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PROTECTIVE ACTIVITY OF THE METHANOLIC EXTRACT AND ITS SOLVENT FRACTIONS OF THE FRUITS OF SOLANUM NIGRUM (MAKO) ON GENTAMICIN-INDUCED NEPHROTOXICITY IN ALBINO RATS
Objective: Mako (Solanum nigrum L.), Black Nightshade in English, belongs to the family Solanaceae is an edible plant. The whole plant is used as a green source of vegetables and berries as a fruit. It is a good source of antioxidant and has potent anti-inflammatory, diuretic, lithotriptic, wound healing properties. Unani scholars have advocated the berries to treat many renal ailments, including ...
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AN UPDATE ON PHYTOCHEMICALS, NUTRITIONAL COMPOSITION, AND PHARMACOLOGICAL SIGNIFICANCE OF PRUNUS AMYGDALUS BATSCH: A COMPREHENSIVE REVIEW
Prunus amygdalus Batsch (family-Rosaceae), popularly known as Badam, Almond, is the most important familiar nuttree for global nut production that includes apples pears, prunes and raspberries. Almond seed skin is a prominent source of polyphenolic compounds, mainly phenolic acids, bioflavonoids, flavanones, isoflavones, flavonol glycosides and lignans that are reported in a ripened nut. Bioflavon...
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SYNTHESIS AND IN-VIVO ACTIVITY OF SOME ANTIHYPERTENSIVE AGENT BASED ON PYRIDAZINE SCAFFOLD DESIGN
The main objective presents research work to synthesize, characterization, and in-vivo evaluation of Pyridazine derivatives. To study the different synthesized derivatives by using different analytical parameters like IR, Mass, and NMR analysis. And also find out the antihypertensive activity. The studies on the hydralazine group drugs led to the synthesis of many Pyridazine derivatives with a wid...
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MICROSPONGES DRUG DELIVERY SYSTEM
Microsponges are novel drug delivery systems made up of cross-linked spongy, polymeric, porous, spherical microspheres particles which vary in size from 5-300 μm. This delivery system as the advantage of producing controlled release formulations of poorly soluble drugs. It increases drug stability, reduces side effects and modifies drug release profiles making it a versatile drug delivery vehicle...
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CHARACTERIZATION OF NOVEL SOFT ROT CAUSING GRAM-NEGATIVE BACTERIA SJCTSSP01 & ITS MANAGEMENT USING PHYTOEXTRACTS
Aim: The present study focuses on studying the soft rot-causing bacteria in Solanum tuberosum and the activity of phytoextracts against the pathogen to prevent/control this infection. Lantana camara and Clerodendrum infortunatum has been well known for their antibacterial activity and widely used in Ayurveda, these plants were investigated for their antibacterial activity against the isolated path...
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MESENCHYMAL STEM CELLS (MSCS) AS POTENTIAL SOURCES OF TREATMENT OF NEURODEGENERATION DISEASE: A STRATEGIC REVIEW
Mesenchymal Stem Cells are multipotent adult stem cells that are found in tissues of the body, including umbilical lines, bone marrow, fat cells, etc. Mesenchymal stem cells incline to self–restore tissues, such as bone, fat cells, connective tissues, and microglia cells, which are obtained from the mesoderm layer and act as macrophages in the central nervous system. So, MSCs can be used to prom...
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EXCISIONAL NEW ATTACHMENT PROCEDURE
Periodontitis is a complex infectious disease of supporting structures of teeth caused by specific microorganisms or groups of microorganisms. Formation of a new connective tissue attachment and bone deposition are the main goals of periodontal therapy. The excisional new attachment procedure (ENAP) is especially sub-gingival curettage performed with a knife performed by internal bevel incision pe...
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ANTIBACTERIAL POTENTIAL OF PARTIALLY PURIFIED FRACTIONS OF LEAF EXTRACT OF SPONDIAS MOMBIN
This study was conducted to investigate the antibacterial activity and rate of kill of the various partially purified fractions of Spondias mombin’s leaf extract on selected pathogenic bacteria. Fresh leaves of Spondias mombin were air-dried and then ground into fine powder. The powdered leaves of Spondias mombin were extracted using ethanol-water in the ratio 1:1 (v/v). The crude extract was fr...
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COLD-ACTIVE EXO-INULINASE ENZYME: ISOLATION AND SCREENING OF ENDOPHYTIC MICROBES FROM FRUITS
Microbial inulinases have a great potential for industrial use in the production of fructose from inulin. Optimization of the growth parameters of the microbes is essential to obtain inulinase in sufficient quantity. The present work aims to obtain inulinase from different fruits of endophytic bacteria and optimize its growth parameters. In a total of 22 isolates and among them, each one isolates ...
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AN INTELLIGENT DATA ANALYTICS SYSTEM FOR THERAPEUTIC OF ANGINA PECTORIS IN CARDIOVASCULAR DISEASE MANAGEMENT: A MODEL METHODOLOGY
Medical Case taking process in any field of medicine science is considered to be a significant stage for the treatment management of various diseases. Cardio Vascular diseases (CVD) are one of the life-threatening diseases across the globe, and its prognosis entirely depends on the right intuition of the clinicians; cases may account for 31% of deaths worldwide, based on a recent study. Big Data M...
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