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EFFECT OF MORINGA OLEIFERA LAM. ROOT ON COLONIC MOTILITY DISORDERS INDUCED BY WATER AVOIDANCE STRESS IN RATS
Irritable bowel syndrome (IBS) is a chronic condition that affects the lower gastrointestinal tract. It affects the function and behavior of the intestine resulting in abdominal pain, flatulence, loose stools, frequent stools, feeling of being unable to completely empty bowel and nausea. Moringa oleifera, also commonly known as drumstick tree, is a highly valued plant with a wide range of medicina...
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STABILITY INDICATING ASSAY OF TELMISARTAN IN TABLETS
An accurate, simple, precise, rapid stability-indicating assay method was developed and subsequently validated for the estimation of Telmisartan in API and Tablets. The best separation of the drug was achieved on Kromasil C18 (4.6 × 150 mm, 5 µm) with the mobile phase consisted of mixture of 0.01 M Phosphate buffer (pH: 3) and Acetonitrile in ratio of (40:60%) at flow rate of 2 ml/min, with dete...
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482
LIPOSOME IN COSMETIC DRUG DELIVERY SYSTEM OF PHOSPHOLIPID AND PHENOLIC COMPONENT
Liposomes are considered to be safe for usage; they have been used hugely in cosmetics. Biologically obtained compounds of phospholipids have a high affinity to the skin's surface. Liposomes are highly permeable and have more storage capacity on the stratum corneum and also it is considered a chemically active agent to the skin. Most future studies on liposomes involve drug delivery in cosmetics. ...
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512
CARDIOPROTECTIVE ROLE OF AMLODIPINE UNDER ACUTE HYPOBARIC HYPOXIA: ROLE OF AKT-1 IN REDOX BALANCE
Hypobaric hypoxia induced systolic heart dysfunction and arrhythmia is prevalent in ascendants. L-type calcium channel blocker amlodipine plays important role in modulating cardiac function. We tested if amlodipine could impart cardio protection and restore oxidative balance under hypobaric hypoxia, by modulating HIF-1α activity and calcium accumulation, thus, protects from cardio-toxicity. Exper...
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306
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME NOVEL 1, 2, 3, 4-TETRAHYDROQUINAZOLINONE DERIVATIVES
In the study, we have successfully synthesized N-3 substituted tetrahydroquinazolinone by the reaction of isotonic anhydride with aniline derivatives. Thereafter novel derivative would be subjected to synthesize (1, 2, 3, 4-tetrahydroquinazoline) by Mannich reaction with ciprofloxacin and norfloxacin. These synthesized compounds (2a, 2b, 2c, 2d, 2e, 2f, 2g, and 2h) were characterized by FT-IR, 1H ...
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DEVELOPMENT AND VALIDATION OF NITECAPONE IN HUMAN PLASMA USING TOLCAPONE AS INTERNAL STANDARD BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
The present LC-MS/MS method for estimation of Nitecapone in human plasma using Tolcapone as an internal standard is established and validated as per FDA guidelines. A good response was obtained with ZORBAX Eclipse plus C18 column (150 mm × 4.6 mm ID, 5 μm) and mobile phase with a mixture of 0.01 M Ammonium phosphate buffer with pH adjusted to 5.0 with OPA and Acetonitrile (70:30, v/v) at a flow ...
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672
SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ANAGLIPTIN AND METFORMIN HCL BY SECOND DERIVATIVE METHOD
A Simple, accurate, and precise spectrophotometric method (1st order derivative method) was developed and validated for the estimation of Anagliptin and Metformin HCl in synthetic mixture. In this method, Anagliptin was estimated at 244 nm where Metformin HCl showed zero absorbance. Metformin HCl is estimated at 234 nm at which Anagliptin showed zero absorbance. The method was linear over the conc...
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658
ISOLATION, IDENTIFICATION OF NON-POLAR TERPENES AND TOTAL ANTIOXIDANT ACTIVITY FROM CHLOROFORM EXTRACT OF BOUGAINVILLEA GLABRA LEAVES
This study reports the isolation and antioxidant activity of non-polar terpenes extracted from the leaves of Bougainvillea glabra choicy. To characterize the phytochemical constituents of Bougainvillea glabra leaves using the GC-MS method. The 95% ethanol extract was filtered, distilled, and concentrated to obtain the solid greenish residue. The residue was further fractioned by n-hexane, chlorofo...
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525
A SENSITIVE LC-MS/MS ASSAY FOR THE DETERMINATION OF NAFTOPIDIL IN HUMAN PLASMA AND ITS APPLICATION TO A PHARMACOKINETIC STUDY
A specific, rapid, and sensitive LC-MS/MS assay was developed and validated for the determination of Naftopidil in human plasma. Naftopidil d7 was used as an internal standard (IS). A faster and one-step protein precipitation (PP) technique was employed for sample preparation. The processed samples were chromatographed on a C18 column using ammonium formate (5mM) buffer in combination with acetoni...
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IN-VITRO MUTAGENIC AND CYTOTOXIC ACTIVITY OF NIGELLA SATIVA SEED EXTRACT BY AMES AND MTT ASSAY
In the modern lifestyle, people are prone to disease. The epidemiology study shows that the lung and colon cancer leading position in both the gender around the world at any group. As based on the traditional systems of medicine, the plants can be used for the discovery of new medicine. The aqueous and ethanol extract of Nigella sativa (N. sativa) seeds were evaluated for their genotoxicity using ...
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