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VALIDATED RP-HPLC STABILITY-INDICATING METHOD OF ANTICOAGULANT ACTIVE PHARMACEUTICAL INGREDIENT; APIXABAN
A simple and precise stability-indicating reversed-phase (RP-HPLC) method was developed and validated for the determination of Apixaban active pharmaceutical ingredient. The chromatographic condition was carried out on Phenomenex Luna 5 µm C18 100 Å (150 × 4.6 mm) HPLC column with prepared buffer solution 1.0 ml of Orthophosphoric acid mixed with 0.2% of potassium dihydrogen phosphate solution,...
1966
1067
SYNTHESIS, CHEMICAL CHARACTERIZATION AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF SOME NOVEL QUINOXALINES
Substituted quinoxaline has received considerable attention during the last few years as they are endowed with various biological activities and have a wide range of therapeutic properties. Piperazine has proven its worth in numerous clinically active drugs broader areas of therapeutic index. Hence, biologically important quinoxaline derivatives containing a piperazine moiety and Schiff base scaff...
1966
3270
PHYSICOCHEMICAL AND PHYTOCHEMICAL CHARACTERIZATION OF THE FLOWERS OF IMPATIENS BALSAMINA
Traditional herbal remedies predate all other medicinal systems for thousands of years. The physicochemical and phytochemical analysis of Impatiens balsamina flowers reveals valuable insights into its composition, emphasizing its potential in herbal medicine and food science. The total ash content was 7.45 g/100 g, with significant portions of acid-insoluble (2.67 g/100 g) and water-soluble ash (3...
1966
1391
GREEN SYNTHESIS OF SILVER NANOPARTICLES USING MILLETS, ITS CHARACTERIZATION AND EVALUATION OF ANTIMICROBIAL ACTIVITY
The development of Nanotechnology has paved the way to study various nanomaterials. Nanoparticles are structures that measure the size from 1-100nm. Widely used nanoparticles are usually prepared using noble metals, that is, gold, silver, palladium, and platinum. At the same time, they find their way into a wide range of applications in medicine, electronics, energy saving, environment, textile, c...
1964
1179
PROTECTIVE EFFECT OF CURCUMIN ON LIPID PEROXIDATION AND ANTIOXIDANT STATUS AGAINST CADMIUM CHLORIDE TOXICITY IN HEART (AURICLES AND VENTRICLES) OF ALBINO MICE
Cadmium can cause various health problems even at low concentrations by inducing oxidative damage in tissues of organisms. Nowadays, the focus has been raised toward the use of herbal treatment against heavy metal toxicity. Hence, the present research work was aimed to investigate the protective effect of curcumin against Cd-induced toxicity in the auricles and ventricles of the heart in albino mi...
1964
991
SQUALENE: A POTENTIAL ANTI-ALZHEIMER’S COMPOUND IN ALBINO RAT
Alzheimer’s disease, the most scattered neurodegenerative disease causes progressive destruction in serviceable performances and continuous reduction in cognitive activities and memory in aged people. It is estimated that people suffering from AD is about 10% between 65-70 years and 50% in people above 85years of age and this number will double every two decades. Even though extensive research h...
1963
1055
FUNGICIDAL ACTIVITY OF FIVE DISINFECTANTS ON ISOLATES OF CANDIDA SPECIES
Determine the fungicidal activity of five disinfectants on Candida auris of clinical and environmental origin. Assess the fungicidal efficiency of each disinfectant on the microorganism. Calculate the percentage of efficiency (% E) of each disinfectants on Candida strain and determine the specific death rate (k) and decimal reduction time for microorganisms. Analytic and experimental researc...
1961
1001
FORMULATION AND EVALUATION OF SUSTINED RELEASE MATRIX TABLET OF METRONIDAZOLE
In this study matrix tablets of metronidazole were prepared by direct compression method which is now days considered a cost effective and simple method of manufacturing. It is considered as an appropriate method for hygroscopic and thermolabile substances. Six formulations of different polymer percentages were formulated (F1-F9). The mean hardness values were measured for all the formulation usin...
1961
1691
DEVELOPMENT AND EVALUATION OF SILVER SULPHADIAZINE LOADED NANOFIBROUS SCAFFOLD FOR WOUND DRESSING APPLICATIONS
Electrospinning is the fiber-forming process using an electric field where electrostatic forces are employed. By this process, continuous nanofibers range from 0.01 to 10 micrometers can be obtained. Nanofibers produced by the electrospinning technique has application in various fields such as tissue engineering, wound dressing, filtration, protective clothing, drug delivery, and sensor applicatio...
1960
963
POTENTIAL OF NANOPARTICLES IN THE EFFECTIVE MANAGEMENT OF BREAST CANCER
Breast cancer (BC) is one of the most prevalent cancers in women; there were 2.3 million women diagnosed with breast cancer globally. Unfortunately, most anticancer drugs have reported high Potential toxicity, mutagenic and carcinogenic side effects. Existing treatments can neither stop its propagation and/or recurrence nor are specific for cancer cells. Hence the side effects on healthy tissues a...
1959
1069