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HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF ETHANOLIC LEAVES EXTRACT OF ABROMA AUGUSTA AGAINST NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) IN SD RATS
To study the hepatoprotective activity of ethanolic leaves extracts of Abroma augusta against non-alcoholic fatty liver disease to validate ethnobotanical claim regarding the plant used in the above mentioned disease. Materials and Methods: The hepatoprotective potential of Abroma augusta leaves extract (AALE) (250 and 500 mg/kg/ body weight) was studied on Methionine and Choline deficient diet (M...
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A REVIEW ON HEALTH ISSUES AND PLAUSIBLE REMEDIES IN MENTALLY CHALLENGED CHILDREN
The bioavailability of conventional ophthalmic solutions is very poor due to efficient protective mechanisms of the eye, blinking, reflex Mental health problems are characterized by in definite persistently depressed mood, low self-esteem, loss of interest in normal life activities. A common problems were the chances to occurs from generation to generation, i.e., genetic in nature, and these may a...
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A COMPREHENSIVE REVIEW OF SYNTHESIS, DOCKING TARGETS AND PHARMACOLOGICAL ACTIVITIES OF PYRAZOLINE DERIVATIVES
Pyrazolines, among the various 5-membered heterocyclic compound derivatives, have drawn attention towards it because of their various pharmacologic activities. They are nitrogenous heterocyclic compounds containing two nitrogens in the adjacent position, which possess considerable biological activity. The synthesis of pyrazolines was initiated after the pioneering work of Fischer and Knoevenagel i...
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PHYTOCHEMICAL SCREENING AND IN-VITRO ANTI-CATARACT ACTIVITY ON THE SEED OF CUCUMIS MELO L. ETHANOLIC EXTRACT
Objective: Evaluation of in-vitro anti-cataract activity on the Cucumis melo L ethanolic extract seeds by glucose-induced cataract in incubated goat lenses. Methods: Anticataract activity is performed by using an isolated goat lens. The goat lens was divided into six groups. Group I: Lens was incubated in artificial aqueous Humor (Glucose 5.5 mM). Group II: Lens was incubated with artificia...
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PHYLOGENETIC CHARACTERIZATION OF POTENTIAL BIOACTIVE METABOLITES PRODUCING ACTINOMYCETES FROM MANGROVE SEDIMENTS
An attempt has been made in the present study to isolate and identify actinomycetes, which can produce bioactive metabolites possessing antimicrobial activity. The soil samples were collected from mangrove sediments of Krishna district, Andhra Pradesh. The potent secondary metabolite producing strains were isolated and designated as VLK-15, VLK-24, and VLK-56. Identification of the strains was car...
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DISSOLUTION ENHANCEMENT OF ROSUVASTATIN CALCIUM BY USING VARIOUS GENERATIONS OF HYDROPHILIC POLYMERS: A COMPARATIVE STUDY
Oral administration is the preferred route of drug administration owing to its convenience, patient compliance, and cost-effectiveness. The study aspired to augment the solubility and dissolution rate of Rosuvastatin calcium (RST) by using the solid dispersion (SD) technique with various generations of hydrophilic polymers. Hot melt and solvent evaporation methods were employed to prepare SD using...
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1471
FORMULATION AND EVALUATION OF GASTRO RETENTIVE MUCOADHESIVE FILM OF RITONAVIR
Objective: The research work aims to formulate and evaluate the Gastro retentive mucoadhesive film of Ritonavir using polymers like HPMC K15M, Polyvinyl alcohol, and PEG 400 as a plasticizer by solvent casting method for treatment of AIDS. Method: Prepared gastro retentive mucoadhesive films were evaluated for various parameters such as in-vitro unfolding behavior of film, Folding endurance, Perce...
2110
1275
EUGENIA JAMBOLANA LAM. (BLACK PLUM): A FUTURE SOURCE OF AN ANTIDIABETIC DRUG
Traditional medicine has been aware about and made use of "medicinal herbs," for millennia. Numerous chemical compounds are produced by plants to serve a variety of purposes, including defence and protection against diseases and disorders. Type 1 diabetes mellitus (T1DM) and Type 2 diabetes mellitus (T2DM) are prevalent forms of DM, characterised by deficient insulin secretion (in T1DM) or impaire...
2110
919
IN-VIVO TOXICITY PROFILE OF METHANOLIC EXTRACT OF TERMINALIA ARJUNA (ROXB. EXDC) BARK IN MALE ALBINO WISTAR RATS
The bio-active compounds present in Terminalia arjuna (Roxb. ExDC) have anti-oxidant, anti-proliferative, anti-obesity, anti-hyperglycemic, and lipid-lowering activity. In addition, it has cardioprotective, hepatoprotective, and renoprotective properties. The study evaluated in-vivo toxicity profile of the methanolic extract of Terminalia arjuna (META) bark on male albino Wistar rats before undert...
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NEURODEGENERATIVE DISORDERS: ROLE OF MEDICINAL PLANTS IN TREATMENT
Neurons are the nervous system's basic components that involve the spinal cord and brain. Neurons do not usually replicate or substitute them because the body cannot replace them as they get impaired or die. Neurological conditions are untreatable and disabling diseases that result in irreversible deterioration/death of the human brain's nerve cells or neurons. Treating these conditions with exten...
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