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A SIMPLE METHOD DEVELOPMENT, VALIDATION AND QUANTIFICATION OF LENVATINIB IN PHARMACEUTICAL DOSAGE FORM USING ZERO ORDER AND FIRST-ORDER DERIVATIVE NOVEL SPECTROPHOTOMETRIC METHODS
Simple, very Sensitive, rapid, and accurate novel spectro-photometric methods were developed to estimate Lenvatinib in Pharmaceutical dosage form using zero- and first-order derivative spectrophotometry. The solutions of Lenvatinib standard and sample were prepared using analytical grade methanol. The spectrophotometric estimation of lenvatinib was carried out at 240 nm in the zero-order method an...
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2D QSAR APPROACH TO DEVELOP NEWER GENERATION SMALL MOLECULES ACTIVE AGAINST SARS-COVID
We are in the half past of 2022, but still, we are facing the coronavirus pandemic situation. When a patient is hospitalized, only some FDA-approved drugs were administered to cure the patient. In treating coronavirus infection, nitazoxanide, granulocyte-macrophage colony-stimulating factor inhibitors, and various monoclonal antibodies are present. But all the molecules used in the treatment were ...
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OCULAR INSERTS: A PROMINENT TECHNIQUE FOR OCULAR DRUG DELIVERY
The eye is a sensitive organ, and the administration of drugs into the ocular cavity is a tedious task. Ocular insert is the prominent technique to overcome problems associated with conventional dosage forms like repeated administration, drug drainage via lacrimal fluids drainage, formation of crystalline deposits on the cornea, pH instability, pulsed dosing of drugs, etc. This review focuses on d...
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COST EFFECTIVE, ROBUST PRECISE & STABILITY INDICATING ANALYTICAL METHOD VALIDATION OF RELATED SUBSTANCES FOR PIMECROLIMUS CREAM BYRP-HPLC
A new, precise, economical and gradient reverse-phase high-performance liquid chromatography (RP-HPLC) method has been validated for the relative substance determination in pimecrolimus cream. The chromatographic separation was achieved with phenomenax luna, C18, 150 x 4.6mm and 3 µm particle size column. The flow rate was 1.5 mL/min and eluents were detected at 210 nm using PDA detector. The ret...
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MORINGA OLEIFERA (MO) SEED CATALYZED THE SYNTHESIS OF BENZIMIDAZOLE DERIVATIVES
A simple, one-pot, and efficient method for the synthesis of benzimidazole derivatives via the condensation of o-phenylenediamine and substituted aromatic aldehydes in the presence of Moringa oleifera (MO) seed extract acts as a biocatalyst under microwave irradiation. The method provides several advantages such as simple operation, clean reaction ways, and high to the excellent yield of product. ...
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ANTI-ARTHRITIC POTENTIAL OF BIOPOLYMERIC FRACTION OF SEEDS OF TRIGONELLA FOENUM GRACEUM ALONE AND ITS COMBINATION WITH GLYCYRRHIZIN AS A BIO-ENHANCERS IN ARTHRITIC RATS
Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disorder. It is characterized by inflammation of the synovial joints and concomitant destruction of cartilage and bone. However, rheumatoid arthritis is typically a progressive illness that has potential to cause joint destruction and functional disability. In the present research, GSH content were significantly decreased in art...
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IN-VITRO EVALUATION OF ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF MEDICINAL PLANT BAUHINIA VAHLII
The present study evaluated the antibacterial and antifungal activities of the medicinal plant Bauhinia vahlii. The antibacterial and antifungal activities of vacuum dried ethanol extract of the stem and leaves of Bauhinia vahlii (EEBVS and EEBVL) were performed using the Disc diffusion method. The antibacterial and antifungal activities recorded significant effects against five bacterial strains,...
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ISOLATION OF ANTIBACTERIAL PEPTIDE FROM VIGNA ACONITIFOLIA L.
Vigna aconitifolia L. represents a genus in the Fabaceae family and is one of the most drought-resistant legumes, commonly grown in arid and semi-arid regions of India. Therapeutic effects of Vigna aconitifolia L. have been reported in several publications, but there are only a few reports on the biological activities of the Vigna aconitifolia L. proteins. In the present study, antibacterial a...
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DESIGN, DEVELOPMENT AND STATISTICAL OPTIMIZATION OF ACYCLOVIR-LOADED PROTEIN NANOPARTICLES
To solve the problem of low drug availability in the body, acyclovir was fabricated into biodegradable gelatin nanoparticles by step-wise two-times desolvation method where gelatin was used as biodegradable polymer and glutaraldehyde was utilized as a cross-linking agent. Optimization was conceded by design expert computational application whereby the outcome of gelatin polymer concentration (X1...
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QUALITY STANDARDIZATION OF AYURVEDIC FORMULATIONS – SANSHAMANI VATI AND MAHALAXMIVILAS RASA
Purpose: Sanshamani Vati (SHV) is useful in all types of Jwara, and Mahalaxmivilas Rasa (MLVR) is the best drug in various cardiovascular and respiratory disorders. To maintain the enormous trust in Ayurveda, it’s necessary to ascertain the quality, efficacy & safety of Ayurvedic formulations on scientific lines using modern techniques. Present work attempts have been made to standardize the...
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