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IN-VITRO ANTILEISHMANIAL EVALUATION OF AMPHOTERICIN B-MILTEFOSINE NANOVESICLES
Leishmaniasis is a neglected tropical infectious disease affecting poor people, especially in the developing countries of the world. It is a systemic disease caused by a protozoan parasite leishmania donovani and is fatal if left untreated. The aim of the present study is to develop and evaluate the in-vitro antileishmanial activity of the combination of amphotericin B and mitefosinenano vesicles ...
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VITAMIN C, THIAMINE AND HYDROCORTISONE IN SEPTIC SHOCK: A RETROSPECTIVE ANALYSIS
Background: Sepsis leads to approximately 11 million deaths annually. Objectives: We studied the effectiveness of using a combination of intravenous hydrocortisone (50mg QID), Ascorbic Acid (1.5g QID), and Thiamine (200mg BD) (HAT) to reduce mortality among septic patients compared to a historical control group. Materials and Methods: This retrospective, observational study was conducted between J...
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CHARACTERIZATION OF NOVEL SOFT ROT CAUSING GRAM-NEGATIVE BACTERIA SJCTSSP01 & ITS MANAGEMENT USING PHYTOEXTRACTS
Aim: The present study focuses on studying the soft rot-causing bacteria in Solanum tuberosum and the activity of phytoextracts against the pathogen to prevent/control this infection. Lantana camara and Clerodendrum infortunatum has been well known for their antibacterial activity and widely used in Ayurveda, these plants were investigated for their antibacterial activity against the isolated path...
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NEUROTHERAPEUTIC EFFECT OF BERGENIN ON CUPRIZONE-INDUCED DEMYELINATION BY REGULATING NEUROLOGICAL FUNCTIONS ASSOCIATED WITH MOTOR ACTIVITY, OXIDATIVE STRESS, AND HISTOLOGICAL ALTERATIONS IN THE CORPUS CALLOSUM OF C57BL/6 MICE
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system characterized by Neuroinflammation, oligodendrocyte loss, and axonal pathology. Bergenin, a chief phytochemical constituent of Bergenia species, has been shown to exert anti-inflammatory and antioxidant effects. The cuprizone (CPZ) model is an established mouse model of MS and causes demyelination and induces ...
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A CUMULATIVE REVIEW ON THERAPEUTICFLORAE USED TOTREAT DIABETES MELLITUS
Diabetes Mellitus is a chronic ailment characterized by clinical manifestations like hyperglycaemia. The development of novel drugs is based on the understand ding of insulin resistance and oxidative damage leading to secondary complications of diabetes such as Retinopathy, Nephropathy etc. In the modern era, there are numerous allopathic drugs available for the treatment of the ailment. Herbs inc...
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ANTIPARKINSONIAN ACTIVITY OF HYDROALCOHOLIC EXTRACT OF THE STEMS OF CAPPARIS DECIDUA (FORSSK.) EDGEW.
The goal of the research is to analyze the antiparkinsonian activity of hydroalcoholic extract of the stems of Capparis Decidua (HECD). Themost common neurodegenerative condition which stand second is Parkinson. It is reported by dopaminergic neuron loss in the striatum's substantia nigra & dopamine loss (DA). Capparis Decidua plant is used as anti-inflammatory, laxative, anti-diabetic, anthel...
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3D BIOPRINTING AND BEYOND: A TECHNOLOGICAL TRANSFORMATION FOR PHARMACEUTICAL AND BIOMEDICAL APPLICATIONS
3D Bioprinting is a transformational technology that is an indispensable part of the pharmaceutical and biomedical fields. It has been used globally as a cutting-edge tool to improve future prospects. This review encompasses a brief explanation of what exactly 3d bioprinting is, its processing, and how it differs from 3d printing. The elemental segment of bioprinting is bioinks which are biomateri...
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A STUDY ON THE NOSE TO BRAIN DRUG DELIVERY SYSTEM
Drugs have been controlled by the nasal route for remedial & therapeutic use since ancient times. Enthusiasm & importance for the basic impacts of drugs directed via the nasal route has developed to last decades. Intra-nasal drug organization provides an attractive substitute for achieving the important beneficial impacts of drugs virtually similar to the parenteral route, that may be impr...
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DESIGN OF EXPERIMENT (DOE) APPROACH FOR A SIMPLER HPLC TECHNIQUE ESTIMATING THYMOQUINONE FROM NIGELLA SATIVA SEEDS, COMMERCIAL FORMULATION, POLYMERIC NANOPARTICLES, AND ITS STABILITY INDICATION
To the best of our knowledge, the factorial design methodology has never been used to estimate Thymoquinone (TQ) using the reverse phase High-Performance Liquid Chromatography (RP-HPLC) method, making our work unique. The study aimed to create, verify and validate a simple stability-indicating analytical technique for quantitative detection of TQ in Ayurvedic formulations, black seed and polymeric...
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ANTI-DIABETIC AND ANTI-HYPERTENSIVE ACTIVITIES OF CITRUS FRUIT PEELS
Orange (Citrus sinensis), Kinnow (Citrus reticuleta), and Mosambi (Citrus limetta) methanolic, the aqueous extract showed the inhibitory activity on α-amylase and α-glucosidase assay where methanolic, acetone and aqueous extract of these fruit peels exhibited the anti-hypertensive activities. The results showed that the methanol and aqueous extract of Orange, Kinnow, and Mosambi peels inhibited ...
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