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PUTATIVE ROLE OF ISATIN DERIVATIVES SYNTHESIS AND THEIR BIOLOGICAL APPLICATIONS- A REVIEW
Isatin (1H-indole-2,3-dione) and its derivatives represent an important class of heterocyclic compounds that can be used as precursors for drug production. Erdmann1 and Laurent2 first discovered isatin in 1840 as an oxidation product of indigo dye for nitric acid and chromic acid. Isatin is one of the most important heterocyclic compounds. For example, Schiff foundations of isatin are used for the...
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ETHNOMEDICINAL AND PHARMACOLOGICAL IMPORTANCE OF BACOPA MONNIERI: A REVIEW
Despite the considerable advancement in medical sciences and allopathic medicines, the use of complementary and alternative medicines has dramatically increased worldwide. Bacopa monnieri is one of the most important and highly studied medicinal plants that is being used as an ayurvedic or ethnomedicine for thousands of years. It improves intelligence rejuvenation and treats mental illness, fever,...
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FORMULATION AND EVALUATION OF SUSTAIN RELEASE MATRIX TABLET OF FLUVOXAMINE MALEATE USING MORINGA OLEIFERA GUM
Fluvoxamine Maleate, an oral serotonin reuptake inhibitor, has been used widely for the treatment of anxiety. Sustained-release matrix-type drug delivery system has advantages over conventional modes of drug administration, enhancing drug bioavailability as it avoids the first-pass metabolism and improves patient compliance. Optimization of the formulation was performed by varying the concentratio...
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DEVELOPMENT AND EVALUATION OF HERBO SYNTHETICGEL: A NOVEL TREATMENT FOR PSORIASIS
Background: Psoriasis is an immune-mediated inflammatory disease characterized by excessive growth and abnormal differentiation of keratinocytes. Objective: In the present research work, an attempt has been made to formulate and evaluate gel containing cyclosporine, aloe vera and tree tea oil. Methods: The gel was prepared by a conventional method and evaluated for various parameters viz., physica...
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EVALUATION OF COGNITION ENHANCING ACTIVITY OF SESBANIA GRANDIFLORA (L.) FRUITS EXTRACT ON HIGH FAT DIET INDUCED DEMENTIA
The study was aimed to justify the traditional claim of fruits of Sesbania grandiflora (Leguminosae) as a medhya rasayana. Dementia was induced with chronic administration of a high fat diet for 90 days. Petroleum ether, benzene, chloroform, acetone, ethanol extracts of fruits of Sesbania grandiflora were evaluated for cognition-enhancing activity in high-fat diet-induced dementia in rats using an...
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ESTIMATION OF FOSTEMSAVIR USING A NOVEL HPLC ANALYTICAL METHOD
Fostemsavir was quantified using a simple and reliable HPLC technique developed and validated. PhenomenexC18 column was used to achieve chromatographic segregation (150 x 4.6 mm, 5m). The mobile phase was a 55:45 mixture of 0.01N disodium orthophosphate and acetonitrile pumped through the column at 1.0ml/min. The temperature was maintained at 30 °C and the buffer used was 0.01N sodium dihydrogen ...
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SIMULTANEOUS QUANTIFICATION OF ROSUVASTATIN AND TELMISARTAN IN BULK AND TABLET – A VALIDATED UV-SPECTROPHOTOMETRIC TECHNIQUE
Rosuvastatin and Telmisartan are used together as a fixed dosage combination to treat hypertension associated with dyslipidemia. Objective: To develop and validate a simple, sensitive, precise, ecofriendly and cost-effective method for the determination of Rosu-vastatin and Telmisartan in bulk and pharmaceutical formulation as per ICH Guidelines. Methods: an effort has been made to develop a simpl...
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EMERGING ROLE OF NUTRACEUTICALS IN THE MANAGEMENT OF HYPERTENSION: A SYSTEMATIC REVIEW
Nutraceutical is a word obtained from Nutrition and Pharmaceuticals. Nutrients are a feed constituent that helps to support the life of human beings or animals. Pharmaceutical components are non-toxic food constituents, including prevention and treatment of disease. They commonly inhabit the disorders associated with oxidative stress, for instance, cardiovascular disease, Diabetes, and Hypertensio...
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SIMULTANEOUS DETERMINATION OF PREDNISOLONE AND ASPIRIN IN SYNTHETIC MIXTURE BY VIERORDT´s METHOD
Prednisolone (10mg/day) plus low dose Aspirin (80mg/day) improve the implantation rate in women with autoimmune condition who are undergoing in-vitro fertilization. A new, simple, precise, accurate, and validated simultaneous equation method (Vierordt´s Method) has been developed for simultaneous determination of Prednisolone and Aspirin in the synthetic mixture. The method was based on the measu...
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SYNTHESIS, CHARACTERIZATION AND IN-VITRO ANTICANCER SCREENING OF VITIS VINIFERA SEED ETHANOLIC EXTRACT LOADED CHITOSAN NANOPARTICLES IN H-29 COLON CANCER CELL LINE
Nanotechnology can be applied to deliver and protect antioxidants in order to control the oxidative stress phenomena in several chronic pathologies. Chitosan (CS) and its carboxymethyl derivatives are smart biopolymers that are non-toxic, biocompatible, and biodegradable, and, hence, suitable for various biomedical applications, such as drug delivery gene therapy and tissue engineering. Vitis vini...
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