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DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR THE PHARMACOKINETIC STUDY OF FAMOTIDINE SNEDDS IN RATS USING RP-HPLC
A selective and high throughput RP-HPLC method was developed to detect and quantify Famotidine in rat plasma using Ranitidine hydrochloride as an internal standard (IS). After liquid-liquid extraction, the analyte and the internal standard were chromatographed on Enable 18H (5µ, 250×4.6mm) C18 column using 20 µL injection volume with a run time of 15 minutes. An isocratic mobile phase consistin...
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ANTIBACTERIAL ACTIVITY FROM BARK EXTRACTS OF PTEROSPERMUM ACERIFOLIUM (L.) WILLD.
Although there are many studies on antimicrobial activities of different plants, there is no report on antibacterial activity of Pterospermum acerifolium (Sterculiaceae). Therefore, a microbiological study was conducted to detect antibacterial activity of P. acerifolium. Successive ethanolic extract of bark of P. acerifolium were fractionated with hexane, butanol, methanol and water. In vitro anti...
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EVALUATION OF ADDITION OF PARACETAMOL AS ADD ON THERAPY TO LOW DOSE ETORICOXIB FOR ANALGESIA IN ACUTE PAIN: AN EXPERIMENTAL STUDY
Objective: To study the influence of paracetamol on analgesia when given separately with low dose etoricoxib for treatment of acute pain in mice. Materials and methods: Animals were divided into 6 groups consisting of six animals in each group. Dose was calculated by using conversion factor for mice from human dose. Group I, II, III and IV received 2% Gum acacia 10ml/kg, paracetamol 84.5mg/kg, eto...
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PHYTOCHEMICAL CHARACTERIZATION OF COLD MACERATED METHANOLIC LEAF EXTRACT OF CADABA INDICA LAM. USING GC-MS
Cadaba indica Lam (Indian Cadaba), an Indian traditional medicinal plant has been used for various diseases. The cold macerated methanolic leaf extract of Cadaba indica was assessed using Agilent GC 7890A gas chromatography connected with an MS- 5975C mass spectrometer and the mass spectra were matched with NIST 14.0 – data library. Several chemical constituents were identified within 28 min of ...
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CHEMICAL COMPOSITION, ANTIMICROBIAL AND ANTIOXIDANT PROPERTIES OF BARRINGTONIA ACUTANGULA BARK EXTRACT
Barringtonia acutangula (L.) Gaertn. (Family: Lecythidaceae), is a medium-sized tree found throughout India. It has been used in folk medicine to treat tuberculosis, skin disease, inflammation, hemorrhoids and diarrhea. The present study deals with in-vitro antioxidant, antimicrobial and GC-MS study on the bark extract of B. acutangula. In order to investigate the antioxidant activity, reduci...
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RETROSPECTIVE ANALYSIS OF CUTANEOUS ADVERSE DRUG REACTION AT TERTIARY CARE HOSPITAL
Introduction: Skin and subcutaneous tissue adverse drug reactions (ADR) are among the most common types of Cutaneous Reaction. The incidence rate of Cutaneous ADR is 1-3% for admitted patients in developed countries, whereas, in developing countries, it is 2-5% for admitted patients. Aims & Objective: To analyze the patient demographics, characteristics of the reaction, type of reaction, serio...
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SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING STUDIES AND ANTHELMINTIC AND ANTI-CANCER ACTIVITY OF PYRAZOLE CONTAIN NOVEL INDOLIN-2-ONE DERIVATIVES
Background: Imidazole-5-one scaffold has been predicted in the important synthetic drug analogs, which gave valuable information for treatment and high binding affinity to the multiple receptors helpful drug development. Objective: To synthesize and evaluate the anthelmintic, anticancer, and Insilco docking studies of pyrazole contain novel Indole derivatives (4a-4h). Methods: In the present work,...
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FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF CIMETIDINE FOR ITS GASTRO RETENTIVE DRUG DELIVERY EFFICACY
The Aim and objective of this work were to build up a gastro retentive drug delivery system. Cimetidine is used as a model drug for making mucoadhesive dosage forms. The formulation can be achieved by using the ionic gelation method. The model drug used in this work plan is categorized in antiulcer treatment. The extended-release mucoadhesive microspheres of the drug provide constant plasma concen...
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FORMULATION AND EVALUATION OF MUCOADHESIVE GEL FOR ORAL CANDIDIASIS
Oral candidiasis (OC) is a common fungal infection characterized by white patches on the oral mucosa, often triggered by factors like immunosuppression and medication use. It can affect anyone, regardless of age or background. The formulation of mucoadhesive gels for the treatment of oral candidiasis is a promising area of research. The gel enhances the residence time of the drug at the site of in...
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IS HOARDING A NORMAL PHENOMENON, PERSONALITY DEFORMITY, OR A MENTAL DISORDER
Hoarding behavior is a normal phenomenon commonly observed in all corners of the world to prevent future scarcity of resources and overcome challenges of survival. Hoarding signs typically develop in childhood or early adolescence, which may become a serious disorder in the late phase of life. At present, hoarding disorder has been covered under the chapter of ‘Obsessive-Compulsive and Related D...
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