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A REVIEW ON SUSCEPTIBILITY OF HYPERTENSIVE PATIENTS TOWARDS COVID-19: LIFESTYLE MODIFICATION FOR BETTERMENT AND CONTROL
Hypertension is a major global health challenge due to its prevalence and increased risk of cardiovascular disorder. Non-pharmacological intervention or lifestyle modification is a safer option to control blood pressure and shows effective results in regulating high blood pressure. In this review, we have described the pathophysiology of a hypertensive patient infected with severe acute respirator...
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ROLE OF MRP–1 IN THE REGULATION OF STEROID RESPONSIVENESS IN UNCONTROLLED ASTHMA
Introduction: Inhaled Corticosteroids remain the mainstay therapy for asthma. Uncontrolled asthma (UA) dose not respond to the highest inhaled corticosteroids, which remains a challenge for clinicians. Multidrug resistance-associated protein 1 (MRP-1) are molecular "pumps," which expel toxins and modulate corticosteroids' pharmacokinetics and may lead to UA. Moreover, their role in UA is still not...
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ESTIMATION OF DACLATASVIR IN PHARMACEUTICAL DOSAGE FORM BY ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY
Daclatasvir is an antiviral drug used in combination with other drugs includes sofosbuvir, ribavirin, and interferon, depending on the virus type to treat cirrhosis caused by hepatitis C (HCV). Several methods have been found for quantification, but those are not cost-effective, and they are time-consuming. The present study developed a simple, precise, accurate and cost-effective UPLC method to d...
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MICRONEEDLES: AN EMERGING TECHNOLOGY FOR THE EFFECTIVE TRANSDERMAL DRUG DELIVERY
Topical drug delivery is the conventional route of drug administration to the surface of the skin. Barrier present in the various layers of skin hinders the permeability of drug molecules, specifically large size of drug substance into the systemic circulation. A small-sized needle in micron range is found to be a promising approach to penetrate the uppermost layer of the skin i.e., epidermis to t...
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SCHIFF BASE: A REVIEW OF PHARMACOLOGICAL ACTIVITIES
Schiff bases are generally aldehyde or ketone-like compounds in which an imine or azomethine group replaces the carbonyl group. They are versatile and exhibit a broad range of pharmacological activities as antimicrobial, antibacterial, antifungal, antiviral, and anticonvulsant. Anti-cancer activity has been used widely for industrial purposes or therapeutic use. Thus, Schiff bases are highly desir...
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AN AMALGAMATION OF SGLT-2 AND DPP-4 INHIBITORS: A PLAUSIBLE NOVEL TREATMENT FOR DIABETES MELLITUS
Diabetes Mellitus is characterized as metabolic chronic disease spreading all over the world ata high pace. Due to its speedily wide population spreading it is termed as 3rd most populated country in the world since the number of individuals diagnosed with diabetes is just behind population of China and India. To date treatment therapy concerning diabetes majorly responds to insulin-dependent mech...
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3D-QSAR STUDY OF BENZOTHIAZOLE DERIVATIVES AS p56lck INHIBITORS
3D-QSAR models of Comparative of Molecular Field Analysis (CoMFA) and Comparative of Molecular Similarity Indices Analysis (CoMSIA) of 44 potent p56lck inhibitors were performed. The conventional ligand-based 3D-QSAR studies were performed for a series of Benzothiazole derivatives as p56lck inhibitors. The model gave q2 values of 0.710 and 0.642, r2 values of 0.966 and 0.956 for CoMFA and CoMSIA, ...
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ISOLATION, CHARACTERIZATION AND EVALUATION OF ANTI-ULCER ACTIVITY OF PHYTOCONSTITUENTS PRESENT IN MORINGA OLEIFERA LEAF
Moringa oleifera leaf is widely used in the traditional medicine system and also used as a food by different communities and local tribes of Assam in India. Moringa oleifera leaf contains various bioactive compounds such as alkaloids, flavonoids, rutin, steroids, etc. The flavonoids quercetin act as an anti-ulcer agent, and rutin have a gastro cytoprotective effect i.e., present in M. oleifera lea...
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FORMULATION AND EVALUATION OF VERNONIA ELAEAGNIFOLIA PHYTO-FORMULATION FOR THE MANAGEMENT OF HYPERLIPIDAEMIA
The aim of the present investigation was to formulate and evaluate phytoformulation prepared from the ethanolic extract of Vernonia elaeagnifolia. Vernonia elaeagnifolia whole plant was collected and extracted with ethanol by soxhlation. Dried ethanolic extract of Vernonia elaeagnifolia was used to formulate the nanosuspension by homogenization method to enhance the bioavailability of phytoconstit...
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A COMPARATIVE STUDY ON PROXIMATE AND MINERAL COMPOSITION OF UNPROCESSED AND PROCESSED UNDERUTILIZED JERUSALEM ARTICHOKE TUBER FLOUR
Jerusalem artichoke is one of the underutilized tuber crops distributed worldwide in temperate areas. It is considered healthy and functional food due to its chemical composition as it contains proteins, mono or poly-unsaturated fatty acids, dietary fibers, vitamins, and minerals. In this present research work, the effect of processing on the proximate and mineral composition of Jerusalem artichok...
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