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A REVIEW ON HERBAL DRUGS WITH POTENTIAL ANTI-ARTHRITIC ACTIVITY
Rheumatoid arthritis (RA) is a general inflammatory disorder touching about 1.3% of the grown-up census of the world. Over the last two decades, a significant development has been done in the thoughtfulness of RA pathophysiology, best outcomes, and successful treatment strategy, and the credit of the significance of diagnostic agents and treating RA near the beginning. Earlier than novel treatment...
1957
980
FORMULATION AND EVALUATION OF CANDESARTAN CILEXETIL LOADED SOLID LIPID NANOPARTICLES WITH IMPROVED BIOAVAILABILITY
In this present work, BCS class II Candesartan celexitil, as an angiotensin receptor blocker used mainly for the treatment of high blood pressure and congestive heart failure, was successfully loaded in the solid lipid nanoparticles (SLNs) by using hot high-speed homogenization method. The SLN formulations were prepared and optimized by Box Benhken design study. The SLN was characterized by Nanoph...
1956
974
IN-SILICO MOLECULAR DOCKING STUDIES, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL FURAN-AZETIDINONE HYBRIDS AS POTENTIAL ANTI-CANCER AGENTS
Furan and Azetidinone have been reported to possess various therapeutic activities, including anti-microbial and anti-cancer activity. Increasing drug resistance and high toxicity to the existing drugs have dictated the need to develop novel, effective agents with different scaffolds. With the perspective of identifying novel anti-cancer molecules, an approach was made to hybridize the different h...
1956
1263
IN-SILICO ADMET PREDICTION ON PHYTOCHEMICAL COMPONENTS OF CITRUS SINENSIS
Citrus sinensis are treasuries to deliver novel drugs and a significant aromatic medicinal plant reported to possess a broad spectrum of medicinal uses. The compounds present in these plants can deliver the potential therapeutic drug. A free web tool, SWISS ADME predictor, was used to evaluate the pharmacokinetics, drug-likeness, and medicinal chemistry friendliness of phytoconstituents under inve...
1956
996
UNDERSTANDING OF PHYTO-NANOMEDICINE FOR THE MANAGEMENT OF INFLAMMATION AND WOUND HEALING: AN OUTLOOK
Nanoparticles are the modern-day drug delivery system for biocompatible drugs. Numerous products have developed from nanotechnology to develop effective wound healing and inflammatory treatments. Plant extracts (phytoconstituents) have a lot of therapeutically potential because of their distinctive properties, including anti-inflammatory, antioxidant and insulin-sensitizing properties etc. Furthe...
1956
1274
ANTIAPOPTOTIC MECHANISM FOR THE IMPLEMENTATION OF THE HEPATOPROTECTIVE EFFECT OF PYRIMIDINE DERIVATIVES
The present study aimed to study the effect of the drug Xymedon and its conjugate with L-ascorbic acid exhibiting hepatoprotective activity on the apoptosis of rat liver cells against the background of the influence of hepatotoxic agent tetrachloromethane. Though the general effects of Xymedon and its conjugates with various biogenic acids have been studied, the molecular markers affected by the c...
1954
998
MARINE-DERIVED INGREDIENTS AND THEIR POTENTIAL USE IN SKIN-LIGHTENING AND COSMETIC FORMULATIONS
The advancement and changes in the pharmaceutical and cosmetic industry are governed utilizing the interests of clients for biologically energetic elements obtained naturally in place of synthetic manufacture and resources. One such novel technique within the beauty enterprise is using marine life as a supply of active components like micro and macroalgae, sea corals, marine bacteria, and seaweeds...
1954
948
ISOLATION AND CHARACTERIZATION OF CHOLESTEROL OXIDASE FROM AMYCOLA-TOPSIS STRAIN USING 16S rRNA PARTIAL SEQUENCE
The aim of the present research work is to isolate and characterize microbial strain using partial sequencing of 16S rRNA gene region of Amycolatopsis strain K1. Five Amycolatopsis strains from soil samples were collected from the effluent sediments from Jajmau, Kanpur in U.P. India, and it was confirmed by polymerase chain reaction (PCR) that the isolates were different and not re-isolates of t...
1954
990
DRY COATING OF PHARMACEUTICAL POWDERS
This manuscript aims to figure out updated information on the dry coating of powder (DCP). In pharmaceutical processes, the inevitable is handling of fine and ultra-fine particles (FUFP). Their higher surface area associated surface and surface attributes contribute chiefly to exhibited complex phenomenon like bulk behaviors, physicochemical property, performances and functionalities of pharmaceut...
1953
1172
QUALITATIVE ANALYSIS OF PHYTOCHEMICAL CONSTITUENTS OF CERTAIN ETHNOMEDICINAL PLANTS IN BHADRAVATHI TALUK OF SHIVAMOGGA DISTRICT, KARNATAKA
Medicinal plants are an abundant source of bioactive compounds, which have been used for thousands of years against different diseases because plants have antibacterial, anti-inflammatory, and antifungal activities. All of the medicinal plants that may be found on earth today have specific therapeutic use and importance. Our research work is based on the qualitative phytochemical studies of extrac...
1953
930