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A PROSPECTIVE STUDY ON CORTICOSTEROID USAGE AND INCIDENCE OF CORTICOSTEROID-INDUCED HYPERGLYCEMIA IN A TERTIARY CARE HOSPITAL
Corticosteroids are a widely used class of drugs for respiratory, autoimmune, gastrointestinal, and dermatological conditions. Despite the efficacy of steroids, they have a wide variety of side effects. However, SIH remains the most misdiagnosed side effect. Undiagnosed SIH will precipitate DM, increases the morbidity and length of hospital stay, especially when pre-existing risk factors are prese...
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PHARMACOLOGICAL EVALUATION OF ALCOHOLIC EXTRACT OF EUPHORBIA ANTIQUORUM WITH SPECIAL EMPHASIS ON DIABETIC COMPLICATION
Diabetes is a metabolic disorder of carbohydrate, fat and protein metabolism characterized by increased fasting and post prandial blood sugar levels. Diabetes is the most common cause of progressive kidney failure leading to dialysis or transplantation. Nephropathy is reported to develop in 30-40% of patients with diabetes and has become a leading cause of end-stage renal failure worldwide. The va...
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DETERMINATION OF PHYTOCHEMICAL CONTENTS AND ANTIOXIDANT ACTIVITIES OF ETHANOL EXTRACT OF THE LEAVES OF SCURRULA PARASITICA L.
The phytochemical analysis of ethanol extract of Scurrula parasitica showed positive results for alkaloid, saponins, tannin, terpenoids, flavonoids, phenol, reducing sugar and phytosterols whereas glycoside is found to be absent. Total phenol and flavonoid contents were evaluated and found to be total phenolic compounds (101.9-379.1 µg/g tissue) and total flavonoids (72-174.1 µg/g tissue), respe...
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SYNTHESIS AND CHARACTERIZATION OF NOBLE ANTICANCER DRUG OF CHITOSAN-5FU CONJUGATED FORMULATION
Cancer is one of the emergings, and best-understood neoplasm’s from a genetic perspective, yet it remains the second most common cause of cancer-related death, indicating that some of its cancer cells are not removing completely by current therapies. Chitosan is a polysaccharide β-linked D-glucosamine and N-acetyl-D-glucosamine were used as conjugate to 5Fluorouracil. 5FU is one of the most com...
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A NEW TARGET FOR DIABETES: HOMOLOGY MODELING AND IDENTIFICATION OF POTENTIAL LEADS THROUGH VIRTUAL SCREENING
Monocarboxylate transporter 11 (MCT11) is a transporter protein encoded by the SLC16A11 gene. MCT11 protein is found to play an important role in many biological activities in different species. MCT11 helps in hepatic lipid metabolism by catalyzing the transport of pyruvate molecules across the membrane. It is also found to be involved in regulation of Diabetes. Therefore, MCT11 protein is taken i...
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A PROSPECTIVE OBSERVATIONAL STUDY ON ADVERSE DRUG REACTION AMONG PATIENTS IN A TERTIARY CARE HOSPITAL
Adverse drug reactions (ADRs) cause considerable morbidity and mortality worldwide. The pharmacovigilance activities continuously update about the adverse reactions related to medications and provide information regarding the nature and severity of ADRs. The study aims to assess the causality assessment of ADRs among patients in a tertiary care hospital. A prospective observational study was condu...
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DESIGN AND CHARACTERIZATION OF POLYHERBAL FORMULATION FOR HAIR GROWTH CONTAINING ECLIPTA ALBA, HIBISCUS ROSA-SIENSIS, TRIGONELLA FOENUM-GRAECUM LINN.
Gelling agents such as Carbopol 934 and HPMC K 100 were used in different concentrations for the preparation of Topical polyherbal extract gel formulations containing (%w/w) Eclipta alba, Hibiscus rosa-siensis, Trigonella foenum-graecum Linn. Prepared gel extract of various herbal ingredients were characterized by different parameters like gelling capacity, pH, Homogeneity, Grittiness, Extrudabili...
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REVIEW ON DERIVING A HYPOTHESIS FOR ACHIEVING SUPERIOR BIOAVAILABILITY OF CURCUMIN AS AN ANTITUMOR AGENT
Curcumin, chemically 1,7-bis (4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5-dione derived from Curcuma longa L. is an active chemical constituent used medicinally worldwide from ancient times. Though Curcumin enjoying the reputation of many pharmacological actions, it has certain setbacks with poor bioavailability. The poor water solubility is said to be the reason for poor bioavailability, rathe...
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EVALUATION OF ANTIGENOTOXIC POTENTIAL OF BEET ROOT EXTRACT AGAINST HAIR DYE INDUCED GENOTOXICITY
In-vitro investigations toward DNA damage reported that the biological effect of genotoxic exposures could influence the life cycles of different human cells. Sister chromatid exchange (SCE) assay is broadly used, sensitive cytogenetic biomarker of exposure to genotoxic agents. Naturally available products may play a significant role against the cytogenetic damage but available research data is no...
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INCIDENCE AND ANTIBIOTICS SUSCEPTIBILITY PATTERN OF BACTERIA OF EAR ORIGIN
This study is aimed at investigating both the Gram-positive and the Gram-negative bacteria of ear swabs and their antibiotic susceptibility pattern. Ear samples of one hundred (100) subjects using sterile swab sticks were collected. Sixty-seven (67) out of 100 samples collected yielded growth when incubated at 37 ºC for 24 h. Microbiological tests were carried out to characterize the bacterial is...
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