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THE ROLE OF GRANULOCYTE-COLONY STIMULATING FACTOR FOR THE MANAGEMENT OF CHEMOTHERAPY-INDUCED NEUTROPENIA IN ACUTE LYMPHOBLASTIC LEUKEMIA
Chemotherapy-induced neutropenia (CIN) is a common and sometimes fatal side effect of treatment for acute lymphoblastic leukemia (ALL), the most common malignancy in individuals over 40. Antibiotics are used in addition to supportive care as a current treatment. Granulocyte-colony stimulating factor (G-CSF) has been tested in clinical studies as a supplementary treatment to reduce febrile neutrop...
1990
1203
REPLACEMENT OF ORGANIC SOLVENTS WITH ENVIRONMENTAL ECO-FRIENDLY SOLVENTS FOR RP-HPLC ANALYSIS
Background: Solvents are major part in chemical industry. Solvents have major impact on cost as well as safety and health issues. Many more organic solvents are considered toxic. Thus the concept of green chemistry is introduced which eliminate or reduce the use of hazardous solvents/chemicals from analytical process for the eco-friendly environment and health without any compromise in Analytical ...
1988
1260
RECENT ADVANCES IN ORAL THIN FILM DRUG DELIVERY SYSTEMS: A REVIEW
Several fast-dissolving drug delivery systems have been designed to address issues like accurate dosing in liquid dosage formulation (suspension, emulation, syrup etc.) and swelling problems in solid dosage form (capsule, Tablet etc.). To fill these gaps fast-dissolving drug delivery system have been designed to address these issues. Biggest advantage of having Oral thin Film is, it can be taken w...
1988
1696
BIOACTIVE CHEMICAL CONSTITUENTS OF BLEPHARIS AND LEPIDAGATHIS (ACANTHACEAE) – A REVIEW
The herbal drugs derived from plant sources are used in traditional pharmacopeia and also act as precursor in lab to synthesize medicines at large scale. Acanthaceae is a large family comprising of various medicinally valuable species. In traditional use, the leaves of this family are commonly recognized to alleviate the poisonous bites of reptiles and insects and whole plants for the treatment of...
1987
1464
COST EFFECTIVE, ROBUST PRECISE & STABILITY INDICATING ANALYTICAL METHOD VALIDATION OF RELATED SUBSTANCES FOR PIMECROLIMUS CREAM BYRP-HPLC
A new, precise, economical and gradient reverse-phase high-performance liquid chromatography (RP-HPLC) method has been validated for the relative substance determination in pimecrolimus cream. The chromatographic separation was achieved with phenomenax luna, C18, 150 x 4.6mm and 3 µm particle size column. The flow rate was 1.5 mL/min and eluents were detected at 210 nm using PDA detector. The ret...
1986
1540
FORMULATION AND IN-VITRO EVALUATION OF ANTI-AGING FACE CREAM CONTAINING LACTIC ACID AND COCOA BUTTER
The main aim of the current research is to formulate and evaluate the anti-aging cream containing lactic acid and cocoa butter. Skin health and beauty is regarded as one of the most important variables influencing general "well-being" and "health" perception in humans because of that, various anti-aging techniques have been created in recent years. Uneven pigmentation, increased wrinkles, loss of ...
1986
1235
AN UPDATE ON THE THERAPEUTIC POTENTIAL OF HEMIDESMUS INDICUS (INDIAN SARSAPARILLA)
Hemidesmus indicus (H. indicus), also known as Indian Sarsaparilla or Anantmul, is a plant with diuretic, demulcent, and diphoretic properties. It treats various illnesses, detoxifies the blood, and reduces Vata, Pitta, and Kaphadoshas. It has been shown in pre-clinical trials to reduce illnesses in everyday clinical practice. In order to effectively promote this herbal medicine, clinical trials a...
1986
1341
EFFECT OF AQUEOUS EXTRACT OF CRYPTOLEPIS SANGUINOLENTA ADMINISTRATION ON THE METABOLISM OF CHLOROQUINE VIA CYTOCHROME P450 ISOZYMES
Concurrent administration of herbal medicines and conventional drugs is a common practice globally, especially as the patronage of medicinal plants increases across the world. This study aimed to determine the effect of Cryptolepis sanguinolenta administration on the metabolism of chloroquine by evaluating specific Cytochrome P450 isozymes. Reconstituted freeze dried Cryptolepis sanguinolenta was ...
1985
1225
QUANTITATIVE AND QUALITATIVE PHYTOCHEMICAL ANALYSIS IN BARK OF NOTHOPEGIA RACEMOSA (DALZ.) RAMAM. COLLECTED FROM GADIKALLU, SHIMOGGA, KARNATAKA
Plants are a source of bioactive compounds produced by different parts of the plant, maybe bark, leaves, flowers, roots, fruits, and seeds, during metabolic activities. These secondary metabolites may have protective and disease preventive properties, hence used by Traditional practioner to treat various ailments. Most plants of the Western Ghats of India remain unknown, poorly understood or unest...
1983
1317
THE ORPHAN DRUG ACT: INCENTIVES, CHALLENGES, AND MARKET TRENDS
Orphan drugs are used to treat rare diseases that affect fewer than 200,000 people in the United States. Development and approval of orphan drugs are challenging due to the limited patient population and substantial development costs; the U.S. Food and Drug Administration (FDA) has established several programs, such as the Orphan Drug Designation program and Orphan Product Grants program to encour...
1983
948