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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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24.

GASTRPROTECTIVE & ANTI-ULCER ACTIVITY OF SACCHARUM OFFICINARUM FRESH JUICE IN CHEMICAL INDUCED ULCER IN ALBINO RATS

Objects: In the present study the anti-ulcer activity of Saccharum officinarum fresh juice was investigated in the chemical-induced ulcer. The efficacy of the plant based juice was compared with standard reference anti-ulcer drug Ranitidine. Methods: The fresh juice collected from the plant of S. officinarum. Firstly, washes the sugarcanes well and peel the outer layer of the cane with a big knife...

R. Singh * and R. Shukla

School of Pharmaceutical Science, Shri Venkateshwara University, Gajraula, Amroha, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.12(3).1546-52

1546-1552

2174

1244

39.

CYTOPROTECTIVE ROLE OF ENCAPSULATED ASTAXANTHIN AGAINST HEPATO-CELLULAR CARCINOMA (HepG2) CELL LINE

Astaxanthin (3,3′-dihydroxy-β, β′-carotene-4,4′-dione) is a xanthophyll carotenoid, which is found in Haematococcus pluvialis, Chlorella zofingiensis, Chlorococcum, and Phaffiarhodozyma. Astaxanthin play major role as a nutritional supplement, antioxidant and anticancer agent, anti-diabetes, cardiovascular diseases, and neurodegenerative disorders. In our previous study, astaxanthin was fi...

V. Suganya and V. Anuradha *

PG and Research Department of Biochemistry, Mohamed Sathak College of Arts & Science, Sholinganallur, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(1).372-84

372-384

2173

1309

39.

FORMULATION DEVELOPMENT OF ORAL FAST-DISSOLVING SUBLINGUAL FILM OF RESVERATROL

This research aimed to develop an inclusion complex of resveratrol (RSV)/hydroxypropyl-β-cyclodextrin (HP-β-CD) using a quality-by-design (QbD) approach to improve the solubility and stability of RSV and formulate it into a fast-dissolving sublingual film (FDSF). The RSV/HP-β-CD inclusion complex was prepared by the kneading method using a Box–Behnken Design to assess the effect of the molar ...

Vaishali Ashish Shirsat *, Anushree Anil Hukeri and Sneha Balu Govind

Department of Pharmaceutical Analysis, Bombay College of Pharmacy, Kalina, Santacruz East, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(5).2447-66

2447-2466

2172

1163

14.

DEVELOPMENT & CHARACTERIZATION OF MOUTH DISSOLVING TABLET OF VOGLIBOSE

The study was aimed at development of voglibose mouth dissolving tablets which can disintegrate or dissolve rapidly once place in the oral cavity. Voglibose is alpha glycosidase inhibitor, drug which is used in a treatment of type 2 diabetes mellitus. The tablets were prepared with different super disintegrant like crospovidone, sodium starch glycolate and lactose at different concentrations. The ...

Jayesh R. Tundlayat *, Abhay Kumar D. Sakhare and Kailash R. Biyani

Department of Pharmaceutics, Anuradha College of Pharmacy, Chikhli, Buldhana, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).3019-25

3019-3025

2172

1056

22.

COMPARATIVE STUDY OF ANTI-ANXIETY AND ANTI-DEPRESSANT POTENTIALS OF LEAVES AND ROOT OF METHANOLIC EXTRACT FROM ACHYRANTHES BIDENTATA BLUME ON MICE

Anxiety and Depression is the most prominent and crippled Neuropsychiatric Disease. World Health Organization (WHO) reported is the most burdensome disease of society. We therefore aimed at evaluating the Anti-Anxiety and Anti-depressant potential using Achyranthes bidentata Blume (Chinese name Huainiuxi). This study compared Leaves and Root part of Achyranthes bidentata methanolic extract (ABME) ...

M. Kumar and G. Thamotharan *

Department of Pharmaceutical Chemistry, Vinayaka Mission’s College of Pharmacy, Salem, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.12(10).5378-87

5378-5387

2170

1160

18.

PAPAIN LIKE PROTEASE: A POTENTIAL TARGET FOR MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS (MERS-COV): THE BATTLE CONTINUES

Middle-East Respiratory Syndrome coronavirus (MERS-CoV) can trigger severe acute pneumonia, renal, digestive failure and even death. Coronaviruses express papain-like proteases (PLpro), multipurpose enzymes which had protease activity and can lacerate nonstructural proteins to manipulate the viral polyprotein responsible for replication. They also have deubiquitinating function, which can modify t...

Neeldeep Ganguly, Swagata Roy and Tamalika Chakraborty *

Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F, Nilgunj Road, Sodepur Panihati, Kolkata, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4476-84

4476-4484

2170

920

61.

GEOGRAPHICAL BASED GENOMIC AND PATHOGENIC STUDY OF THE SARS-COV-2

The current pandemic COVID 19 caused by SARS-CoV-2 is very contagious and causes respiratory disease. Genomic analysis of different strains in SARS-CoV-2 were found to infect different geographical locations of the world (India, USA, and Brazil) and also in different parts of India (Kerala, Surat, and Ahmedabad). These sequences were downloaded from the viral genome sequence database of the Nation...

G. Dhanalakshmi * and Anadi

Department of Biochemistry, Padmashree Institute of Management and Sciences, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2411-16

2411-2416

2169

1022

40.

ROLE OF MRP–1 IN THE REGULATION OF STEROID RESPONSIVENESS IN UNCONTROLLED ASTHMA

Introduction: Inhaled Corticosteroids remain the mainstay therapy for asthma. Uncontrolled asthma (UA) dose not respond to the highest inhaled corticosteroids, which remains a challenge for clinicians. Multidrug resistance-associated protein 1 (MRP-1) are molecular "pumps," which expel toxins and modulate corticosteroids' pharmacokinetics and may lead to UA. Moreover, their role in UA is still not...

R. Mishra, Z. Hashim, A. Nath, H. Singh, V. Agarwal and R. Chaturvedi *

Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6260-66

6260-6266

2167

1102

14.

SCHIFF BASE: A REVIEW OF PHARMACOLOGICAL ACTIVITIES

Schiff bases are generally aldehyde or ketone-like compounds in which an imine or azomethine group replaces the carbonyl group. They are versatile and exhibit a broad range of pharmacological activities as antimicrobial, antibacterial, antifungal, antiviral, and anticonvulsant. Anti-cancer activity has been used widely for industrial purposes or therapeutic use. Thus, Schiff bases are highly desir...

Neelam Singh *, Mojahid Ul Islam and Himanchal Sharma

Department of Pharmacy, IIMT College of Medical Science, Meerut, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).688-95

688-695

2167

2411

7.

BIOSIMILARS: A COMPLETE REVIEW ON MANUFACTURING, FDA APPROVAL, CASE STUDIES

A developing class of medications called biosimilars is created to be used interchangeably with biologics. In living cells, biologics are often large, complicated proteins with a range of potential applications. Biologics are utilised to treat malignancies, endocrine problems, and inflammatory bowel diseases just within the discipline of gastroenterology. Despite the fact that many diseases can be...

Ismail Khalid Hashmi and Maaz Ahmed Shaik *

Sultan-ul-Uloom College of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).2963-72

2963-2972

2167

776