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POLYPHENOLS AS ADJUVANT IN TOSSING OUT ACNE VULGARIS (PUSTULES): A NOVEL FORMULATION STRATEGY
Acne vulgaris is a skin condition in which people lose their self-esteem and ultimately lead to depression. It is more common among the adolescent age groups. According to GBD (Global burden of disease) study, about 85% of the populations are being affected. Various medications are available for the treatment, but, its uses are limited due to side effects like skin irritation. In our study, we hav...
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ROLE OF MRP–1 IN THE REGULATION OF STEROID RESPONSIVENESS IN UNCONTROLLED ASTHMA
Introduction: Inhaled Corticosteroids remain the mainstay therapy for asthma. Uncontrolled asthma (UA) dose not respond to the highest inhaled corticosteroids, which remains a challenge for clinicians. Multidrug resistance-associated protein 1 (MRP-1) are molecular "pumps," which expel toxins and modulate corticosteroids' pharmacokinetics and may lead to UA. Moreover, their role in UA is still not...
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EVALUATION OF ANTIDIABETIC ACTIVITY OF ECHINOCHLOA COLONA PLANT EXTRACT
The current work comprises the assessment of antidiabetic activity of chloroform, ethyl acetate, and ethanol fractions and isolation of some phytoconstituents from chloroform fraction obtained from ethanolic extract of Echinochloa colona. The antidiabetic activity was performed using streptozocin induced diabetic model in male Wistar rats (150-200 g). The best restraint results were for metformin,...
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THERAPEUTIC RELEVANCE OF AEGLE MARMELOS: A REVIEW
Aegle marmelos, commonly known as Bael or Bilva, is a traditional tree belonging to the family Rutaceae with enormous value in ethnobotany, Ayurveda, and has been used since time immemorial for its spiritual significance as an offering to Lord Shiva while worshipping. Looking at its religious perspective and medicinal benefits, people have conserved trees of Bael in sacred groves. It is a sub-trop...
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A REVIEW OF THE ANALYTICAL METHODS FOR THE DETERMINATION OF FAVIPIRAVIR
Favipiravir is, an antiviral agent, used to treat diseases caused by RNA viruses like Ebola virus, SARS-CoV-2, Influenza virus, Polio measles etc. The prodrug Favipiravir enters the infected cells through endocytosis and undergo metabolism to become an active drug. An active form of Favipiravir selectively targets the catalytic domain of RNA-dependent RNA polymerase and then interrupts the nucleot...
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SYNERGISTIC CONVERGENCE: EXPLORING COMBINATIONS OF DIVERSE PHYSIOLOGICAL ACTIVITIES – A REVIEW
The development of effective therapeutic strategies for various remedial conditions often involves the exploration of synergistic interaction between two pharmacophores. The most frequent methods for multidrug therapy combining two or more active ingredients into a single, and creating hybrid molecular entities that can modulate numerous targets interaction gives a synergistic effect. As a result,...
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FORMULATION AND EVALUATION OF VERNONIA ELAEAGNIFOLIA PHYTO-FORMULATION FOR THE MANAGEMENT OF HYPERLIPIDAEMIA
The aim of the present investigation was to formulate and evaluate phytoformulation prepared from the ethanolic extract of Vernonia elaeagnifolia. Vernonia elaeagnifolia whole plant was collected and extracted with ethanol by soxhlation. Dried ethanolic extract of Vernonia elaeagnifolia was used to formulate the nanosuspension by homogenization method to enhance the bioavailability of phytoconstit...
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ANDROGRAPHOLIDE AND HESPERIDIN – A BRIEF OVERVIEW
Andrographolide is a labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata Nees (Acanthaceae). Andrographolide is isolated by various processes and the simple method is the maceration process. It is bitter in taste and used as hepatoprotective, cholinergic, antispasmodic, stomachic, anthelmentic, alterative, blood purifier, and febrifuge. It promotes the secretion of bi...
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DoE ASSISTED UV-VISIBLE SPECTROPHOTOMETRIC METHOD DEVELOPMENT FOR CRITICAL FACTOR ESTIMATION INVOLVED IN NORFLOXACIN DEGRADATION
Degradation studies are essential to determine the inference of degradation routes and stability of pharmaceuticals at different stress conditions. Norfloxacin is an extensively used antibiotics; hence, it is also commonly found in wastewater effluent. For proper risk assessment of norfloxacin and for better understanding of the factors involved in its environmental fate, different factors were st...
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TO COMPARE THE EFFECTS OF DEXMEDETOMIDINE (WITHOUT BOLUS DOSE) AND PROPOFOL (SEDATIVE DOSE) ON ATTENUATION OF HEMODYNAMIC CHANGES DURING LAPAROSCOPIC SURGERIES
Introduction: Laparoscopic surgery is one of the most important diagnostic and therapeutic tools in the present surgical era. Laparoscopic surgeries require insufflation of the abdomen with some gas; usually, Carbon Dioxide is called pneumoperitonium, which induces pathophysiologic changes that complicate anesthetic management. To prevent and counteract these effects, appropriate monitoring and ph...
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