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METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF CILNIDIPINE AND OLMESARTAN MEDOXOMIL IN TABLET DOSAGE FORM BY UPLC USING DAD
Olmesartan Medoxomil and Cilnidipine combination lowers blood pressure effectively. Olmesartan Medoxomil is an angiotensin receptor blocker (ARB), and Cilnidipine is a calcium channel blocker (CCB). Cilnidipine and Olmesartan Medoxomil are widely used in hypertension. The scope of the study is to optimize the chromatographic conditions to develop a new RP-UPLC method for the simultaneous estimatio...
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GENERAL INVESTIGATIONS ON THE HEPATOPROTECTIVE POTENTIAL OF PHYLLANTHUS NIRURI
Phyllanthus niruri commonly known as Keezhanelli is traditionally used as a medicinal plant in many parts of the world. In this study, phytochemical screening was the hepatoprotective potential of the plant investigated. Two plant forms, namely, dry powder and fresh leaves were used. Aqueous and methanolic extracts were prepared from both forms, and the experiments were carried out. The hepatoprot...
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RETROSPECTIVE ANALYSIS OF CUTANEOUS ADVERSE DRUG REACTION AT TERTIARY CARE HOSPITAL
Introduction: Skin and subcutaneous tissue adverse drug reactions (ADR) are among the most common types of Cutaneous Reaction. The incidence rate of Cutaneous ADR is 1-3% for admitted patients in developed countries, whereas, in developing countries, it is 2-5% for admitted patients. Aims & Objective: To analyze the patient demographics, characteristics of the reaction, type of reaction, serio...
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IS HOARDING A NORMAL PHENOMENON, PERSONALITY DEFORMITY, OR A MENTAL DISORDER
Hoarding behavior is a normal phenomenon commonly observed in all corners of the world to prevent future scarcity of resources and overcome challenges of survival. Hoarding signs typically develop in childhood or early adolescence, which may become a serious disorder in the late phase of life. At present, hoarding disorder has been covered under the chapter of ‘Obsessive-Compulsive and Related D...
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MOLECULAR DOCKING STUDY ON SARS-COV-2 PROTEASE INHIBITION BY EXPLORING BIOACTIVE COMPOUNDS FROM DIFFERENT PLANTS
The novel human coronavirus which has been designated as SARS-CoV2 initially appeared in December 2019 in Wuhan, China causing a respiratory illness called COVID-19. The SARS-CoV2 is a β coronavirus belonging to the family Coronaviridae is a global public health emergency infecting many people all around the world, especially in India with more than 10.8 million cases. Henceforth there is an urge...
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ENHANCEMENT OF SOLUBILITY OF AN ORAL HYPOGLYCAEMIC DRUG, GLIMEPERIDE BY THE TECHNIQUE COCRYSTALLISATION
Co-crystallization is one of the most reliable alternative approaches to increase the solubility of poorly water-soluble drugs without affecting their physicochemical properties. Pharmaceutical cocrystals are neutral organic compounds connected to the API preferentially by loosely formed bonds as dipole-dipole interaction. Our present study aims at improving the solubility of an effective oral hyp...
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PREPARATION AND IN-VITRO EVALUATION OF APREMILAST EFFERVESCENT FLOATING TABLETS
Apremilast, the new PDE4 inhibitor drug, exhibits low solubility and low permeability; therefore, shows variable bioavailability. Effervescent floating tablets of apremilast were developed to sustain the drug release rate by increasing gastric retention time. These tablets were prepared by wet granulation technique, using different polymers like carbopol 934P, hydroxypropyl methylcellulose K4M, tr...
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DNA INTERACTION STUDIES BY UV OF COPPER COMPLEX BASED ON HETEROCYCLIC CHALCONES
Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Chalcones, considered as the precursors of flavonoids and isoflavonoids, are abundant in edible plants. Chalcone metal complexes and their derivatives have been known over the past fifty years. Copper is an...
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QUALITATIVE AND QUANTITATIVE ESTIMATION OF TYROSINE KINASE INHIBITORS IN PHARMACEUTICAL AND BIOLOGICAL MATRICES – AN OVERVIEW
Tyrosine kinase inhibitors generally having a narrow therapeutic window and large inter-patient variability. In order to support its therapeutic drug monitoring, fast and accurate methods are needed to supporting the pharmacokinetic-guided dosing in patients treating with various tyrosine kinase inhibitors (TKIs) either alone or in combination in bulk, formulations or human plasma using HPLC and d...
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FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF CIMETIDINE FOR ITS GASTRO RETENTIVE DRUG DELIVERY EFFICACY
The Aim and objective of this work were to build up a gastro retentive drug delivery system. Cimetidine is used as a model drug for making mucoadhesive dosage forms. The formulation can be achieved by using the ionic gelation method. The model drug used in this work plan is categorized in antiulcer treatment. The extended-release mucoadhesive microspheres of the drug provide constant plasma concen...
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