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RP-HPLC BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF METFORMIN AND LEVOTHYROXINE IN HUMAN PLASMA- DRUG INTERACTION STUDIES
A simple, sensitive, robust and specific high performance liquid chromatographic (HPLC) method was developed and validated for the simultaneous determination metformin and levothyroxine in human plasma. In the current study, the analysis was performed on Phenomenex Luna 5µ C18 100A (250 x 4.6mm, 5 micron) column using acetonitrile: methanol: 0.03M phosphate buffer (pH 2- 3.5) 50:10:40 v/v/v as mo...
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STUDIES ON SOLID DISPERSION OF CURCUMIN USING HYDROPHILIC POLYMER WITH SYLOID XDP AND LOZENGE CHARACTERIZATION
Curcumin, an active phytochemical compound of the rhizome Curcuma longa, shows several pharmacological activities. Curcumin shows high permeability and low dissolution rate, and its incomplete absorption leads to very poor oral bioavailability. The present study aimed to enhance curcumin's solubility and dissolution rate by forming internal ternary solid dispersion using hydrophilic polymer PVP K3...
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THERAPEUTIC CARRIERS FOR THE VAGINAL DELIVERY OF ANTI-HIV DRUG
HIV is a pandemic disease that is rapidly spreading across the world. The current review's objective is to present how comprehensive various advanced anti-HIV drug delivery systems are. The use of a new drug delivery system helps in overcoming the challenges of dosage form growth, such as drug instability, insolubility, and restricted entrapment. Several delivery routes for ARV therapy have been i...
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PRECLINICAL STUDY ON URINARY TRACT INFECTED EXPERIMENTAL RATS TREATED SPHAERANTHUS INDICUS L.
A model of ascending Urinary tract infection (UTI) in rats was developed to study the significance of antibacterial activity of Sphaeranthus indicus L. and compared with standard antibiotic ofloxacin as a positive control. This plant used in folk medicine as a remedy for urinary tract infections is belong to Asteraceae family. Outbred female wistar rats were used throughout the study and Escherich...
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IN-VIVO EVALUATION OF GLICLAZIDE SOLID DISPERSIONS INCORPORATED TABLETS FOR CONTROLLED DRUG RELEASE
Gliclazide is an anti-diabetic medication used to treat diabetes mellitus type 2.It suffers from deprived solubility, reduced drug dissolution, and bioavailability. The current paper is aimed to formulate and evaluate gliclazide solid dispersion with HP β Cyclodextrin for enhanced solubility and incorporate into controlled-release tablet formulation. Gliclazide solid dispersion (SD) was prepared ...
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QUERCETIN LOADED POLY VINYL ALCOHOL- ALGINATE HYDROGEL ATTENUVATES INFLAMMATION
The flavonoid compound quercetin is widely acknowledged for its diverse biological properties including anti-inflammatory, antioxidant, anti-bacterial, anti-ageing, anticancer however the constraints like poor solubility, low bioavailability, lack of stability and decreased permeability limits its pharmacological applications. Hydrogel assisted delivery systems especially for transdermal delivery ...
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ADDITIVE MANUFACTURING: EXPLORING THE IMPACT OF 3D PRINTING ON SOCIETY AND INDUSTRY
3D printing (a.k.a. fast prototyping or advanced manufacturing process) is estimated to be a highly innovative technology within the healthcare devices industry and pharmaceutical industry. With the use of digitally controlled material deposition straight from a computer-aided design, 3D printing technology can create 3D pharmaceutical items layer by layer. It facilitates the making of dosage form...
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PREPARATION AND CHARACTERIZATION OF Fe3O4@SiO2@L-VALINE NANOPARTICLES AS AN EFFECTIVE AND NOVEL NANOCATALYST FOR THE SYNTHESIS OF PERIMIDINE DERIVATIVE UNDER MILD CONDITIONS
We presented an eco-friendly procedure for effective and fast preparation of biologically active substituted pyrimidine ligand through a condensation reaction of 1,8-diaminonaphthalene and 2-methoxy-benzaldehyde with Fe3O4@SiO2@L-valine magnetic nanoparticles (MNPs) as a new recyclable catalyst. In this experiment, we aim to increase reaction efficiency for the synthesis of 2-(2-methoxyphenyl)-2,3...
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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF METFORMIN AND SAXAGLIPTIN
The present study aims to develop a verse phase HPLC method for the simultaneous estimation of Metformin and Saxagliptin. In bulk and pharmaceutical dosage form and to validate the proposed method in accordance with ICH guidelines for the intended analytical application. Multiple trials were run to Metformin and Saxagliptin, get eluted with good peak symmetric properties. Mobile phase Phosphate bu...
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EFFECT OF SELENIUM-ENRICHED AZOLLA ON BIOCHEMICAL AND GROWTH PERFORMANCE PARAMETERS IN JAPANESE QUAILS (COTURNIX COTURNIX JAPONICA) BROILERS
Azolla is a fern plant through conducting 27 % of protein content and involves actively in bioremediation. So, this property of this plant is exploited in the production of chelated minerals. In this study, selenium-enriched azolla is evaluated with Japanese quails on the performance of growth and serological parameters. The present study is designed with 525 quails divided into 7 treatments, each...
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