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MECHANISM OF ACTION OF A MULTI-HERBAL EXTRACT BLEND (KARALLIEF EASY CLIMB) IN SUPPORTING JOINT HEALTH
Osteoarthritis (OA) commonly affects many joints in the human body, including the knee joints. The knee joint is made up of two parts - the patella-femoral (PF) and tibiofemoral (TF) compartment. Animal models for OA studies are well-established and serve as an important tool for understanding the impact of OA in humans. This study evaluates the anti-OA potential of a multi-herbal extract blend pr...
2203
1206
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF AZELNIDIPINE AND TELMISARTAN IN PHARMACEUTICAL DOSAGE FORM BY QBD APPROACH
“Quality by Design” (QbD) serves as a bridge between industry and drug regulatory authorities to move towards a scientific, risk based holistic and proactive approach for development of pharmaceutical products. So, the present work describes the development of RP-HPLC method for simultaneous estimation of azelnidipine and telmisartan in pharmaceutical dosage form by QbD approach. The Box-Behnk...
2203
1384
FORMULATION AND EVALUATION OF SOLID-SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM OF FAMOTIDINE
The main objective of the study was to formulate and evaluate solid self nano emulsifying drug delivery systems (SNEDDS) of famotidine (BCS class-IV drug), a histamine receptor antagonist used in case of ulcers, Zollinger-ellison syndrome. Liquid SNEDDS was formulated using oils like oleic acid, arachis oil, surfactants like Tween 20, Tween 80, etc., and co-surfactants like Transcutol-P, polyethyl...
2202
1393
DEVELOPMENT OF HERBAL NANO EXTERNAL FORMULATION AS OINTMENT WITH URENA LOBATA EXTRACT AND VALIDATION OF ITS WOUND HEALING ACTIVITY IN EXPERIMENTALLY INDUCED OPEN WOUNDS IN SWISS ALBINO RATS
Urena lobata is used by traditional practitioners for treating external wounds. A preclinical study was conducted to evaluate the efficacy of the ointment formulations containing ethanolic extract of Urena lobata (EO) (5%) and nanosized extract (NO) of U. lobata (5%) for their wound healing activity by assessing wound contraction, tensile strength, superoxide dismutase, catalase, reduced glutathio...
2201
1060
HERBAL INTERVENTIONS FOR DERMATOLOGICAL DISORDERS
Herbal medicines have gained recognition for their potential in treating various skin disorders, driven by both traditional practices and modern scientific research. The efficacy of these natural remedies can be attributed to their diverse chemical compositions, which often include bioactive compounds with antimicrobial, anti-inflammatory, and antioxidant properties. The skin is the body's largest...
2201
955
A COMPARATIVE STUDY ON PROXIMATE AND MINERAL COMPOSITION OF UNPROCESSED AND PROCESSED UNDERUTILIZED JERUSALEM ARTICHOKE TUBER FLOUR
Jerusalem artichoke is one of the underutilized tuber crops distributed worldwide in temperate areas. It is considered healthy and functional food due to its chemical composition as it contains proteins, mono or poly-unsaturated fatty acids, dietary fibers, vitamins, and minerals. In this present research work, the effect of processing on the proximate and mineral composition of Jerusalem artichok...
2201
1232
FORMULATION AND IN-VIVO EVALUATION OF MESALAMINE MICROSPONGES FOR COLON TARGETING
The present study aims to develop and characterize colon-targeted mesalamine microsponges for treating inflammatory bowel disease, requiring long-term therapy. Mesalamine microsponges were prepared with different ratios of eudragit S100, by quasi-emulsion solvent diffusion method and evaluated. The drug release from in-vitro dissolution for all the prepared microsponges was extended to 12 hrs and ...
2199
1189
AN AMALGAMATION OF SGLT-2 AND DPP-4 INHIBITORS: A PLAUSIBLE NOVEL TREATMENT FOR DIABETES MELLITUS
Diabetes Mellitus is characterized as metabolic chronic disease spreading all over the world ata high pace. Due to its speedily wide population spreading it is termed as 3rd most populated country in the world since the number of individuals diagnosed with diabetes is just behind population of China and India. To date treatment therapy concerning diabetes majorly responds to insulin-dependent mech...
2199
1836
COMPARATIVE STUDY OF ANTI-ANXIETY AND ANTI-DEPRESSANT POTENTIALS OF LEAVES AND ROOT OF METHANOLIC EXTRACT FROM ACHYRANTHES BIDENTATA BLUME ON MICE
Anxiety and Depression is the most prominent and crippled Neuropsychiatric Disease. World Health Organization (WHO) reported is the most burdensome disease of society. We therefore aimed at evaluating the Anti-Anxiety and Anti-depressant potential using Achyranthes bidentata Blume (Chinese name Huainiuxi). This study compared Leaves and Root part of Achyranthes bidentata methanolic extract (ABME) ...
2198
1188
THERAPEUTIC RELEVANCE OF AEGLE MARMELOS: A REVIEW
Aegle marmelos, commonly known as Bael or Bilva, is a traditional tree belonging to the family Rutaceae with enormous value in ethnobotany, Ayurveda, and has been used since time immemorial for its spiritual significance as an offering to Lord Shiva while worshipping. Looking at its religious perspective and medicinal benefits, people have conserved trees of Bael in sacred groves. It is a sub-trop...
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