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TOXICITY AND ANTIHYPERTENSIVE ACTIVITY OF LIPPIA MULTIFLORA EXTRACTS IN THE DIFFERENT REGIONS OF BENIN
The objective was to study the antihypertensive effects of the aqueous decoctycrude of Lippia multiflora from the region of Djidja at a dose of the plant as well as the effects of this extract on some biochemical parameters in the rat were made hypertensive by 500 mg/kg of body weight during the 14 days and were treated with losartan potassium at a dose of 100 mg/kg of body weight, of L-NAME at a ...
2075
1025
IN-VITRO AND IN-VIVO STUDIES OF PHB CAST FILMS BLENDED WITH VARIOUS HERBS AND ITS BIOCOMPATIBLE CHARACTERIZATION
The present study deals with the PHB made cast film with different plant and algal formulations. Its biocompatibility was tested in-vitro and in-vivo. The anti-inflammatory activity was higher in F4 and F5, close to the standard Diclofenac. The F7 and F8 exhibited moderate cytotoxicity, and formulation F2 exhibited low cytotoxicity. The maximum zone of inhibition was exhibited in F5 followed by F4...
2074
1178
A COMPREHENSIVE REVIEW OF MEDICINAL HERBS USED AS ANTI-DEPRESSANT
Depression is a significant contributor to the global burden of disease and affects people in all communities across the world. Today, depression is estimated to affect 350 million people. The World Mental Health Survey conducted in 17 countries found that, on average, about 1 in 20 people reported having an episode of depression in the previous year. Depressive disorders often start at a young ag...
2073
1148
IS ATTENTION DEFICIT HYPERACTIVE DISORDER – A NEUROGENETIC DISORDER
An overview of the neurodevelopmental disorder ADHD (attention deficit hyperactivity disorder), its consequences, and details on the brain regions impacted by ADHD are the driving forces behind this review. The hereditary basis of ADHD has been investigated. Throughout the investigation, numerous reviews and research publications were compared and examined. The themes covered in this article are (...
2073
1059
THE AFRICAN BAOBAB SEED OIL AND ITS POTENTIAL FOR SOLUBILISING POORLY SOLUBLE DRUGS
Most lipids used in solubilizing poorly soluble drugs are synthetic or semi-synthetic. In this study, the African Baobab seed oil (natural oil) was investigated for its potential in solubilizing poorly soluble drugs in a microemulsion formulation. Oil was extracted from untreated seeds by hydraulic pressing. Physicochemical characteristics of the oil were determined. The solubility of Furosemide, ...
2072
1384
FORMULATION AND EVALUATION OF GASTRO RETENTIVE MUCOADHESIVE FILM OF RITONAVIR
Objective: The research work aims to formulate and evaluate the Gastro retentive mucoadhesive film of Ritonavir using polymers like HPMC K15M, Polyvinyl alcohol, and PEG 400 as a plasticizer by solvent casting method for treatment of AIDS. Method: Prepared gastro retentive mucoadhesive films were evaluated for various parameters such as in-vitro unfolding behavior of film, Folding endurance, Perce...
2072
1255
METHOD DEVELOPMENT AND VALIDATION OF PARA-PHENYLENEDIAMINE IN PURE AND MARKETED DYES BY USING RP-HPLC
To estimate the presence of para-phenylenediamine in various commercial hair colors, a straightforward, speedy, precise investigation used High-Performance Liquid Chromatography to find PPD in henna and determine its presence. In order to do the chromatography, stationary phase Phenomenox C18 100 mm x 4.6 mm, 5µm column system was used for UV detection with a242 nm wavelength. The mobile phase Me...
2071
1119
MANAGEMENT OF PSORIATIC ARTHRITIS: AN OVERVIEW OF SYNTHETIC, RECOMBINANT DNA, MONOCLONAL ANTIBODY AND NATURE-DERIVED AGENTS
Psoriatic arthritis is an inflammatory condition of the skin and musculoskeletal system with cutaneous psoriasis that leads to joint deformity and disability and is commonly seen in 40-50-year-old population. Clinically, TNF-α inhibitors and JAK inhibitors form the main line of treatment of this rare disorder. A systematic review was conducted via an electronic search of Google Scholar, PubMed, S...
2071
1058
ROLE OF VITAMIN D IN CARDIOMETABOLIC DISORDERS – A REVIEW BASED ON PATHOPHYSIOLOGY AND CLINICAL EVIDENCES
Background: Cardiometabolic syndromes are the co-occurrence of metabolic abnormalities such as obesity, insulin resistance, atherogenic dyslipidemia, and hypertension. Cardiometabolic disorders includes type2 diabetes mellitus, metabolic syndrome, and cardiovascular diseases. The prevalence of cardiometabolic disorders are growing in epidemic proportions all over the world; hence cardiometabolic d...
2070
1322
ANTI-CANCEROUS ACTIVITY OF MEDICINAL PLANTS
The rising burden of cancer worldwide calls for an indispensable treatment result. Herbal drug provides a veritably doable volition to western drug against cancer. This composition reviews the named plant species with active phytochemicals, the animal models used for these studies, and their nonsupervisory aspects. This study is grounded on a scrupulous literature review conducted through the hunt...
2069
1492