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ONGOING ADVANCEMENT IN THE COMPREHENSION OF MITOCHONDRIAL PRO-GRESSION WITH AN EXCEPTIONAL SPOTLIGHT ON ITS RELATIONSHIP WITH CANCER AND POSSIBLE THERAPEUTIC STRATEGY
Cancer is one of the main reasons of death around the world and the quantity of new incidents keeps on rising. Despite ongoing advances in conclusion and remedial systems, many malignancy-related passes happen, demonstrating the requirement for better treatments and symptomatic methodologies. Mitochondrial morphology is dependent on continuous fusion and fission strategies that are essential for m...
1968
1121
IN-VITRO DRUG RELEASE KINETICS FROM CONTROLLED-RELEASE GLIPIZIDE MATRIX TABLETS AND THE INFLUENCE OF TWO DIFFERENT DILUENTS ON DRUG RELEASE PATTERNS
The objective of the study was to formulate and evaluate controlled release glipizide matrix tablets for the release rate, release patterns, and the mechanism involved in the release process of the drug. Formulations with hydrophobic and hydrophilic polymer in several drug-to-polymer ratios and using water-soluble and water-insoluble diluents were compressed into tablets using the direct compressi...
1968
816
ISOLATION, SCREENING AND IDENTIFICATION OF PECTINASE-PRODUCING BACTERIAL STRAIN BACILLUS CEREUS FROM MARINE SEDIMENT SAMPLES
Marine environment is an enormous pool of biodiversity resources that cover approximately 70% surface of the earth. Marine microorganisms have unique properties since they have to adapt to extreme marine environmental conditions in deep-sea water. The present study aims to isolate, screen and identify bacterial strains from marine sediment samples that produce an enzyme pectinase with clinical and...
1968
1150
RECENT REVIEW ON HERBAL APPROACHES TO REGULATE CANDIDA INFECTIONS
Herbal plants have long been known to have antifungal properties. The medicinal plants are prospective in aquaculture as an alternative to antibiotics and other anti-candida drugs. This article aims to review the reported herbal medicines with their research findings that have an enormous future prospective for the effective treatment of Candida infections. Various species of Candida were classifi...
1967
1078
DRUG-INDUCED URTICARIA: IMPLICATED DRUGS, REACTION RECOVERY TIME AND CAUSALITY ASSESSMENT -A FIVE-YEAR RETROSPECTIVE STUDY
Introduction: Cutaneous Adverse drug reactions presenting as urticaria are the most frequent local and systemic adverse reactions (ADR). Urticaria is a skin disorder resulting from the vascular reaction of the skin characterized by erythema and wheal formation due to a localized increase of vascular permeability. It affects up to 20 % of the population at some point during their life and can be ac...
1967
943
SYNTHESIS OF SILVER NANOPARTICLES USING LEAVES AND STEM BARK OF PTEROCARPUS INDICUS AND ITS ACTIVITY ON HUMAN BREAST CANCER CELL LINE (MCF-7)
In the present study, synthesis of silver nanoparticles (AgNPs) using leaves and stem bark of Pterocarpus indicus were tested against human breast cancer cell line (MCF-7) separately. The synthesized AgNPs were characterized using UV-visible spectroscopy, X-ray powder diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), Scanning Electron Microscope (SEM) and zeta potential. The synth...
1966
1314
DEVELOPMENT OF NANOGEL OF OFLOXACIN FOR OCULAR DRUG DELIVERY
Multiple anatomical and physiological obstacles have always made ocular drug administration difficult. Different novel drug delivery systems, including nanogels, nanoparticles, liposomes, dendrimers, implants, contact lenses, nanosuspensions, microneedles, and in situ thermosensitive gels, have been developed to get around the barriers to improve ocular Bioavailability. For the encapsulation of vi...
1965
1001
A REVIEW ON DIABETIC PERIPHERAL NEUROPATHY: PATHOPHYSIOLOGY, DIAGNOSIS AND PHARMACOTHERAPY
Diabetic Peripheral Neuropathy (DPN) is a prevalent and debilitating complication of diabetes mellitus, impacting the global well-being of millions. This review provides a concise overview of the key aspects related to DPN, including its pathophysiology, diagnostic approaches, and current pharmacotherapeutic interventions. The pathophysiology involves intricate mechanisms driven by hyperglycemia-i...
1965
679
STRESS STUDIES OF METFORMIN AND GLICLAZIDE BY HPLC METHOD AND EXTENSION OF METHOD APPLICATION FOR ELUTION OF SOME ANTIVIRAL, ANTI-BACTERIAL AND ANTI-INFLAMMATORY DRUGS
A simple reverse phase SI-HPLC method was developed for the simultaneous estimation of antidiabetic combination of metformin and gliclazide. The method was based on HPLC separation on a reversed-phase C18 column using a mobile phase consisting of phosphate buffer: acetonitrile (40:60, v/v) at a flow rate of 0.8 ml/min. UV determination was achieved at 240 nm. The analytes were subjected to various...
1964
1365
EFFICACY AND SAFETY PROFILE OF DPP-4 INHIBITORS AS ADD-ON THERAPY IN PATIENTS WITH TYPE 2 DIABETES: A COMPREHENSIVE REVIEW
Aim: This study aimed to evaluate the efficacy and safety profile of DPP-4 inhibitors as add-on therapy in patients with type 2 diabetes. The study is important because DPP-4 inhibitors have been widely prescribed, and understanding their comprehensive effects is essential for better patient outcomes. Methods: An extensive literature search has been conducted using multiple databases, such as PubM...
1963
1108