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FORMULATION AND EVALUATION OF CURCUMIN-LOADED CHITOSAN NANOPARTICLES AND ITS INTRANASAL EFFICACY FOR CNS DELIVERY
Hydrophobic medications that are taken orally having poor bioavailability due to permeability issues. They experience a chemical and enzymatic breakdown in the digestive system and exhibit a significant amount of hepatic first-pass metabolism. Similar obstacles prevent the development of effective therapeutic molecule delivery systems and the discovery of new drugs. It has been revealing that curc...
1928
1033
AN EXPERIMENTAL STUDY TO ASSESS THE MEMORY-ENHANCING PROPERTY OF PITAVASTATIN AND GEMFIBROZIL IN MICE USING THE MORRIS-WATER MAZE MODEL. EVIDENCE TO CATEGORIZE THEM AS SMART DRUGS
Introduction: Discovery of smart drugs is part of advancing the science of molecular and biochemical mechanisms of memory. Smart drugs are not just memory boosters; they also act as memory enhancers that help quick decision-making. Pitavastatin and gemfibrozil both cause lipid-lowering effects by different mechanisms of action. A few studies show they can act on CREB (c-AMP response elemental bind...
1927
760
EFFECT OF AQUEOUS EXTRACT OF CRYPTOLEPIS SANGUINOLENTA ADMINISTRATION ON THE METABOLISM OF CHLOROQUINE VIA CYTOCHROME P450 ISOZYMES
Concurrent administration of herbal medicines and conventional drugs is a common practice globally, especially as the patronage of medicinal plants increases across the world. This study aimed to determine the effect of Cryptolepis sanguinolenta administration on the metabolism of chloroquine by evaluating specific Cytochrome P450 isozymes. Reconstituted freeze dried Cryptolepis sanguinolenta was ...
1926
1197
METHOD DEVELOPMENT AND VALIDATION OF AMOXICILLIN TRIHYDRATE BY HPTLC IN BULK AND PHARMACEUTICAL DOSAGE FORM
Amoxicillin Trihydrate is an extensively used antibiotic, and the accurate determination of its content in bulk and pharmaceutical dosage forms is of greatest importance. This thesis focuses on the development and validation of a High-Performance Thin-Layer Chromatography (HPTLC) method for the analysis of Amoxicillin Trihydrate. The study begins with an inclusive review of the existing analytical...
1926
1131
STRESS STUDIES OF METFORMIN AND GLICLAZIDE BY HPLC METHOD AND EXTENSION OF METHOD APPLICATION FOR ELUTION OF SOME ANTIVIRAL, ANTI-BACTERIAL AND ANTI-INFLAMMATORY DRUGS
A simple reverse phase SI-HPLC method was developed for the simultaneous estimation of antidiabetic combination of metformin and gliclazide. The method was based on HPLC separation on a reversed-phase C18 column using a mobile phase consisting of phosphate buffer: acetonitrile (40:60, v/v) at a flow rate of 0.8 ml/min. UV determination was achieved at 240 nm. The analytes were subjected to various...
1925
1338
DETERMINATION OF QUERCETIN IN EUPHORBIA THYMIFOLIA AND MANILKARA HEXANDRA EXTRACTS USING RP-HPLC
High-Performance Liquid Chromatography is an important and powerful analytical technique for the identification, quantification and isolation of natural products. In the present investigation, a Reversed-Phase- HPLC method was developed for the identification and quantification of the marker compound quercetin in Euphorbia thymifolia Linn. (whole plant) and Manilkara hexandra Roxb. (leaves). Both ...
1925
1051
ESTIMATING THE ECONOMIC BURDEN OF CHRONIC KIDNEY DISEASE: A COST OF ILLNESS STUDY
The study aims to estimate the cost expenditure in chronic kidney disease patients. A prospective, observational study was carried out in a tertiary care hospital in south India for around 6 months. In the 201 patients enrolled in the study, 137 were males and 64 were females, aged 18 years or older, diagnosed with 3-5 and 5D stages of chronic kidney disease included in the study. Patient data wer...
1923
992
SYNTHESIS, CHARACTERIZATION AND ANTICANCER STUDIES OF NOVEL SULPHONAMIDES
Currently, the arise of drug resistance and undesirable off-target effects of anti-cancer agents are major challenges for cancer treatment, which energizes medicinal chemists to develop more anti-cancer agents with high efficiency and low toxicity continuously. sulphonamide derivatives are a class of promising compounds with diverse biological activities including anti-cancer, and parts of them ha...
1922
1495
EVIDENCE-BASED HEALTH BENEFITS OF MULTIFACETED PLANT GREEN TEA: A REVIEW
In response to the increasing popularity and greater demand for medicinal plants, several conservation groups recommend cultivating wild medicinal plants. Green Tea is among the most ancient and popular therapeutic beverages worldwide. This product is made from the plant leaf called “Camellia sinensis.” It can be prepared as a drink, which can have many systemic health effects or an “extract...
1922
1449
EVALUATION AND ASSESSMENT OF ADVERSE DRUG REACTIONS DEVELOPED USING NEWLY PRESCRIBED DRUGS IN PATIENTS WITH ACUTE DISEASE
The objective of current research is to assess the type of Adverse Drug Reactions (ADR) and associated risk factors, assess the prevalence, estimate the incidence of serious and fatal ADR and the severity of ADRs based on data collected from patients with ADRs caused by drug initially prescribed. Data of patients with acute diseases were collected and analyzed using SAS version 9.1. About 252 ADRs...
1921
922