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ROLE OF AYURVEDA INTERVENTION (CHATURJATADI SAMBHARAK AVALEHA) IN THE MANAGEMENT OF MALNUTRITION IN CHILDREN
Balashosha is a disease caused by nutritional deficiencies in which the body gets slowly emaciated. This condition is very much similar to malnutrition. It reduces the baby's growth and increases the chances of having a low birth weight and later suffering from childhood infections and mortality. In Ayurveda, Balashosha is described as Apatarpana janya vyadhi and due to Rasavaha Shrotodusti, where...
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NEW HETEROCYCLIC DERIVATIVES OF CHALCONE AS ANTIHYPERGLYCEMIC AGENTS
Protein tyrosine phosphatase 1B (PTP1B) is an important target for diabetes since inhibition of PTP1B offers therapeutic benefits in insulin-resistant diabetes. Considering this fact in present investigation various heterocyclic derivatives of chalcone were synthesized and evaluated for their PTP1B inhibitory activity as antihyperglycemic agents. Heterocyclic derivatives; isoxazoline (II A-II E), ...
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INHIBITORY EFFECT OF ETHANOL EXTRACT OF MELASTOMA MALABATHRICUM LEAVES ON INFLAMMATORY SPLA2 ENZYME AND ITS ABILITY TO REDUCE THE CELL VIABILITY OF PC3 CELL LINE
Melastoma malabathricum is a medicinal plant found throughout Southeast Asian countries. Traditionally M. malabathricum was used for treating diseases such as hemorrhoids, cuts and wounds, toothache, and stomachache. Scientific findings also revealed the wide pharmacological actions of various parts of M. malabathricum such as anti-nociceptive, anti-inflammatory, wound healing, anti-diarrheal...
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VALIDATION OF TRADITIONAL SIDDHA ANTHROPOMETRIC DIAGNOSTIC METHODOLOGY MAṆIKKAṬAI-NŪL- AN OBSERVATIONAL FIELD STUDY
Maṇikkaṭai-nūl (MK) is an exclusive diagnostic method particular to Siddha Medicine, where the subject's Finger breadths (FB) calculated from the Antebrachial circumference (ABC) is accessed for predicting the symptom, disease, or the pathological sequence. The present observational field studies (Study 1 & 2) aim to validate the clinical significance of MK as a reliable diagnostic tool....
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DEVELOPMENT AND VALIDATION OF NOVEL RP- HPLC METHOD FOR SIMULTANEOUS ANALYSIS OF PREGABALIN AND DULOXETINE IN SYNTHETIC MIXTURE
A sensitive, rapid, precise and accurate RP-HPLC method was developed for simultaneous estimation of Pregabalin and Duloxetine in synthetic mixture. To introduce a chromophoric group in Pregabalin structure, derivatization was carried out through benzoylation reaction. RP- HPLC method is carried out using Hypersil BDS column C18 (250 cm × 4.6 cm, 5 μm). Mobile phase used as combination of Methan...
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FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF VORTIOXETINE HBr
Vortioxetine, a well-established antidepressant for major depressive disorder, faces limitations in traditional formulations regarding patient compliance and rapid onset of action. Mouth dissolving tablets (MDTs) offer a patient-friendly alternative, particularly beneficial for drugs with narrow therapeutic windows. This study aimed to formulate and evaluate MDTs of vortioxetine using super disint...
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HIGH-THROUGHPUT STRUCTURE BASED VIRTUAL SCREENING TARGETING CNS FOR INHIBITED ACETYLCHOLINESTERASE REACTIVATION
Organophosphorus (OP) nerve agents blocks acetylcholinesterase and do not allow the degradation of acetylcholine. Post-treatment of organophosphate poisoning involves the treatment with oxime reactivators as an antidote, which will dephosphorylate the phosphate bond between enzyme and nerve agent. Due to CNS permeability failure of these oximes, the introduction of low molecular non-oximes has bec...
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UTILIZATION OF MAIZE EXTRACT FOR THE SYNTHESIS AND CHARACTERIZATION OF GOLD NANOPARTICLES AT ROOM TEMPERATURE
In present work, the gold nanoparticles have been prepared through green synthesis using maize extract at room temperature, the maize extract was used as reducing and stabilizing agents for AuNPs (gold nanoparticles), synthesized gold nanoparticles were confirmed by the color change of the aqueous solution, and the PH of the solution was 7.8, after the confirmation, green gold nanoparticles were c...
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A COMPARATIVE STUDY TO ASSESS THE EFFICACY OF CLINDAMYCIN WITH TRETINOIN VERSUS CLINDAMYCIN WITH NICOTINAMIDE IN MILD TO MODERATE ACNE VULGARIS
Introduction: Acne is characterized by non-inflammatory follicular papules or comedones and by inflammatory papules, pustules and nodules and is estimated to affect 9.4% of the global population. Topical combination therapy is the first-line approach for facial acne. Objectives: To compare the efficacy and safety of topical clindamycin 1% with tretinoin 0.025% and clindamycin 1% with nicotinamide...
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DFT INVESTIGATION OF GEOMETRICAL STRUCTURE, IR AND RAMAN SPECTRA OF VINYL HALIDES CH2=CH–X (X IS F, Cl AND Br)
The geometrical structure and conformational energy stability of vinyl halides CH2=CH–X (X = F, Cl, and Br) were examined by using Density Functional Theory calculations (B3LYP method in combination with 6-311G* basis sets). The values of HOMO-LUMO gap (DE) for vinyl halides (fluoride, chloride and bromide) were 7.68 (eV), 7.10 (eV) and 6.55 (eV) respectively. The calculated geometrical paramete...
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