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CYTOTOXICITY, ANTIMICROBIAL ACTIVITIES AND CHEMICAL PROPERTIES OF TEN PLANTS FROM THE BENIN PHARMACOPOEIA USED FOR ORAL CARE
This study aims to valorizeten medicinal plants traditionally used for oral care in Benin by producing scientific data on their toxicities, antimicrobial activities, and chemical properties. The ten medicinal plants (Zanthoxylum zanthoxyloides, Vitellaria paradoxa, Prosopis africana, Dialium guineense, Pseudocedrela kotschyi, Parkia biglobosa, Azadirachta indica, Diospyros mespiliformis, Anogeissu...
2055
890
IN-VIVO TOXICITY PROFILE OF METHANOLIC EXTRACT OF TERMINALIA ARJUNA (ROXB. EXDC) BARK IN MALE ALBINO WISTAR RATS
The bio-active compounds present in Terminalia arjuna (Roxb. ExDC) have anti-oxidant, anti-proliferative, anti-obesity, anti-hyperglycemic, and lipid-lowering activity. In addition, it has cardioprotective, hepatoprotective, and renoprotective properties. The study evaluated in-vivo toxicity profile of the methanolic extract of Terminalia arjuna (META) bark on male albino Wistar rats before undert...
2055
1122
IN-VITRO CYTOTOXIC STUDY ON ROOT EXTRACTS OF APAMA SILIQUOSA LAMK.
The demand for herbal medicines is growing at a drastic rate due to their improved pharmacological actions, minimal side effects, and cost-effectiveness. The ever-increasing cost of chemotherapy ruined the economic stability of many families. This led to the discovery of herbal medicines for cancer treatment. Tribes of Western Ghats have been using the roots of Apama siliquosa for cytotoxic activi...
2055
1183
REVIEW ON VOSORITIDE: ACHLONDROPLASIA
BioMarin Pharmaceutical is developing Vosoritide, a modified recombinant human C-type natriuretic peptide (CNP) analogue for the treatment of achondroplasia. A gain-of-function mutation in the fibroblast growth factor receptor 3 gene (FGFR3), a negative regulator of bone growth, causes achondroplasia. Vosoritide works to restore chondrogenesis by attaching to the natriuretic peptide receptor B (NP...
2054
903
IMPACT OF GENETICS IN NEURODEVELOPMENTAL DISORDERS
A category of illnesses known as neurodevelopmental disorders is predominantly linked to neurodevelopmental dysfunctions. The two most prevalent neurodevelopmental disorders, “Attention Deficit/Hyperactivity Disorders (ADHD)” as well as“Autism Spectrum Disorders (ASD)”, affect both humans and lower-class species like rats, mice and zebra fish. The purpose of this review is to identify the ...
2054
895
AN ANTIPLASMODIAL ACTIVITY OF LEAVES EXTRACTS OF CASSIA OBTUSIFOLIA AND HYPTIS SUAVEOLENS FROM GHANA
A number of the population in developing countries use herbs and herbal products to treat various diseases including malaria. However, most of them have not been evaluated for their efficacy and toxicity and their use is not standardized in some instances. Poly-herbal extracts may yield better treatment outcomes compared to extracts from a single plant due to the combined effects of bioactive comp...
2054
1083
TOWARDS FURTHER UNDERSTANDING THE MECHANISM OF BIOSORPTION THROUGH VARIOUS BIOSORBENTS
Biosorption is a cure to atmosphere containing heavy metals and also an alternative to physical and chemical methods used for heavy metal removal. The main aim of this review is to highlight the various mechanisms of biosorption by using various biosorbent viz. microorganisms, no-living biomass, herbal plants for the removal of heavy metals. Industrialization, globalization has provided an ease to...
2053
1090
NANOSTRUCTURED LIPID CARRIERS –A PROMISING CARRIER FOR IMPROVING ORAL BIOAVAILABILITY OF DRUGS
To deliver both conventional as well as novel drugs, the oral route was considered as the most preferable one because it reduces patient’s non-compliance, well accepted by the patients, and can also eliminate the discomfort and pain accompanied by parenteral preparations. Even while oral formulations offer numerous advantages, several drawbacks substantially affect bioavailability. In recent yea...
2053
1417
SIGNIFICANT ROLE OF NUTRACEUTICALS AND FUNCTIONAL FOODS IN THE MANAGEMENT OF METABOLIC SYNDROME
Metabolic syndrome is the most widely and prevailing health concern globally. It is a cluster of biochemical and physiological abnormalities that involve obesity, insulin resistance, dyslipidemia, and hypertension. Several studies have reported that the prevalence of the overall metabolic syndrome rate in adults is about 25% (approx. 31% in women and 18.5% in men) in India. Whereas the global prev...
2053
1373
ANTIMICROBIAL STUDIES OF NEW RARE EARTH METAL(III) COMPLEXES OF SCHIFF BASE LIGANDS WITH 1-H INDOLE-(2, 3-DIONE): SYNTHESIS, PHYSIO-CHEMICAL, MAGNETIC, ELECTROCHEMICAL AND SPECTRAL STUDIES
New complexes of La (III) and Nd (III) with bidentate Schiff base ligands, 1-H indole-(2, 3-dione) hydrazinecarbothioamide (L1H), 1-H indole-(2, 3-dione) hydrazinecarboxamide (L2H) have been synthesized and characterised. The stoichiometry of the complexes is originated in the type of [Ln (L1, 2) 3].3H2O for both metals. The characterization and nature of bonding of these complexes were elucidated...
2053
1133