Most Popular
ABELMOSCHUS ESCULENTUS L. MITIGATES NAFLD PATHOLOGIC PHENOTYPES IN C57BL/6J MOUSE MODEL
Purpose: Lifestyle modification is recommended as a primary strategy for the management of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Recently, metabolic regulations of diets containing parts of Abelmoschus esculentus (okra) were investigated using the NAFLD mouse model. Methods: Five groups of C57BL/6J mice (n = 6) were arranged. Each received a distinct d...
2125
894
A REVIEW ON HUMAN IMMUNODEFICIENCY VIRUS INFECTION AND RETROVIRUSES
Human Immunodeficiency Virus or HIV is generally known, is a unique type of virus (retrovirus). HIV is a slow virus that causes acquired immunodeficiency syndrome, a human condition in which the progressive failure of the immune system allows opportunistic infections and life-threatening cancers to spread. Retroviruses are a single positive susceptible RNA virus with a DNA mediator and binding par...
2125
1148
FORMULATION AND EVALUATION OF SUSTAINED-RELEASE TABLET HAVING GENISTEIN
Genistein is phytoestrogens that function on estrogen receptors through a receptor-dependent mechanism. Genistein is commonly used to alleviate menopause symptoms, lower breast cancer risk, protect against prostate problems, improve bone health and lower the risk of heart disease. This research aims to create Genistein oral tablets with a long release time. In a rotary tableting machine, tablets w...
2125
1095
ROLE OF DEOXYCHOLIC ACID IN MODULATING HUMORAL AND CELL MEDIATED IMMUNE SYSTEM
Deoxycholic acid (DCA) is a secondary bile salt that is a major active constituent of Chinese traditional medicine, “Niuhuang” which is known to have immunoregulatory and anti-inflammatory properties. Although data from the literature indicate possible immunomodulatory effects of Deoxycholic acid on the immune system, little has been reported regarding the mode of activity of DCA in modulating...
2125
1166
MOLECULAR MODELLING OF HIV-1 DRUG RESISTANT MUTANTS WITH REFERENCE TO WILD TYPE
Drug resistance mutations M184V and M184I are associated with lamivudine. Y181C and H221Y drug resistance mutations are associated with nevirapine and efavirenz and G190R and M230I drug resistance mutations are associated with efavirenz in the reverse transcriptase gene of HIV-1. In the present study, we attempted to identify the drug resistance mutations and interacting amino acids in the reverse...
2124
1178
SYNTHESIS AND 2D-QSAR STUDY OF SOME NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTITUBERCULAR AGENTS
In the present work, a series of some novel substituted benzimidazole derivatives were efficiently synthesized, and a thin layer chromatography study confirmed the completion of the reaction on silica gel-G plates. The characterization was done through recording spectra of FTIR using Jasco FTIR-460 plus spectrophotometer, recording spectra of 1HNMR with the help of spectrometer, specifically BRUKE...
2124
1064
MOLECULAR DOCKING IS AN IDEAL TOOL IN PHARMACEUTICAL DRUG DEVELOPMENT OF ANTI-TUBERCULOSIS MOLECULES
Advancements in X-ray crystallography, Nuclear magnetic resonance (NMR) spectroscopy, and innovation projects like the human genome project left gigantic amounts of biological information accessible to the common public, academicians, and industries. Computer-Aided Drug Design (CADD), such as molecular docking, is an ideal method to exploit this biological information in rapid drug development and...
2124
1520
SYNERGISTIC CONVERGENCE: EXPLORING COMBINATIONS OF DIVERSE PHYSIOLOGICAL ACTIVITIES – A REVIEW
The development of effective therapeutic strategies for various remedial conditions often involves the exploration of synergistic interaction between two pharmacophores. The most frequent methods for multidrug therapy combining two or more active ingredients into a single, and creating hybrid molecular entities that can modulate numerous targets interaction gives a synergistic effect. As a result,...
2124
1550
DEVELOPMENT AND EVALUATION OF CYCLODEXTRIN BASED NANOSPONGE LOADED TAZORETENE GEL
The objective of the present study was to develop cyclodextrin-based nanosponge based topical gel of tazoretene using cross-linker diphenylcarbonate and Carbopol® Ultrez 10 NF polymer. The β-Cyclodextrin nanosponges were prepared using various concentrations of β-Cyclodextrin and diphenyl carbonate and characterized. Based on evaluation parameters the β-Cyclodextrin nanosponges formulations (N...
2123
1490
RECUPERATION OF DIABETES INDUCED OXIDATIVE DAMAGE IN LIVER BY TREATMENT WITH CURCUMIN IN STZ INDUCED DIABETIC RATS
The aim of the present study was to investigate the effect of Curcumin on blood glucose levels, body weight changes, and oxidative stress markers in the diabetic rat liver. Diabetes exacerbates hepatic injury induced by hyperglycemia mediated oxidative stress. A marked decrease in the blood glucose levels, body weight changes and anti-oxidant marker enzymes, superoxide dismutase (SOD), catalase (C...
2123
1140