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GASTRPROTECTIVE & ANTI-ULCER ACTIVITY OF SACCHARUM OFFICINARUM FRESH JUICE IN CHEMICAL INDUCED ULCER IN ALBINO RATS
Objects: In the present study the anti-ulcer activity of Saccharum officinarum fresh juice was investigated in the chemical-induced ulcer. The efficacy of the plant based juice was compared with standard reference anti-ulcer drug Ranitidine. Methods: The fresh juice collected from the plant of S. officinarum. Firstly, washes the sugarcanes well and peel the outer layer of the cane with a big knife...
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CYTOPROTECTIVE ROLE OF ENCAPSULATED ASTAXANTHIN AGAINST HEPATO-CELLULAR CARCINOMA (HepG2) CELL LINE
Astaxanthin (3,3′-dihydroxy-β, β′-carotene-4,4′-dione) is a xanthophyll carotenoid, which is found in Haematococcus pluvialis, Chlorella zofingiensis, Chlorococcum, and Phaffiarhodozyma. Astaxanthin play major role as a nutritional supplement, antioxidant and anticancer agent, anti-diabetes, cardiovascular diseases, and neurodegenerative disorders. In our previous study, astaxanthin was fi...
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PAPAIN LIKE PROTEASE: A POTENTIAL TARGET FOR MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS (MERS-COV): THE BATTLE CONTINUES
Middle-East Respiratory Syndrome coronavirus (MERS-CoV) can trigger severe acute pneumonia, renal, digestive failure and even death. Coronaviruses express papain-like proteases (PLpro), multipurpose enzymes which had protease activity and can lacerate nonstructural proteins to manipulate the viral polyprotein responsible for replication. They also have deubiquitinating function, which can modify t...
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FORMULATION DEVELOPMENT OF ORAL FAST-DISSOLVING SUBLINGUAL FILM OF RESVERATROL
This research aimed to develop an inclusion complex of resveratrol (RSV)/hydroxypropyl-β-cyclodextrin (HP-β-CD) using a quality-by-design (QbD) approach to improve the solubility and stability of RSV and formulate it into a fast-dissolving sublingual film (FDSF). The RSV/HP-β-CD inclusion complex was prepared by the kneading method using a Box–Behnken Design to assess the effect of the molar ...
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COMPARATIVE STUDY OF ANTI-ANXIETY AND ANTI-DEPRESSANT POTENTIALS OF LEAVES AND ROOT OF METHANOLIC EXTRACT FROM ACHYRANTHES BIDENTATA BLUME ON MICE
Anxiety and Depression is the most prominent and crippled Neuropsychiatric Disease. World Health Organization (WHO) reported is the most burdensome disease of society. We therefore aimed at evaluating the Anti-Anxiety and Anti-depressant potential using Achyranthes bidentata Blume (Chinese name Huainiuxi). This study compared Leaves and Root part of Achyranthes bidentata methanolic extract (ABME) ...
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GEOGRAPHICAL BASED GENOMIC AND PATHOGENIC STUDY OF THE SARS-COV-2
The current pandemic COVID 19 caused by SARS-CoV-2 is very contagious and causes respiratory disease. Genomic analysis of different strains in SARS-CoV-2 were found to infect different geographical locations of the world (India, USA, and Brazil) and also in different parts of India (Kerala, Surat, and Ahmedabad). These sequences were downloaded from the viral genome sequence database of the Nation...
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ANTIMYCOBACTERIAL SCREENING OF SELECTED MEDICINAL PLANTS USING MTT AND THE MICROPLATE RESAZURIN ASSAY
Tuberculosis holds one of the top places on the list of the main cause of death in India. At times, the patients fail to respond to treatment with anti-Tb drugs, drug resistance being one of the reasons. The increasing incidence of MDR and XDR-TB highlights the urgent need to search for newer anti-Tb drugs. For last many years, plants have beneficial activity in a different types of diseases produ...
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ROLE OF MRP–1 IN THE REGULATION OF STEROID RESPONSIVENESS IN UNCONTROLLED ASTHMA
Introduction: Inhaled Corticosteroids remain the mainstay therapy for asthma. Uncontrolled asthma (UA) dose not respond to the highest inhaled corticosteroids, which remains a challenge for clinicians. Multidrug resistance-associated protein 1 (MRP-1) are molecular "pumps," which expel toxins and modulate corticosteroids' pharmacokinetics and may lead to UA. Moreover, their role in UA is still not...
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FORMULATION AND STATISTICAL OPTIMIZATION OF S-SMEDDS OF NICARDIPINE HYDROCHLORIDE BY USING BBD AND PCA DESIGN
The study purpose is to further enhance the rate of dissolution for poorly water-soluble drug Nicardipine Hydrochloride by dissolving NH in surfactant, Co-surfactant, and oil; phase diagram was plotted by using oil (Capmul MM C8 EP), surfactant (Labrasol), and co-surfactant (PEG 400) through which a region called microemulsifying region was obtain. The batches were optimized by holding a 3-factor ...
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MICROSCOPIC CHARACTERIZATION, TRADITIONAL USES, PHYTOCHEMISTRY AND PHARMACOLOGY OF NYCTANTHES ARBOR-TRISTIS: AN UPDATED SYSTEMATIC REVIEW
Introduction: Being an Oleaceae family member, Nyctanthes arbor-tristis, known as Night jasmine or Harashingar, is a legendary plant with enormous therapeutic potential. Research on the different plant parts, such as the leaf, flower, fruit, seed, and bark revealed the phytochemicals that were responsible for the primary pharmacological activities. These phytochemicals included glucose, oleanic ac...
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