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MANAGEMENT OF PSORIATIC ARTHRITIS: AN OVERVIEW OF SYNTHETIC, RECOMBINANT DNA, MONOCLONAL ANTIBODY AND NATURE-DERIVED AGENTS
Psoriatic arthritis is an inflammatory condition of the skin and musculoskeletal system with cutaneous psoriasis that leads to joint deformity and disability and is commonly seen in 40-50-year-old population. Clinically, TNF-α inhibitors and JAK inhibitors form the main line of treatment of this rare disorder. A systematic review was conducted via an electronic search of Google Scholar, PubMed, S...
2067
1054
IDENTIFICATION AND OPTIMIZATION OF BINDING SITE FOR AN ACTIVE METABOLITE OF CLOPIDOGREL, PRASUGREL AND TICLOPIDINE ON RECEPTOR P2Y12
In this article, an attempt was made to develop molecular docking studies on active metabolites of Prasugrel, Clopidogrel, and Ticlopidine acting as protein P2Y12 inhibitors. Molecular docking analysis was performing by using autodock version 4.3 adjoin with discovery studio to better understand the interactions between P2Y12 targets and inhibitors in this series. Hydrophobic and hydrogen bond int...
2066
1361
ANTI-CANCEROUS ACTIVITY OF MEDICINAL PLANTS
The rising burden of cancer worldwide calls for an indispensable treatment result. Herbal drug provides a veritably doable volition to western drug against cancer. This composition reviews the named plant species with active phytochemicals, the animal models used for these studies, and their nonsupervisory aspects. This study is grounded on a scrupulous literature review conducted through the hunt...
2066
1491
GENERAL AWARENESS TO COMMON MEDICINAL HERBS, “THE NATURAL, DOESN’T MEANS SAFE” – A REVIEW
The term "Naturals are the safer" is quite trendy, but the incomplete knowledge of the natural herbs interaction may result in several allergies and unwanted effects that may even take life and sometimes be critical to a life-threatening extent. The responsibility of the FDA is to ensure that the safety and efficacy of the drug consumed by humans and veterinary should be worthful and should cause ...
2065
1829
FLOWERS – THE NOBLE ROLE OF THE MOST BEAUTIFUL, PLENTIFUL, BUT NEGLECTED BIO-RESOURCE IN INDIA
The Greek words “angeion” (vessel) and “sperma” (seed) constitute angiosperm which together define enclosed seeds. The angiosperms differ from closely related gymnosperms in seed being naked and not enclosed within a fruit. Moreover, angiosperms are distinguished plants having colorful flowers. Having originated about 130 million years ago, the flowering plants are more diverse and largest...
2064
1056
RECENT BREAKTHROUGHS IN THE MANUFACTURE OF MICROBIAL PROTEASES AND THEIR APPLICATIONS: A REVIEW
Enzymes are biocatalysts that accelerate biotic reactions positively or negatively. Proteases are small types of enzymes that cleave peptide bonds. These proteases can be produced by microbes (fungi, bacteria, and viruses), plants, and animals. The catalytic site is only visible from the outside and is broadly dispersed on the surfaces of different cell types. Based on the position of the cleavage...
2063
985
GC-MS ANALYSIS OF CURCUMA ZEDOARIA TUBER EXTRACTS AND ITS ANTIBACTERIAL ACTIVITY
This study investigates the presence of bioactive compounds present in the tubers of Curcuma zedoaria using GC-MS analysis. Different compounds, including alkaloids, tannins, flavonoids, and proteins, were identified using the preliminary phytochemical screening for aqueous, ethanol and methanol extracts. The present study reports the antimicrobial activity analysis using aqueous, ethanol and meth...
2063
1223
EVALUATION OF THE GENETIC DIVERGENCE OF VARIOUS ACCESSIONS OF THE SPECIES CARISSA CARANDAS USING INTER SIMPLE SEQUENCE REPEAT PRIMERS
Carissa carandas Linn. belonging to the family Apocynaceae, is an underutilized fruit plant. C. carandas has been used in many ethno medicines 6, 40, 30. Genetic diversity is a ubiquitous feature of all species in nature. ISSR markers are useful in areas of genetic diversity, phylogenetic studies, gene tagging, genome mapping, and evolutionary biology in a wide range of plant species 4, 12. In thi...
2063
1175
BIOCATALYSIS OF DIFFERENT NITRILES TO VALUABLE ACIDS
The biotransformation of different nitrile compounds into valuable acids was attempted using whole cells of nitrile hydrolyzing enzyme produced from a bacteria strain (BITSN007) isolated from sludge sample of Hot spring Surajkund, Jharkhand. Based on the biochemical characterization, the isolate producing nitrilase is predicted as Bacillus sp. The nitrilase production was observed as intracellular...
2062
1136
IN-SILICO ANALYSIS OF MTA1 AS DRUG TARGET AGAINST NATURAL ANTIOXIDANTS
The protein MTA1 with histone deacetylase activity is a member of the nucleosome remodeling complex encoded by the mta1 gene is frequently overexpressed in biologically aggressive epithelial neoplasms. MTA1 is a nuclear co-regulatory molecule that is highly expressed in many cancers and correlates with tumor metastasis and progression. MTA1 alters signaling events in the tumor micro-environment. M...
2061
1118