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ANTIEPILEPTIC ACTIVITY OF RUBIADIN ISOLATED FROM THE ROOTS OF RUBIA CORDIFOLIA IN MICE
Epilepsy is a disorder of the central nervous system. A seizure occurs when the brain’s nerve cells misfire and generate a sudden uncontrolled surge of electrical activity in the brain. Seizures can be controlled with modern medicines and surgical techniques and are found to have so many side effects. Natural products from folk remedies are an alternative source of anti-epileptic drugs with bett...
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A CRITICAL REVIEW ON THE EFFECT AND TOXICITY OF CADMIUM MEDIATED STRESS IN PLANTS
Cadmium (Cd) is one of the non-essential and highly toxic environmental pollutants. It causes serious environmental and agricultural problems. It ranks seventh on the list of the twenty most toxic metals. Dietary cadmium intake is much higher than the upper limit reported by FAO/WHO. Sources of environmental Cd contamination, soil factors affecting Cd uptake, Cd dynamics in the soil rhizosphere, u...
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A RECENT SURVEY ON CHEMICAL AND BIOLOGICAL SIGNIFICANCE OF ISATIN DERIVATIVES
Isatin, a heterocyclic moiety, is a significant scaffold in medicinal chemistry. Isatin contains a nitrogen atom at position 1 and two ketone groups at positions 2 and 3. It consists of two cyclic rings, one of which is a six-membered ring, and the other is a five-membered ring. It is a resourceful nucleus for the synthesis of several pharmacologically active molecules. Isatin itself acquires an e...
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CURRENT LAWS GOVERNING COMPARATIVE STUDIES AND CLINICAL TRIALS IN INDIA, THE UNITED STATES, EUROPE, AND SINGAPORE
Clinical trials (CTs) are carried out to investigate novel, patient-acceptable, and more effective interventional procedures. Specific regulatory criteria for conducting CTs are recommended by the country's drug regulatory authority, and these guidelines are followed when conducting CTs. The USFDA oversees regulating CTs in the USA in accordance with the Federal Food, Drug, and Cosmetic Act's 21 C...
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COVID19: PATHOPHYSIOLOGY, CLINICAL FEATURES, DIAGNOSIS AND MANAGEMENT
SARS-CoV-2 viral cause infection called COVID-19 was initially reported in China has resulted in a pandemic because it has spread in over 210 countries. This review summarized pathophysiology, clinical features, diagnosis, and COVID 19. The spread of SARS-CoV-2 viral infections is a matter of concern because of a mutant variant of virus. The COVID-19 infection is having 14 days incubation period. ...
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NEUROBIOLOGICAL EVALUATION OF DERIVATIVES OF SUBSTITUTED PHENYL-ETHYLAMINE AND ETHYLAMINE
Cognitive functions are mainly categorized into memory, attention, creativity, and intelligence. Cognitive enhancement may be defined as the amplification or extension of core capacities of the mind. Phenylethylamine is an organic compound which is also known as β-phenylethylamine (β-PEA) and is the name of a class of chemicals which shows psychoactive and stimulant effects. It is a trace amine ...
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EFFECT OF SATWA FROM THREE TINOSPORA SPECIES ON LIPID METABOLISM AND INFLAMMATORY MARKERS IN ACETAMINOPHEN AND ALCOHOL-INDUCED HEPATO-TOXICITY IN RATS
To investigate the possible protective effects of satwa from three Tinospora species against acetaminophen and alcohol-induced hepatotoxicity in rats. Male albino wistar rats were divided into six groups (n=6); healthy control, negative control (Acetaminophen 1000mg/kg b.w./day, p.o. or 30%; alcohol 1ml/100g b.w./day, p.o.), positive control (Silymarin; 100mg/kg b.w./day, p.o.), Treatment 1 (Tinos...
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FABRICATION AND CHARACTERIZATION OF CICLOPIROX OLAMINE LOADED NONIONIC SURFACTANT BASED NIOSOMES FOR TOPICAL DELIVERY
A number of strategies to deliver antifungal using nanocarriers are developed to facilitate drug targeting infected cells that result in improved antifungal activity. Objective: Ciclopirox olamine has a broad spectrum of action against dermatophytes, yeasts, filamentous fungi and bacteria. It has a biological half-life of 1.7 h and bioavailability of < 5% with prolonged use. A remarkable featur...
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FORSKOLIN INDUCED MORPHOLOGICAL AND OVARIAN DEFORMITIES IN THE EXORISTA BOMBYCIS (UZI FLY) AND ANTI-FEEDENT ACTIVITY OF FORSKOLIN
Forskolin is a heterocyclic labdane-type diterpenoid extracted from the roots of the plant of Coleus forskohlii (Lamiaceae) has been studied in depth for its broad range of pharmacological properties. Coleus forskohlii aids in the control of pestilence of Uzi fly, Exorista sorbillans, and Exorista bombycis one of the gravest ecumenical pests in sericulture industry. Forskolin affected moulting; de...
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ADVERSE DRUG REACTION MONITORING IN DRUG SENSITIVE TUBERCULOSIS PATIENTS: A CROSS-SECTIONAL STUDY IN A TERTIARY CARE HOSPITAL
Tuberculosis (TB) continues to rank among the world's most serious health problems despite the remarkable biomedical achievements. The objective of the study is to describe and characterize the adverse drug reactions associated with Anti Tubercular Therapy (ATT) in a tertiary care hospital. This was a cross sectional study done in the Department of Thoracic medicine, Government Medical College Kri...
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