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STABILITY INDICATING ANALYTICAL METHOD VALIDATION FOR SIMULTANEOUS ESTIMATION OF FENTICONAZOLE NITRATE, TINIDAZOLE AND LIDOCAINE BY REVERSED PHASE-HPLC
The current study aims to develop a reversed-phase HPLC method for quantifying the active substances of Fenticonazole Nitrate (FENTI), Tinidazole (TINI) and Lidocaine base (LIDO) simultaneously and to validate the proposed method for the intended analytical application in the bulk and pharmaceutical dosage form by ICH guidelines. In this work, the behaviour of f FENTI, TINI and LIDO was studied un...
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COMPARING THE EFFICACY AND PHARMACOECONOMICS OF ATORVASTATIN AND ROSUVASTATIN
The aim of the research work was to determine and compare the efficacy and pharmacoeconomics of Atorvastatin and Rosuvastatin. The cohort, observational, and prospective studies were conducted at KMC multispeciality hospital, Trichy. The hyperlipidemic patient was treated with Atorvastain (10 mg) and Rosuvastatin (5 mg) every day over a period of six months. Contemplating the inclusion and exclusi...
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DESIGN IN-SILICO MULTIPATHOGENIC VACCINE OF DENGUE AND ZIKA VIRUSES USING ENVELOPE PROTEIN
The Flaviviridae family of viruses includes the dengue virus (DENV) and the Zika virus (ZIKV). Which have already caused outbreaks and epidemics in a number of countries in the entire world. Dengue fever and Zika fever are two and among the most widely disseminated mosquito-borne viral illnesses in the world both of these diseases have the potential to erupt in many places of the world at the same...
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FORMULATION OF HERBAL GEL FOR POTENTIAL ANTIBACTERIAL ACTIVITY AGAINST PSEUDOMONAS AERUGENOSA
The present work deals with the formulation of containing aqueous extract of Tectona grandis (Teak) Leaves and prepared formulation against some Gram-positive and Gram-negative bacteria. The antibacterial activity of various T. grandis leaves extracts was measured by determining minimum inhibitory concentration (MIC) by cube dilution method and zone of inhibition by disc diffusion method agains...
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL5, 6-DIHYDRO-3-(SUBSTITUTED PHENYL) [1, 2, 4] TRIAZOLE (3, 4-B) [1, 3, 4] THIADIAZINE-7-ONE DERIVATIVES FOR ANTIMICROBIAL AND FREE RADICAL SCAVENGING ACTIVITY
The present research aims to synthesize novel 5, 6-dihydro-3-(substituted phenyl) [1, 2, 4] triazolo (3, 4-b) [1, 3, 4] thiadiazine-7-one derivatives and their physiochemical evaluation for antibacterial and antioxidant activities. Novel synthetic schemes were designed to synthesize compounds (1-6), which were then characterized using physicochemical and spectroscopic methods (IR, 1HNMR). In-vitro...
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STANDARDIZATION OF AMUKKARA CHOORANUM- SIDDHA DRUG
Siddha medicine originated from Tamil culture in southern India. Worldwide there are 75% of herbal plants are used for AYUSH and Allopathy medicines. Amukkara Choornam is a polyherbal Siddha formulation. Amukkara Choornam has anti-arthritic activity, and it helps to cure rheumatoid arthritis. The demand for Siddha medicines in India is increasing daily; we have to overcome some problems like quali...
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ANTI-DIABETIC ACTIVITY OF THE METHANOLIC EXTRACT OF SEEDS OF SYZYGIUM CUMINI IN STZ-INDUCED TYPE I DIABETES IN RATS
Background: Syzygium cumini (SC) usually acknowledged as Jamun. All components of the Jamun may keep used medicinally because of a wide range of diseases like cough, diabetes, dysentery and inflammation. Objectives: Present investigational on the anti-diabetic activity of the methanolic extract seeds of SC in STZ-induced Type I Diabetes in rats. Methods: Extracted SC was to be evaluated the toxici...
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ASSESSING THE ANTIOXIDANT ACTIVITIES OF METHANOLIC EXTRACT OF SARACA ASOCA LEAVES AND BARK
Chronic diseases such as cardiovascular, cancer, and respiratory diseases are being increased. Reactive oxygen species, free radicals, and oxidative stress play a major role in aggravating these diseases. Plants and plant-derived compounds have shown a greater potential in combating the detrimental effects of free radicals and other toxic agents. The current research work has been done on the leaf...
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EFFECT OF SELENIUM-ENRICHED AZOLLA ON BIOCHEMICAL AND GROWTH PERFORMANCE PARAMETERS IN JAPANESE QUAILS (COTURNIX COTURNIX JAPONICA) BROILERS
Azolla is a fern plant through conducting 27 % of protein content and involves actively in bioremediation. So, this property of this plant is exploited in the production of chelated minerals. In this study, selenium-enriched azolla is evaluated with Japanese quails on the performance of growth and serological parameters. The present study is designed with 525 quails divided into 7 treatments, each...
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PHARMACEUTICAL PROCESSING AND ANALYTICAL CHARACTERIZATION OF METAL-BASED AYURVEDIC DRUG “TAMRA BHASMA”
The preparation of metal-based Indian traditional drugs involves the conversion of pure metal into its therapeutically effective form. “Tamra Bhasma” (calcined copper) is one such herbometallic preparation used for various medical conditions like anaemia, obesity, and skin disease, disorders of the liver and spleen, hyper-acidity, rhinitis, hemorrhoids. A detailed evaluation of the changes occ...
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