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VALIDATED RP-HPLC STABILITY-INDICATING METHOD OF ANTICOAGULANT ACTIVE PHARMACEUTICAL INGREDIENT; APIXABAN
A simple and precise stability-indicating reversed-phase (RP-HPLC) method was developed and validated for the determination of Apixaban active pharmaceutical ingredient. The chromatographic condition was carried out on Phenomenex Luna 5 µm C18 100 Å (150 × 4.6 mm) HPLC column with prepared buffer solution 1.0 ml of Orthophosphoric acid mixed with 0.2% of potassium dihydrogen phosphate solution,...
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DESIGN AND EVALUATION OF MUCOADHESIVE BUCCAL PATCHES OF SALBUTAMOL SULPHATE BY USING HUPU GUM AND LANNEA GUM
The purpose of the present investigation is to evaluate the applicability of hupu gum and lannea gum in the design of buccoadhesive patches for extended-release over a period of 6 hours, using Salbutamol sulphate as a model drug. The efficiency of these polymers was compared with already established synthetic polymer PEO coagulant. The patches were prepared by using the solvent casting method in w...
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DRUG UTILISATION STUDY OF ANTI-EPILEPTIC DRUGS IN PEDIATRIC PATIENTS IN A TERTIARY CARE HOSPITAL
Few studies are available to study the drug utilization pattern and adverse drug reactions of anti-epileptic drugs (AEDs) in paediatric population. Hence, this study was planned with the primary objective of studying the drug utilization pattern of anti-epileptic drugs in a tertiary care centre pediatric population. The secondary objective was to assess adverse drug reactions in the same populatio...
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ESTABLISHMENT OF QUALITY STANDARDS FOR SHYONAK: AN IMPORTANT INGREDIENT OF THE DASHMOOLA GROUP OF DRUGS
Shyonak is botanically equated to Oroxylum indicum (L.) Kurz. of family Bignoniaceae. It is extensively used in the Indian system of medicine as an important ingredient of ‘Dashmoola and also one of the important constituents of a reputed Ayurvedic formulation ‘Chyavanprash’. The drug consists of root bark of Oroxylum indicum (L.) Kurz. Ayurvedic Pharmacopoeia of India (API) advocates that t...
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HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF CAYRATIA PEDATA VAR. GLABRA AGAINST PARACETAMOL-INDUCED LIVER DAMAGE IN ALBINO RATS
The present pharmacological examination was purely focused on the assessment of the efficacy of ethanolic extract of C. pedata var. glabra for their protection against Paracetamol overdose-induced hepatotoxicity arbitrate with their phytoconstituents and also observe whether synergistic hepato-protection exists with Silymarin. For animal studies, the Albino rats (150–200 g) were divided into six...
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STATISTICAL ANALYSIS ON EFFECT OF SITAGLIPTIN AND GLIMEPIRIDE ON PANCREATIC BETA-CELLS DURING THE TREATMENT OF TYPE-2 DIABETIC MELLITUS
The study aimed to analyze the treatment of Sitagliptin with Glimepiride to improve pancreatic beta-cells in T2DM patients. Beta cells are a type of cell found in the pancreatic islet and also synthesize, secrete insulin and amylin. Sitagliptin is found to be maintaining the beta-cells function and glycemic control in T2DM patients. Randomly diabetes mellitus type-2 (T2DM) patients’ data is coll...
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SYNTHESIS AND IN-VIVO ACTIVITY OF SOME ANTIHYPERTENSIVE AGENT BASED ON PYRIDAZINE SCAFFOLD DESIGN
The main objective presents research work to synthesize, characterization, and in-vivo evaluation of Pyridazine derivatives. To study the different synthesized derivatives by using different analytical parameters like IR, Mass, and NMR analysis. And also find out the antihypertensive activity. The studies on the hydralazine group drugs led to the synthesis of many Pyridazine derivatives with a wid...
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ANTIBACTERIAL POTENTIAL OF PARTIALLY PURIFIED FRACTIONS OF LEAF EXTRACT OF SPONDIAS MOMBIN
This study was conducted to investigate the antibacterial activity and rate of kill of the various partially purified fractions of Spondias mombin’s leaf extract on selected pathogenic bacteria. Fresh leaves of Spondias mombin were air-dried and then ground into fine powder. The powdered leaves of Spondias mombin were extracted using ethanol-water in the ratio 1:1 (v/v). The crude extract was fr...
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DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF OLANZAPINE AND FLUOXETINE FROM BULK AND TABLET DOSAGE FORM BY Q-ABSORBANCE RATIO METHOD
Depression is a common mental disorder that presents with depressed mood, loss of interest or pleasure, decreased energy, feelings of guilt or low self-worth, disturbed sleep or appetite and poor concentration with anxiety. Olanzapine is a second-generation antipsychotic (SGA) or atypical antipsychotic. It has attracted considerable interests due to its wide range of therapeutic and pharmacologica...
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PREVALENCE AND KNOWLEDGE ABOUT OVER THE COUNTER (OTC) MEDICINE USE AMONG PREGNANT WOMEN IN THE ASIR REGION OF SAUDI ARABIA
Self-medication with OTC drugs is observed in many countries and deserves due concern as it may adversely affect maternal and fetal health. This practice may have an association with socio-demographic factors and knowledge about OTC medicine. A descriptive study was done using a questionnaire that collects information on socio-demographic status, prevalence and knowledge of OTC medicine use among ...
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