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DEVELOPMENT OF STABILITY-INDICATING UPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF TIPIRACIL ANDTRIFLURIDINE IN FORMULATION
Aim of the present research work was to develop a sensitive, precise, and robust stability-indicating UPLC method for the simultaneous estimation of tipiracil and trifluridine in formulations. The chromatographic separation of a mixture of tipiracil and trifluridine was attained in isocratic method utilizing a mobile phase of 0.1% orthophosphoric acid: acetonitrile in the proportion of 50:50% v/v ...
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EVALUATION OF TOTAL POLYPHENOLIC CONTENT AND FREE RADICAL SCAVENGING ACTIVITY OF ETHANOLIC AND AQUEOUS EXTRACTS OF CORDIA OBLIQUA FRUITS
The present study was carried out to investigate the phytochemicals, Total polyphenolic content and In-vitro antioxidant activity of ethanolic and aqueous extracts of Cordia obliqua fruits. Objective: To determine the primary and secondary metabolites present in different extracts, to aces the quantity of phenolic compounds by total phenolic content and to evaluate the % inhibition of free radical...
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NICKEL OXIDE NANOPARTICLES SYNTHESIS BY CHEMICAL REDUCTION TECHNIQUE AND IT’S APPLICATION AS ANTIMICROBIAL AND DYE DEGRADING AGENT
Nanoparticles are fascinating materials that find many applications in basic and applied research. The chemical reduction technique is one of the easiest methods for synthesizing Nickel Oxide Nanoparticles (NiO NPs) in low-temperature ranges. Nickel Nitrate Hexahydrate (Ni(NO3)2.6H2O), Ascorbic acid, NaOH, and NaBH4 were applied as starting reagents to synthesize NiO NPs. Noble metal oxide nanopar...
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OPTIMIZATION OF CULTURAL CONDITIONS TO ENHANCE BIOACTIVE METABOLITE PRODUCTION BY STREPTOMYCES OLIVOVERTICILLATUS VLK-15
The study was designed to optimize cultural conditions for enhanced production of bioactive compounds by Streptomyces olivo-verticillatus VLK-15 isolated from mangrove ecosystem of South Coast of Andhra Pradesh, India. The soil dilution plate technique was employed for the isolation of actinobacteria using starch-casein agar (ISP-6) medium. The potent strain was identified as Streptomyces olivov...
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IN-VITRO STUDIES OF EXTRACTS OF PLUMBAGO ZEYLANICA IN CERVIX CARCINOMA CELLS
The present study evaluated the antimicrobial and cytotoxic activities of chloroform, hexane methanol, and petroleum ether extracts of Plumbago zeylanica (PEC, PEH, PEM, and PEP). Antimicrobial activities of the extracts were evaluated against gram-positive bacteria (Staphylococcus aureus-ATCC 6538 and Bacillus cereus-NCIM 2155) and gram-negative bacteria (E. coli-ATCC 8739) along with cytotoxicit...
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ALZHEIMER’S DISEASE AND PATHOLOGICAL ANGIOGENESIS
In spite of huge investigations, the pathology of Alzheimer’ sdisease (AD) is uncertain. Vessels dysfunction is a critical mark of AD. Research has stated like beta-amyloid (Aβ) results augmented vascular development in brains, a pathway observed in AD patients. In AD, cerebral endothelium releases pro substances for β-amyloid plaque and neurotoxins that kill cortical neurons. Vascular vulnera...
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SEASONAL FLUCTUATIONS IN ARBUSCULAR MYCORRHIZAL FUNGAL COMMUNITIES: A REVIEW
Arbuscular mycorrhizal fungi (AMF) enjoy being the cynosure in most agro-ecosystems. These fungi benefit the plant in multiple ways. They improve plant growth by enhancing nutrient uptake and protecting the plant from various plant pathogens, thereby promoting plant diversity. These fungi improve plant tolerance to various abiotic stresses, such as salinity, drought, extreme temperatures, and heav...
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SEMECARPUS ANACARDIUM LINN: AN ETHNOMEDICAL, PHYTOCHEMICAL AND PHARMACOLOGICAL REVIEW
Semecarpus anacardium Linn. (Family Anacardiaceae), generally known 'Ballataka' or' Bhilwa', is a factory well-known for its medicinal value in ayurvedic and siddha system of the drug; it's also used for non-medicinal purpose like marking of cloth, hair color, etc. since ancient time. Phytochemical analyses of Semecarpus anacardium nut shows that, its nut contains a variety of biologically active ...
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A NOVEL APPROACH TOWARDS GREEN SYNTHESIS OF ZINC NANOPARTICLES FROM BANIUM PERSICUM AND ITS PHARMACOLOGICAL EFFICACY
Integration of nano-science in medicine leads to the development of biomedical products that help society in a faster and safer manner. In the present studies, Zinc nanoparticles were synthesized by green synthesis route using aqueous extracts of Banium persicum, and characterization was done through UV, SEM, TEM, FT-IR, and XRD. The synthesized nanoparticle was spherical in shape with an average ...
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ANTIMICROBIAL ACTIVITY OF NYCTANTHES ARBOR-TRISTIS AGAINST STAPHYLOCOCCUS AUREUS, STREPTOCOCCUS PYOGENS, PSEUDOMONAS AERUGINOSA AND SALMONELLA TYPHI
In today’s world, the medicine enterprise is among the quickest developing companies because of outbreaks of diverse sicknesses and antimicrobial opposition of diverse microbes towards typically utilized antibiotics. The control of diverse sicknesses and the traditional topic of treatment along with Ayurveda and home-based treatments also carries out a vital function within the part. Consequentl...
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