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PHARMACOKINETIC DRUG INTERACTIONS BETWEEN HMG-COA REDUCTASE INHIBITORS PITAVASTATIN WITH CONCOMITANTLY USED TICAGRELOR
In the present research, the pharmacokinetic Drug-drug interactions between HMG-COA reductase inhibitors Pitavastatin with concomitantly used Ticagrelor have been studied. Pitavastatin is a member of the blood cholesterol lowering medication class of statins while Ticagrelor is a platelet aggregation inhibitor. Combination therapy with statins and other cardiovascular medications is recommended fo...
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EVALUATION AND COMPARISON OF HEPATOPROTECTIVE ACTIVITY OF LIVSPLIN SYRUP AND LI- VERVE TONIC FORMULATIONS AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RATS
Liver diseases are a worldwide problem. Conventional drugs used in the treatment of liver diseases are sometimes inadequate and can have serious adverse effects like mild digestive problem, headache, nausea etc. It is necessary to search for alternative drugs and for treatment of liver disease to replace currently used drugs of doubtful efficacy and safety. Herbal therapies are free from side effe...
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FORMULATION AND IN-VITRO EVALUATION OF MESALAMINE MUCOADHESIVE TABLETS FOR COLONIC DRUG DELIVERY
The objective of the present study is to develop a colon targeted drug delivery system by using sodium alginate as a carrier for Mesalamine. Matrix tablets containing various excipients and sodium alginate were prepared by wet granulation technique using different binder systems. The prepared tablets were evaluated for hardness, weight variation, drug uniformity, friability, and in-vitro drug rele...
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EVALUATION OF ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF METHANOLIC ROOT EXTRACTS OF WITHANIA SOMNIFERA, BOERHAAVIA DIFFUSA AND THEIR COMBINATION IN DEXAMETHASONE INDUCED DIABETIC RATS
Diabetes mellitus is one of the major public health problems throughout the world. Current therapies, especially synthetic drugs, often fail to bring back normal glycemic control without complications. Numerous herbal medicines are widely explored as alternative medicine in diabetes. The objective of this work was to evaluate the antidiabetic activity of such herbal extracts of roots of Withania s...
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TEMPERATURE TRIGGERED IN-SITU GELLING SYSTEM FOR OCULAR ANTIVIRAL DRUG
The bioavailability of conventional ophthalmic solutions is very poor due to efficient protective mechanisms of the eye, blinking, reflex lachrymation, and drainage, which remove rapidly various foreign substances, including drug, from the surface of the eye. Frequent installation of a drug solution is necessary to maintain a therapeutic drug level in the tear or at the site of action. The recent ...
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ACUTE AND SUB ACUTE TOXICITY STUDY OF HYDROALCOHOLIC EXTRACT OF UNANI FORMULATION: (MAJOON HAJRUL YAHOOD) USED IN UROLITHIASIS
Background: Majoon hajrul yahood is a polyherbomineral formulation commonly used in the Unani system of medicine for the management of urolithiasis. In this study safety of a hydroalcoholic extract of majoon hajrul yahood was evaluate in Wistar rats. Materials and Methods: The hydroalcoholic extract of the formulation were tested for acute and sub-acute toxicity study. The single-dose (300, 2000, ...
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DEVELOPMENT OF TOPICAL NAIL LACQUER FORMULATION FOR THE MANAGEMENT OF ONYCHOMYCOSIS
Nail plate being a formidable barrier, drug permeation through this layer is limited. Taking this as a challenging task, the present study focuses on the formulation of an antifungal topical nail lacquer using Oxiconazole nitrate. The novelty of the studies can be stated as the use of a combination of permeation enhancers like salicylic acid, thioglycolic acid, and urea for effective therapeutic t...
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MICROSPONGES: A PROMISING APPROACH FOR DRUG DELIVERY
Micro sponges are patented polymeric drug delivery systems consisting of porous microspheres. The physical appearance of microsponges is tiny spherical sponge-like with the surface with large spores. Micro sponges are typically used and nowadays used as the oral dosage form. The inert and indestructible tiny spherical particles do not pass through the skin. But, it collects in the tiny nooks and c...
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AN OVERVIEW ON HUMAN ETHER-A-GO-GO-RELATED GENE ASSAY
hERG (human ether-à-go-go-related gene) encodes a potassium ion channel which involved in ventricular repolarization at the end of a cardiac action potential. Mutations in hERG channel result in torsade’s de pointes. The cardiotoxicity is mainly due to the prolongation of the QT interval caused by the blockage of hERG. Indeed, many therapeutic drugs are withdrawn from the market as well as drug...
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KARKATSHRINGI (PISTACIA INTEGERRIMA): PHYTOPHARMACOLOGICAL REVIEW
Karkatshringi (Pistacia integerrima) is an essential Ayurvedic medicinal plant belonging to the family Anacardiaceae. The plant originated in India and grows in the ranges of the north-western Himalayas. It is distributed over China, Afghanistan, Pakistan, and Nepal. The flowers of this plant is small and red, fruits are shiny and brown. Galls are hollow, horn-shaped, bitter and used for medicinal...
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