Most Popular
A COMPARATIVE EVALUATION OF ANTIPLATELET REGIMENS FOR PREVENTION OF RECURRENCE IN PATIENTS WITH ISCHEMIC STROKE – A PILOT STUDY
Background: Prevention of recurrence is important for patients with ischemic stroke. The purpose of the study was to compare the effectiveness of two antiplatelet regimens-aspirin plus clopidogrel versus aspirin plus cilostazol in early secondary stroke prevention using National Institutes of Health Stroke Scale (NIHSS) Scores. Methods: In this study, we randomly assigned 30 patients to receive as...
2108
1077
IN-VITRO AND IN-VIVO STUDIES OF PHB CAST FILMS BLENDED WITH VARIOUS HERBS AND ITS BIOCOMPATIBLE CHARACTERIZATION
The present study deals with the PHB made cast film with different plant and algal formulations. Its biocompatibility was tested in-vitro and in-vivo. The anti-inflammatory activity was higher in F4 and F5, close to the standard Diclofenac. The F7 and F8 exhibited moderate cytotoxicity, and formulation F2 exhibited low cytotoxicity. The maximum zone of inhibition was exhibited in F5 followed by F4...
2108
1197
EVALUATION OF THE GENETIC DIVERGENCE OF VARIOUS ACCESSIONS OF THE SPECIES CARISSA CARANDAS USING INTER SIMPLE SEQUENCE REPEAT PRIMERS
Carissa carandas Linn. belonging to the family Apocynaceae, is an underutilized fruit plant. C. carandas has been used in many ethno medicines 6, 40, 30. Genetic diversity is a ubiquitous feature of all species in nature. ISSR markers are useful in areas of genetic diversity, phylogenetic studies, gene tagging, genome mapping, and evolutionary biology in a wide range of plant species 4, 12. In thi...
2107
1201
SELF–MICROEMULSIFYING DRUG DELIVERY SYSTEM: SPECIAL EMPHASIS ON VARIOUS SURFACTANTS USED IN SMEDDS
The majority of novel chemical entities getting discovered are having low water solubility and it must be addressed to distribute the drug more effectively. SMEDDS, a lipid-based drug delivery approach, is thought to boost oral absorption of less hydrophilic drugs. Surfactants are the major excipients used in SMEDDS as they are responsible for the emulsification process. The two main criteria whil...
2106
1561
SAFETY AND EFFICACY OF FORMOTEROL/TIOTROPIUM BROMIDE AND FORMOTEROL/GLYCOPYRRONIUM COMBINATION IN COPD WITH GOLD GRADE 3 PATIENTS
An increasing airflow limitation that is not entirely reversible is a hallmark of chronic obstructive pulmonary disease (COPD). In patients with COPD, the present study investigated the effectiveness and safety of formoterol/tiotropium bromide vs formoterol/glycopyrronium in fixed combinations. In conjunction with formoterol, the long-acting anti-muscarinic drug glycopyrrolate has recently receive...
2105
782
ROLE OF VITAMIN D IN CARDIOMETABOLIC DISORDERS – A REVIEW BASED ON PATHOPHYSIOLOGY AND CLINICAL EVIDENCES
Background: Cardiometabolic syndromes are the co-occurrence of metabolic abnormalities such as obesity, insulin resistance, atherogenic dyslipidemia, and hypertension. Cardiometabolic disorders includes type2 diabetes mellitus, metabolic syndrome, and cardiovascular diseases. The prevalence of cardiometabolic disorders are growing in epidemic proportions all over the world; hence cardiometabolic d...
2104
1352
TOWARDS FURTHER UNDERSTANDING THE MECHANISM OF BIOSORPTION THROUGH VARIOUS BIOSORBENTS
Biosorption is a cure to atmosphere containing heavy metals and also an alternative to physical and chemical methods used for heavy metal removal. The main aim of this review is to highlight the various mechanisms of biosorption by using various biosorbent viz. microorganisms, no-living biomass, herbal plants for the removal of heavy metals. Industrialization, globalization has provided an ease to...
2104
1103
ANTI-INFLAMMATORY, ANTI-CANDIDAL ACTIVITY AND IN-SILICO PREDICTION OF PHARMACOKINETIC PROPERTIES OF NARDOSTACHYS JATAMANSI
The earlier reports on Nardostachys jatamansi show contain a various class of chemical constituents that have influenced the anti-inflammatory and anti-candidal activities. The present study reports the evaluation of anti-inflammatory and anti-candidal activities of N. jatamansi and also studies pharmacokinetic properties using in-silico model. In ongoing research work, we used individual extracts...
2104
1022
LITHIUM CHLORIDE RESCUES RETINAL GANGLION CELLS IN RAT MODEL OF GLUTAMATE EXCITOTOXICITY
Retinal ganglion cell (RGC) death is distinctive of many ophthalmic disorders, such as glaucoma, optic neuropathies, and various retinovascular diseases. N-methyl-D-aspartate (NMDA)-type glutamate receptor (NMDAR)-mediated excitotoxicity is thought to be an important contributor to RGC death. Uninterrupted activation of a large number of NMDARs leads to increases in intracellular calcium loads, in...
2102
1210
IDENTIFICATION AND OPTIMIZATION OF BINDING SITE FOR AN ACTIVE METABOLITE OF CLOPIDOGREL, PRASUGREL AND TICLOPIDINE ON RECEPTOR P2Y12
In this article, an attempt was made to develop molecular docking studies on active metabolites of Prasugrel, Clopidogrel, and Ticlopidine acting as protein P2Y12 inhibitors. Molecular docking analysis was performing by using autodock version 4.3 adjoin with discovery studio to better understand the interactions between P2Y12 targets and inhibitors in this series. Hydrophobic and hydrogen bond int...
2102
1399