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INFLUENCE OF ALLICIN ON PHARMACOKINETICS AND PHARMACODYNAMICS OF PIOGLITAZONE: AN HERB-DRUG INTERACTION STUDY IN RATS
Many herbs/phytochemicals are proved to have anti-diabetic properties and patients in the treatment of diabetes increased their usage. Administration of herbs and allopathic drugs has a chance of interaction between them, leading to alterations in pharmacokinetics and pharmacodynamics of the drug. The present study was aimed to know the influence of phytoconstituent (Allicin) on the pharmacokineti...
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DEVELOPMENT OF NASAL DRUG DELIVERY SYSTEM OF ATORVASTATIN CALCIUM FOR ENHANCING BIOAVAILABILITY
Atorvastatin calcium is a synthetic lipid-lowering agent used in hyperlipidemia. An oral dose of Atorvastatin calcium ranges from 10mg to 80mg per day. Atorvastatin calcium belongs to BC’s class II drug having low solubility and high permeability. The absolute bioavailability of Atorvastatin calcium is approximately 12%, and the systemic availability of HMG-CoA reductase inhibitory activity is a...
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ANTI-BACTERIAL EFFICACY OF PHYTOGENIC SILVER AND GOLD NANOPARTICLES OF LANTANA CAMARA. LINN AGAINST ENTERIC PATHOGENS
Antibiotic resistance could be a natural phenomenon that occurs when an antibiotic loses its ability to control or kill the bacterial growth; in other words, the bacteria become "resistant" and still continue to multiply in the presence of therapeutic levels of an antibiotic. Nano-technology is one of the foremost active areas in modern science. Nano particles exhibit a completely new or improved ...
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SOLID DISPERSION EXTENDED-RELEASE SYSTEM: A REVIEW
Solid dispersion extended-release system involves amorphization of drug material that leads to creating an alternative pathway for poorly water-soluble drugs. The drug increases solubility due to an increase in apparent solubility of the particular drug. Crystalline lattices of the drug are disturbed during its manufacture, which minimizes the crystal packing energy for solubilization. Along with ...
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IN-SILICO DESIGN AND DOCKING STUDY OF SOME 4-(10-ACETYL-10H-PHENO-THIAZINES-3-YL)-1-PHENYLAZETIDIN-2-ONE DERIVATIVES
Background: The current study used computational approaches to investigate the molecular, physicochemical and drug-like properties of some 4-(10-acetyl-10H-phenothiazines-3-yl)-1-phenylazetidin-2-one derivatives. Methods: The structures of the compounds were drawn using Chemdraw ultra12 and smiles were generated using ACD chem sketch software. The physicochemical and molecular properties were calc...
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PHYTOCHEMICAL AND IN-VITRO ASSESSMENT OF ANTIHISTAMINIC AND ANTICHOLINERGIC ACTIVITY OF LEAVES OF HIBISCUS SABDARIFFA LINN.
Objective: The aim of the present study was to find out the herbal drug which has potential antihistaminic properties. Studying the in-vitro antagonistic effect of crude extracts on isolated goat tracheal chain preparation for assessment of direct antihistaminic activity using two agonists like histamine and acetylcholine. Methods: The ethanolic extract of leaves of Hibiscus sabdariffa was found q...
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TOTAL PHENOLS, ALKALOIDS, TANNINS AND ANTIOXIDANT ACTIVITY OF WILD PRUNUS ARMENIACA L. SEED COLLECTED FROM GARHWAL REGION OF UTTARAKHAND, INDIA
Plants are the important constituents of folk and traditional medicines and fulfill nutrition and dietary needs from ancient times. The aim of this study to evaluate phytochemicals and antioxidant activity of seed oil of wild apricot (Prunus armeniaca L). Thenon-cultivated seed of wild Prunus armeniaca L. from the Garhwal, Uttarakhand, India was analyzed for its phytochemicals e.g., total phenols,...
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THE FUTURE OF NON-INVASIVE WAYS TO TREAT CANCER
The non-invasive technique in which a variety of nanoparticles are used to deliver the chemotherapy drug to the location of metastatic cancer has fewer side effects, high bio-availability, and high bio-stability of a drug. The anti-proliferative activity of EGCG is very efficient against a variety of cancer, but the problem is that it can’t withstand the environment of an intestine. One of the n...
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ETHNO PHARMACOLOGICAL AND PHYTO PHARMACOLOGICAL PERCEPTION ON KALANCHOE (CRASSULACEAE) – A COMPREHENSIVE REVIEW
Natural molecules from plants are vital sources to explore potent lead molecules in the drug discovery process. Plants as A source of medicine is an ancient practice in India. The Indian subcontinent is a wide repository of medicinal plants that are being used in the traditional system of medicines. Kalanchoe is one of the medicinal plants; the succulent leaf juice is prepared by grinding the leav...
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A CRITICAL REVIEW ON NIDIGDHIKADI LEHA IN THE MANAGEMENT OF RECURRENT UPPER RESPIRATORY TRACT INFECTION IN CHILDREN
Upper respiratory tract infections are the major cause of childhood morbidity leading to limit the day to day activities and school absenteeism. Diseases like tonsillitis, cough, and cold account for the maximum respiratory tract morbidities. Studies document that, in developing countries, on average, every child has five episodes of acute respiratory infections per year accounting for 30%-50% of ...
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