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EPLONTERSEN: A NEW HOPE FOR CARDIAC COMPLICATIONS IN ATTR POLYNEUROPATHY
Transthyretin is essential for transporting retinol and thyroxine, produced mainly in the liver. TTR amyloidosis occurs when misfolded TTR aggregates form amyloid fibrils, leading to organ dysfunction. FAP (Familial amyloid polyneuropathy linked to mutations like the V30M variant, causes progressive sensory and autonomic neuropathy with a poor prognosis if untreated. TTR-related cardiomyopathy inv...
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DESIGN AND CHARACTERIZATION OF TASTE MASKED DEXTROMETHORPHAN HBR ORAL DISINTEGRATING TABLET BY USING NATURAL SUPERDISINTEGRANTS
Objective: Our work was to develop an ordispersible tablet of Dextromethorphan HBr with acceptable palatability to help patients of all age groups. Methods: The bitter taste of the drug was masked by entrapping the drug into Eudragit RL 100. The microspheres were prepared from solvent evaporation method. The effect of particle size, drug entrapment efficiency, % yield and % drug release of the mic...
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RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF AZELNIDIPINE AND TELMISARTAN IN PHARMACEUTICAL DOSAGE FORM BY QBD APPROACH
“Quality by Design” (QbD) serves as a bridge between industry and drug regulatory authorities to move towards a scientific, risk based holistic and proactive approach for development of pharmaceutical products. So, the present work describes the development of RP-HPLC method for simultaneous estimation of azelnidipine and telmisartan in pharmaceutical dosage form by QbD approach. The Box-Behnk...
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FORMULATION OF CINNAMOMUM ZEYLANICUM IMMEDIATE RELEASE TABLETS AS AN ANTHELMINTIC
Globally, a vast number of people are affected by helminth parasites. The emergence of anthelmintic resistance has paved the way for new leads into potential anthelmintic agents, which may be alternatives to already existing ones. The mode of presentation of herbal medicines affects patient compliance. Traditionally, Cinnamomum zeylanicum is used in the management of helminth infestations. This st...
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ADSORPTION KINETICS OF THE REMOVAL OF CIPROFLOXACIN FROM PHARMACEUTICAL WASTEWATER BY SURFACTANT MODIFIED KAOLINITE
In recent years, the extensive use of antibiotics has resulted in their frequent detection in the effluent discharge of wastewater discharge plants (WWTPs). In this study, the feasibility of using Surfactant-Modified Kaolinite (SMK) to remove the antibiotic, Ciprofloxacin (CIP) from wastewater was evaluated from batch experiments. The batch adsorption system was utilized to evaluate the CIP remova...
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A REVIEW OF THE ANALYTICAL METHODS FOR THE DETERMINATION OF FAVIPIRAVIR
Favipiravir is, an antiviral agent, used to treat diseases caused by RNA viruses like Ebola virus, SARS-CoV-2, Influenza virus, Polio measles etc. The prodrug Favipiravir enters the infected cells through endocytosis and undergo metabolism to become an active drug. An active form of Favipiravir selectively targets the catalytic domain of RNA-dependent RNA polymerase and then interrupts the nucleot...
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FORMULATION AND DEVELOPMENT OF HYDROGEL CONTAINING TRIAMCINOLONE ACETONIDE LOADED NANOSPONGES
The ideal of the exploration is to formulate hydrogel containing nanosponges of Triamcinolone acetonide for the treatment of Psoriasis. Psoriasis is presently treated with a numerous of topical and systemic remedies. Numerous of these treatments, still, are costly and involve adverse effects, similar as immunosuppression. As a result, there is a need to develop curatives that are effective, have l...
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METHOD DEVELOPMENT AND VALIDATION OF DISSOLUTION METHOD FOR SITAGLIPTIN TABLETS BY UPLC
A fast, efficient and defined method was developed for the real-time assessment of Sitagliptin in tablet dosage form. Dissolution method was developed and carried out to predict in-vivo drug release profiles of Sitagliptin tablets. Rate and extent of dissolution of Sitagliptin tablets was studied in different dissolution medias i.e. 0.1 N HCL, pH 4.0 Acetate buffer and pH 6.8 Phosphate buffer usin...
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CARDIOPROTECTIVE ROLE OF AMLODIPINE UNDER ACUTE HYPOBARIC HYPOXIA: ROLE OF AKT-1 IN REDOX BALANCE
Hypobaric hypoxia induced systolic heart dysfunction and arrhythmia is prevalent in ascendants. L-type calcium channel blocker amlodipine plays important role in modulating cardiac function. We tested if amlodipine could impart cardio protection and restore oxidative balance under hypobaric hypoxia, by modulating HIF-1α activity and calcium accumulation, thus, protects from cardio-toxicity. Exper...
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IN-SILICO MODELING AND VALIDATION OF L-GLUTAMINASE ENZYME, AN ANTICANCER DRUG USING WEB-BASED COMPUTATIONAL TOOLS
The L-Glutaminase enzyme is a therapeutic agent that can be employed for the treatment of human cancer, specifically lymphocytic leukemia. Microbes are exploited commercially to produce L-Glutaminase on a large scale. The L-Glutaminase is an economic anti-cancer drug and can be easily administered into patients. The L-Glutaminase is also employed in food industries in the processing of fermented f...
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