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CARDIOPROTECTIVE ROLE OF AMLODIPINE UNDER ACUTE HYPOBARIC HYPOXIA: ROLE OF AKT-1 IN REDOX BALANCE
Hypobaric hypoxia induced systolic heart dysfunction and arrhythmia is prevalent in ascendants. L-type calcium channel blocker amlodipine plays important role in modulating cardiac function. We tested if amlodipine could impart cardio protection and restore oxidative balance under hypobaric hypoxia, by modulating HIF-1α activity and calcium accumulation, thus, protects from cardio-toxicity. Exper...
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FORMULATION, OPTIMIZATION AND EVALUATION OF RESVERATROL LOADED NANOEMULSION USING RESPONSE SURFACE METHODOLOGY
Phytochemicals are intensively addressed for clinical uses, and nanostructured phytochemical delivery vehicles are on the limelight. A viable potential treatment for neurological disorders is resveratrol. In the current investigation, we sought to create a nanoemulsion containing resveratrol utilising the response surface methodology. Using Neem oil, Pluronic-f 68, and Tween 80, the effects of the...
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IN-SILICO MODELING AND VALIDATION OF L-GLUTAMINASE ENZYME, AN ANTICANCER DRUG USING WEB-BASED COMPUTATIONAL TOOLS
The L-Glutaminase enzyme is a therapeutic agent that can be employed for the treatment of human cancer, specifically lymphocytic leukemia. Microbes are exploited commercially to produce L-Glutaminase on a large scale. The L-Glutaminase is an economic anti-cancer drug and can be easily administered into patients. The L-Glutaminase is also employed in food industries in the processing of fermented f...
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THERAPEUTIC RELEVANCE OF AEGLE MARMELOS: A REVIEW
Aegle marmelos, commonly known as Bael or Bilva, is a traditional tree belonging to the family Rutaceae with enormous value in ethnobotany, Ayurveda, and has been used since time immemorial for its spiritual significance as an offering to Lord Shiva while worshipping. Looking at its religious perspective and medicinal benefits, people have conserved trees of Bael in sacred groves. It is a sub-trop...
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ASSESSMENT OF THE AWARENESS LEVELS TOWARDS VITAMIN D CHECK, MEDICATION AND RELATED DISORDERS
Background: Vitamin D deficiency and its associated disorders are prevalent in Saudi Arabia. This study aimed to assess the awareness levels towards vitamin D, check, medication, and related disorders. Methodology: In this cross-sectional study, a total of 500 Saudi volunteers living in the city of Hail (A region in Northern Saudi Arabia) and surrounding towns were included during the period from ...
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MUCOADHESIVE BIO-FLEXY FILM OF PHOENIX DACTYLIFERA LOADED WITH PHENYTOIN FOR TRANSLABIAL DRUG DELIVERY
Translabial drug delivery system is an attractive approach for drug delivery system possess advantages as a bypass of the first-pass metabolism, prevent from digestive enzymes and rapid action of suitable drugs. The purpose of the current research work is to isolate the biopolymer from Phoenix dactylifera (date palm) and prepare mucoadhesive bio-flexy films loaded with Phenytoin. The isolated biop...
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AMELIORATIVE ROLE OF SELENIUM AND ZINC AGAINST REPRODUCTIVE TOXICITY DUE TO EXPOSURE TO A MIXTURE OF HEAVY METALS LEAD, CADMIUM AND ARSENIC IN MALE ALBINO RATS
Introduction: Reproductive organs are the major target of heavy metal toxicity; oxidative stress plays a vital role in induction of such toxicity. Toxicity due to chronic exposure to a low dose mixture of three heavy metal lead (Pb), cadmium (Cd) and arsenic (As) and ameliorative potentials of two antioxidant micronutrients selenium (Se) and zinc (Zn) were evaluated in male albino rats. Materials ...
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A STUDY ON EFFECT OF THERMAL SINTERING ON GASTRIC FLOATING TABLETS
The purpose of this study was to develop a gastroretentive controlled release drug delivery system using sintering for enhanced oral bioavailability using carnauba wax polymer. Formulations (CC1-CC3) were prepared by wet granulation method and then exposed to sintering temperature at different time intervals. The optimized formula showed zero-order drug release kinetics for the period of 12 h. The...
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PHARMACOGNOSTICAL EVALUATION OF TERMINALIA CHEBULA FRUIT EXTRACT AGAINST RESPIRATORY TRACT INFECTIOUS PATHOGENS
To evaluate the antibacterial activity of methanolic extract of Terminalia chebula, commonly called Haritaki was tested against respiratory tract infection-causing bacteria. The antibacterial activities were assessed by agar well diffusion, broth dilution and time-kill methods. It showed the best antibacterial activity against Klebsiella pneumoniae among the tested respiratory infection-causing ba...
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DESIGN AND IN-VITRO CHARACTERIZATION OF CHLORDIAZEPOXIDE EFFERVESCENT FLOATING TABLETS
Chlordiazepoxide is a sedative and hypnotic medication which is used to treat anxiety, insomnia, and withdrawal symptoms from alcohol and/or drug abuse. Chlordiazepoxide has a medium to the long half-life, but its metabolite is pharmacologically active and has a very long half-life. In the present work, an attempt has been made to develop effervescent floating tablets of Chlordiazepoxide. Methocel...
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