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BIOACTIVE COMPOUNDS FROM MARINE INVERTEBRATES AND THEIR PHARMACEUTICAL POTENTIAL
Marine environment is an exceptional storehouse of novel bioactive natural products that are mainly found in invertebrates such as sponges, arthropods, annelids, molluscs, etc. This diversity has been the source of unique chemical compounds. A large portion of these natural compounds has been extracted from marine invertebrates. Marine invertebrates are rich sources of bioactive compounds and thei...
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EVALUATION OF IN-VITRO ANTI-BACTERIAL AND CYTOTOXIC ACTIVITY OF LEEA MACROPHYLLA
Studies have confirmed the medicinal potential of the Leea macrophylla mentioned in traditional medicine. While the effects of the Leea macrophylla extract on some bacteria and Brine shrimp lethality using their different concentrations has not been previously explored. The present study shows that the standardized aqueous and ethanolic extract of Leea macrophylla exhibited antibacterial and cytot...
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DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF MANGIFERIN AND BERBERIN HCL IN BULK AND SYNTHETIC MIXTURE
Introduction: There are so many promising plant-based chemical constituents are present which act as an alternative therapy for the control of diabetes. But due to the lack of its proper quality control parameters, they are not widely used. The USFDA patent is approved for a fixed dosage combination of Mangiferin (MF) and Berberin HCl (BER) as antidiabetic herbal formulation. Objective: The litera...
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CHEMOPREVENTIVE POTENTIAL OF CAPPARIS DECIDUA FRUIT EXTRACT AGAINST DMBA INDUCED SKIN CARCINOGENESIS IN SWISS ALBINO MICE
Chemoprevention is the novel approach that inhibits and delays or reverses the process of cancer development by using natural herbs and plant products. The aim of the present study was to evaluate the anticancer efficacy of orally administered Capparis decidua fruit extract (CDE) on skin carcinogenesis model in swiss albino mice by the single topical application of the 7,12 dimethylbenz (a)anthrac...
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EVALUATION OF ORGANOLEPTIC, PROXIMATE PARAMETERS AND ANALYSIS OF NUTRITIONAL COMPOSITION OF FIVE WILD WEEDS: A SEARCH FOR LOW-COST NUTRACEUTICALS
Medicinal plants are the predominant source of phytochemicals and nutraceuticals, and it is used for the treatment of many diseases for its high effectiveness, low cost, and wide availability. In the current research study five, commonly used ethnomedicinal weeds of West Bengal, and India namely; Heliotropium indicum, Tridax procumbens, Cleome rutidosperma, Commmelina benghalensis, and Euphorbia h...
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WRIST ACTION SHAKER: A NOVEL METHOD FOR COLLECTING POLLEN GRAINS FROM THE INFLORESCENCE OF COCONUT (COCOS NUCIFERA L.) FOR ITS STABLE NUTRITIONAL COMPONENTS
To predict the cocos anther dehiscence, a novel method was devised to compile the colossal amount of pollen grains. The matured inflorescence enveloped by the spathe was collected and the anther dehiscence were noticed day by day until the shedding of entire pollen. This study was experimented for a period of eight months between (February) 2018 to 2018 (September). After an experimental trails, s...
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ESTIMATION OF HMG-COA REDUCTASE INHIBITOR HAS CHRONOPHARMACEUTICAL DELIVERY SYSTEM VIA NOVEL COATING METHOD
Introduction: The aim of the present study is to formulate and evaluate the simvastatin chronopharmaceutical delivery system using a novel coating method to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined lag time of 6 h. Observation: Simvastatin is a hyperlipidemia drug that inhibit the synthesis of cholesterol by inhibiting the HMG-COA reductase enzy...
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FORMULATION AND DEVELOPMENT OF CURCUMIN AND MAG LOADED ENTERIC COATED TABLET IN THE TREATMENT OF IBD
The incidence of Inflammatory Bowel Disease (IBD) is now rising in developing countries and increasingly considered an emerging global disease. IBD is a chronic, intermittent disease. Symptoms of IBD varies from person to person and segment of the intestinal tract involved. IBD diagnosis depends on the various test, which requires blood testing, stool testing, endoscopy, biopsies as well as physic...
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POLYMER GRAFTING AND ITS APPLICATIONS: A REVIEW
Grafting polymerization is a process in which polymer chains are covalently bonded (grafted) onto a backbone polymer, leading to the formation of a new material with enhanced properties or functionalities. This process involves the attachment of polymer chains (known as "graft chains" or "grafts") onto the surface or within the bulk of the substrate material. Polysaccharides have numerous applicat...
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MITIGATION OF PAIN AND INFLAMMATION-INDUCED IN MICE AND ANTIMICROBIAL ACTIVITY OF CRUDE HYDROALCOHOLIC EXTRACT DE BEGONIA CUCULLATA WILLD. (BEGONIACEAE)
Begonia cucullata Willd. (Begoniaceae) is a native medicinal species from Paraguay popularly used to combat stomatitis, pharyngitis, respiratory ailments in children, and inflammatory conditions among others. The limited literature did not report these plants as having analgesic, anti-inflammatory, or antimicrobial properties. This work aims to determine the acute toxicity, general behavior, analg...
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