Most Popular
ISOLATION AND CHARACTERIZATION OF THE CHEMICAL CONSTITUENTS OF STELLARIA MEDIA LINN.
The studies on the constituents of aerial parts of Stellaria media Linn. (Caryophyllaceae) have led to the isolation and characterization of three new compounds ─ (1), (2) and (3). Structure elucidation of the new compounds was carried out using 1H NMR, 13C NMR, Mass spectrometry together with other complementary techniques (UV and IR). The major findings of the study include: Compound 1 was sep...
1463
580
THERAPEUTIC EFFECT OF MORINGA OLEIFERA LEAF EXTRACTS ON OXIDATIVE STRESS AND KEY METABOLIC ENZYMES RELATED TO OBESITY
Obesity ailments, commonly known as “New World Syndrome,” has drawn the attention of the scientific community to explore novel natural product-based therapeutics as effective alternatives. In this study, different solvent extracts of Moringa oleifera (M. oleifera; Drumstick tree) leaves were prepared, and their phytochemical analysis was done. The therapeutic effect of M. oleifera leaf extra...
1462
807
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF LEDIPASVIR AND SOFOSBUVIR IN FIXED DOSAGE FORM
Ledipasvir and Sofosbuvir Combination have been approved for the treatment of Chronic Hepatitis C Viral Infection. Here an accurate, valid, elementary, and error-free reverse-phase liquid chromatography strategy was developed for the quantitation of Ledipasvir and Sofosbuvir in its bulk form as well as in fixed dosage form. Effective chromatographic separation of Ledipasvir and Sofosbuvir was achi...
1462
550
CHEMICAL CONSTITUENTS OF ANDROGRAPHIS PANICULATA (BURM.F) NEES: A REVIEW
Andrographis paniculata Nees is a valuable medicinal herb of Acanthaceae family, is used for centuries to treat several diseases including viral hepatitis, cirrhosis, malaria and diabetes. This medicinal plant has hepato-protective, immunological, anti-bacterial, anti-inflammatory, anti-oxidant and antithrombotic qualities. It has many important bioactive compounds such as diterpenoids, flavonoids...
1462
558
GC-MS ANALYSIS AND ANTI-INFLAMMATORY ACTIVITY OF MUREX TRIBULUS
The aim of this study was to screen the presence of bioactive compounds through GC-MS analysis and carry out the ant-inflammatory test of the methanolic tissue extract of Murex tribulus, a spiny predatory gastropod that is widespread from the Central Indian Ocean to Western Pacific Ocean. The GC-MS analysis of the methanolic flesh extract revealed the presence of four bioactive compounds, 1, 2 dim...
1460
709
SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN AND METRONIDAZOLE IN BULK AND TABLET FORMULATION BY UV SPECTROPHOTOMETRY
Three simple and economical UV-spectrophotometric methods have been developed and validated for simultaneous estimation of ciprofloxacin (CIP) and metronidazole (MET) in a tablet dosage form using distilled water as a green solvent. The proposed methods were; simultaneous equation method (method A), Q-absorbance ratio method (method B), and area under curve method (method C). λmax of CIP & ME...
1460
669
METHOD DEVELOPMENT AND FORMULATING REBAMIPIDE SUSTAINED RELEASE TABLETS AND ITS EVALUATION
Last few eras, the remarkable advancement in the drug delivery system has been done; the oral route remains the important and picks up the safest route of drug delivery. Regardless of outstanding advancements in the oral route medication, the current study focused on the formulation of rebamipide SR tablets by studying several blends and their characteristics, including drug-excipients compatibili...
1459
873
PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF AEGLE MARMELOS FRUIT IN CYCLOPHOSPHAMIDE INDUCED TOXICITY IN RATS
Aegle marmelos commonly known as Bael has been widely used traditionally due to its various medicinal properties. Cyclophosphamide is an alkylating agent used in the treatment of various types of cancer by slowing or stopping the growth of cancer cells but also affecting the normal cells leading to immunosuppressant effect. The present study has been aimed to see the protective effect of hydroalco...
1458
700
IN-VITRO AND EX-VIVO STUDIES ON SYNERGISTIC EFFECTS OF LIMONIA ACIDISSIMA AND APPLE CIDER VINEGAR ON ANTI-UROLITHIATIC ACTIVITY
Kidney stones are aggregations of minerals such as calcium, oxalate, phosphates, uric acid, cysteine, etc. which can obstruct any part of the urinary system. This can turn fatal if left untreated as the major route of excretion is blocked causing the toxicity level to rise in the body which might lead to organ failure, coma and death. Limonia acidissima (wood apple) and Apple cider vinegar were fo...
1458
814
FREE RADICAL SCAVENGING ACTIVITY AND DETAILED FLAVONOID PROFILING OF ALGERIAN YEW (TAXUS BACCATA L.) BY LC–ESI–MS/MS
According to recent studies, the antioxidant related properties of Taxus baccata L. needle extracts are remarkable making it a possible raw material for the pharmaceutical industry, hence requiring the identification of major bioactive compounds and the assessment of the antioxidant properties of the extracts. The aim of this study was to investigate for the first time the individual flavonoids an...
1458
572