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A CUMULATIVE REVIEW ON THERAPEUTICFLORAE USED TOTREAT DIABETES MELLITUS
Diabetes Mellitus is a chronic ailment characterized by clinical manifestations like hyperglycaemia. The development of novel drugs is based on the understand ding of insulin resistance and oxidative damage leading to secondary complications of diabetes such as Retinopathy, Nephropathy etc. In the modern era, there are numerous allopathic drugs available for the treatment of the ailment. Herbs inc...
1828
1197
DERIVATIVE SPECTROPHOTOMETRIC METHODS FOR THE ANALYSIS AND STABILITY STUDIES OF RANOLAZINE IN BULK AND DOSAGE FORMS
Objectives: The present study aimed to develop simple and accurate first and second-order derivative spectrophotometric methods (1D and 2D) for the assay and stability studies of Ranolazine (RAN) in bulk and dosage forms. Methods: The original UV spectrum of RAN solution in methanol was differentiated instrumentally to generate the first and second derivative spectra which were measured at 278 nm ...
1827
905
IN-VITRO ANTHELMINTIC EFFECTS OF MEDICINAL PLANT CASSIA FISTULA EXTRACT ON THE TEGUMENT OF FASCIOLA GIGANTICA BY LIGHT MICROSCOPE
The efficacy of alcoholic Cassia fistula leaves extract on the tegument of Fasciola gigantic was studied by light microscopy. Live liver fluke Fasciola gigantica parasites were collected from the infected liver and bile duct of freshly slaughtered domestic goat (Capra hircus) at the local zoo abattoir in Udaipur. Liver flukes F. gigantica were maintained in 0.9% physiological saline and divided in...
1826
977
A RETROSPECTIVE AUDIT OF DRUG PRESCRIBING PATTERNS AMONG THE PATIENTS VISITED THE DENTAL CLINIC OF A PRIVATE MEDICAL UNIVERSITY IN KEDAH, MALAYSIA
Introduction: Irrational use of drugs is widespread in present-day medical practice. Hence, the present study aimed to analyze the drug prescribing pattern among the patients who visited the Faculty of Dentistry dental clinic, AIMST University. Methods: A retrospective, cross-sectional study was conducted to analyze the drug prescribing pattern of dentists of AIMST University, Kedah, Malaysia. A t...
1826
994
NOVEL DRUG DELIVERY SYSTEMS FOR EFFECTIVE DELIVERY OF DRUGS IN THE MANAGEMENT OF RHEUMATOID ARTHRITIS
Chronic joint inflammation is a hallmark of the systemic inflammatory illness known as rheumatoid arthritis (RA), which eventually causes severe disability and early death. RA may impact any joint in the body. However, it mostly impacts the wrist and knee joints' proximal interphalangeal, metacarpophalangeal and metatarsophalangeal joints. Around 1% of people worldwide are affected by it and women...
1826
1043
ANTI-HYPERGLYCAEMIC EFFECTS OF AQUEOUS PREPARATION OF MEYNA SPINOSA ROXB. FRUIT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
The unripe fruit of Meyna spinosa / Laxiflora is used for the treatment of diabetes by traditional healers. The effect of the aqueous extract of the fruit is investigated on the normal and elevated blood glucose level of the experimental animal rats. The blood glucose level of the rats is elevated with the administration of I.P streptozotocin. The estimation of the blood glucose level is done by u...
1826
1058
IN-VITRO ANTI-BACTERIAL POTENCY AND PHYTOCHEMICAL ANALYSIS OF ANACARDIUM OCCIDENTALE L. LEAF AGAINST SOME GASTROINTESTINAL TRACT INFECTION-CAUSING BACTERIA
Bacterial infections are one of the prominent causes of health problems and mortalities around the world. Medicinal plants are a rich source of antimicrobial agents and provide a safer and cost-effective way of treating bacterial infections. The objective of the present investigation was to evaluate the anti-bacterial potential of petroleum ether and methanol extracts of Anacardium occidentale L. ...
1825
1101
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF GLIPIZIDE AND MOMORDICININ IN RAT PLASMA
Momordicinin (MMR) is a major triterpenoid compound from Momordica charantia Linn fruit having antidiabetic potential, whereas glipizide (GPZ) is a well-known molecule in treatment of diabetes mellitus. The primary objective of the study is to develop and validate a simultaneous RP-HPLC method for upcoming pharmacokinetic studies to analyze herb-drug interactions. The study uses the protein precip...
1825
933
USING IMMUNOINFORMATIC APPROACH DESIGN EPITOPE-BASED VACCINE FOR CHIKUNGUNYA VIRUS
Chikungunya is a mosquito-borne infection of the genus alphavirus. It is vaccines, medications, and other treatments difficult to produce. The CHIK-Virus is carried thru the mosquito, which functions as a vector for the disease. Vaccines, therefore, provide alternate preventative techniques for the spread of viral infection. Structural proteins of CHIK-Virus with T and B cells had been used for im...
1825
871
EVALUATION OF HEPATOPROTECTIVE POTENTIAL OF ALSTONIA SCHOLARIS STEM BARK AGAINST CCL4 INDUCED HEPATOTOXICITY – AN IN-VIVO SCREENING
The hepatoprotective potential of ethanolic extract of stem bark of Alstonia scholaris belonging to the family Apocynaceae and commonly known as Devil’s tree or Saptaparni was assessed against carbon tetrachloride-induced hepatotoxicity in Wistar rats. It is an evergreen tropical tree native to the Indian sub-continent and Southeast Asia and contains various phytoconstituents like alkaloids, tri...
1822
995