Most Popular
PHARMACOLOGICAL EVALUATION OF ALCOHOLIC EXTRACT OF EUPHORBIA ANTIQUORUM WITH SPECIAL EMPHASIS ON DIABETIC COMPLICATION
Diabetes is a metabolic disorder of carbohydrate, fat and protein metabolism characterized by increased fasting and post prandial blood sugar levels. Diabetes is the most common cause of progressive kidney failure leading to dialysis or transplantation. Nephropathy is reported to develop in 30-40% of patients with diabetes and has become a leading cause of end-stage renal failure worldwide. The va...
2582
1235
QUALITY BY DESIGN APPROACH TO OPTIMIZE OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEM
The present investigation deals with the development of the controlled porosity osmotic pump (CPOP) tablet of Garcinia indica fruit rind extract used in the management of colon cancer by implementing the concept of Quality by Design (QbD). The quality target product profile (QTPP) and Critical Quality Attributes (CQA) of the Garcinia indica tablets were defined based on preliminary studies. The ef...
2582
1323
STRATEGIES OF TRADITIONAL SYSTEMS OF MEDICINE COMBATING WITH THE CURRENT PANDEMIC SITUATION OF COVID-19
Coronavirus disease (COVID-19) has become pandemic in no time in the world. Understanding the pathophysiological similarities with previously known viruses of the class gave opportunities to explore various molecular targets against COVID-19. Vaccines unavailability propose different research approaches of treatment, including various previously known and some new synthetic molecules, which are al...
2582
1748
SPHAEROCOCCUS CORONOPIFOLIUS ALLEVIATES OXIDATIVE BRAIN INJURY ASSOCIATED TO DEPRESSION-RELATED BEHAVIOR INFEMALE WISTAR RATS
Neuropathic pain is commonly comorbid with mood disorders, such as depression and anxiety. A state of depression may suggest biochemical imbalance that can increase the oxidative stress into the brain. The present study aimed to investigate the effect of aqueous extract of the red algae Sphaerococcus coronopifolius on depression-induced behavioral alterations and oxidative stress in female Wistar ...
2577
1138
SALUTARY ACTIVITY OF BERBERINE AGAINST DIBUTYLTIN DICHLORIDE INDUCED ACUTE PANCREATITIS IN ALBINO WISTAR RATS
Background: Berberine is a natural alkaloid used as traditional Chinese medicine. Objective: The objective of the present study was to evaluate the effect of berberine on dibutyltin dichloride (DBTC) induced acute pancreatitis in albino Wistar rats. Methods: In this study 24 Wistar rats were randomly selected and divided into four groups. Each group consists of 6 animals. Group-1 (-ve control), Gr...
2577
1289
IMPACT OF CLINICAL PHARMACIST DELIVERED EDUCATION AMONG TYPE 2 DIABETES MELLITUS PATIENTS IN A TERTIARY CARE HOSPITAL
Diabetes mellitus is a metabolic disorder of multiple etiologies characterized by chronic hyperglycemia. The aim is to study the impact of clinical pharmacists delivered education among type 2 diabetes mellitus patients in a tertiary care hospital. A prospective, interventional, randomized control study was carried out over a period of 6 months in the general medicine department of a tertiary care...
2577
1423
PRONIOSOMAL DRUG DELIVERY SYSTEM- A REVIEW
Proniosomes are provesicular dried or anhydrous formulations that are composed using non-ionic surfactants and solvents. The non-ionic surfactant's hydrophilic portion orients outward to form a bilayer, while the hydrophobic portion moves inward. Medicines with hydrophilic properties are contained in vesicles, while hydrophobic drugs get embedded in proniosome bilayers. Proniosomes are physically ...
2577
1617
EVALUATION OF ANTIGENOTOXIC POTENTIAL OF BEET ROOT EXTRACT AGAINST HAIR DYE INDUCED GENOTOXICITY
In-vitro investigations toward DNA damage reported that the biological effect of genotoxic exposures could influence the life cycles of different human cells. Sister chromatid exchange (SCE) assay is broadly used, sensitive cytogenetic biomarker of exposure to genotoxic agents. Naturally available products may play a significant role against the cytogenetic damage but available research data is no...
2576
1282
EFFECT OF OLANZAPINE ON HYPERTHERMIA IN SEROTONIN SYNDROME MODEL
The serotonin syndrome is a life-threatening adverse drug reaction caused by a significant increase in the concentration of 5-hydroxytryptamine (serotonin) in the central nervous system. The aim of this study was to establish the effects of olanzapine, an antipsychotic drug, on the hyperthermic response in rat experimental serotonin syndrome. In this study, we used an animal model of the serotonin...
2576
1058
LARVICIDAL ACTIVITY OF EPALTES PYGMAEA (DC) WHOLE PLANT EXTRACTS AGAINST CULEX QUINQUEFASCIATUS SAY, AEDES AEGYPTI L. AND ANOPHELES STEPHENSI LISTON LARVAE
In the present study, the larvicidal activity of successive n-hexane, chloroform, ethyl acetate and ethanol extracts of Epaltes pygmaea DC (Family: Asteraceae) whole plant was carried out against three mosquito species namely Culex quinquefasciatus, Aedes aegypti L. and Anopheles stephensi. The crude whole plant was successively extracted with n-hexane, chloroform, ethyl acetate, and ethanol. The ...
2575
1185