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HYPERTROPHIC CARDIOMYOPATHY
Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle with preserved or increased ejection fraction. It is commonly asymmetrical, with the most severe hypertrophy involving the basal interventricular septum. The histological features of HCM include myocyte hypertrophy and disarra...
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DEVELOPMENT AND VALIDATION OF UV SPECTROMETRIC METHOD OF ECONAZOLE NITRATE CO-CRYSTAL LOADED IN GEL FORMULATION
A simple, fast, inexpensive, and reliable UV spectrometric method was developed and validated to quantify Econazole Nitrate incorporated in topical gel in the form of co-crystal. This article presents the development and validation of different methods for quantification of Econazole nitrate co-crystal loaded in the topical gel as per ICH [Q2(R1)] guidelines. In method-A, the standard and sample s...
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DEVELOPMENT OF SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM OF DORAVIRINE: SOLUBILITY AND DISSOLUTION RATE IMPROVEMENT
Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI). The aim of the present investigation was to develop a self-nanoemulsifying drug delivery system (SNEDDS) to enhance the solubility and dissolution of poorly water-soluble doravirine. The solubility of doravirinein various oils was determined to identify the oil phase of SNEDDS. Various surfactants and co-surfactants wer...
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FORMULATION AND EVALUATION OF GLIBENCLAMIDE ORAL DISPERSIBLE TABLET BY SOLID DISPERSION TECHNIQUE
Glibenclamide belongs to a group of medicines called sulfonylureas. Glibenclamide is used to manage diabetes. Glibenclamide, also known as glyburide, is an antidiabetic medication used to treat type 2 diabetes. The purpose of the present study was to formulate an Oral dispersible tablet of Glibenclamide using the Solid dispersion technique through using polyethylene glycol ratio as a water-solub...
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STEM CELL – A HOPE FOR FUTURE HEALTHCARE SECTOR
Stem cell-based therapeutics have considerable potential to treat a variety of illnesses that are now incurable. Because of recent scientific advancements, the area of applied medical research has taken a positive turn, and stem cell-based techniques have moved considerably closer to clinical applications. Since their discovery, stem cells have revolutionized medical research and dramatically alte...
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A REVIEW ON ACETYLCHOLINESTERASE INHIBITING THERAPEUTICS AND RECENT BREAKTHROUGHS IN THE FIELD OF ALZHEIMER`S DISEASE
Alzheimer's disease (AD) is one of the most well-studied neurodegenerative conditions. It is a debilitating chronic disease of the central nervous system (CNS). Almost 131.5 million individuals are predicted to be affected by the disease by 2050. The main effects of AD are cognitive decline and language problems. One of the factors contributing to AD is the gradual decrease in the brain's concent...
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CORRELATION OF ANTIOXIDANT, ANTIBACTERIAL AND PHYTOCHEMICALS OF LEAVES AND ROOTS EXTRACTS OF CLERODENDRUM INFORTUNATUM
The leaves and roots extracts of Clerodendrum infortunatum was evaluated for its potential antioxidant and antibacterial properties. The correlation studies with phytochemicals were performed, which has not been widely reported yet. Clerodendrum infortunatum leaves and roots were screened for the presence of phytochemicals and were found positive for carbohydrates, saponins, alkaloids, tannins, ph...
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INVESTIGATIONAL TREATMENT OF COVID-19
The novel coronavirus disorder 2019 (COVID-19) outbreak commenced in early December 2019 in the capital metropolis of Wuhan, Hubei province, People’s Republic of China and precipitated a world pandemic on march 11, 2020. Though some the international locations have succeeded in slowing down the price of the unfold of this pandemic, most the international locations throughout the globe are nevert...
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CHITOSAN CO-CRYSTAL FOR ENHANCING THE SOLUBITY AND DISSOLUTION RATE OF DICLOFENAC SODIUM
The present study is designed to enhance the aqueous solubility of diclofenac sodium. For the said purpose co-crystal employing chitosan with diclofenac sodium is prepared by solvent exchange. The prepared co-crystal was characterized by FTIR, DSC, XRD and TGA studies. Further, solubility, anti-inflammatory activity and in-vitro release study was determined for different batches of the formulation...
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VALIDATED UFLC-MS/MS METHOD FOR THE QUANTITATIVE ESTIMATION OF PALIPERIDONE IN RABBIT PLASMA; ADAPTABILITY TO IN-VIVO BIOAVAILABILITY STUDY
A simple gradient ultrafast liquid chromatography-tandem mass spectrometry method was developed and validated for the quantitative estimation of paliperidone in rabbit plasma matrix as per USFDA, and EMA guidelines using a stable isotope-labeled paliperidone-d4 was added as an internal standard. The separation was achieved on a Hypersil BDS C18 column (4.6 mm × 10 cm, 5 µm) with the mobile phase...
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