVEL SCHIFF’S BASES AND THEIR BIOLOGICAL ACTIVITIES
A new series of Schiff's base compounds were synthesized by condensation of 1-(4-amino-4 phenyl) 3-phenyl triazene-1-ol) and substituted aldehyde and gave high yields of target compounds. Antimicrobial activity of compounds has been tested against bacterial and fungal species, namely gram-positive bacteria as S. aureus and S. pyogenes, gram-negative bacteria as E. coli and P. aeruginosa, and funga...
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EXPLORING THE ANTIOXIDANT POTENTIAL OF FLAVANONES IN STROBILANTHES HAMILTONIANA (STEUD.) BOSSER & HEINE: A COMBINED QUANTUM MECHANICAL, MOLECULAR DOCKING, AND BIOCHEMICAL ASSAY APPROACH
Strobilanthes hamiltoniana (Paalkurinji), a perennial herb of the Acanthaceae family, has traditional use in treating ulcers, diabetes, arthritis, and wounds. S. hamiltoniana leaves were extracted using ethanol, chloroform, and water, and screened for phytochemicals using standard protocols. LC-MS analysis was used to identify flavonoids. Antioxidant activity was evaluated via DPPH, HRS, and FRA...
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HYDROXYAPATITE AND Zn-HYDROXYAPATITE SYNTHESIS USING CALCIUM FROM LAKE MANINJAU PENSI SHELLS AND RESISTANCE TEST ON BACTERIA
HAp and Zn-HAp Synthesis with several concentrations of Zn (5%, 10%, 15%, and 20%) w/w using Ca precursor from Maninjau Lake pensi shells was done with the sol-gel method. XRF for three hours obtained 96.525% Ca content in the form of CaO. XRD result for the synthesized samples showed the same diffraction pattern as the standard HAp (ICSD: 154493) phase which the intensity decreases with the addit...
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DEVELOPMENT OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF AMOXICILLIN AND CARBOCISTEINE IN SOLID DOSAGE FORM BY RP-HPLC
Pharmaceutical analysis is the application of principles of analytical chemistry to drug analysis. The analytical chemistry is the science of developing accurate, precise, and sensitive methods for determining the composition of materials in terms of elements or compounds which they contain. Quality means confirming specifications and standards, and it is never an accident; it is a result of intel...
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HYDROPHILIC AND HYDROPHOBIC MATRIX SYSTEM ENGINEERED DEVELOPMENT OF EXTENDED-RELEASE TABLETS OF OXYBUTYNIN CHLORIDE
The present aim study is the formulation development and evaluation of extended-release matrix tablets of oxybutynin chloride by using hydrophilic and hydrophobic matrix systems. The pilot-scale batches of nine formulations were prepared using Eudragit RSPO, Eudragit RLPO, Carbopol 971NF, ethylcellulose individually, and in the combination of above polymer and Avicel PH102 by adopting direct compr...
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HYPOGLYCEMIC EFFECTS OF LUFFA ACUTANGULA (L.) ROXB. FRUIT EXTRACT IN NORMAL AND STREPTOZOTOCIN-INDUCED DIABETIC RATS
Luffa acutangula (L.) Roxb. (Family: Cucurbitaceae) has been used in the folkloric Indian medicinal system to treat numerous health conditions. The fruits of the plant have been used in dysentery, jaundice, diabetes, hemorrhoids, leprosy, and ringworm infection. The present study aimed to establish the hypoglycemic effect of the aqueous fruit extracts of Luffa acutangula was investigated in normal...
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REVIEW ON ROLE OF NUTRACEUTICALS IN STRESS MANAGEMENT
Stress is a complicated process that affects everyone differently. When the body is exposed to stressors, it initiates a series of coordinated responses called "stress responses," which include behavioral changes, immunological regulation, hormone release, and various physiological changes. Stress is the physiological response to risk or pressure, and it displays physically as fatigue or energy lo...
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A COMPARATIVE SOLUBILITY ENHANCEMENT AND DISSOLUTION STUDY OF RANOLAZINE USING DIFFERENT TECHNIQUES
The aim of the present study was to enhance the solubility of the poorly soluble drug Ranolazine. Solid dispersions were prepared using PVP K-30 and PEG 4000 & 6000 by melting, solvent evaporation using varying polymer ratios (1:1, 1:2, 1:3, 1:4). The prepared formulations were characterized for saturation solubility, IR, PXRD, SEM. The aqueous solubility of Ranolazine was favored by the prese...
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IMPLEMENTATION OF FRACTION OF DESIGN SPACE TO ASSESS PREDICTION CAPABILITY OF RESPONSE SURFACE DESIGN TO OPTIMIZE MODIFIED RELEASE TABLETS OF HYDROCHLOROTHIAZIDE
Selecting the best possible design is an uphill task considering a lot of criteria which must be scrutinized while choosing any design out of many alternative design options available. The experimental design is often compared and selected based on alphabetical design optimality criteria, like A, D, G or V. Each of them attempts to summarize any one important characteristic of the selected design....
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ANTILITHIATIC ACTIVITY OF ETHANOLIC LEAVES EXTRACT OF DALBERGIA SISSOO LINN. ETHYLENE GLYCOL INDUCED LITHIASIS IN RATS
Aim of the Study: The aim of this study was to investigate the antilithiatic activity of ethanolic leaves extract of Dalbergia sissoo Linn. ethylene glycol induced in rats. Materials and Methods: All the chemicals were analytical grade. Cystone was obtained from from Himalaya Health Care Ltd. The ethanolic extract of plant Dalbergia sissoo Linn. leaves were given with tween 80 as vehicle administe...
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