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EFFECT OF HORMONAL CONTRACEPTIVES ON INFLAMMATORY BLOOD BIOMARKER C-REACTIVE PROTEIN
To compare the effect of combined oral contraceptive (COC) and progesterone-only injectable contraceptive (PIC) on the inflammation, we recruited 47 female participants (16 to 43 years old) in 3 groups: control participants (n=10), COC users (n=16) and PIC users (n=21). Using ELISA and Latex agglutination methods, we measured the effect of hormonal contraceptives on the inflammatory blood biomarke...
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CAPSAICIN AS A PROMISING TREATMENT FOR NASO-RESPIRATORY DISEASES: A COMPREHENSIVE REVIEW
Background: Capsaicin, a bioactive compound derived from the dried fruit of the Solanaceae family, is widely recognized for its therapeutic potential. Its mechanism of action involves interaction with TRPV1 receptors, leading to analgesic effects and modulation of neurogenic inflammation. Objective: This review explores the therapeutic applications of capsaicin, particularly its role in treating n...
1829
1812
IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY EVALUATION OF SUCCESSIVE EXTRACTS OF ZIZIPHUS NUMMULARIA
Ziziphus nummularia is commonly found plant in dry regions of South Asia such as India, Pakistan. Z. nummularia contains numerous phytochemicals such as flavonouds, alkaloids that are responsible for numerous biological activities. In current study, elaborative pharmacognostic studies on the leaves of Z. nummularia were done for standardization purposes for future studies. The study includes morph...
1828
824
IN-SILICO ASSESSMENT VIA MOLECULAR DOCKING AND ADMET PROFILE OF BOTANICAL DRUGS (BERGAMOTTIN AND CASTICIN) AGAINST TRIAL DRUGS FOR LASSA VIRUS
Lassa fever is a serious viral haemorrhagic illness caused by Lassa virus, a family of Arenaviridae. This haemorrhagic fever has become rampant in West Africa especially in Sierra Leone, the Republic of Guinea, Liberia and Nigeria, through exposure to food or household items contaminated with urine or faeces of infected Mastomys rats. There has been no vaccines or particular antiviral agents/drugs...
1827
920
ANTI-STAPHYLOCOCCUS AUREUS ACTIVITY, ADMET PROPERTIES AND MOLECULAR DOCKING STUDY OF PHYTOCOMPOUNDS FROM ERIANTHEMUM DREGEI
The constant increase in the emergence of multidrug resistance among Staphylococcus aureus strains threatens public health. The study aimed at evaluating the anti-S. aureus activity, pharmacokinetic properties and interactions of compounds from Erianthemum dregei with proteins in S. aureus. Anti-S. aureus activity was investigated by broth dilution method while gas chromatography-mass spectrometry...
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REVOLUTIONIZING PRODUCTION: THE ASTONISHING POWER OF PELLETS AND PELLETIZING TECHNOLOGY AND THEIR APPLICATION
In today's dynamic industrial landscape, the transformative potential of pellets and pelletizing technology stands as a beacon of innovation. Pellets, compacted forms of raw materials, have emerged as versatile solutions across diverse sectors, from agriculture to pharmaceuticals, offering enhanced efficiency and sustainability. The advent of advanced pelletizing technologies has further elevated ...
1824
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SCHIFF BASE AND ITS METAL COMPLEXES
The biological effects of transition metal complexes that include a wide range of ligands are distinguishable from one another. In an effort to produce a novel metal (II) complexes the conventional reflux method has been used to the interaction of two ligands, N-(2H-benzo[d] [1,2,3] triazol-2-yl)-1-(4-nitrophenyl) ethanimine as L1 and an amino acid Alanine as L2 with freshly produced Zinc, Nickel,...
1824
1249
A NEW ASSAY METHOD DEVELOPMENT AND VALIDATION OF TWO ANTI-CANCER DRUGS BY USING EFFECTIVE LIQUID CHROMATOGRAPHIC METHOD
A simple, sensitive and rapid chromatographic method was developed and validated for quantification of Mitomycin and Fluorouracil in bulk and pharmaceutical dosage form using Symmetry C18 (4.6 × 150 mm, 3.5 µ) column. The mobile phase consists of buffer, 0.1% Ortho Phosphoric acid (OPA), and acetonitrile in the ratio of 50:50 v/v. The flow rate is maintained as at 1.0 ml/min; detection was carri...
1823
822
A STUDY ON THE NOSE TO BRAIN DRUG DELIVERY SYSTEM
Drugs have been controlled by the nasal route for remedial & therapeutic use since ancient times. Enthusiasm & importance for the basic impacts of drugs directed via the nasal route has developed to last decades. Intra-nasal drug organization provides an attractive substitute for achieving the important beneficial impacts of drugs virtually similar to the parenteral route, that may be impr...
1823
1028
QUANTIFICATION OF SPIRONOLACTONE AND ITS IMPURITIES PRESENT IN PHARMACEUTICAL DOSAGE FORMS BY STABILITY-INDICATING HPLC METHOD
Spironolactone belongs to a group of medicine known as aldosterone antagonist used as sparing diuretic, Spironolactone (aldactone) is potassium -aspiring diuretic agent and has half-life of about 16 hours. Spironolactone one diuretics agents which increases renal excretion of water and solutes (mainly sodium salt). It is used mainly in the treatment of refractory edema in patients with congestive ...
1822
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