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ALTERATIONS IN LIPID PROFILE PARAMETERS OF ALBINO RAT AFTER INTOXICATION OF MERCURY SELENIDE NANOPARTICLES
Nanoparticles are of great scientific interest, in fact, a bridge between bulk materials and atomic or molecular structures. The main characteristic of nanoparticles is their extreme smaller size, which falls in the transitional zone between molecules and the corresponding bulk materials. Lipids and fatty acids are a family of molecules classified within the lipid macronutrient class. The present ...
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FORMULATION OF DORZOLAMIDE HYDROCHLORIDE IN-SITU PREPARATION FOR TREATMENT OF GLAUCOMA; IN-VITRO, EX-VIVO AND IN-VIVO CHARACTERIZATION
Present study was planned to prepare a dorzolamide hydrochloride in-situ gel by using Carbopol 974 and HPMC K4M to reduce dosing frequency by increasing residence time as well as sustained drug release from the formulation in cul-de-sac. The concentration of both polymers was optimized by using 32 factorial designs with correlating its impact on dependent variables as cumulative in-vitro drug diff...
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GC-MS ANALYSIS AND IN-VITRO CYTOTOXICITY STUDY OF DENDROPHTHOE FALCATA AND TRIDAX PROCUMBENS EXTRACTS AGAINST HACAT CELLS LINE
The present study shows the cytotoxic effect of Dendrophthoe falcata (L. f) and Tridax procumbens Linn. extracts against HaCat (Skin cancer) cell line by MTT and SRB assay method. The phytochemical screening of extracts dichloromethane: methanol (DM), methanol: water (MW), and ethanol: water (EW) revealed the presence of secondary metabolites such as alkaloids, flavonoids, saponins, tannins, stero...
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HEPATOPROTECTIVE ACTIVITY OF CHENOPODIUM ALBUM LINN. AGAINST PARACETAMOL INDUCED LIVER DAMAGE IN ALBINO RATS
Chenopodium album Linn. is a plant that has a long history of uses in liver disorders. This study was done to evaluate the hepatoprotective effects of methanolic extract of Chenopodium album leaves on paracetamol-induced hepatotoxicity in albino rats. The hepatoprotective effect was evaluated on the basis of liver function parameters viz. Serum glutamic oxaloacetic transaminase (SGOT), Serum gluta...
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RECENT TRENDS IN WOUND CARE HERBAL FORMULATIONS: META ANALYSIS AND SYSTEMATIC REVIEW
Wound healing is a normal and common process that typically involves overlapping roles to increase normal activity by increasing neutrophils. The healing process can be managed by using natural substances that have therapeutic properties. The activity of numerous proteins and their regulation by genes orchestrate a healing performance like no other. The present study is to learn about the recent a...
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STANDARDIZATION OF AMUKKARA CHOORANUM- SIDDHA DRUG
Siddha medicine originated from Tamil culture in southern India. Worldwide there are 75% of herbal plants are used for AYUSH and Allopathy medicines. Amukkara Choornam is a polyherbal Siddha formulation. Amukkara Choornam has anti-arthritic activity, and it helps to cure rheumatoid arthritis. The demand for Siddha medicines in India is increasing daily; we have to overcome some problems like quali...
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EFFECT OF CHROMIUM ON MORPHOLOGICAL AND BIOCHEMICAL RESPONSES ON AQUATIC MACROPHYTE PISTIA STRATIOTES L. (WATER LETTUCE)
The current work reports an ecofriendly approach to study morphological and biochemical responses of Pistia stratiotes L. (Water lettuce) were investigated. The assessment of morphological, biochemical parameters, and accumulation of chromium in free-floating macrophyte exposed at its various concentrations viz. 0.25, 0.50, 1.25, and 2.5 ppm of chromium at the regular intervals of 4, 8, and 12 day...
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ANTI-ULCER ACTIVITY OF POLYHERBAL FORMULATION ACIDEZ IN EXPERIMENTALLY INDUCED GASTRIC ULCERS IN RATS
Aim and Objective: Acid-related health problems mostly affect the quality of life and are a major factor in morbidity and mortality in patients. This study is designed to evaluate the anti-ulcer activity of Polyherbal formulation ACIDEZ against experimentally induced gastric ulcers in rats. Methodology: To determine anti-ulcer activity, ulcers were induced by aspirin plus pylorus ligation and acet...
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METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF CILNIDIPINE AND OLMESARTAN MEDOXOMIL IN TABLET DOSAGE FORM BY UPLC USING DAD
Olmesartan Medoxomil and Cilnidipine combination lowers blood pressure effectively. Olmesartan Medoxomil is an angiotensin receptor blocker (ARB), and Cilnidipine is a calcium channel blocker (CCB). Cilnidipine and Olmesartan Medoxomil are widely used in hypertension. The scope of the study is to optimize the chromatographic conditions to develop a new RP-UPLC method for the simultaneous estimatio...
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GENERAL INVESTIGATIONS ON THE HEPATOPROTECTIVE POTENTIAL OF PHYLLANTHUS NIRURI
Phyllanthus niruri commonly known as Keezhanelli is traditionally used as a medicinal plant in many parts of the world. In this study, phytochemical screening was the hepatoprotective potential of the plant investigated. Two plant forms, namely, dry powder and fresh leaves were used. Aqueous and methanolic extracts were prepared from both forms, and the experiments were carried out. The hepatoprot...
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