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GREEN SYNTHESIS OF SILVER NANOPARTICLES USING MILLETS, ITS CHARACTERIZATION AND EVALUATION OF ANTIMICROBIAL ACTIVITY
The development of Nanotechnology has paved the way to study various nanomaterials. Nanoparticles are structures that measure the size from 1-100nm. Widely used nanoparticles are usually prepared using noble metals, that is, gold, silver, palladium, and platinum. At the same time, they find their way into a wide range of applications in medicine, electronics, energy saving, environment, textile, c...
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FORMULATION AND EVALUATION OF CARBAMAZEPINE BILAYER TABLET FOR BIMODAL RELEASE
Carbamazepine (CBZ) has long been a therapeutic option for bipolar disorder. Carbamazepine is used to treat acute manic and mixed episodes associated with bipolar I disorder. In the present study, bilayer tablet was developed to improve dosing convenience and decrease daily fluctuations in serum CBZ concentration, thereby lowering the incidence of adverse events. In bilayer tablet one layer prov...
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FORMULATION AND EVALUATION OF BI-LAYERED TABLET OF ATENOLOL AND HYDROCHLOROTHIAZIDE
The study focuses on creating and evaluating a specialized bilayer tablet for treating hypertension. It begins with in-depth preformulation analyses of key components like Atenolol, Hydrochlorothiazide, and various excipients. Special emphasis is placed on optimizing the powder blend's flow properties to facilitate tablet compression. A series of tests on resulting tablets (F1 to F8) assess weight...
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FORMULATION EVALUATION OF THE MULTIFUNCTIONAL PARABEN FREEHERBAL SHAMPOO FROM HOUSEHOLD HERBS AND COMPARISON WITH THE COMMERCIAL SHAMPOOS
The study's objectives were to create a pure herbal shampoo, assess its physicochemical qualities, and compare them to those of commercially available synthetic shampoos. The formulation of the herbal shampoo involved combining readily accessible at-home extracts of Reetha, Henna, Neem, Amla, almond powders, Alovera gel and tulsi lemon juice to a 10% aqueous gelatin solution. The pH was then corre...
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A STUDY ON THE PREVALENCE OF RISK FACTORS OF DRUG-INDUCED QTC PROLONGATION AMONG PATIENTS IN INTENSIVE CARE UNIT
Sudden cardiac death (SCD) is the most common cause of mortality among cardiovascular etiologies. Drug-induced Long-QT syndrome (diLQTS) is a prominent occurrence in Intensive Care Units (ICUs), often progressing to Torsades de Pointes (TdP), resulting in SCD. A prospective observational cross-sectional study was conducted to determine the prevalence of risk factors for diLQTS and to identify pati...
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SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NOVEL CARBAZOLE BORONIC ACID DERIVATIVES IN THE TREATMENT OF BREAST CANCER
The present study aimed to synthesize Carbazole boronic acid derivatives and determine their efficacy in treating breast cancer using the MCF-7 cell line. Nine different derivatives (C1-C12) of boronic acid were prepared i.e. 9-ethyl-(9H-carbazol-3-yl)-boronic acid (C1); (9-benzyl-9H-carbazol-3-yl)-boronic acid (C2); [9-(4-fluorobenzyl)-9H-carbazol-3-yl]-boronic acid (C3); [9-(sec-butyl)-9H-carbaz...
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POTENTIAL BIOMARKERS OF RHEUMATOID ARTHRITIS AS A TOOL FOR RESEARCH AND DEVELOPMENT OF NEW DRUG MOLECULE: A REVIEW
Rheumatoid Arthritis (RA) is an autoimmune inflammatory illness characterized by persistent synovial inflammation. It’s the most common form of arthritis that causes inflammatory changes in the tissue of joints, destroys cartilage and bones, and affects the quality of life. This diverse disease has a wide range of disease progression and treatment responses. Because the precise origin of rheumat...
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FORCED DEGRADATION STUDY OF ROSUVASTATIN AND TENELIGLIPTIN, CHARACTERISATION OF ITS DEGRADATION PRODUCTS BY VARIOUS ANALYTICAL TECHNIQUES: A REVIEW
Rosuvastatin is a widely used lipid-lowering medication that belongs to the class of “Statins” whereas Teneligiptin is a novel potent drug that belongs to the class of “DPP-4 inhibitors” which is used for the treatment of Type 2 Diabetes mellitus. The FDA recently approved the combination of these two drugs in 2021 since it proved to be highly effective for treating dyslipidemia associated...
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KNOWLEDGE, ATTITUDE AND PRACTICE OF NON-PHARMACOLOGICAL INTERVENTIONS IN SUBJECTS WITH CHRONIC NEUROPATHIC PAIN ON TARGETED PHARMACOLOGICAL THERAPY
Neuropathic pain (NP) is a chronic debilitating condition that affects all dimensions of health. Though pharmacological therapy is the main treatment of varied neuropathic pain conditions, not all neuropathic pain conditions respond well to drug therapies. Therefore, under-utilized non-pharmacological strategies were tried and implemented in chronic neuropathic pain subjects to provide adequate pa...
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ASSESSMENT OF CLINICAL AND DEMOGRAPHIC PROFILE OF AURICULAR LOBULOPLASTY: A STUDY OF 446 PATIENTS
Objectives: Ears are an important part in our facial aesthetics and cosmetics. Complete and partial ear cleft patients are routine in the ENT outpatient department for surgical repair. The objective of this study is to evaluate the surgical outcomes of auricular lobuloplasty. Methods: Total 446 patients who underwent auricular lobuloplasty were included in this study. Demographic characteristics, ...
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