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COMMON INDIAN MEDICINAL PLANTS AS EMERGING WOUND HEALING AGENTS: DEEP INSIGHTS INTO APPLICATIONS AND MECHANISMS
Any bodily harm, such as damage to the skin's epidermis and disruption of its normal architecture and function, is referred to as a wound. The significance of wound healing has been known since ancient times. Several attempts have been made to design innovative wound dressings composed of the finest materials for speedy and successful wound healing. Medicinal herbs greatly aid the wound healing pr...
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STUDY ON MOLECULAR DOCKING OF ‘NUCLEOCAPSID (N) PROTEIN OF SARS-COV-2’ AND ‘MCF-7’
The process of eliminating viral infection and massive control from spreading furthermore by any variants may lead to a pandemic in the near future. On the other aspect, the impact of eradicating by the initial stage to prevent, treat carcinoma to decline the affected and death rate to maximum amount by Molecular Docking. The quickest and easiest method to search out the potential drugs is by anal...
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OVERVIEW OF SOLID LIPID NANOPARTICLES FOR IMPROVED ANTI-CANCER DRUG DELIVERY
Nanoparticles with lipids as a constituent are called "solid lipid nanoparticles" (SLNs). Based on the most recent trends, SLNS is a promising approach for overcoming multiple barriers in drug delivery. Through SLNs, maximized drug payload to the site of action for different pharmaceutical drugs can be achieved. They range in size from 10nm to 1000nm and possess a solid lipid core matrix that aid...
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QUALITATIVE ANALYSIS OF PHYTOCHEMICAL CONSTITUENTS OF CERTAIN ETHNOMEDICINAL PLANTS IN BHADRAVATHI TALUK OF SHIVAMOGGA DISTRICT, KARNATAKA
Medicinal plants are an abundant source of bioactive compounds, which have been used for thousands of years against different diseases because plants have antibacterial, anti-inflammatory, and antifungal activities. All of the medicinal plants that may be found on earth today have specific therapeutic use and importance. Our research work is based on the qualitative phytochemical studies of extrac...
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DEPRESSION: UNDERSTANDING THE PATHOPHYSIOLOGY AND TREATMENT MODALITIES
Depression is accepted as a condition of misery and is treated as a disorder that includes mental and emotional disorders. Depression is a deadly disease that affects about 5% of the general population. In addition, depression is a heavy burden on patients and families. Furthermore, many epidemiological studies have shown that the occurrence of depressive disorders in the general population is inc...
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HEPATOPROTECTIVE ACTIVITY OF SINIGRIN AND CARVACROL AGAINST PARACETAMOL INDUCED LIVER INJURY IN WISTAR RATS
Background: Sinigrin (allyl-glucosinolate or 2-propenyl-glucosinolate), an aliphatic glucosinolate, is naturally present in Brassicaceae plants, while carvacrol (2-methyl-5-isopropylphenol) is a monoterpene phenolic component of the essential oil generated by many aromatic plants. This study is aimed to determine the hepatoprotective potential of these phytoconstituents on Paracetamol-induced live...
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IN-SILICO ANTI-ULCERATIVE ACTIVITY EVALUATION OF SOME BIOACTIVE COMPOUNDS FROM CASSIA TORA AND BUTEA MONOSPORA THROUGH MOLECULAR DOCKING APPROACH
Background and Aim: In-silico approach is commonly the method for predicting and confirming drug design. Hence the present study was undertaken to evaluate in-silico the anti-ulcerative activity of some bioactive compounds from Cassia tora and Butea monospora through a molecular docking approach. Method: Docking is performed using 22 runs of the Lamarckian Genetic Algorithm with the grid box sized...
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A REVIEW: “SKIN-RELATED RARE DISEASES: PACHYONYCHIA CONGENITAL”
Keratin is a structural protein from the intermediate filament network, i.e., responsible for maintaining the keratinocyte's structural integrity. Pachyonychia congenita is not a lifetime disease. It is a rare dermatosis disease occurred in the sole’s feet and palm’s hand. In this review, we have discussed the keratinization that occurs in the stratum corneum that follows mutation in the ker...
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EFFECT OF SOLANUM TORVUM SW. METHANOLIC EXTRACT ON IN-VITRO AND IN-VIVO MODELS OF INFLAMMATION
The word inflammation comes from the latin word called “inflmmare” which means “To set on fire”. It is a complex biological process that is mediated by several chemicals and biological mediators like pollens, irritants, pathogens and damaged cells. The body's inflammatory reaction destroys such chemical and biological mediators and gets rid of injured tissues. But in chronic state this inf...
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COMPUTATIONAL ANALYSIS OF PHARMACOKINETICS, BIOACTIVITY AND TOXICITY PROFILING OF SOME SELECTED OVULATION-INDUCTION AGENTS TREATING POLYCYSTIC OVARY SYNDROME (PCOS)
PCOS (Polycystic ovarian syndrome) is a prevalent female endocrine disorder with global occurrence ranging from 6-26%. It accounts for the majority of anovulatory infertility in women of reproductive age due to enlarged ovaries with small cysts formation, which the National Institute of Health has reported as a cause of 30% of infertility cases in females worldwide. Anovulatory infertility is gene...
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