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A STUDY OF EPIDEMIOLOGICAL, ETIOLOGICAL AND CLINICAL FACTORS IN HYPER-PIGMENTATION POPULATION IN NORTH GUJARAT
Background: Hyperpigmentation (HP) is a common dermatological disease. Indian population presents in a variety of dermatological pigmentation. Effects of Nutrients and metabolites factor are important for skin hyperpigmentation condition. Aims and Objectives: In this study, we aimed to evaluate the status of Haemoglobin, vitamin B12, Ferritin, and TSH levels in people with hyperpig-mentation from...
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ANTIDIABETIC ACTIVITY OF AVICENNIA ALBA IN STREPTOZOTOCIN INDUCED TYPE-2 DIABETIC RATS
The study was initiated to determine the antidaibetic activity of Avicennia alba in Streptozotocin induced Type-2 diabetic rats. The rats were treated with 100, 200 and 400 mg/kg of Avicennia alba stem and leaf methanolic extract (MLAA) and compared with the diabetic, normal and standard (glibenclamide) rat groups. The blood glucose levels, glycosylated haemoglobin levels, and body weight of the r...
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AMYOTROPHIC LATERAL SCLEROSIS: RAPIDLY ACCELERATING COMPLEX NEURO-DEGENERATIVE DISEASE
An amyotrophic lateral sclerosis is a group of progressive neurodegenerative disorders of motor neurons that leads to weakness, muscle atrophy, progressive paralysis, and respiratory insufficiency with a life anticipation of only three years after the onset of disease symptoms. It impairs the functions of both upper and lower motor neurons. The specific mechanism for the disease remains largely un...
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PRESCRIPTION ANALYSIS AND MONITORING OF ADVERSE DRUG REACTIONS OF ANTICANCER AGENTS IN TERTIARY CARE HOSPITAL
Objective: Cancer being a global threat and deadly disease, necessitate the use of anticancer agents. Hence, continuous drug utilization evaluation studies and Adverse Drug Reaction (ADR) reporting should be carried out in the oncology departments of health care systems. The objective of the study was to identify various types of cancer, assess commonly prescribed anticancer agents using WHO presc...
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HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF ETHANOLIC LEAVES EXTRACT OF ABROMA AUGUSTA AGAINST NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) IN SD RATS
To study the hepatoprotective activity of ethanolic leaves extracts of Abroma augusta against non-alcoholic fatty liver disease to validate ethnobotanical claim regarding the plant used in the above mentioned disease. Materials and Methods: The hepatoprotective potential of Abroma augusta leaves extract (AALE) (250 and 500 mg/kg/ body weight) was studied on Methionine and Choline deficient diet (M...
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NOVEL RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS DETERMINATION OF LECITHIN AND SILYMARIN
Objective: A simple, rapid, accurate, precise and reproducible validated RP- HPLC method was developed for the determination of Lecithin and Silymarin in bulk and tablet dosage forms. Methods: A simple double beam UV spectrophotometric method has been developed and validated with different parameters such as linearity, precision, repeatability, the limit of detection (LOD), Limit of Quantification...
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CYTOTOXICITY EVALUATION OF MORINGA OLEIFERA (M. OLEIFERA) LAM. FLOWERS ON HUMAN LIVER CANCER CELL LINE AND A. SALINA (BRINE SHRIMP) MODELS
Moringa oleifera Lam is a fast-growing deciduous tree widely cultivated in tropical and sub-tropical regions. All parts of the plant have widely acclaimed nutrition and health-promoting values, but little has been done regarding the toxicity. This study evaluated the safety of different extracts from Moringa flowers using brine shrimp and cell line models. The effect of different concentrations (0...
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ANTIMUTAGENIC ACTIVITY OF POMEGRANATE EXTRACT AND 2 – METHOXY-ESTRADIOL IN COMBINATION ON SWISS ALBINO MOUSE – MUS MUSCULAS
Pomegranate extracts (PGEs) exhibit antioxidative, antiproliferative, and antineoplastic activities. 2-Methoxyestradiol (2-ME), the end metabolite of 17β estradiol (E2), an antiangiogenic agent, inhibits tumor growth. Our earlier investigations demonstrated that aqueous PG extract (PGE) in combination with 2-ME showed antineoplastic effect on Sarcoma-180 tumor cells. The present paper has been or...
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IN-VITRO BIOACTIVE POTENTIAL OF ENDOPHYTIC FUNGI CURVULARIA LUNATA ISOLATED FROM MEDICINAL PLANT FICUS RELIGIOSA
Several studies undertaken in the recent past have demonstrated that endophytic fungi are capable of producing a number of important bioactive secondary metabolites, hitherto known only from plants, thereby raising the potential of using endophytes as alternative sources for these metabolites. Occasionally, the compounds produced by endophytic fungi are similar to those produced by the respective ...
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME NOVEL TRIAZOLE DERIVATIVES
Triazole is a diunsaturated heterocyclic compound that contains two nitrogen groups as heteroatoms. In the present study, an attempt was made to synthesize various derivatives of substituted 1, 2, 4-triazol-3-yl) benzene-1-ol and assess their antimicrobial efficiency. The synthesized compounds were subjected to physical characterization and spectral analysis by IR and NMR for structure elucidation...
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