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A BURDEN OF GASTROENTERITIS ASSOCIATED WITH COMORBIDITIES AN EFFECTIVE MANAGEMENT STRATEGY
Acute gastroenteritis prevalent amongst children and newborns is considered a serious infection globally. The Acute diarrhea as a result of gastroenteritis as per logistics suggest that there were more than 1.5 million outpatient visits along with 200,000 hospitalizations and 300 fatalities per year in children in U.S. Diarrhea is the leading cause of deaths amongst children with 30% relapse rate....
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SCOPE OF AZETIDINONE HYBRIDS FOR DIVERSE PHARMACOLOGICAL ACTIVITIES; A REVIEW
Azetidinones (Azetidin-2-ones), more commonly known as β-lactams, are well-known heterocyclic moieties among the medicinal compounds mainly because of their diverse pharmacological activities such as antimicrobial, anti-inflammatory, anticonvulsant, anti-HIV, anti-parkinsonian, antidiabetic and antitubercular activities. Various com-parative studies of current azetidinone derivatives show an alar...
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AN EXPERIMENTAL STUDY TO EVALUATE THE EFFECT OF TRANDOLAPRIL AND NIMODIPINE IN ANXIETY, DEPRESSION AND MOTOR COORDINATION USING BEHAVIORAL MODELS IN SWISS ALBINO MICE
The present study aimed to assess the role of angiotensin-converting enzyme inhibitor (trandolapril) and calcium channel blocker (nimodipine) in anxiety, depression, and motor coordination using behavioral models in mice. This was an experimental study involving 72 swiss albino mice divided into 12 groups. Groups 1 to 4 were used to evaluate the anxiolytic effect using Y maze after 5 days of t...
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DESIGN AND CHARACTERIZATION OF TASTE MASKED DEXTROMETHORPHAN HBR ORAL DISINTEGRATING TABLET BY USING NATURAL SUPERDISINTEGRANTS
Objective: Our work was to develop an ordispersible tablet of Dextromethorphan HBr with acceptable palatability to help patients of all age groups. Methods: The bitter taste of the drug was masked by entrapping the drug into Eudragit RL 100. The microspheres were prepared from solvent evaporation method. The effect of particle size, drug entrapment efficiency, % yield and % drug release of the mic...
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EFFECT OF AQUEOUS EXTRACT OF CRYPTOLEPIS SANGUINOLENTA ADMINISTRATION ON THE METABOLISM OF CHLOROQUINE VIA CYTOCHROME P450 ISOZYMES
Concurrent administration of herbal medicines and conventional drugs is a common practice globally, especially as the patronage of medicinal plants increases across the world. This study aimed to determine the effect of Cryptolepis sanguinolenta administration on the metabolism of chloroquine by evaluating specific Cytochrome P450 isozymes. Reconstituted freeze dried Cryptolepis sanguinolenta was ...
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COMPLETENESS ASSESSMENT OF HANDWRITTEN MEDICAL PRESCRIPTIONS IN SOUTHEAST KINSHASA COMMUNITY PHARMACIES
Medical prescription carefully conceived is essential to provide effective health care to the patient. It is a medicolegal document that should be legible, clear and complete. However, several studies have shown that prescription errors remain common worldwide, particularly in low-income countries the such Democratic Republic of Congo. This study aimed to explore the completeness of medical prescr...
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PATTERN OF ANTIDEPRESSANT PRESCRIPTION IN PATIENTS SUFFERING FROM DEPRESSIVE DISORDER IN A TERTIARY CARE HOSPITAL
Background: Depression is becoming an important health problem worldwide because of its relatively high lifetime prevalence, significant disability, suffering, dysfunction, and economic burden caused by it. Objectives: The present study was conducted with the objective to determine the prescribing pattern of antidepressant drugs in patients suffering from depression disorder in the psychiatric out...
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IN-VITRO ANTHELMINTIC EFFECTS OF MEDICINAL PLANT CASSIA FISTULA EXTRACT ON THE TEGUMENT OF FASCIOLA GIGANTICA BY LIGHT MICROSCOPE
The efficacy of alcoholic Cassia fistula leaves extract on the tegument of Fasciola gigantic was studied by light microscopy. Live liver fluke Fasciola gigantica parasites were collected from the infected liver and bile duct of freshly slaughtered domestic goat (Capra hircus) at the local zoo abattoir in Udaipur. Liver flukes F. gigantica were maintained in 0.9% physiological saline and divided in...
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF GLIPIZIDE AND MOMORDICININ IN RAT PLASMA
Momordicinin (MMR) is a major triterpenoid compound from Momordica charantia Linn fruit having antidiabetic potential, whereas glipizide (GPZ) is a well-known molecule in treatment of diabetes mellitus. The primary objective of the study is to develop and validate a simultaneous RP-HPLC method for upcoming pharmacokinetic studies to analyze herb-drug interactions. The study uses the protein precip...
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QUANTITATIVE ESTIMATION OF MINERAL CONTENT FROM EDIBLE FLOWERS OF ALLIUM CEPA, CUCURBITA MAXIMA AND CARICA PAPAYA: A COMPARATIVE STUDY
Edible flowers have been an integral part of human nutrition for centuries, being used as garnishes of individual dishes and also consumed fresh. This study determines and compares the essential and trace mineral composition of the three edible flowers of Allium cepa (onion), Carica papaya (papaya) and Cucurbita maxima (pumpkin) with four other commonly consumed edible flowers. Also, a comparative...
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