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AN OBSERVATIONAL STUDY REGARDING PRESCRIPTION EVENT MONITORING OF ANTI-HYPERTENSIVE MEDICATIONS AMONGST PATIENTS COMING TO A TERTIARY CARE CENTRE OF NORTHERN INDIA
Hypertension is now defined on the basis of systolic (SBP) and diastolic (DBP) blood pressure levels and classified into stages on the basis of the degree of elevation. The generally recognized cut point for hypertension is an average office BP of 140/90 mmHg or greater, which has been obtained by a recommended standard technique with an accurate manometer and has been confirmed on at least one ot...
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EVALUATION OF PHYTOCHEMICAL, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF CURCUMA LEUCORRHIZA (ZINGIBERACEAE) ROXB. RHIZOME
The aim of the present study was to characterize the petroleum ether, chloroform, and ethanol extracts of rhizomes of Curcuma leucorrhiza Roxb and to evaluate their biological activities such as anti-oxidant, anti-bacterial, and anti-fungal activities. Sequential solvent extraction was performed by Soxhlet apparatus using petroleum ether, chloroform, and ethanol, and respective extracts were named...
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EFFECT OF PIPER BETLE LEAF EXTRACT AND SYZYGIUM AROMATICUM FLOWER EXTRACT AND THEIR ACTIVE COMPONENT EUGENOL ON THE SURVIVAL OF LUNG ADENOCARCINOMA CELLS (A549)
Medicinal plants are one of the most important resources for developing new lead therapeutic compounds used in various traditional medicines worldwide for thousands of years due to the presence of natural bioactive components, which help in preventing various human diseases. Piper betle Linn belongs to the Piperaceae family, commonly known as Betel and Paan. Betel leaves possess several bioactivit...
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SIMULTANEOUS HPTLC METHOD FOR DETERMINATION OF GALLIC ACID, VANILLIC ACID AND SYRINGIC ACID IN AGRO-INDUSTRIAL WASTE OF DATE FRUITS
Phoenix dactylifera is a medicinally important plant. Fruits are traditionally used for the nutritional purpose. Date seeds are the rich sources of phenolic acids which exhibits strong antioxidant property. HPTLC is a simple, versatile method and it provides visualization of separated constituents. The advantage of this method is this method requires a small amount of sample for analysis. The pres...
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DEVELOPMENT OF NASAL DRUG DELIVERY SYSTEM OF ATORVASTATIN CALCIUM FOR ENHANCING BIOAVAILABILITY
Atorvastatin calcium is a synthetic lipid-lowering agent used in hyperlipidemia. An oral dose of Atorvastatin calcium ranges from 10mg to 80mg per day. Atorvastatin calcium belongs to BC’s class II drug having low solubility and high permeability. The absolute bioavailability of Atorvastatin calcium is approximately 12%, and the systemic availability of HMG-CoA reductase inhibitory activity is a...
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EXTRACTION, CHARACTERIZATION AND INHIBITION OF POLYPHENOL OXIDASE IN SOLANUM MELONGENA
Enzymatic browning is a process that occurs in fruits and vegetables by the enzyme polyphenol oxidase, which results in brown pigments reduce shelf life which indirectly causes huge domestic loss to the farmers during the post-harvesting process. In this context, the present study was carried out to preserve and increase the shelf life of Brinjal vegetables from enzymatic browning using ascorbic a...
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REINVESTIGATION OF SYNTHESIS OF ENOXAPARIN UNDER PTC CONDITIONS
Heparin is a mixture of glycosaminoglycan (GAG) chains originating from the porcine intestinal mucosa. It is used therapeutically as an anticoagulant for the treatment and prevention of thrombosis. Glyco-saminoglycans such as heparin (H) and heparan sulfate (HS) are considered attractive therapeutic agents because they modulate many biological processes and have been implicated in numerous patholo...
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FORMULATION AND CHARACTERIZATION OF IBRUTINIB LOADED CYCLODEXTRIN NANOSPONGES
The aim of this study was to explore the feasibility of complexing the poorly water-soluble drug ibrutinib with β-cyclodextrin (β-CD) based nanosponges (NS), which offer advantages of improving dissolution rate and eventually oral bioavailability. Blank NS were fabricated by reacting β-CD with the cross-linker carbonyldiimidazole at different molar ratios (1:2, 1:4 and 1:8). The effect of formu...
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LOOKING FROM PAST TO PRESENT- CHAKSHUSHYA DRUGS IN BHAVAPRAKSHA NIGHANTU AND RESEARCH DONE ON THEM
Bhavaprakasha is unique in the sense that it shows the slow amalgamation of traditional Indian materiamedica with several new additions which came to the Indian subcontinent through trade and exchanges with foreign civilizations. The Nighantuportion of Bhavaprakasha is an excellent repertoire of herbs and minerals used in Ayurveda. Several plants with properties related to augmentation of ocular f...
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ANALYSIS OF KEY SUGAR PHOSPHATE INTERMEDIATES IN GLYCOLYSIS BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY TO ASSES AND EVALUATE POSSIBLE ALTERATIONS IN METABOLITE POOL OF ERYTHROCYTES IN TYPE 2 DIABETES
In previous studies, it has been shown that the activities of the glycolysis cycle enzyme are significantly altered with changes in kinetic attributes of hexokinase, phosphorfructokinase and lactate dehydrogenase. Moreover, the kinetic parameters of the terminal enzyme lactate dehydrogenase also changed significantly. In view of these observed changes, it was of interest to know if and how the flu...
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