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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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55.

SYNTHESIS AND IN-VIVO ACTIVITY OF NOVEL ANTIHYPERTENSIVE AGENT BASED ON PYRIDAZINE SCAFFOLD

The main objective of the present research work to synthesize, characterization, and in-vivo evaluation of Pyridazine derivatives. To study the different synthesized derivatives by using different analytical parameters like IR, Mass, and NMR analysis. And also find out the antihypertensive activity. The studies on the hydralazine group drugs led to the synthesis of many Pyridazine derivatives with...

V. Jakhmola *, S. Jawla, R. Mishra and N. G. R. Rao

Department of Pharmacy, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.12(1).496-06

496-506

2189

1978

51.

ISOLATION AND CYTOTOXIC POTENTIAL OF SILVER NANOSUSPENSION OF THE ROOTS OF APHANAMIXIS POLYSTACHYA

Objective: The study was aimed to isolate the components from the methanolic extract of the root bark of Aphanamixis polystachya and to confirm their potential cytotoxicity of the methanolic extract, silver nanoparticles and silver nanosuspension of the root bark of A. polystachya. Method: Isolation from the methanolic extract of root barks of A. polystachya were performed using column chromatogra...

R. Gude *, A. Joshi, A. Bhandarkar and D. Mayenkar

Goa College of Pharmacy, 18th June Road, Panaji, Goa, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5766-74

5766-5774

2188

1332

42.

IN-VITRO EVALUATION OF THE ANTIBACTERIAL POTENTIAL OF POLYHERBAL HAND WASH FORMULATION AGAINST SOME SKIN PATHOGENS

The aim of the present research work was the in-vitro evaluation of the antibacterial potential of polyherbal hand wash formulation against some skin pathogens. Herbal remedies are widely used in healthcare around the World. Herbal medicines have been widely used as effective preventative and treatment options for various ailments. There are a variety of hand washes available in the market many of...

Preeti Chaudhary *, Rupesh Pingale, Purva Batwal, Yogita Ghode, Jayesh Lodha, Vrushabh Ajmera and Monali Phadtare

Department of Pharmacy, NCRD's Sterling Institute of Pharmacy, Nerul, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(10).4187-98

4187-4198

2188

1014

60.

DESIGN AND PHARMACOKINETIC EVALUATION OF IBRUTINIB BY SELF-NANO-EMULSIFYING DRUG DELIVERY SYSTEM

The objective of present research work is design and in-vivo evaluation of ibrutinib self-nanoemulsifying drug delivery system (SNEDDS) for the enhancement of oral bioavailability. Box-Behnken design was used for the study and the results analysed using response surface methodology. Ibrutinib SNEDDS were prepared with various oils, surfactants and co-surfactants and tested particle size, PDI, zeta...

D. Prasad *, G. P. Mohanta and M. Sudhakar

Mallareddy College of Pharmacy, Department of Pharmaceutics, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(10).5254-61

5254-5261

2187

1397

35.

ASSESSMENT OF PRETERM NEONATES’ RESPONSE TO TACTILE AND KINESTHETIC STIMULATION

Objective: To assess the response of Preterm neonates to Tactile and Kinesthetic Stimulation. Methods: The study was conducted in a Neonatal Intensive Care Unit of a tertiary care hospital in India. Twelve stable preterm neonates were selected as per the inclusion and exclusion criteria and randomized into the intervention and control group. Seven days of tactile and kinesthetic stimulation was gi...

J. Umarani *, S. Ramesh, P. Saldanha, R. D. Mendonsa and E. Kayalvizhi

Yenepoya Nursing College, Yenepoya Deemed to be University, Mangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(6).3298-05

3298-3305

2187

1361

6.

LIPID NANOCARRIERS FOR NOSE TO BRAIN DELIVERY: RECENT UPDATES

In recent years, the nasal route is gaining increasing importance for systemic administration of drugs and targeting to brain. The drug delivery to the brain is limited due to several factors, including presence of blood-brain barrier, enzymatic degradation, and efflux of drug by P-glycoprotein. Nasal route is employed to target the brain using various direct pathways via nasal mucosa and to bypas...

S. S. Deshkar *, M. S. Jadhav, S. A. Todmal and S. V. Shirolkar

Department of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5195-07

5195-5207

2187

1221

25.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ARTEMETHER AND LUMEFANTRINE IN BULK AND PHARMACEUTICAL DOSAGE FORM

A simple, sensitive, specific, precise, and accurate stability-indicating reverse phase liquid chromatographic method was developed to simultaneously determine Artemether and Lumefantrine in bulk drugs and pharmaceutical formulations. The chromatographic analysis was performed by Microsorb MV100-5 C-18 column (250 x 4.6mm, 5 µm), with a mobile phase consisting of buffer and acetonitrile in the ra...

Bakhshi Abdul Rahman *, Masood Siddiqui, Patil Shivam Ravindra, Saba Fatema Raheel Ahmed and Rahmani Taskeen Firdaus Aasif Iqbal

Royal College of Pharmaceutical Education and Research, Abdul Muttalib Campus, Malegaon, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(7).2771-81

2771-2781

2186

1358

24.

PHYTOCHEMICAL AND IN-VITRO ASSESSMENT OF ANTIHISTAMINIC AND ANTICHOLINERGIC ACTIVITY OF LEAVES OF HIBISCUS SABDARIFFA LINN.

Objective: The aim of the present study was to find out the herbal drug which has potential antihistaminic properties. Studying the in-vitro antagonistic effect of crude extracts on isolated goat tracheal chain preparation for assessment of direct antihistaminic activity using two agonists like histamine and acetylcholine. Methods: The ethanolic extract of leaves of Hibiscus sabdariffa was found q...

M. R. M. Usman * and M. K. Kachhava

Department of Pharmacognosy, Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.12(8).4275-81

4275-4281

2185

1403

22.

ANTIHYPERGLYCEMIC POTENTIAL OF TEAK SEEDS IN ALLOXAN INDUCED DIABETIC RATS

Tectona grandis is famous as a valuable timber hold an extensive range of applications around the sphere. In addition to its enormous uses in the timber industry, all the parts are cherishing with extensive use in traditional medicine and possess significant pharmacological properties. In search of drugs for diabetes, the methanolic seed extract which is prepared by the Soxhlet apparatus, was used...

G. J. Rani and N. L. Bhavani *

Department of Botany, University College of Science Saifabad, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.11(5).2169-72

2169-2172

2184

1279

60.

AN OBSERVATIONAL STUDY REGARDING PRESCRIPTION EVENT MONITORING OF ANTI-HYPERTENSIVE MEDICATIONS AMONGST PATIENTS COMING TO A TERTIARY CARE CENTRE OF NORTHERN INDIA

Hypertension is now defined on the basis of systolic (SBP) and diastolic (DBP) blood pressure levels and classified into stages on the basis of the degree of elevation. The generally recognized cut point for hypertension is an average office BP of 140/90 mmHg or greater, which has been obtained by a recommended standard technique with an accurate manometer and has been confirmed on at least one ot...

S. Mishra *, N. Nigam, S. S. Ahmad, P. Shankar, S. Kumar, V. Kumar and S. Gupta

Department of Pharmacology, Rama Medical College Hospital & Research Centre, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2405-10

2405-2410

2183

1174