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CHEMICAL COMPOSITION AND PUPICIDAL ACTIVITY OF ESSENTIAL OIL FROM MENTHA SPICATA AGAINST AEDES AEGYPTIL. (DIPTERA: CULICIDAE)
Mosquito-borne diseases are serious health problems in India, and mosquito vector control is a fundamental approach to control various diseases. Essential oils represent eco-friendly alternatives to costly synthetic pesticides for mosquito control. The essential oil of Mentha spicata in India was used for its activity against Ae. aegypti. The essential oil showed pupicidal activity against this mo...
1824
1002
ANALGESIC ACTIVITY OF ETHANOLIC, HEXANE AND CHLOROFORM EXTRACTS OF SESAME SEED BY THERMAL HEAT METHOD IN ALBINO MICE
Background: Pain is a common symptom having huge public health importance. Conventional analgesics relieve pain effectively but cause various unwanted side effects. Hence the search for a novel analgesic with favourable risk-benefit profile is essential. Objectives: The current study was undertaken to investigate the analgesic activity of the ethanolic, hexane and chloroform extracts of sesame see...
1824
847
ESTIMATION OF ANTIARTHRITIC ACTIVITY OF A POLYHERBAL FORMULATION AGAINST ADJUVANT INDUCED ARTHRITIS IN RATS
Objective: Rheumatoid arthritis (RA) is a systemic disorder which involves the activation of immune system against the self-tissues. The main targets of this disease are the joints. Being systemic, the development of this disease involves different mechanisms, and thus, the exact cause of this disease remains unknown. Although different drugs have been developed, none has been found to be the cure...
1823
1002
IN-VITRO INSIGHT INTO THE IMPACT OF DIABETES AND IMPLANT DEBRIS ON ORTHOPEDIC IMPLANT
Wear particle evoked lysis limits the long-run survivorship of total joint replacement (TJR) in polygenic disease. Monocyte / macrophages area the key cells of this adverse reaction. The aim of this study was to come up with useful human osteoclasts (OCs) in-vitro from sort a pair of diabetes (T2D) and health management to research the potential osteoclastogenic role of T2D and implant detritus in...
1822
981
STATISTICAL ANALYSIS ON EFFECT OF SITAGLIPTIN AND GLIMEPIRIDE ON PANCREATIC BETA-CELLS DURING THE TREATMENT OF TYPE-2 DIABETIC MELLITUS
The study aimed to analyze the treatment of Sitagliptin with Glimepiride to improve pancreatic beta-cells in T2DM patients. Beta cells are a type of cell found in the pancreatic islet and also synthesize, secrete insulin and amylin. Sitagliptin is found to be maintaining the beta-cells function and glycemic control in T2DM patients. Randomly diabetes mellitus type-2 (T2DM) patients’ data is coll...
1822
1839
ANTIMICROBIAL EFFICACY OF METHANOLIC EXTRACT OF WHOLE PLANT OF NELUMBO NUCIFERA GAERTN.ANTIMICROBIAL EFFICACY OF METHANOLIC EXTRACT OF WHOLE PLANT OF NELUMBO NUCIFERA GAERTN.
The aim of the present investigation was to evaluate the antimicrobial efficacy of methanolic extract of whole plant of Nelumbo nucifera Gaertn. The methanolic extract of Nelumbo nucifera were tested for antibacterial efficacy against three gram positive bacteria & three gram negative bacteria and antifungal activity against three fungal strains by disc diffusion method. In present study Cipro...
1821
741
NOVEL LIQUID CHROMATOGRAPHY / TANDEM MASS SPECTROMETRY METHOD OF WARFARIN IN BUFFERED RAT PLASMA AND ANALYSIS PLASMA PROTEIN BINDING ASSAY SAMPLES AS ITS APPLICATION
Sensitive and selective liquid chromatography/tandem mass spectrometry (LC–MS/MS) method was developed and validated for warfarin (WAR) in buffered SD (Sprague Dawley) rat plasma (PBS and Plasma: 50:50, v/v) using propranolol (PRP) as internal standards (IS) with the Plasma protein binding (PPB) assay samples to a determination of free and total warfarin. Plasma protein precipitation extraction ...
1819
1089
SYNTHESIS OF (2, 4-DIMETHOXY – 3 – ((3 – PHENYL – 4, 5 – DIHYDROISOXAZOL – 5 – YL) METHOXY) PHENYL) (PHENYL) METHANONE AND THEIR ANTIBACTERIAL ACTIVITY
In this study, a series of novel Synthesis of (2,4-dimethoxy-3-((3- phenyl-4, 5- dihydroisoxazol-5-yl) methoxy) phenyl) (phenyl) methanone (8a-p), were synthesized from condensation of an equimolar quantity of aryl (3- hydroxy-2, 4-dimethoxyphenyl) methanones (4a-d) and 5-(bromomethyl)-3- phenyl-4,5-dihydroisoxazole (7a-d) in DMF solvent by employing anhydrous potassium carbonate (K2CO3) as a base...
1817
911
POLYPHARMACY IN GERIATRIC PATIENTS WITH DRUG-DRUG INTERACTIONS AND COMORBID CONDITIONS
Background: Geriatrics refers to the population of 60 years and older. The geriatric population is considered a significant consumer of prescription medications. Polypharmacy is a global phenomenon, and on the elderly population, the impact of polypharmacy is substantial. Aging is a multidimensional process, and it is a growing concern. Multiple comorbidities are one of the reasons for polypharmac...
1817
794
WOUND HEALING POTENTIAL OF CARALLUMA ADSCENDENS
The purpose of this current investigation was for screening the wound healing potential of Ethanolic extract of Caralluma adscendens (EECA) whole plant. Caralluma adscendens (Apocynaceae), a common medicinal plant in traditional Indian medicine. Mentions in folk medicine and existing data raised an outlook on this plant for evaluating wound healing potential. Ethanolic extract of Caralluma adscend...
1816
927