Most Popular
DESIGN AND EVALUATION OF ZERO-ORDER DRUG-RELEASING RIVASTIGMINE TRANSDERMAL SYSTEM
Rivastigmine is used for the treatment of mild to moderate dementia of the Alzheimer’s type. Transdermal delivery of Rivastigmine is preferable to improve gastrointestinal tolerability. A novel transdermal system with zero-order release kinetics was developed following a hybrid technique in a combination of the micro reservoir and adhesive dispersion system. The transdermal system was prepared b...
1942
1224
STRUCTURAL TRANSFORMATION OF LUPEOL AND EVALUATION THEIR IN-VITRO ANTIOXIDANT ACTIVITY
Lupeol (I) is a naturally occurring triterpene that has been isolated from the stem bark of Crataeva nurvala in appreciable amount. Due to the presence of a single hydroxyl group and a large, apolar skeleton, lupeol acts as an amphiphile. The two possible sites for chemical modification present in lupeol are ring-A and isopropenyl side chain. We modified it in three naturally occurring analogous d...
1941
1118
A QUESTIONNAIRE STUDY ON KNOWLEDGE AND ATTITUDE TOWARDS EVIDENCE BASED MEDICINE AMONG INTERNS AND POSTGRADUATES IN A TERTIARY CARE TEACHING HOSPITAL
Background: Evidence based medicine (EBM) integrates the best available data from clinical research into clinical practice. Residents (PGs & CRRIs) are at the frontiers of healthcare who are still struggling to adapt the paradigm shift in the practice of medicine. This study aims to explore the knowledge and attitude of EBM among residents in a tertiary teaching hospital. Materials and Methods...
1941
797
THE ROLE OF GRANULOCYTE-COLONY STIMULATING FACTOR FOR THE MANAGEMENT OF CHEMOTHERAPY-INDUCED NEUTROPENIA IN ACUTE LYMPHOBLASTIC LEUKEMIA
Chemotherapy-induced neutropenia (CIN) is a common and sometimes fatal side effect of treatment for acute lymphoblastic leukemia (ALL), the most common malignancy in individuals over 40. Antibiotics are used in addition to supportive care as a current treatment. Granulocyte-colony stimulating factor (G-CSF) has been tested in clinical studies as a supplementary treatment to reduce febrile neutrop...
1941
1182
UTILIZATION OF GLUTEN-FREE COMPOSITE FLOUR NUTRITIONAL, PHYTO-CHEMICAL AND FUNCTIONAL PROPERTIES EVALUATION
Celiac disease an antibody-mediated enteropathy which is a lifelong condition where there is intolerance towards gluten. The only treatment till now is the gluten-free diet. The aim of this study was to investigate proximate, phytochemical and functional property analysis of gluten-free composite flour. The proximate analysis of composite flour for the most acceptable sample showed moisture (10.97...
1938
934
ANTI-TUBERCULAR DRUGS: A REVIEW ON CURRENT TRENDS AND NOVEL DRUGS
Tuberculosis remains a challenge globally affecting the health of several individuals globally. The emergence of drug resistant tuberculosis has further increased the threat. Despite having several drugs available the peril of the mycobacterium continues to loom. Across the globe several scientists are putting in efforts to come up with newer drugs with novel mechanism of action and belonging to s...
1938
901
EFFECT OF CHROMIUM ON IN-VITRO GROWTH AND ANTIOXIDANT POTENTIAL OF DIANTHUS CARYOPHYLLUS L.
Catalase, guaiacol peroxidase and polyphenol oxidase are antioxidant enzymes that are important in the metabolism of reactive oxygen species and can be induced by environmental stresses including chromium (Cr), heavy metal toxic to living organisms. In-vitro regenerated shoots of carnation (Dianthus caryophyllus L.) were exposed to K2Cr2O7, and the activities of these antioxidant enzymes were anal...
1938
1118
ONGOING ADVANCEMENT IN THE COMPREHENSION OF MITOCHONDRIAL PRO-GRESSION WITH AN EXCEPTIONAL SPOTLIGHT ON ITS RELATIONSHIP WITH CANCER AND POSSIBLE THERAPEUTIC STRATEGY
Cancer is one of the main reasons of death around the world and the quantity of new incidents keeps on rising. Despite ongoing advances in conclusion and remedial systems, many malignancy-related passes happen, demonstrating the requirement for better treatments and symptomatic methodologies. Mitochondrial morphology is dependent on continuous fusion and fission strategies that are essential for m...
1938
1104
COMPARATIVE NON-ENZYMATIC AND ENZYMATIC ANTIOXIDANT POTENTIAL SCREENING IN SPECIES OF GENUS URTICA
Objective: The current study has been conducted to analyze the potential of antioxidant activity found in two species of genus Urtica, i.e., Urtica dioica and Urtica urens. Methodology: The antioxidant analysis was performed on the crude extract of root, stem and leaves of both the plants, employing both non-enzymatic and enzymatic methods. For non-enzymatic antioxidant activity determination, met...
1938
1554
APPLICATION OF ANALYTIC NETWORK PROCESS: WEIGHTING OF SELECTION CRITERIA TO SELECT THE SUITABLE METHOD FOR THE PREPARATION OF NANOCRYSTALS
This article presents a logical technique to select the best method for the preparation of nanocrystals by implementing the analytic network process. One of the most significant decision-making tools to make excellent decisions is Analytic Network Process which includes Model construction, Paired assessments between each two clusters or node, Super matrix assessment based on outcomes from paired c...
1938
939