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DEVELOPMENT OF NANOGEL OF OFLOXACIN FOR OCULAR DRUG DELIVERY
Multiple anatomical and physiological obstacles have always made ocular drug administration difficult. Different novel drug delivery systems, including nanogels, nanoparticles, liposomes, dendrimers, implants, contact lenses, nanosuspensions, microneedles, and in situ thermosensitive gels, have been developed to get around the barriers to improve ocular Bioavailability. For the encapsulation of vi...
1917
981
TOTAL PHENOLS, ALKALOIDS, TANNINS AND ANTIOXIDANT ACTIVITY OF WILD PRUNUS ARMENIACA L. SEED COLLECTED FROM GARHWAL REGION OF UTTARAKHAND, INDIA
Plants are the important constituents of folk and traditional medicines and fulfill nutrition and dietary needs from ancient times. The aim of this study to evaluate phytochemicals and antioxidant activity of seed oil of wild apricot (Prunus armeniaca L). Thenon-cultivated seed of wild Prunus armeniaca L. from the Garhwal, Uttarakhand, India was analyzed for its phytochemicals e.g., total phenols,...
1916
1248
PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIUROLITHIATIC ACTIVITY OF PUNICA GRANATUM AQUEOUS LEAF EXTRACT
Pashanabheda is used as antiurolithiatic in Ayurveda. In the present study, Punica granatum is used for screening in-vitro antiurolithiatic potentials. Screening of in-vitro antiurolithiatic potentials of aqueous leaf extract of Punica granatum. The extract was subjected to Preliminary phytochemical analysis. In-vitro anti-urolithiatic activity was screened by nucleation and aggregation assay in w...
1916
1227
CHEMOPREVENTIVE EFFICACY OF ZINGERONE ON MASTOCYTE INFLAMMATION, CELL PRO-LIFERATION AND APOPTOSIS AGAINST DMBA-INCITED MAMMARY CARCINOGENESIS IN FEMALE SPRAGUE-DAWLEY RATS
Zingerone is an active phenolic acid and the least pungent component of Zingiber officinale. It is known to exhibit different pharmacological properties which include anti-inflammatory, antioxidant, anticancer and antimicrobial activities. But, so far there has been no information available on the role of zingerone in experimental breast carcinogenesis. The objective of this experiment is to untwi...
1914
1034
ISOLATION, SCREENING AND IDENTIFICATION OF PECTINASE-PRODUCING BACTERIAL STRAIN BACILLUS CEREUS FROM MARINE SEDIMENT SAMPLES
Marine environment is an enormous pool of biodiversity resources that cover approximately 70% surface of the earth. Marine microorganisms have unique properties since they have to adapt to extreme marine environmental conditions in deep-sea water. The present study aims to isolate, screen and identify bacterial strains from marine sediment samples that produce an enzyme pectinase with clinical and...
1914
1098
A QUALITY BY DESIGN APPROACH: DEVELOPMENT AND EVALUATION OF HERBAL HYDROGEL
The current study was undertaken to formulate and evaluate herbal hydrogel containing ethanolic seed extract of plant Coix lacryma jobi L. Hydrogel was prepared by ethanolic seed extract, carbapol 934p, aloevera gel extract, triethanolamine and methylparaben. The effects of critical parameters (concentration of Carbapol 934p and Aloe vera gel extract) were investigated by executing design of the e...
1914
1224
NEW CO-PROCESSED EXCIPIENTS WITH MICROCRYSTALLINE CELLULOSE AND ISOMALT BY FLUID BED. AN OPTION FOR DIRECT COMPRESSION EXCIPIENTS
Objective: To elaborate and characterize new co-processed excipients for direct compression use. Methods: The new co-processed excipients were obtained with different proportions of microcrystalline cellulose (Avicel® PH101) and Isomalt (galenIQ® 800), using Starch® 1500 and Plasdone® K-25as binding agents in a fluid bed. Rheological characterization was performed; to determine their deformati...
1913
1077
STEM CELL – A HOPE FOR FUTURE HEALTHCARE SECTOR
Stem cell-based therapeutics have considerable potential to treat a variety of illnesses that are now incurable. Because of recent scientific advancements, the area of applied medical research has taken a positive turn, and stem cell-based techniques have moved considerably closer to clinical applications. Since their discovery, stem cells have revolutionized medical research and dramatically alte...
1913
918
RADIOLOGICAL AND GENE-EXPERT PATTERN: IN RELATION WITH TREATMENT OUTCOME OF SENSITIVE AND RESISTANT TUBERCULOSIS
Even if there are so many diagnostic tests available for the detection of tuberculosis, still the diagnosis of TB is a challenging problem in this decade due to differences or non-specificity in symptoms, radiological signs, false negatives, and positives. Chest X-ray can identify the location, area, and morphology of lesions; hence analyzed the pattern and relation of chest X-ray and Gene expert ...
1912
1110
FORMULATION AND EVALUATION OF SATRANIDAZOLE BY SELF EMULSIFYING DRUG DELIVERY SYSTEM
Background: Satranidazole is a class II drug per biopharmaceutical classification systems with poor aqueous solubility and antiprotozoal and anti-bacterial properties. Aim: Therefore, the purpose of the present study was to enhance the solubility of Satranidazole using a self-emulsified drug delivery system (SEDDS). Methods: SEDDS was prepared using Satranidazole (10 mg) and dissolved in the oil p...
1912
963