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BIOLOGICS AND BIOSIMILARS- A MEDICINE FROM THE LIFE AND FOR THE LIFE: THE COMPLETE REVIEW
In this review, we are completely discussing different eras in pharmaceutical drugs/medicines, i.e., Biologics and biosimilars. These biologics can be called life drugs because they are deriving from living organisms, microbes, yeast, bacteria, and human blood products. These biologics are biopharmaceutical products that are derived from living organisms and are very complex in molecular structure...
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF GLIPIZIDE AND MOMORDICININ IN RAT PLASMA
Momordicinin (MMR) is a major triterpenoid compound from Momordica charantia Linn fruit having antidiabetic potential, whereas glipizide (GPZ) is a well-known molecule in treatment of diabetes mellitus. The primary objective of the study is to develop and validate a simultaneous RP-HPLC method for upcoming pharmacokinetic studies to analyze herb-drug interactions. The study uses the protein precip...
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ANTIOXIDANT, ANTI-ANGIOGENIC AND CYTOTOXIC EFFECT OF ALOE BARBADENSIS, A MEDICINAL PLANT FROM INDIA
Background: Aloe barbadensis (AB) is a member of the Liliaceae family, traditionally used for thousands of years in some parts of India and well known for its anti-inflammatory, antimicrobial, and wound healing properties. The purpose of the study is to evaluate the antioxidant, anti-angiogenic and antiproliferative effect of AB methanolic root extract on A549 lung cancer cell line. Methods: The A...
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COMPARISON BETWEEN STEROID AND PRP INJECTIONS IN MEDIAL EPICONDYLITIS (GOLFER’S ELBOW) PATIENTS
Background: Golfer's elbow, commonly known as medial epicondylitis, is an overuse syndrome caused by an eccentric overload of flexor-pronator mass on the medial epicondyle. This is produced by repetitive actions causing micro-trauma to insert the flexor-pronator mass, which affects the pronator teres more than the flexor carpi radialis. This study evaluates the efficacy of platelet-rich plasma and...
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3D BIOPRINTING AND BEYOND: A TECHNOLOGICAL TRANSFORMATION FOR PHARMACEUTICAL AND BIOMEDICAL APPLICATIONS
3D Bioprinting is a transformational technology that is an indispensable part of the pharmaceutical and biomedical fields. It has been used globally as a cutting-edge tool to improve future prospects. This review encompasses a brief explanation of what exactly 3d bioprinting is, its processing, and how it differs from 3d printing. The elemental segment of bioprinting is bioinks which are biomateri...
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A REVIEW ON THE CURRENT STATUS OF MULTI-DRUG RESISTANT STAPHYLOCOCCUS AUREUS AND ITS FUTURE PROSPECTS
Infectious diseases are the most significant cause of fatalities worldwide. Staphylococcus aureus could be a common human infective microorganism that will trigger various infectious diseases, like soft tissue and skin infections, osteomyelitis, bacteremia, endocarditis, and fatal respiratory illnesses. In recent decades, because of the evolution of microorganisms and the abuse of antibiotics, the...
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ANTIDIABETIC ACTIVITY OF AVICENNIA ALBA IN STREPTOZOTOCIN INDUCED TYPE-2 DIABETIC RATS
The study was initiated to determine the antidaibetic activity of Avicennia alba in Streptozotocin induced Type-2 diabetic rats. The rats were treated with 100, 200 and 400 mg/kg of Avicennia alba stem and leaf methanolic extract (MLAA) and compared with the diabetic, normal and standard (glibenclamide) rat groups. The blood glucose levels, glycosylated haemoglobin levels, and body weight of the r...
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GERMINATION STUDIES AND BIOCHEMICAL PROFILE IN SEEDS OF WHEAT EXPOSED TO MAGNESIUM NANOPARTICLES
Nanotechnology has gained a lot of importance and application in agriculture in the last decade. The present work was focused on the synthesis and characterization of magnesium oxide nanoparticles and on studying the effect of these nanoparticles on wheat (PBW-677 variety). Magnesium oxide nanoparticles were synthesized by chemical synthesis method and were characterised by using UV- Visible spect...
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NEWER COUMARIN DERIVATIVES AS ANTIMICROBIAL AGENTS
For the synthesis of a series of novel Coumarin derivatives, an efficient and easy approach has been designed. 1H-NMR and Fourier Transformed Infrared (FTIR) characterize the structures of freshly synthesized compounds, which are then evaluated for antibacterial activity in vitro by calculating the zone of inhibition and minimum inhibitory concentration. The antibacterial and antifungal activity o...
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DESIGN OF EXPERIMENT (DOE) APPROACH FOR A SIMPLER HPLC TECHNIQUE ESTIMATING THYMOQUINONE FROM NIGELLA SATIVA SEEDS, COMMERCIAL FORMULATION, POLYMERIC NANOPARTICLES, AND ITS STABILITY INDICATION
To the best of our knowledge, the factorial design methodology has never been used to estimate Thymoquinone (TQ) using the reverse phase High-Performance Liquid Chromatography (RP-HPLC) method, making our work unique. The study aimed to create, verify and validate a simple stability-indicating analytical technique for quantitative detection of TQ in Ayurvedic formulations, black seed and polymeric...
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