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BIO ANALYTICAL VALIDATED TECHNIQUE FOR THE SIMULTANEOUS ESTIMATION OF AMLODIPINE, ROSUVASTATIN AND VALSARTANIN HUMAN PLASMA BY RP-HPLC METHOD
A reverse phase high-performance liquid chromatographic bio analytical Technique (RP-HPLC) was developed and validated as per ICH 2019, US FDA 2018 guidelines for the quantification of amlodipine besylate, Rosuvastatin and Valsartan in human plasma using RP - C18 column. The mobile phase in composition (acetonitrile: water in the ratio 75:25% v/v, pH adjusted to 4.0 with acetic acid) was pumped an...
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DEVELOPMENT OF NATEGLINIDE MODIFIED RELEASE DOSAGE FORM USING ELEMENTARY OSMOTIC PUMP (EOP) AND PUSH-PULL OSMOTIC PUMP (PPOP) METHODS
Objective: The aim of the study was to develop osmotic tablets of nateglinide by two methods, namely elementary osmotic pump (EOP) and push-pull osmotic pump (PPOP) method for controlled drug release. Methods: Initially, pre-compression parameters were studies for the tablet blend in both EOP and PPOP methods. The tablets were prepared by the wet granulation method in both methods. The prepared t...
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ANTI-STAPHYLOCOCCUS AUREUS ACTIVITY, ADMET PROPERTIES AND MOLECULAR DOCKING STUDY OF PHYTOCOMPOUNDS FROM ERIANTHEMUM DREGEI
The constant increase in the emergence of multidrug resistance among Staphylococcus aureus strains threatens public health. The study aimed at evaluating the anti-S. aureus activity, pharmacokinetic properties and interactions of compounds from Erianthemum dregei with proteins in S. aureus. Anti-S. aureus activity was investigated by broth dilution method while gas chromatography-mass spectrometry...
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USING IMMUNOINFORMATIC APPROACH DESIGN EPITOPE-BASED VACCINE FOR CHIKUNGUNYA VIRUS
Chikungunya is a mosquito-borne infection of the genus alphavirus. It is vaccines, medications, and other treatments difficult to produce. The CHIK-Virus is carried thru the mosquito, which functions as a vector for the disease. Vaccines, therefore, provide alternate preventative techniques for the spread of viral infection. Structural proteins of CHIK-Virus with T and B cells had been used for im...
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SIMULTANEOUS DETERMINATION OF FLAVONOIDS IN POLYHERBAL FORMULATION BY A VALIDATED HPTLC METHOD
A rapid, sensitive, selective and robust quantitative densitometric high-performance thin-layer chromatographic method is developed and validated for separation and quantification of flavonoids namely rutin, quercetin, kaempferol and myricetin in herbal formulations. The separation is performed on silica gel 60F254 high-performance thin-layer chromatography plates using phase cyclohexane: ethyl ac...
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FORMULATION AND EVALUATION OF TOPICAL POLYHERBAL GEL CONTAINING COCCULUS HIRSUTUS AND TRIDAX PROCUMBENS
Topical medications are frequently used to treat skin conditions. Antibiotic-resistant bacteria have emerged. As a result, the man has looked to nature for healing. Traditional medicines work better because they are less likely to cause side effects and are more effective. The Cocculu shirsutus and Tridax procumbens leaves were authenticated, dried, and extracted. Phytochemical screening and physi...
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EVALUATION OF HEPATOPROTECTIVE POTENTIAL OF ALSTONIA SCHOLARIS STEM BARK AGAINST CCL4 INDUCED HEPATOTOXICITY – AN IN-VIVO SCREENING
The hepatoprotective potential of ethanolic extract of stem bark of Alstonia scholaris belonging to the family Apocynaceae and commonly known as Devil’s tree or Saptaparni was assessed against carbon tetrachloride-induced hepatotoxicity in Wistar rats. It is an evergreen tropical tree native to the Indian sub-continent and Southeast Asia and contains various phytoconstituents like alkaloids, tri...
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ANTI-HYPERGLYCAEMIC EFFECTS OF AQUEOUS PREPARATION OF MEYNA SPINOSA ROXB. FRUIT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
The unripe fruit of Meyna spinosa / Laxiflora is used for the treatment of diabetes by traditional healers. The effect of the aqueous extract of the fruit is investigated on the normal and elevated blood glucose level of the experimental animal rats. The blood glucose level of the rats is elevated with the administration of I.P streptozotocin. The estimation of the blood glucose level is done by u...
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A RETROSPECTIVE AUDIT OF DRUG PRESCRIBING PATTERNS AMONG THE PATIENTS VISITED THE DENTAL CLINIC OF A PRIVATE MEDICAL UNIVERSITY IN KEDAH, MALAYSIA
Introduction: Irrational use of drugs is widespread in present-day medical practice. Hence, the present study aimed to analyze the drug prescribing pattern among the patients who visited the Faculty of Dentistry dental clinic, AIMST University. Methods: A retrospective, cross-sectional study was conducted to analyze the drug prescribing pattern of dentists of AIMST University, Kedah, Malaysia. A t...
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DEVELOPMENT AND EVALUATION OF TEA TREE OIL INFUSED ANTIFUNGAL NAIL LACQUER: A PROMISING ALTERNATIVE FOR TREATING ONYCHOMYCOSIS
Onychomycosis is a fungal infection of fingernails and toenails which accounts for majority of all nail disorders caused by Dermatophytes, Candida and Nondermatophytic Molds. Numerous Antifungal formulations are available in the market in the form of cream, ointment, lotion, powder, and solutions which require high concentration of active agents to be incorporated and have short residence time on ...
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