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ALZHEIMER’S DISEASE AND PATHOLOGICAL ANGIOGENESIS
In spite of huge investigations, the pathology of Alzheimer’ sdisease (AD) is uncertain. Vessels dysfunction is a critical mark of AD. Research has stated like beta-amyloid (Aβ) results augmented vascular development in brains, a pathway observed in AD patients. In AD, cerebral endothelium releases pro substances for β-amyloid plaque and neurotoxins that kill cortical neurons. Vascular vulnera...
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EVALUATION OF HYDROCHLOROTHIAZIDE AND METHYLDOPA SIMULTANEOUSLY BY APPLYING CHEMOMETRIC SPECTROPHOTOMETRIC METHOD
In the present work, simultaneous estimation of Hydrochlorothiazide and Methyldopa was carried out by applying chemometric assisted UV spectro-photometric methods. The Two chemometric methods, classical least square (CLS) and inverse least square (ILS) were applied for estimation of Hydrochlorothiazide and Methyldopa simultaneously in tablets without any prior separation, and no graphical treatmen...
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INVESTIGATIONAL TREATMENT OF COVID-19
The novel coronavirus disorder 2019 (COVID-19) outbreak commenced in early December 2019 in the capital metropolis of Wuhan, Hubei province, People’s Republic of China and precipitated a world pandemic on march 11, 2020. Though some the international locations have succeeded in slowing down the price of the unfold of this pandemic, most the international locations throughout the globe are nevert...
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AMELIORATION OF INFLAMMATION AND CARDIOPROTECTIVE EFFECT OF TERMINALIA ARJUNA BARK EXTRACT IN HIGH-FAT DIET RAT MODEL
The objective of this study is to investigate the protective effect of aqueous bark extract of Terminalia arjuna (TA) on high-fat diet-induced cardiovascular changes in Wistar rats using histological, immunohistochemical, and gene expression analysis. Group 1- without treatment served as control, group 2- High fat diet (HFD) received corn oil orally at a dose of 10 mL/kg, group 3 - HFD+atorvastati...
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WOUND-HEALING PROPERTY OF THE FORMULATED OINTMENT USING EXTRACTED CURCUMIN FROM THE CURCUMA LONGA L. (FAM. ZINGIBERACEAE) POWDER AMONG DIABETES-INDUCED SPRAGUE-DAWLEY RATS
Diabetes mellitus can lead to impaired healing of wounds and can cause life-long complications. Curcumin is reported as one of the promising therapeutic agents in the management of impaired wound healing in diabetics. This study aimed to formulate a wound-healing ointment from the extracted curcumin and evaluate its efficacy among diabetes-induced rats. The extract was subjected to organoleptic ev...
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EFFICACY OF IVERMECTIN AND DOXYCYCLINE AS AN ADJUNCT TO REMDESIVIR IN SEVERE COVID-19 CASES – A RETROSPECTIVE ANALYSIS
Introduction: Covid-19 pandemic has posed new challenges to humanity. The definitive cure is yet to be found, while drug repurposing holds the key so far. Remdesivir had been used for the treatment of novel corona-virus. Ivermectin and Doxycycline have also been recommended for treating Covid-19, but their efficacy has not been studied extensively. Methods: We conducted a retrospective study durin...
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ROLE OF DEMINERALIZED FREEZE-DRIED BONE ALLOGRAFT AROUND IMMEDIATE IMPLANTS IN EXTRACTION SOCKETS – A REVIEW
Implant insertion in a "fresh extraction socket" is reliable and effective. Often little discrepancy is there between the size of the implant and the wall of the socket, which needs to be filled before placing the implant. Hence, there is a need for graft material to fill this space. The main objective of this article is to review the role of “demineralized freeze-dried bone allograft” (DFDBA)...
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ANTIBACTERIAL ACTIVITY OF FIVE SPECIES OF MARINE MICROALGAE
Antibacterial activity of five marine microalgae Isochrysis galbana, Chaetoceros calcitrans, Tetraselmis suecica, Nannochloropsis oculata, Aphanocapsa sp. was studied from Visakhapatnam. The ethanolic extract of T. suecica, C. calcitrans, and N. oculata s howed inhibitory activity against V. harveyi and S. Aureus with inhibition zone between 11.5 and 20mm. The ethanolic extract of I. galbana showe...
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IN-VITRO EVALUATION OF ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF MEDICINAL PLANT BAUHINIA VAHLII
The present study evaluated the antibacterial and antifungal activities of the medicinal plant Bauhinia vahlii. The antibacterial and antifungal activities of vacuum dried ethanol extract of the stem and leaves of Bauhinia vahlii (EEBVS and EEBVL) were performed using the Disc diffusion method. The antibacterial and antifungal activities recorded significant effects against five bacterial strains,...
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A SYSTEMATIC REVIEW ON THE EFFECTIVENESS OF PUNICA GRANATUM EXTRACT FOR THE TREATMENT OF RECURRENT APHTHOUS STOMATITIS
Recurrent aphthous Stomatitis (RAS) is a painful ulcerous condition that was conservatively treated using topical corticosteroids, immuno-suppressants, thalidomide with some potential risks and reactions. Considering this, herbal extracts are found to be a better alternative with very minimum side effects. Punica granatum (pomegranate) extract is one such flavonoid-containing food supplement with ...
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