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USING IMMUNOINFORMATIC APPROACH DESIGN EPITOPE-BASED VACCINE FOR CHIKUNGUNYA VIRUS
Chikungunya is a mosquito-borne infection of the genus alphavirus. It is vaccines, medications, and other treatments difficult to produce. The CHIK-Virus is carried thru the mosquito, which functions as a vector for the disease. Vaccines, therefore, provide alternate preventative techniques for the spread of viral infection. Structural proteins of CHIK-Virus with T and B cells had been used for im...
1819
866
DERIVATIVE SPECTROPHOTOMETRIC METHODS FOR THE ANALYSIS AND STABILITY STUDIES OF RANOLAZINE IN BULK AND DOSAGE FORMS
Objectives: The present study aimed to develop simple and accurate first and second-order derivative spectrophotometric methods (1D and 2D) for the assay and stability studies of Ranolazine (RAN) in bulk and dosage forms. Methods: The original UV spectrum of RAN solution in methanol was differentiated instrumentally to generate the first and second derivative spectra which were measured at 278 nm ...
1818
901
COMPARING THE EFFICACY AND PHARMACOECONOMICS OF ATORVASTATIN AND ROSUVASTATIN
The aim of the research work was to determine and compare the efficacy and pharmacoeconomics of Atorvastatin and Rosuvastatin. The cohort, observational, and prospective studies were conducted at KMC multispeciality hospital, Trichy. The hyperlipidemic patient was treated with Atorvastain (10 mg) and Rosuvastatin (5 mg) every day over a period of six months. Contemplating the inclusion and exclusi...
1818
771
NOVEL DRUG DELIVERY SYSTEMS FOR EFFECTIVE DELIVERY OF DRUGS IN THE MANAGEMENT OF RHEUMATOID ARTHRITIS
Chronic joint inflammation is a hallmark of the systemic inflammatory illness known as rheumatoid arthritis (RA), which eventually causes severe disability and early death. RA may impact any joint in the body. However, it mostly impacts the wrist and knee joints' proximal interphalangeal, metacarpophalangeal and metatarsophalangeal joints. Around 1% of people worldwide are affected by it and women...
1818
1036
ANTI-HYPERGLYCAEMIC EFFECTS OF AQUEOUS PREPARATION OF MEYNA SPINOSA ROXB. FRUIT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
The unripe fruit of Meyna spinosa / Laxiflora is used for the treatment of diabetes by traditional healers. The effect of the aqueous extract of the fruit is investigated on the normal and elevated blood glucose level of the experimental animal rats. The blood glucose level of the rats is elevated with the administration of I.P streptozotocin. The estimation of the blood glucose level is done by u...
1818
1052
FORMULATION, OPTIMIZATION AND EVALUATION OF NORFLOXACIN TRANSDERMAL PATCH FOR ANTI-BACTERIAL ACTIVITY
Objective: This investigation aimed to formulate, optimize and evaluate the matrix-type transdermal patch of norfloxacin for antibacterial activity by incorporating different polymer concentrations and penetration enhancers. Methods: Nine formulations were prepared by a solvent evaporation method using ethyl cellulose dibutyl phthalate, tea tree oil, and tulsi oil at concentrations (0.25%, 0.5%, 1...
1817
975
EVALUATION OF HEPATOPROTECTIVE POTENTIAL OF ALSTONIA SCHOLARIS STEM BARK AGAINST CCL4 INDUCED HEPATOTOXICITY – AN IN-VIVO SCREENING
The hepatoprotective potential of ethanolic extract of stem bark of Alstonia scholaris belonging to the family Apocynaceae and commonly known as Devil’s tree or Saptaparni was assessed against carbon tetrachloride-induced hepatotoxicity in Wistar rats. It is an evergreen tropical tree native to the Indian sub-continent and Southeast Asia and contains various phytoconstituents like alkaloids, tri...
1816
990
NOVEL ANTI-DIABETIC POTENTIAL OF “SUGAR CARE” A MIRACLE DRINK EVALUATED ON HUMAN DIABETIC SUBJECTS
The herbal-based formulation “Sugar Care” a product of Miracle Drinks was assessed for an anti-diabetic property on 12 diabetic patients. Each patient was prescribed 15ml of Sugar Care (S10) morning and evening after meal and 15ml of cardiovascular care (S3) in the afternoon. Morning and night doses of sugar care were given along with 15ml of Liver Care (S4) and Renal Care (S5). After 30 days ...
1816
888
A RETROSPECTIVE AUDIT OF DRUG PRESCRIBING PATTERNS AMONG THE PATIENTS VISITED THE DENTAL CLINIC OF A PRIVATE MEDICAL UNIVERSITY IN KEDAH, MALAYSIA
Introduction: Irrational use of drugs is widespread in present-day medical practice. Hence, the present study aimed to analyze the drug prescribing pattern among the patients who visited the Faculty of Dentistry dental clinic, AIMST University. Methods: A retrospective, cross-sectional study was conducted to analyze the drug prescribing pattern of dentists of AIMST University, Kedah, Malaysia. A t...
1815
987
NANOCRYSTALS FOR IMPROVED DRUG DELIVERY: A REVIEW
Nanocrystals are crystalline particles having particle size range of 100 to 1000 nm. However, these nano-sized systems are thermodynamically unstable, stabilizers are required to incorporate them. The poorly soluble drugs lead to problems like poor absorption and therapeutic failure. One such method to overcome these solubility problems is the development of nanocrystals. These systems reduce part...
1815
700