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IN-VITRO AND IN-SILICO STUDIES ON SELECTED PHYTOCONSTITUENTS OF MITRAGYNA PARVIFOLIA (ROXB.) STEM BARK FOR ANTI-CANCER ACTIVITY
Cancer is a dreadful disease all over the world. The death rate had been increasing because of different types of cancers even though several drugs, treatment models and regimens are invented by scientists. Natural drugs have been showing remarkable results in the treatment of different cancers with less or no side effects. Advancements in screening methods using computer aided tools helping the r...
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STUDIES ON ANTIMICROBIAL ACTIVITY OF HIBISCUS SPECIES OF KARNATAKA AGAINST CLINICAL ISOLATES
Antimicrobial activity of the various species of Hibiscus like Hibiscus sabdariff, Hibiscus rosa-sinensis, Hibiscus trionum, Hibiscus cannabinus, Hibiscus mutabilis against various pathogens like Staphylococcus aureus, E. coli, Bacillus subtilis, Streptococcus species, Salmonella typhimurium, Klebsiella pneumonia, Pseudomonas aeruginosa, Serratia marcescens, were studied with the help of agar well...
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EVALUATION OF ANTI-DIABETIC ACTIVITY OF CARALLUMA ADSCENDENS WHOLE PLANT IN DITHIZONE INDUCED DIABETIC RATS
This study was aimed to evaluate the anti-diabetic activity of Ethanolic extract of the whole plant administered at different dosages (100 mg/kg and 200 mg/kg) for 21 days in Dithizone-induced diabetic rats using Glibenclamide as a standard drug (hypoglycemic drug). For the study, rats were divided into five groups of six animals each. Group, I served as control, Group II served as diabetic contro...
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IN-VITRO ANTILEISHMANIAL EVALUATION OF AMPHOTERICIN B-MILTEFOSINE NANOVESICLES
Leishmaniasis is a neglected tropical infectious disease affecting poor people, especially in the developing countries of the world. It is a systemic disease caused by a protozoan parasite leishmania donovani and is fatal if left untreated. The aim of the present study is to develop and evaluate the in-vitro antileishmanial activity of the combination of amphotericin B and mitefosinenano vesicles ...
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ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITY OF DIFFERENT EXTRACTS OF THREE VARIETIES OF CARISSA CARANDAS FRUITS AND INHIBITION OF DIGESTIVE ENZYMES RELEVANT TO TYPE 2 DIABETES MELLITUS
Carissa carandas is a well-known traditional medicinal plant with a wide range of pharmaceutical properties. In the present studies, three Carissa carandas fruit extract varieties were investigated for the activities relevant to type 2 diabetes mellitus, including inhibition of α-amylase and α-glucosidase. Different solvent extracts such as methanol, ethanol, and aqueous extracts of Carissa cara...
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ANALGESIC ACTIVITY OF ETHANOLIC, HEXANE AND CHLOROFORM EXTRACTS OF SESAME SEED BY THERMAL HEAT METHOD IN ALBINO MICE
Background: Pain is a common symptom having huge public health importance. Conventional analgesics relieve pain effectively but cause various unwanted side effects. Hence the search for a novel analgesic with favourable risk-benefit profile is essential. Objectives: The current study was undertaken to investigate the analgesic activity of the ethanolic, hexane and chloroform extracts of sesame see...
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SPECTRAL ANALYSIS AND HYPOGLYCEMIC EFFECT OF CRUDE SAPONIN EXTRACTED FROM PHOENIX PUSILLA ROOT
In this present study, the objective was to extract crude saponins from the root of Phoenix pusilla (PP) and to check its inhibitory potential of α- amylase and α- glucosidase enzyme. Saponins were isolated by partitioning between butanol and water. Further, the presence of saponin was confirmed by the foam test. Then the crude saponins were analyzed by UV- spectroscopy in the range of 200-400 n...
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IN-VITRO CULTURE CHARACTERISTICS OF YOUNG AND OLD RAT MESENCHYMAL STEM CELLS
Mesenchymal stem cells are a small number of undifferentiated cells located in various tissues of the body. They have the ability to self-renew and differentiate into lineages of mesenchymal origin. They serve as most promising candidates for various regenerative medicine and tissue engineering applications. Their use in various clinical applications depend on their proliferative capacity to expan...
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DENSITY FUNCTIONAL THEORY STUDY ON IMIDAZOLINONE DERIVATIVES
Theoretical studies on two previously synthesized 3-((2, 4-dinitrophenyl) amino)-5-methyl-2-phenylimidazolidin-4- one (1) and 3-((2,4-dinitrophenyl) amino)-2-phenylimidazolidin-4- one (2) were carried out using the Density Functional Theory method. The geometrical parameters of the molecules in the ground state was optimized at the DFT-B3LYP level of theory and ab initio method using 6-31G (d,p) b...
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ANTI-BACTERIAL EFFICACY OF PHYTO-SYNTHESIZED ZINC OXIDE NANOPARTICLES USING MURRAYA PANICULATA L. LEAF EXTRACT
Human beings always tried to protect their body from pathogenic microbes, whereas these pathogens always mimic and mutate themselves to infect humans. Nanotechnology is new and upgrading itself as well as enhancing its applicability in pharmaceuticals. Due to their nano-size structure, property drastically changes from their parent elements. Nanoparticles are used widely in biomedical sciences. Fo...
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