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QUANTIFICATION OF URSOLIC ACID AND MINERALS FROM HEDYOTIS HERBACEA LINN.
The whole plant of Hedyotis herbacea Linn. which was claimed to have wound healing activity, was evaluated for phytoconstituent ursolic acid determination. The literature review suggests that ursolic acid was scientifically validated for wound healing activity. So the research work aims to screen the various extract of H. herbacea to determine the ursolic rich fraction. So a high-performance thin-...
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THERAPEUTIC CARRIERS FOR THE VAGINAL DELIVERY OF ANTI-HIV DRUG
HIV is a pandemic disease that is rapidly spreading across the world. The current review's objective is to present how comprehensive various advanced anti-HIV drug delivery systems are. The use of a new drug delivery system helps in overcoming the challenges of dosage form growth, such as drug instability, insolubility, and restricted entrapment. Several delivery routes for ARV therapy have been i...
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EFFECT OF HORMONAL CONTRACEPTIVES ON INFLAMMATORY BLOOD BIOMARKER C-REACTIVE PROTEIN
To compare the effect of combined oral contraceptive (COC) and progesterone-only injectable contraceptive (PIC) on the inflammation, we recruited 47 female participants (16 to 43 years old) in 3 groups: control participants (n=10), COC users (n=16) and PIC users (n=21). Using ELISA and Latex agglutination methods, we measured the effect of hormonal contraceptives on the inflammatory blood biomarke...
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THE ICH GUIDELINES IN PRACTICE: FORCED DEGRADATION STUDIES OF DORIPENEM BY AN LC-MS COMPATIBLE RP-HPLC METHOD
In this manuscript, a fast, stability-indicating RP-HPLC method with UV detection was developed and validated to quantify doripenem in the bulk drug and its injectable formulation. The analysis was performed using Phenomenex (250 x 4.6mm, 5µm) ODS column with a flow rate of 1 mL min–1 and a SPD 20 A UV detector to monitor the eluate at 316 nm. The mobile phase was acetonitrile and 10 mM ammoniu...
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NEUROPROTECTIVE POTENTIAL OF ETHANOLIC ASHWAGANDHA ROOT EXTRACT, DOXYCYCLINE AND ELLAGIC ACID AGAINST ROTENONE INDUCED PARKINSON’S DISEASE: A IN-VIVO MODEL STUDY
Parkinson's disease (PD) is the second most prevalent type of neurodegenerative disorder and is a chronic, progressive condition. In the current investigation, we used a rotenone (ROT)-developing rat model of PD to assess the neuroprotective efficacy of ethanolic Withania somnifera root extract (EWSR) in comparison to the known neuroprotectants i.e., Doxycycline (Doxy), and ellagic acid (EA) indiv...
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FORMULATION AND EVALUATION OF ORAL ANTI-DIABETIC IN-SITU GEL SYSTEM OF PIOGLITAZONE
Pioglitazone is an oral anti-diabetic agent used in treating class – II diabetes mellitus. T1/2of pioglitazone was 3-6 hrs and is eliminated rapidly. Hence sustained release is needed to prolong its duration of action and to increase its oral bioavailability. The study's main aim was formulation and evaluation of an in-situ gel system of pioglitazone to increase its bioavailability as a convenie...
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FORMULATION AND EVALUATION OF BUTENAFINE HYDROCHLORIDE LOADED CUBOSOMAL GEL
The aim of this research was to develop and evaluate a cubosomal gel for the treatment of skin diseases such as athlete's foot (tineapedis), ringworm (tineacruris) and ringworm (tineacorporis). To increase the penetration of the drug and to provide longer duration of treatment this study was performed. Cubosomes are a novel nanoparticle system loaded with butenafine hydrochloride as an antifungal ...
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DIGITAL SCREEN USE AND DRY EYE DISEASE: THE ROLE OF MUCINS, DIETARY NUTRIENTS AND PHYTOCHEMICAL CONSTITUENTS IN DRY EYE DISEASE RELIEF
Dry eye disease (DED) is one of the most common conditions in today’s digitalized society. DED is associated with decreased tear production, an unstable tear film, and ocular inflammation. Due to the COVID-19 pandemic, the use of digital screens (computers, laptops or smartphones) for work, study or entertainment has increased. As a result, the constant use of digital screens affects the eyes an...
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NANOCRYSTALS FOR IMPROVED DRUG DELIVERY: A REVIEW
Nanocrystals are crystalline particles having particle size range of 100 to 1000 nm. However, these nano-sized systems are thermodynamically unstable, stabilizers are required to incorporate them. The poorly soluble drugs lead to problems like poor absorption and therapeutic failure. One such method to overcome these solubility problems is the development of nanocrystals. These systems reduce part...
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ANTI-PROLIFERATIVE AND APOPTOSIS INDUCING EFFECT OF NARAVELIA ZEYLANICA L. AGAINST LUNG CANCER CELL LINE A549
Cancer is one of the most dangerous diseases globally, and it appears due to extreme free radical damage, some chemicals, and a lack of physical activity which dispute causes damage to the cellular DNA, protein, and lipids. A number of treatment methods are available, but they cause unwanted side effects. The use of plant-derived products in the treatment of cancer prominently reduces adverse and ...
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