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TREATMENT STRATEGIES FOR NEURODEGENERATIVE DISEASES THROUGH IMPORTANT MEDICINAL PLANTS USED IN UNANI MEDICINE
Neurodegenerative diseases (NDs) that are characterized by progressive loss of functioning and structure of neurons are of great burden to the individuals and the society. With several hypotheses, the existent cause still remains a mystery for various NDs in healthcare. Protein degradation, inflammation, oxidative stress, environmental factor, mitochondrial defects, abnormal protein accumulation i...
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SYNTHESIS AND CHARACTERIZATION OF MUTUAL PRODRUGS OF MEFENAMIC ACID WITH OTHER NSAIDS
Inflammation and pain have all been successfully treated using nonsteroidal anti-inflammatory drugs. Today's nonsteroidal anti-inflammatory drugs (NSAIDs) are typically taken with restriction due to the gastric intolerance they create. The prodrug approach is quite effective in reducing the side effects caused by NSAIDs. Many nonsteroidal anti-inflammatory drug molecules have been modified in seve...
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EFFECT OF DIALLYL DISULFIDE (DADS) ON GLUCOSE UTILIZATION IN DIABETIC ERYTHROCYTES
Background & objectives: Diallyl disulphide (DADS) is an active component of garlic that has been claimed to have hypoglycemic effect and are beneficial in achieving glycemic control in diabetes mellitus (DM). The present study was conducted to assess the glucose utilization in erythrocytes in diabetic subjects after the exposure of DADS. Methods: The blood samples were collected from diabetic...
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ANTIDEPRESSANT EFFECT OF IBANDRONATE ON DEPRESSION MODELS
This study was designed to evaluate and compare the Antidepressant effect of Ibandronate with Amitriptyline on depression models in albino mice. Eighteen Swiss albino mice weighing 20-25 grams were selected and divided into three groups of six animals each. Group 1: Normal Saline- 0.5 ml, Group 2: Amitriptyline - 39 mg/kg, Group 3: Ibandronate 0.325 mg/kg administered orally every day for 30 days....
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DESIGN AND EVALUATION OF CANDESARTAN CILEXETIL SOLID DISPERSION INCORPORATED IN HARD GELATIN CAPSULE
Candesartan cilexetil is widely used for the treatment of hypertension. Candesartan cilexetil is a pro-drug administered orally, rapidly converted to its active metabolite candesartan during absorption in the gastrointestinal tract. Candesartan cilexetil is a BCS II drug that is practically insoluble in the water of 0.00771 mg/ml & it has a low dissolution rate, hence; to improve dissolution r...
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ALLOPOLYHERBAL GEL FORMULATION AGAINST MICROORGANISM: IN-VITRO STUDIES
The cases of skin infections are increasing daily, and the conventional treatment loses its strength in treating those skin infections because of resistance of the microorganisms against the medications, including antibacterial as well as antifungal with the topical and oral administration, or both. The advancement of the treatment of treating skin infections by the combination with the synthetic ...
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A STUDY ON KNOWLEDGE, PRACTICE AND EXPERIENCE ON THE USE OF GENERIC MEDICINES AMONG PATIENTS, HEALTHCARE PROFESSIONALS & COMMON PEOPLE
Generic medicines have the same efficacy, route of administration, strength, indication and side effects as branded medicines. In spite of the lower price, generic medicines are not popular among healthcare professionals. The study's objective was to explore knowledge, practice and experience in using generic medicines among patients, common people, & healthcare professionals (nurses, pharmaci...
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DRUG DISCOVERY AND DEVELOPMENT: A BASIC APPROACH TO IMPROVE THE SUCCESS OF DRUG DISCOVERY
Drug discovery is a process that aims at identifying a compound therapeutically useful in curing and treating disease. This process involves the identification of candidates, synthesis, characterization, validation, optimization, screening, and assays for therapeutic efficacy. Once a compound has shown its significance in these investigations, it will initiate the drug development process earlier ...
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ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF CRUDE FLAVONOID FRACTION OF MITRAGYNA PARVIFOLIA
Inflammation is considered a primary physiologic defense mechanism that helps the body to protect itself against infection, burn, toxic chemicals, allergens, or other noxious stimuli. Inflammatory diseases are currently treated with steroidal and non-steroidal anti-inflammatory drugs (NSAIDs). Unfortunately, both of these widely prescribed drug classes have significant negative side effects. Hence...
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COMPARISON OF FUNCTIONAL AND RADIOLOGICAL OUTCOMES BETWEEN CANNULATED CANCELLOUS SCREW FIXATION AND TENSION BAND WIRING IN CLOSED MEDIAL MALLEOLUS FRACTURES
Introduction: Medial malleolus fractures are among the most common fractures encountered around the ankle joint. This study was performed to assess the functional outcome between cannulated cancellous screw fixations versus tension band wiring in managing these fractures. Method: A total of 30 patients were selected and were randomly segregated into two groups, Group A and Group B. Group A patient...
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