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A STUDY ON TERNARY MIXTURE OF PEPTIDE USING ULTRASONIC, IN-VITRO AND IN-SILICO PROCESSES
Penetrating biomolecules by ultrasonic techniques is an innovative and influential tool for characterizing their physicochemical properties. Peptides have been used as extensive applications in drug construction and as an ingredient in nutritional complements. An investigation based on the behavior of promulgation of ultrasonic waves in solids and the liquid system is now rather well recognized as...
1946
1114
ANTIAPOPTOTIC MECHANISM FOR THE IMPLEMENTATION OF THE HEPATOPROTECTIVE EFFECT OF PYRIMIDINE DERIVATIVES
The present study aimed to study the effect of the drug Xymedon and its conjugate with L-ascorbic acid exhibiting hepatoprotective activity on the apoptosis of rat liver cells against the background of the influence of hepatotoxic agent tetrachloromethane. Though the general effects of Xymedon and its conjugates with various biogenic acids have been studied, the molecular markers affected by the c...
1946
995
COST EFFECTIVE, ROBUST PRECISE & STABILITY INDICATING ANALYTICAL METHOD VALIDATION OF RELATED SUBSTANCES FOR PIMECROLIMUS CREAM BYRP-HPLC
A new, precise, economical and gradient reverse-phase high-performance liquid chromatography (RP-HPLC) method has been validated for the relative substance determination in pimecrolimus cream. The chromatographic separation was achieved with phenomenax luna, C18, 150 x 4.6mm and 3 µm particle size column. The flow rate was 1.5 mL/min and eluents were detected at 210 nm using PDA detector. The ret...
1946
1496
SEXUAL DIMORPHISM OF FEMUR IN THE POPULATION OF ODISHA: AN ANTHROPOMETRIC OBSERVATIONAL STUDY
Introduction: Femur is the key bone among the skeletal remains to determine sex for anatomists, anthropologists, and forensic experts. In the present study, we considered most of the parameters to determine sex from the femur. Methods: We studied eighty-four undamaged, intact femora of unknown sex. The present study were carried out in S. C. B. Medical College Cuttack from December 2019 to April 2...
1945
1116
QUALITATIVE ANALYSIS OF PHYTOCHEMICAL CONSTITUENTS OF CERTAIN ETHNOMEDICINAL PLANTS IN BHADRAVATHI TALUK OF SHIVAMOGGA DISTRICT, KARNATAKA
Medicinal plants are an abundant source of bioactive compounds, which have been used for thousands of years against different diseases because plants have antibacterial, anti-inflammatory, and antifungal activities. All of the medicinal plants that may be found on earth today have specific therapeutic use and importance. Our research work is based on the qualitative phytochemical studies of extrac...
1945
926
SCALE-UP OF EXTRACTION PROCESS FOR DILL SEED OIL
Concentrated preparations called extracts are made from raw materials by isolating specific components through specific methods. Essential oils, tinctures, liquid extracts, and dry extracts are among the different kinds of extracts. The type of input material, the solvent employed, the temperature, and the extraction time are all important variables. Efficiently isolating and condensing particular...
1945
1355
FERULIC ACID: A NATURAL ESSENTIAL COMPOUND HAVING POTENTIAL INDUSTRIAL AND MEDICINAL PROPERTIES
The ubiquitous compound 4-Hydroxy-3-methoxy cinnamic acid, also known as ferulic acid, constitute. A bioactive ingredient of many food that may offer a potential therapeutic effects useful in the treatment of cancer, diabetes, lung and cardiovascular disease. It is also effective against the disorders relative to oxidative stress, including certain neurodegenerative diseases. Ferulic acid is widel...
1944
1364
FORMULATION AND IN-VITRO EVALUATION OF SOLID LIPID NANOPARTICLES CONTAINING NADOLOL
The solid lipid nanoparticles are sub-micron colloidal carriers (50-100 nm) that are composed of physiological lipid dispersed in water or in aqueous surfactant solution. Nadolol-loaded SLNs were prepared by modified high shear homogenization. It was observed that all formulations contain a good product yield. The highest drug content was found in formulation F5 98.37%. Entrapment efficiency for f...
1943
1093
IDENTIFYING TUBULIN AS A NEW TARGET OF A DIHYDROPYRIDINE DERIVATIVE, AMLODIPINE BESYLATE
The quest for new antimitotic drugs is an ongoing process where microtubules act as an attractive target for anti-cancer drugs. In this work, we report on the anti-cancer activity of Amlodipine besylate (AB), a salt derivative of the dihydropyridine groupdrug Amlodipine, a long-acting third-generation calcium channel blocker. Cytotoxicity assay revealed that AB demonstrated cytotoxic effects again...
1942
893
HIGHLY BIOACTIVE ULTRA SMALL VANCOMYCIN DOPED SILVER NANOPARTICLES GROWN BY SOL-GEL METHOD
Highly bioactive ultra-small vancomycin doped silver nanoparticles were synthesized by the sol-gel method. The samples were characterized by UV, FR-IR, XRD, Photoluminescence, and TEM analysis. Continuous stirring helped in preparing ultra-small drug conjugate silver nanoparticles. Observation of weak (broadened peak) in XRD diffractograms indicates the formation of very small size drug conjugate ...
1941
1049