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AN IN-VIVO STUDY TO EVALUATE THE ANTI-ULCER ACTIVITY OF NĀRIKELĀ LAVANA IN PYLORIC LIGATION INDUCED ULCER IN WISTAR ALBINO RATS
Lavana kalpanas are pharmaceutical preparation in which the ‘Lavana’ and the selected ‘auṣadhadravyā’ are igniting together in a closed sampuṭā to obtain the drug ash as medicinal product. Nārikelā lavana, one among the lavana kalpana mentioned in Bhaiṣajyaratnāvali 30th chapter and in Rasa taraṇgiṇi14th chapter. Nārikelā lavaṇa proved to have a high amount of electrolyt...
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873
SYNTHESIS, IN-VITRO ANTIMICROBIAL EVALUATION AND MOLECULAR DOCKING STUDIES OF SOME NOVEL ACETOPHENONES SUBSTITUTED QUINOXALINE THIOSEMICARBAZIDE DERIVATIVES
In the present research worked aims to increase the antimicrobial activity of quinoxaline thiosemicarbazide derivatives by substitution of some acetophenones and their antimicrobial evaluation against various antimicrobial strains with molecular docking studies. Lead molecule (1E, 4E)-1-(7-chloro-3-isopropylquinoxalin-2(1H)-ylidene) thiosemicarbazide was synthesized and condensed with various subs...
1815
1138
A STUDY ON THE ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF SCUTELLARIA DISCOLOR COLEBR IN EXPERIMENTAL ANIMALS
The genus Scutellaria has many species. But only a few species are investigated for the treatment of many ailments. Despite the extensive use of traditional medicine against several diseases, scientific studies of Scutellaria discolor are less. The present study is taken up to investigate the analgesic and anti-inflammatory actions of the acetone extract of S. discolour (SDA)using tail flick met...
1814
952
FUSION OF ZNO NANO/MINT EXTRACT LOADED PVP/PVA COMPOSITE BLEND: CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY
ZnO is used as a nanofiller in various concentrations to create flexible self-standing films of PVP-PVA mix composites. This work presents the results of structural, compositional, morphological, and optical analyses carried out using X-ray diffraction (XRD), Fourier Transform Infra-Red spectroscopy (FTIR), scanning electron microscopy (SEM), Thermo gravimetric analysis (TGA), and ultraviolet-visi...
1814
1060
WOUND-HEALING PROPERTY OF THE FORMULATED OINTMENT USING EXTRACTED CURCUMIN FROM THE CURCUMA LONGA L. (FAM. ZINGIBERACEAE) POWDER AMONG DIABETES-INDUCED SPRAGUE-DAWLEY RATS
Diabetes mellitus can lead to impaired healing of wounds and can cause life-long complications. Curcumin is reported as one of the promising therapeutic agents in the management of impaired wound healing in diabetics. This study aimed to formulate a wound-healing ointment from the extracted curcumin and evaluate its efficacy among diabetes-induced rats. The extract was subjected to organoleptic ev...
1814
1016
EFFICACY OF IVERMECTIN AND DOXYCYCLINE AS AN ADJUNCT TO REMDESIVIR IN SEVERE COVID-19 CASES – A RETROSPECTIVE ANALYSIS
Introduction: Covid-19 pandemic has posed new challenges to humanity. The definitive cure is yet to be found, while drug repurposing holds the key so far. Remdesivir had been used for the treatment of novel corona-virus. Ivermectin and Doxycycline have also been recommended for treating Covid-19, but their efficacy has not been studied extensively. Methods: We conducted a retrospective study durin...
1813
907
DOCKING STUDY OF FLT3 RECEPTOR WITH TYROSINE KINASE FOR LEUKEMIA DISEASE
Leukemia is a disease of cancer that affects blood-forming tissues i.e., bone marrow and lymph nodes, which is associated with uncontrolled growth of WBCs. These cells are unable to fight against infection and weaken the ability of bone marrow to make RBCs and platelets. When leukemic cells overproduce, they interfere in circulatory cells' functioning, i.e., RBCs and platelets. Along this, leukemi...
1813
794
DESIGN, SYNTHESIS AND IN-VITRO ANTIMICROBIAL EVALUATION OF MANNICH BASE METAL COMPLEXES
Succinimide and its derivatives are important substitutes of many medicinal compounds in the pharmaceutical field. One of the essential objectives in heterocyclic and medicinal chemistry is the synthesis of molecules having importance as therapeutic agents. Heterocyclic compounds and their derivatives contain an imide ring that can easily cross biological membranes in-vivo. Mannich reactions are o...
1813
967
COMPARISON OF THREE TECHNIQUES FOR THE DIAGNOSIS OF MALARIA IN RESOURCE-LIMITED SETTINGS: A MINI-REVIEW
Objective of this article is to review three techniques, routinely used rapid diagnostic tests (lateral flow immune chromatography) versus nucleic acid amplification test (NAT) versus Paper-based microfluidics for DNA diagnostics of Malaria, as diagnostic tests in detecting malarial infection among febrile illnesses, suspected of malaria. The major constraint for implementing NAT as a routine scre...
1812
896
FORMULATION AND EVALUATION OF BOSWELLIC LOADED TRASFEROSOMES HYDROGEL TO TREAT PSORIASIS
Transfersomes, which may penetrate mammalian skin, are notably ultra deformable (ultraflexible) lipid supramolecular aggregates. A type of formulation carrier system called a transfersome can transport medications with both low and high molecular weights transdermally. Transfersomes enter the underlying viable skin in an undamaged state through skin's stratum corneum pores that are smaller than it...
1810
1150