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EXPLOITING NATURAL POLYMER REINFORCED MICROSPHERES AND INVESTIGATING ITS CHARACTERISTICS FOR SUSTAINED RELEASE
The objective of current research work is exploring the use of natural mucilage for sustained release characteristics for the formulation of microspheres. Orifice ionic gelation method was used to formulate the microspheres by using complex-forming polymer sodium alginate in combination with isolated mucilage. Mucilage from Colocacia esculenta corms were isolated and combined with sodium alginate ...
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PHARMACOGNOSTICAL STUDY OF THE AUTHENTICITY OF MORINGA OLEIFERA LEAVES
Moringa oleifera is widely used in Asia and Africa as an anti-inflammatory, anti-diabetic, and cold agent. However, there are no Moringa medicines on the Russian pharmaceutical market; therefore, it is of interest for research as a promising source of raw materials and introduction to the State Pharmacopoeia of Russian Federation. This study was conducted to compare the characteristics of the auth...
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PHARMACOGNOSTIC STANDARDIZATION OF POLYHERBAL FORMULATION PALASHA BEEJADI CHOORNA
Herbs are the main source of Ayurvedic formulations. Polyherbalism concept of Ayurveda enables fortified therapeutic effect when compared to single herb. The potency of polyherbal formulations depends on their ingredients. Plants tend to vary in their efficacy due to the influence of environmental factors, such as temperature, humidity, light, oxygen, moisture content. The quality of polyherbal fo...
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A REVIEW ON TRANSLATIONAL PERSPECTIVE AND EFFICACY OF DIFFERENT ENGINEERED THERAPEUTIC ANTIBODIES
From bench to bedside, clinical research had always played as a convenient tool in the field of cancer biology to inquire about the effectiveness of different anticancer drugs on different human-derived cancer cell lines. According to the American Cancer Society, nearly 4000 new cases and 1600 deaths predicted in 2019 in the United States. Besides, to these alarming statistics, rising cost and hea...
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ANALYSIS OF MULTIPLE ANTIBIOTICS RESISTANT AND MOLECULAR EPIDEMIOLOGY OF ESCHERICHIA COLI AND PSEUDOMONAS AERUGINOSA
The present investigation aimed at the study of resistant plasmid patterns of multidrug-resistant Escherichia coli and Pseudomonas aeruginosa isolated from hospital-acquired infection in urinary tract site are causes serious public health hazard throughout the world. A total of 100 urine samples were collected from patient admitted to the hospital. The antibiotic sensitivity of isolated uropathoge...
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EVALUATION OF NOOTROPIC ACTIVITY OF SEMECARPUS ANACARDIUM LEAVES IN RODENTS
Evaluation of nootropic activity of Semecarpus anacardium leaves ethyl alcohol extract on exteroceptive behavior and interoceptive behavior was investigated by use of Shuttle box, Continuous Avoidance Response Apparatus and Elevated plus-maze test, Scopolamine-induced amnesia, Diazepam-induced amnesia, and Sodium nitrite-induced amnesia. The beha-vioral study was done using Lithium- induced head t...
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A REVIEW ON TRADITIONAL MEDICINAL PLANTS USED AS ANTIDOTES IN THE TREATMENT OF SNAKE BITES IN INDIA
Envenoming and deaths resulting from snakebites are particularly important public health problems in the rural tropics. Snake envenomation is included since 2009 in the World Health Organization (WHO) list of Neglected Tropical Diseases, as this condition remains largely neglected by national and international health authorities. The only available specific treatment is antivenom therapy, which co...
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EVALUATION OF PESTICIDE CHLORPYRIFOS TOXICITY ON DROSOPHILA MELANOGASTER
Chlorpyrifos is one of the commonly detected pesticides found in food and water. Extensive use of it in agriculture and its persistence in the environment have raised public concern to overcome the pollution and toxicity problems. Exposure to chlorpyrifos poses several harmful effects to animal and human health. And the pathology in neurodegenerative diseases is mainly because of mitochondrial dys...
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ANTITOXIC EFFECTS OF GUM ARABIC (ACACIA SENEGAL) AND GUAR GUM (CYAMOPSIS TETRAGONOLOBUS) AGAINST HEPATORENAL TOXICITY INDUCED BY MERCURIC CHLORIDE IN RATS
Heavy metal accumulates mostly in the liver and kidney as these organs involved in the detoxification and excretion of foreign materials. In the present study, we explored the effect of Gum Arabic (GA) and Guar Gum (GG) on mercuric chloride (HgCl2) induced hepatorenal toxicity. Twenty-eight adult male albino rats “Sprague Dawely” weighing 250-300 g were divided into four equal groups: the firs...
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ANALYTICAL METHODS OF TICAGRELOR: A REVIEW
Ticagrelor is a platelet aggregation inhibitor. It is used for the prevention of stroke, heart attack, and other events in people with the acute coronary syndrome, meaning problems with the blood supply in the coronary arteries. It acts as a platelet aggregation inhibitor by antagonising the P2Y 12 receptor. Its half-life is up to 12 h with the hepatic type of metabolism and biliary excretion. Thi...
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