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SYNTHESIS, CHARACTERIZATION AND ANTICANCER ACTIVITY OF PIPERAZINE AMIDE DERIVATIVE
Piperazine is a nitrogen-containing heterocyclic compound and has fascinating applications in drug discovery and development. In the present study, novel 4-(benzo[1,3]dioxol-5-ylmethyl) piperazine amide derivative was prepared by acid amine coupling of 1-piperonyl piperazine derivative and benzoic acid. Synthesized compound was characterized by IR, NMR and mass spectral studies. Further, in-vitro ...
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COMPARATIVE PHYTOCHEMICAL SCREENING AND ANTIMICROBIAL ACTIVITY OF CALOTROPIS SP. OF ETHNOMEDICINAL SIGNIFICANCE
The global prevalence of infectious diseases caused by microorganisms is a major public health concern worldwide. The emergence of antibiotic resistance and related toxicity issues are limiting the use of antibiotics and prompting research for alternative therapy. Plant-derived drugs are gaining popularity due to their efficacy and safety. Calotropis procera and Calotropis gigantea are two commo...
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NEW HETEROCYCLIC DERIVATIVES OF CHALCONE AS ANTIHYPERGLYCEMIC AGENTS
Protein tyrosine phosphatase 1B (PTP1B) is an important target for diabetes since inhibition of PTP1B offers therapeutic benefits in insulin-resistant diabetes. Considering this fact in present investigation various heterocyclic derivatives of chalcone were synthesized and evaluated for their PTP1B inhibitory activity as antihyperglycemic agents. Heterocyclic derivatives; isoxazoline (II A-II E), ...
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DFT INVESTIGATION OF GEOMETRICAL STRUCTURE, IR AND RAMAN SPECTRA OF VINYL HALIDES CH2=CH–X (X IS F, Cl AND Br)
The geometrical structure and conformational energy stability of vinyl halides CH2=CH–X (X = F, Cl, and Br) were examined by using Density Functional Theory calculations (B3LYP method in combination with 6-311G* basis sets). The values of HOMO-LUMO gap (DE) for vinyl halides (fluoride, chloride and bromide) were 7.68 (eV), 7.10 (eV) and 6.55 (eV) respectively. The calculated geometrical paramete...
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CLINICAL DIAGNOSIS AND SAFETY OF VILDAGLIPTIN VERSUS GLIMEPIRIDE WITH METFORMIN OVER PATIENTS OF TYPE-2 DIABETES MELLITUS
The aim of the study to compare the efficacy of vildagliptin (50 mg) and glimepiride (2 mg) metformin (500 mg) for type-2 diabetes mellitus. Vildagliptin and glimepiride are found to be regulated the blood plasma glucose by stimulating beta cell in the pancreas. The treatment course duration of 34 weeks comparative observational study was conducted over 160 patients with type-2 diabetes mellitus w...
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AI-DRIVEN INNOVATIONS IN PHARMACOVIGILANCE: TRANSFORMING DRUG SAFETY SURVEILLANCE FOR THE FUTURE
The practice of Pharmacovigilance focuses on identifying, evaluating and preventing drug-related adverse events, also referred to as ADRs, which ensure the safety of pharmaceuticals. Regarding these changes in healthcare systems, it is becoming very important to implement new technologies, such as artificial intelligence, in pharmacovigilance operations that promise to enhance drug safety monitori...
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FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF VORTIOXETINE HBr
Vortioxetine, a well-established antidepressant for major depressive disorder, faces limitations in traditional formulations regarding patient compliance and rapid onset of action. Mouth dissolving tablets (MDTs) offer a patient-friendly alternative, particularly beneficial for drugs with narrow therapeutic windows. This study aimed to formulate and evaluate MDTs of vortioxetine using super disint...
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Cr AND Pb CONTAMINATION IN AGRICULTURAL SOIL IN TWO DIFFERENT SEASONS AND THREE DEPTH OF THE SOIL LAYER SAMPLES NEARBY TANNERY WASTE DISPOSAL ZONES AT RANIPET, VELLORE DISTRICT IN THE SOUTHERN INDIA
This paper investigates the determination of trace metals named Chromium and Lead set down in the soil as well as in the groundwater due to the tanning industries area of Ranipet town, Vellore city. The tanneries discharge untreated tannery effluents, which get mixed with the soil, water of the Palar river, and underground in this area. The determination of metals was performed for the soil that ...
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FACTORIAL DESIGN BASED OPTIMIZATION AND IN-VITRO – EX-VIVO EVALUATION OF CLOBETASOL LOADED NANO STRUCTURED LIPID CARRIERS
The aim of the present work was to develop and evaluate the potential of nanostructured lipid carriers (NLCs) loaded with Clobetasol-17-propionate (CP) as a new approach for the topical treatment of psoriasis. CP-loaded NLCs were prepared by melt emulsification and ultra-sonication method and optimized using 33 full factorial designs (Design-Expert software 11.0), by using solid lipid (compritol A...
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EFFECTIVENESS OF PHENYLPROPANOID DERIVATIVES AS PRESERVATIVE IN ALUMINIUM HYDROXIDE GEL-USP
A growing concern of microbial resistance and potential risks associated with existing synthetic preservatives have put industries and researchers under immense pressure to develop newer and safer alternatives based on moieties obtained from natural sources. The purpose of this study was to evaluate the preservative effect of the selected derivatives of naturally occurring phenylpropanoids. Alumin...
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