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IN-SILICO DESIGN AND COMPUTATIONAL STUDY OF NOVEL QUINAZOLIN-4-ONE DERIVATIVES AS POTENTIAL AFFINITY WITH EGFR FOR ANTICANCER ACTIVITY
Molecular object precise healing designed for the malignancy be unrelated as of the predictable therapy, as well as radio healing in conditions of selectivity and specificity target to the malignant tyrosine kinase, is well-thought-out additional shows potential molecular intention for invention and expansion of the new cytotoxic drug molecules. Epidermal growth factor receptor is overexpression i...
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ANTIMICROBIAL RESISTANCE ANALYSIS AMONG ESCHERICHIA COLI ISOLATED FROM EXTRAINTESTINAL SITES: A CROSS-SECTIONAL STUDY
Background: Escherichia coli (E. coli) is one of the most common agents of bacterial infections, the emergence of multidrug resistance in E. coli has posed major threat to global health resulting in failure of treatment that leads to increased mortality and cost of healthcare facilities. Material and Methods: For this study, a total of 500 specimens like urine, blood, pus, stool, sputum and differ...
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BIOEQUIVALENCE STUDY OF LUMEFANTRINE RECTAL ENEMA AND THE COMMERCIALLY AVAILABLE GENERIC ORAL SUSPENSION. A PILOT STUDY
Children under five years of age, with severe or cerebral malaria, cannot consume oral medication especially if they are vomiting or are unconscious. In such situations they are given an injectable drug until they can tolerate oral medication. The situation is bad in Sub-Saharan Africa, especially in rural areas as children are sometimes referred to the closest referral health care facility for pr...
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ISOLATION AND CHARACTERISATION OF L-GLUTAMINASE PRODUCING FUNGI FROM MARINE SOURCE
L-glutaminase [EC.3.5.1.2] is an amidohydrolase that catalyzes the hydrolytic deamination of L-glutamine, resulting in the production of L-glutamic acid and ammonia. The L-glutaminase has received a significant attention due to its potential as an anticancer agent. In the present study, soil sediments were collected from the estuaries region of Parangipettai, Cuddallore District, Tamil Nadu. The i...
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HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY OF MORINGA OLEIFERA LEAF POWDER IN ALLOXAN-INDUCED DIABETIC RABBITS
The present study was carried out to investigate the hypoglycemic and hypolipidemic effect of Moringa oleifera leaf powder (MO) in alloxan-induced diabetic rabbits by administering oral doses (100, 200, and 400 mg/kg body weight). Diabetes was induced intravenously into rabbits with a single dose of alloxan (150 mg/kg). Diabetic rabbits were treated with MO (100, 200, and 400 mg/kg) and Glibenclam...
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VITAMIN C, THIAMINE AND HYDROCORTISONE IN SEPTIC SHOCK: A RETROSPECTIVE ANALYSIS
Background: Sepsis leads to approximately 11 million deaths annually. Objectives: We studied the effectiveness of using a combination of intravenous hydrocortisone (50mg QID), Ascorbic Acid (1.5g QID), and Thiamine (200mg BD) (HAT) to reduce mortality among septic patients compared to a historical control group. Materials and Methods: This retrospective, observational study was conducted between J...
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NATURAL ALKALOIDS AS POTENTIAL ANTIMALARIAL DRUGS FROM BAUHINIA PURPUREA LEAVES -AN IN-SILICO APPROACH
Malaria is the most important parasitic disease in humans, with transmission occurring in over 100 countries with a population of three billion people. Protozoan parasites of the genus Plasmodium cause it. These parasites are transmitted from one person to another by the female anopheles mosquito. Medicinal plants possess many phytochemicals of great therapeutic value, and many effectively kill ma...
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VIRTUAL SCREENING OF NEWER POTENTIAL COLONY STIMULATING FACTOR 1 INHIBITORS AS POTENT ANTIEPILEPTIC AGENTS
Background: Epilepsy is a chronic disorder that causes unprovoked, recurrent seizures like a sudden rush of electrical activity in the brain. Neuronal hyperexcitability in epilepsy is due to an imbalance between glutamate-mediated excitation and GABA-mediated inhibition. Aim: This prompted us to design newer CSF1R inhibitors as efficient therapeutic drugs for the treatment of epilepsy. Materials a...
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BIO ANALYTICAL VALIDATED TECHNIQUE FOR THE SIMULTANEOUS ESTIMATION OF AMLODIPINE, ROSUVASTATIN AND VALSARTANIN HUMAN PLASMA BY RP-HPLC METHOD
A reverse phase high-performance liquid chromatographic bio analytical Technique (RP-HPLC) was developed and validated as per ICH 2019, US FDA 2018 guidelines for the quantification of amlodipine besylate, Rosuvastatin and Valsartan in human plasma using RP - C18 column. The mobile phase in composition (acetonitrile: water in the ratio 75:25% v/v, pH adjusted to 4.0 with acetic acid) was pumped an...
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PERIPHERAL NEUROPATHY-THE LEADING CAUSE FOR GENERAL WEAKNESS
Peripheral neuropathy refers to many conditions that involve damage to the peripheral nervous system. In this article, we would like to discuss various aetiological factors and their manifestations, pathophysiology, diagnosis and treatment strategies of peripheral neuropathy. Generally, peripheral neuropathy is caused by many underlying disease conditions such as Diabetes mellitus, Shingles (posth...
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