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IN-VITRO SCREENING OF EXTRACTS OF CENTELLA ASIATICA (LINN) URBAN FOR ANTIBACTERIAL PROPERTIES
Centella asiatica (Linn) Urban, a herb of immense medicinal properties, has been widely used by traditional healers in the treatment of skin diseases, mental fatigue, anxiety, rheumatism, eoilepsy and leprosy. In the present investigation, the antibacterial activity of ethanol, acetone and aqueous extracts of Centella asiatica were tested in-vitro against seven bacterial species viz. Staphylococcu...
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MORPHOLOGICAL AND BIOCHEMICAL CHARACTERIZATION OF CYANOBACTERIAL ISOLATES FROM BIOLOGICAL SOIL CRUST OF RAJASTHAN, INDIA
The BSC sample was collected at four sites from the arid region of Rajasthan and these isolates were characterized based on morphological and biochemical parameters. We have to isolate both heterocysts and non-heterocysts cyanobacterial species. Oscillatoria tenuis species showed maximum chlorophyll accumulation and Phormium showed maximum carotenoids compared to heterocystous forms. The soluble p...
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AN IN-SILICO APPROACH ON ANTIDIABETIC ACTIVITY OF COMPOUNDS IN MOMORDICA CHARANTIA LINN.
The use of natural compounds has become more preferable for reducing the severe complications of diabetes mellitus due to having a minimum cost and the least side effects. The recent study is aimed to diagnose in-vitro α-amylase inhibition activity and the molecular interactions of various phytocompounds like momordicoside A, momordicoside B, momordicoside C, momordicoside D, momor-dicoside E, ga...
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A REVIEW OF CLINICAL STUDIES IN TUBERCULOSIS REGISTERED IN THE CLINICAL TRIALS REGISTRY OF INDIA
Background: Currently, 23 drugs for treating drug-susceptible TB, MDR-TB, or latent TB infection are in Phase I, II, or III trials. Bedaquiline, Delamanid and Pretomanid are new approved drugs. Still, TB is more prevalent in many countries. So, ideally, the countries facing this problem should do extensive research. Aim: The aim of our study is to find the number of studies, their design, sponsors...
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THE CURRENT REGISTRATION REGULATIONS OF COSMETIC PRODUCTS IN “BRICS” COUNTRIES
Cosmetic products are produced by the most inventive and technically driven methods to reach more consumers in the developing world. Cosmetic products are also regulated, similar to pharmaceutical products. BRICS countries are emerging markets with a partial regulatory system similar to well-regulated countries. BRICS countries have a registration or notification process for cosmetics based on the...
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DRUG DISCOVERY AND DEVELOPMENT: A BASIC APPROACH TO IMPROVE THE SUCCESS OF DRUG DISCOVERY
Drug discovery is a process that aims at identifying a compound therapeutically useful in curing and treating disease. This process involves the identification of candidates, synthesis, characterization, validation, optimization, screening, and assays for therapeutic efficacy. Once a compound has shown its significance in these investigations, it will initiate the drug development process earlier ...
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IN-VITRO AND IN-VIVO NEUTRALIZING POTENTIAL OF RAUVOLFIA SERPENTINA ROOT EXTRACT AGAINST BUNGARUS CAERULEUS VENOM
Snakebite is an international health hazard that needs attention in terms of effective management and better treatment to recover the health of the affected individuals and society. Tribal populations and folk therapists across the world have been using innumerable plants to treat snakebite difficulties. In the present study, the efficacy of aqueous extracts of Rauvolfia serpentina root for neutra...
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QBD APPROACH TO DEVELOP RP-HPLC METHOD FOR CAPECITABINE IN BULK AND DOSAGE FORM
A simple, specific, accurate, reliable, and precise reverse-phase high-performance liquid chromatographic method was developed by quality by design approach and validated for the estimation of Capecitabine in bulk and tablet dosage forms. A surface methodology was used to optimize the data with a three-level Box Behnken Design (BBD) was used. Mobile phase composition, flow rate, and column oven te...
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NANOGEL BASED TOPICAL DRUG DELIVERY: SAGA OF PROGRESSIVE PHARMACOTHERAPEUTIC JOURNEY AND RECENT APPLICATION PERSPECTIVES
Systems made of nanogel have been researched from a theoretical and practical standpoint. They are frequently utilized for coatings, cosmetics goods, targeted delivery systems, controlled delivery systems, and controlled delivery systems. Using the approach of making nanogels from polymer precursors, the gels are produced. The manufactured nanogels are acceptable to consumers since they are stable...
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MICHELIA CHAMPACA LEAF EXTRACTS EXHIBIT HYPOGLYCEMIC EFFECT AND HYPOLIPIDEMIC ACTIVITY IN STREPTOZOTOCIN-NICOTINAMIDE-INDUCED DIABETIC RATS
A metabolic disease called diabetes mellitus in which blood glucose levels are abnormally high. It could be due to tissue glucose intolerance and impaired insulin production. In a Type II diabetes model generated by Streptozotocin and nicotinamide, the antidiabetic potential of ethanolic and aqueous leaf extracts of Michelia champaca (Magnoliaceae) was compared to a control group of diabetes. Th...
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