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IN-VITRO AND IN-VIVO SYNERGISM BETWEEN VALSPODAR (PSC833) AND ANTIBIOTICS AGAINST STAPHYLOCOCCUS AUREUS STRAINS
Here, we report the in-vitro and in-vivo effects of Valspodar (PSC833), a second-generation mammalian efflux pump inhibitor on the susceptibility of methicillin-resistant and methicillin-sensitive Staphylo-coccus aureus (MRSA and MSSA) towards two antibiotics, Oxacillin (OX) and Cefoxitin (FOX). Checkerboard microdilution assays revealed various degrees of strain-dependent synergy demonstrated in ...
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IMPACT OF CLINICAL PHARMACIST DELIVERED EDUCATION AMONG TYPE 2 DIABETES MELLITUS PATIENTS IN A TERTIARY CARE HOSPITAL
Diabetes mellitus is a metabolic disorder of multiple etiologies characterized by chronic hyperglycemia. The aim is to study the impact of clinical pharmacists delivered education among type 2 diabetes mellitus patients in a tertiary care hospital. A prospective, interventional, randomized control study was carried out over a period of 6 months in the general medicine department of a tertiary care...
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CADD: AN ABSOLUTE REPLACEMENT FOR TRADITIONAL DRUG DISCOVERY
CADD is a powerful method to discover possible therapeutic compounds in conventional drug discovery. It has now surpassed all other high-throughput screening options, commonly used in drug discovery and development. The creation and optimization of several clinically utilized medications have significantly advanced thanks to CADD, or computer-aided drug design. Computer-aided drug design can take ...
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SPHAEROCOCCUS CORONOPIFOLIUS ALLEVIATES OXIDATIVE BRAIN INJURY ASSOCIATED TO DEPRESSION-RELATED BEHAVIOR INFEMALE WISTAR RATS
Neuropathic pain is commonly comorbid with mood disorders, such as depression and anxiety. A state of depression may suggest biochemical imbalance that can increase the oxidative stress into the brain. The present study aimed to investigate the effect of aqueous extract of the red algae Sphaerococcus coronopifolius on depression-induced behavioral alterations and oxidative stress in female Wistar ...
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STRATEGIES OF TRADITIONAL SYSTEMS OF MEDICINE COMBATING WITH THE CURRENT PANDEMIC SITUATION OF COVID-19
Coronavirus disease (COVID-19) has become pandemic in no time in the world. Understanding the pathophysiological similarities with previously known viruses of the class gave opportunities to explore various molecular targets against COVID-19. Vaccines unavailability propose different research approaches of treatment, including various previously known and some new synthetic molecules, which are al...
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IN-VITRO COMPARATIVE STUDY AND QUALITY ANALYSIS OF DIFFERENT MARKETED BRAND OF METFORMIN HCL TABLETS AVAILABLEIN INDIA WITH BRAND AVAILABLE IN JAN AUSHADHI STORES
The objective of this research study is to assess the quality standards of various brands of Metformin hydrochloride tablets that are locally available in Hyderabad, India, by comparing and contrasting them with the brand available in the Jan Aushadhi stores in India (MET-3). Eight brands of Metformin tablets (500 mg) were selected and compared for their physical and chemical parameters as per the...
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ANTIMICROBIAL ACTIVITY OF INSTANT COFFEE AGAINST SOME MULTI-DRUG RESISTANCE BACTERIA AND PATHOGENIC FUNGI
This paper presents the antimicrobial activity of instant coffee, a prevalent beverage utilized by millions of people worldwide every day. Several studies have shown that instant coffee contains many useful bioactive compounds, the most important: caffeine, trigonelline, chlorogenic acid, ferulic acid, caffeic acid, nicotinic acid, and phenolic compounds which are responsible for the antimicrobial...
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FABRICATION AND CHARACTERIZATION OF CICLOPIROX OLAMINE LOADED NONIONIC SURFACTANT BASED NIOSOMES FOR TOPICAL DELIVERY
A number of strategies to deliver antifungal using nanocarriers are developed to facilitate drug targeting infected cells that result in improved antifungal activity. Objective: Ciclopirox olamine has a broad spectrum of action against dermatophytes, yeasts, filamentous fungi and bacteria. It has a biological half-life of 1.7 h and bioavailability of < 5% with prolonged use. A remarkable featur...
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EFFECT OF SATWA FROM THREE TINOSPORA SPECIES ON LIPID METABOLISM AND INFLAMMATORY MARKERS IN ACETAMINOPHEN AND ALCOHOL-INDUCED HEPATO-TOXICITY IN RATS
To investigate the possible protective effects of satwa from three Tinospora species against acetaminophen and alcohol-induced hepatotoxicity in rats. Male albino wistar rats were divided into six groups (n=6); healthy control, negative control (Acetaminophen 1000mg/kg b.w./day, p.o. or 30%; alcohol 1ml/100g b.w./day, p.o.), positive control (Silymarin; 100mg/kg b.w./day, p.o.), Treatment 1 (Tinos...
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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF TENELIGLIPTIN AND DAPAGLIFLOZIN API IN MARKETED FORMULATION
A simple, novel, precise, rapid, accurate, specific reverse phase high performance liquid chromatography (RP-HPLC) method for estimation of Teneligliptin hydrobromide hydrate and Dapagliflozin propanediol monohydrate API in marketed formulation was developed and validated. The separation was carried out on a Prontosil C18 (250 x 4.6 mm, 5 m) column using an acetonitrile: 3.5 pH Potassium dihydroge...
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