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ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICE IN HYPERTENSIVE PATIENTS IN A TERTIARY CARE TEACHING HOSPITAL
Background: In India, Hypertension is becoming more common and severe, and it is linked to various socio-demographic factors. Many people are ignorant of their illness's severity and the significance of managing it due to a lack of adequate support and education. The first step in developing a preventive program for any health condition is obtaining information regarding the level of awareness. O...
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mRNA EXPRESSIONPROFILINGOF GLUTATHIONE PEROXIDASE (GPX GENE) USING FIVE MEDICINAL PLANTS ON S. CEREVISIAE
Glutathione peroxidase gene expression profiling has been determined using budding yeast, S. cerevisiae, as a model organism mainly used for extensively reliable microbial studies of various cellular processes evolved in evolutionarily distant species. Roots of five medicinal plants were used: Withania somnifera, Terminalia arjuna, Ranunculus sceleratus, Bacopa monnieri and Acalypha indica. The ma...
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CHITOSAN CO-CRYSTAL FOR ENHANCING THE SOLUBITY AND DISSOLUTION RATE OF DICLOFENAC SODIUM
The present study is designed to enhance the aqueous solubility of diclofenac sodium. For the said purpose co-crystal employing chitosan with diclofenac sodium is prepared by solvent exchange. The prepared co-crystal was characterized by FTIR, DSC, XRD and TGA studies. Further, solubility, anti-inflammatory activity and in-vitro release study was determined for different batches of the formulation...
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OPTIMISATION AND EVALUATION OF CAFFEINE ORALLY DISSOLVING FILMS
Caffeine anhydrous is used as a stimulant to improve individual alertness and mental focus due to its ability of inhibiting the function of phosphodiesterase enzyme in the cells. Recent studies also discovered where caffeine reduced the risk of Parkinson’s disease by its inhibitory action on adenosine receptor. With the aim of masking the bitter taste of caffeine, increasing the compliance and c...
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SCREENING OF RANDIA DUMETORUM LAMK. EXTRACTS FOR ANTI-INFLAMMATORY ACTIVITY USING MOUSE MODEL OF HCL-INDUCED ALI
Acute Lung Injury (ALI) and its more severe form Acute Respiratory Distress Syndrome (ARDS) is a clinical syndrome with a high mortality rate (27-41%). There is no pharmacological therapy for ALI treatment so far because of the complex mechanism and involvement of multiple pathways. So, the present study was designed to test the role of different extract/fractions of fruits of a traditional plant ...
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HERBAL BASED ANTI-MICROBIAL BOOSTER FOR THE TREATMENT OF RESISTANT MYCOBACTERIUM TUBERCULOSIS
Persistent Mycobacterium tuberculosis (Mtb) attributable to resistant strains has increased the burden leading to poor quality of life to the patients. Drugs of herbal origin have been identified as potential sources of new anti-tubercular agents for the treatment of this disease and emerging resistant strains of the bacterium. In this research, therefore, five herbs/plants that have been indicate...
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FORMULATION AND EVALUATION OF GLIBENCLAMIDE ORAL DISPERSIBLE TABLET BY SOLID DISPERSION TECHNIQUE
Glibenclamide belongs to a group of medicines called sulfonylureas. Glibenclamide is used to manage diabetes. Glibenclamide, also known as glyburide, is an antidiabetic medication used to treat type 2 diabetes. The purpose of the present study was to formulate an Oral dispersible tablet of Glibenclamide using the Solid dispersion technique through using polyethylene glycol ratio as a water-solub...
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A COMPREHENSIVE REVIEW ON REGULATION CONCERNS FOR IMPORT AND EXPORT OF PHARMACEUTICAL DRUGS AND GENETIC PRODUCTS IN INDIA, BRITAIN AND SWITZERLAND
Biopharmaceutical technologies used to create biodegradable materials from biological agents fall within a broad spectrum. The production of bioproducts has grown cleaner and more dependable with the adoption of novel biotechnological approaches. The original study objective was to investigate the legal difficulties surrounding the purchase and sale of biological as well as pharmaceutical products...
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HETEROCYCLIC COMPOUNDS WITH THEIR RECENT DEVELOPMENT: AN INTEGRATED APPROACH
Organic chemist has developed the number of heterocyclic compounds. The heterocyclic compounds have gained more attention in medicinal and organic chemistry because of their numerous biological activities. There are various types of the heterocyclic compound available for several biological activities such as antibacterial activity, anticancer activity, antiepileptic activity, antipsychotic activi...
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INVESTIGATING AND SEQUENCING OF THIOL-SPECIFIC ANTIOXIDANT GENE IN A SYRIAN STRAIN OF LEISHMANIA TROPICA
Cutaneous leishmania is a common medical problem in Syria, which has become yet more widespread in most of the Syrian governorates after the current war. An effective vaccine is needed to prevent a large scale spread of leishmaniasis in the country. In this regard, protein vaccination has shown promising prospects of creating this much-needed vaccine. Thiol Specific Antioxident (TSA) plays a funda...
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