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SYNTHESIS, SPECTRAL ELUCIDATION, ANTIBACTERIAL, ANTIOXIDANT AND DNA STUDIES OF ONNO TETRADENTATE SCHIFF BASE METAL(II) COMPLEXES DERIVED FROM 2-AMINOPHENOL DERIVATIVES
The new asymmetrical tetradentate (ONNO) Schiff base (L) 4-chloro- 2- ((E)- (4- ((E)-((2-hydroxy-5-nitrophenyl)imino)methyl)benzylidene) amino)phenol was prepared by the condensation of terephthalaldehyde with 2-amino 4-chlorophenol and 2-amino 4-nitrophenol in 1:1:1 molar ratio in methanol. The homo binuclear metal(II) complexes were synthesized in ligand to metal ratio 2:2 from the template meth...
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SIMULTANEOUS HPTLC METHOD FOR DETERMINATION OF GALLIC ACID, VANILLIC ACID AND SYRINGIC ACID IN AGRO-INDUSTRIAL WASTE OF DATE FRUITS
Phoenix dactylifera is a medicinally important plant. Fruits are traditionally used for the nutritional purpose. Date seeds are the rich sources of phenolic acids which exhibits strong antioxidant property. HPTLC is a simple, versatile method and it provides visualization of separated constituents. The advantage of this method is this method requires a small amount of sample for analysis. The pres...
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EFFECT OF PIPER BETLE LEAF EXTRACT AND SYZYGIUM AROMATICUM FLOWER EXTRACT AND THEIR ACTIVE COMPONENT EUGENOL ON THE SURVIVAL OF LUNG ADENOCARCINOMA CELLS (A549)
Medicinal plants are one of the most important resources for developing new lead therapeutic compounds used in various traditional medicines worldwide for thousands of years due to the presence of natural bioactive components, which help in preventing various human diseases. Piper betle Linn belongs to the Piperaceae family, commonly known as Betel and Paan. Betel leaves possess several bioactivit...
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EVALUATION OF PHYTOCHEMICAL, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF CURCUMA LEUCORRHIZA (ZINGIBERACEAE) ROXB. RHIZOME
The aim of the present study was to characterize the petroleum ether, chloroform, and ethanol extracts of rhizomes of Curcuma leucorrhiza Roxb and to evaluate their biological activities such as anti-oxidant, anti-bacterial, and anti-fungal activities. Sequential solvent extraction was performed by Soxhlet apparatus using petroleum ether, chloroform, and ethanol, and respective extracts were named...
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ULTRASOUND SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITIES OF FE (III) COMPLEXES OF Β-DIKETONES
Consistently the preparation of transition metal complexes of β-diketones has been (and it still is) an area of the highest interest for inorganic and organic chemists, as can be inferred considering the quantity and diversity of research developed in this field. 1,3- Diketones are wide range of valuable molecules including several types of carbocycles and heterocycles hence have high interest....
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TRENDING MICROBIOLOGICALS AND THEIR ROLE TO ENHANCE GROWTH AND ESSENTIAL OIL CONTENT OF DILL (ANETHUM GRAVEOLENS)
A greenhouse and field experiment was conducted to investigate the effects of Azotobacter (Azotobacter chroococcum), Phosphate solubilizing bacteria (Pseudomonas fluorescens), and Arbuscular mycorrhiza-like fungi (Sebacinca vermifera) on seed germination, physiology, and essential oil production of dill (Anethum graveolens). The experimentation was comprised of a randomized complete block design w...
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DEVELOPMENT OF NASAL DRUG DELIVERY SYSTEM OF ATORVASTATIN CALCIUM FOR ENHANCING BIOAVAILABILITY
Atorvastatin calcium is a synthetic lipid-lowering agent used in hyperlipidemia. An oral dose of Atorvastatin calcium ranges from 10mg to 80mg per day. Atorvastatin calcium belongs to BC’s class II drug having low solubility and high permeability. The absolute bioavailability of Atorvastatin calcium is approximately 12%, and the systemic availability of HMG-CoA reductase inhibitory activity is a...
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EXTRACTION, CHARACTERIZATION AND INHIBITION OF POLYPHENOL OXIDASE IN SOLANUM MELONGENA
Enzymatic browning is a process that occurs in fruits and vegetables by the enzyme polyphenol oxidase, which results in brown pigments reduce shelf life which indirectly causes huge domestic loss to the farmers during the post-harvesting process. In this context, the present study was carried out to preserve and increase the shelf life of Brinjal vegetables from enzymatic browning using ascorbic a...
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FORMULATION AND CHARACTERIZATION OF IBRUTINIB LOADED CYCLODEXTRIN NANOSPONGES
The aim of this study was to explore the feasibility of complexing the poorly water-soluble drug ibrutinib with β-cyclodextrin (β-CD) based nanosponges (NS), which offer advantages of improving dissolution rate and eventually oral bioavailability. Blank NS were fabricated by reacting β-CD with the cross-linker carbonyldiimidazole at different molar ratios (1:2, 1:4 and 1:8). The effect of formu...
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BIOLOGICAL ACTIVITIES AND THERAPEUTIC POTENTIAL OF PERILLA FRUTESCENS (PURPLE MINT): A REVIEW
Perilla frutescens (Linn.) is an annual herbal medicinal, aromatic, vitamins-rich food and ornamental plant that belongs to the mint family, Lamiaceae. It is distributed throughout India, extending to China, Japan, Korea, Taiwan, Vietnam, and other Asian countries. Perilla frutescens seeds, leaves and stems contain fixed oil which is useful edible oil. It is an alternative source of polyunsaturate...
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