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AMINO ACID PROFILING AND PROTEIN CONTENT DETERMINATION OF BOVINE MILK COLLECTED FROM DIFFERENT TEHSIL OF SINGRAULI DISTRICT
Milk and milk products are nutritious food items containing numerous essential nutrients. This study was carried out to determine the influence of variable season on profiling of amino acid and protein content from 90 bovine milk collected (March 2018 to February 2019) samples belongs to four tehsils of Singrauli district. The most abundant amino acid was glutamic acid, followed by proline and leu...
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AN EXPERIMENTAL STUDY TO EVALUATE THE EFFECT OF TRANDOLAPRIL AND NIMODIPINE IN ANXIETY, DEPRESSION AND MOTOR COORDINATION USING BEHAVIORAL MODELS IN SWISS ALBINO MICE
The present study aimed to assess the role of angiotensin-converting enzyme inhibitor (trandolapril) and calcium channel blocker (nimodipine) in anxiety, depression, and motor coordination using behavioral models in mice. This was an experimental study involving 72 swiss albino mice divided into 12 groups. Groups 1 to 4 were used to evaluate the anxiolytic effect using Y maze after 5 days of t...
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REVIEW OF ANALYTICAL METHODS FOR IDENTIFICATION AND QUANTIFICATION OF ZOLMITRIPTAN
Zolmitriptan is a selective serotonin receptor agonist of 1B and 1D receptors belonging to the triptan class. Zolmitriptan binds to the serotonin (5-HT) 1B receptors, receptor binding leads to inhibition of nociceptive transmission, constriction of cranial vessels, and reduction of vessel pulsation, thereby providing relief of migraine headaches, as Zolmitriptan holds great importance in migraine...
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DEVELOPMENT OF STABILITY-INDICATING UPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF TIPIRACIL ANDTRIFLURIDINE IN FORMULATION
Aim of the present research work was to develop a sensitive, precise, and robust stability-indicating UPLC method for the simultaneous estimation of tipiracil and trifluridine in formulations. The chromatographic separation of a mixture of tipiracil and trifluridine was attained in isocratic method utilizing a mobile phase of 0.1% orthophosphoric acid: acetonitrile in the proportion of 50:50% v/v ...
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EVALUATION OF ANTI-ARTHRITIC ACTIVITY OF MICROSPONGE FORMULATION IN FREUND’S COMPLETE ADJUVANT-INDUCED ARTHRITIC RAT MODEL
The aim of the present study was to improve the release rate of herbal drugs by microsponges prepared through quasi-emulsion solvent diffusion technique using ethyl cellulose and PVA as carriers. The microsponges were characterized by FTIR, DSC and SEM studies followed by the determination of total drug content and entrapment efficiency. Anti-arthritic activity was evaluated by Freund’s Complete...
1828
1083
ROLE OF DEMINERALIZED FREEZE-DRIED BONE ALLOGRAFT AROUND IMMEDIATE IMPLANTS IN EXTRACTION SOCKETS – A REVIEW
Implant insertion in a "fresh extraction socket" is reliable and effective. Often little discrepancy is there between the size of the implant and the wall of the socket, which needs to be filled before placing the implant. Hence, there is a need for graft material to fill this space. The main objective of this article is to review the role of “demineralized freeze-dried bone allograft” (DFDBA)...
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OPSONIZATION AS A LONG CIRCULATORY APPROACH: A CHALLENGE IN DRUG DELIVERY
Opsonisation is the process of coating infections with antibodies to make them more receptive to phagocyte ingestion. Opsonization is a crucial step in host defence that prepares particles or complexes for easy ingestion by phagocytic cells. It has been acknowledged that activated macrophages could proactively capture opsonized nanoparticles in the bloodstream and then accumulate in the reticulo...
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PHYTOCHEMICAL ANALYSIS, ELEMENTAL CONTENT, AND FIBROBLAST PROLIFERATION ACTIVITY OF THE HYDRO-ETHANOLIC EXTRACT OF MORINGA OLEIFERA LAM LEAVES
Moringa oleifera is one plant that is multi-purposefully used for the prevention and treatment of numerous diseases. This study analyzed the phytochemical and elemental contents of M. oleifera leaf extract, and evaluated its effect on fibroblast proliferation, which is crucial for wound healing. M. oleifera leaf samples were collected, identified, and extracted using solvents of different polariti...
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PREPARATION AND IN-VIVO EVALUATION OF SIMVASTATIN CRYSTALLO-CO-AGGLOMERATES
The purpose of this research was to obtain directly compressible agglomerates of simvastatin using a crystallo-co-agglomeration technique and determine its in-vivo performance in rats. Simvastatin Dicalcium phosphate co agglomerates were prepared from Dichloromethane: Isopropyl Myristate: Distilled water system containing polyvinyl pyrrolidone (PVP). Dichloromethane acted as a good solvent for si...
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ESTIMATION OF PHYTOCHEMICAL CONSTITUENTS IN THREE PLANTS WIDELY USED FOR TRADITIONAL TREATMENT OF ASTHMA IN MYANMAR
The crude drug powder extracts from three plants Datura metel L., (Solanaceae), Leucas cephalotes (Roth.). Spreng, Piper betel L., (Piperaceae) were screened for estimating phytochemical constituents. Phytochemical analysis of the extracts revealed that glycoside; tannin, saponin, carbohydrate and phenolic compounds are present in Piper and Leucas species. Besides glycoside, tannin, saponin, carbo...
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