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A NEW SERIES OF CHALCONES INCORPORATED WITH PYRIDINE MOIETY AS POTENTIAL ANTI-BACTERIAL AGENTS
A new series of chalcones have been designed and synthesized, which are incorporated with pyridine moiety chalcones possess heterocyclic rings like pyridine, pyrazole, indole, etc. These heterocycles are cyclic compounds in which one or more atoms of the ring are hetero atoms: O, N, S, P, etc. These are important components in many of the pharmaceuticals and therapeutic drugs. These are present in...
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EVALUATION OF ORGANOLEPTIC, PROXIMATE PARAMETERS AND ANALYSIS OF NUTRITIONAL COMPOSITION OF FIVE WILD WEEDS: A SEARCH FOR LOW-COST NUTRACEUTICALS
Medicinal plants are the predominant source of phytochemicals and nutraceuticals, and it is used for the treatment of many diseases for its high effectiveness, low cost, and wide availability. In the current research study five, commonly used ethnomedicinal weeds of West Bengal, and India namely; Heliotropium indicum, Tridax procumbens, Cleome rutidosperma, Commmelina benghalensis, and Euphorbia h...
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HUMAN AChE SELECTIVE INHIBITION OF PHYTOCHEMICALS OF SONCHUS WIGHTIANUS OF NEPAL ORIGIN: AN IN-SILICO APPROACH
Background: Alzheimer's disease (AD) is the most common type of dementia, which represents one of the major difficult challenges for drug discovery. Currently, 62% of the people are suffering from Alzheimer's disease around the world is expected to reaching 131.5 million people, and this will reach 71% by 2050. So far, only five drugs have been registered for the treatment of AD, including four ac...
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PHYTOCHEMICAL CHARACTERIZATION OF COLD MACERATED METHANOLIC LEAF EXTRACT OF CADABA INDICA LAM. USING GC-MS
Cadaba indica Lam (Indian Cadaba), an Indian traditional medicinal plant has been used for various diseases. The cold macerated methanolic leaf extract of Cadaba indica was assessed using Agilent GC 7890A gas chromatography connected with an MS- 5975C mass spectrometer and the mass spectra were matched with NIST 14.0 – data library. Several chemical constituents were identified within 28 min of ...
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DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR THE PHARMACOKINETIC STUDY OF FAMOTIDINE SNEDDS IN RATS USING RP-HPLC
A selective and high throughput RP-HPLC method was developed to detect and quantify Famotidine in rat plasma using Ranitidine hydrochloride as an internal standard (IS). After liquid-liquid extraction, the analyte and the internal standard were chromatographed on Enable 18H (5µ, 250×4.6mm) C18 column using 20 µL injection volume with a run time of 15 minutes. An isocratic mobile phase consistin...
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DESIGN AND CHARACTERIZATION OF TOPICAL ANTIBACTERIAL FORMULATION CONTAINING EXTRACT OF QUERCUS INFECTORIA GALLS
Presently, the surge in the consumption of herbal formulations is encouraged by several factors; the main factor is that they are relatively safe and effective. Plant extracts are considered an alternative source of synthetic drugs and are expected to produce promising results for treating several diseases. The present study aimed to formulate and evaluate antibacterial thermosensitive mucoadhesiv...
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MITIGATION OF PAIN AND INFLAMMATION-INDUCED IN MICE AND ANTIMICROBIAL ACTIVITY OF CRUDE HYDROALCOHOLIC EXTRACT DE BEGONIA CUCULLATA WILLD. (BEGONIACEAE)
Begonia cucullata Willd. (Begoniaceae) is a native medicinal species from Paraguay popularly used to combat stomatitis, pharyngitis, respiratory ailments in children, and inflammatory conditions among others. The limited literature did not report these plants as having analgesic, anti-inflammatory, or antimicrobial properties. This work aims to determine the acute toxicity, general behavior, analg...
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STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF INOTUZUMAB OZOGAMICIN IN BULK DRUG AND INJECTION DOSAGE FORM
A simple, rapid, accurate, precise, and reproducible stability indicating RP-HPLC method for the estimation of Inotuzumab Ozogamicin in bulk and injection dosage form was developed and validated as per ICH guidelines. The separation was done using BDS C18 150 × 4.6 mm, 5 µ column. The mobile phase (Water and Acetonitrile 55:45% v/v) was pumped at 1.0 ml/min, and effluent was detected at 240 nm u...
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PHYTOCHEMICAL SCREENING, IN-VITRO EVALUATION OF ANTIOXIDANT AND ANTIBACTERIAL EFFICACY OF METHANOLIC LEAF EXTRACT OF CLINOPODIUM NEPETA (L.) KUNTZE
The objective of the present study is to evaluate the phytochemical constituents, antioxidant and antibacterial activities of methanolic leaf extract of Clinopodium nepeta (L.) Kuntze. Total phenolic content of leaf extracts was assessed using Folin-Ciocalteu and AlCl3 reagent. Antioxidant assays were evaluated using DPPH, ABTS radical scavenging, and ferric, reducing antioxidant power (FRAP) meth...
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EVALUATION OF ANTICONVULSANT, ANTIANXIETY ACTIVITY OF IPOMOEA PES-TIGRIDIS EXTRACTS IN MICE
Ipomoea pes-tigridis (IP) is a twinning hairy herb grown in India. Based on the ethnopharmacological information of the plant, the ethanolic extract of the whole plant of Ipomoea pes-tigridis was evaluated for its anticonvulsant, antianxiety activity in mice. The Antiepileptic activity was assessed by using MES (maximal electroshock) model (200 and 400 mg/kg), and antianxiety activity was assessed...
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