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HEPATOPROTECTIVE ACTIVITY OF CHENOPODIUM ALBUM LINN. AGAINST PARACETAMOL INDUCED LIVER DAMAGE IN ALBINO RATS
Chenopodium album Linn. is a plant that has a long history of uses in liver disorders. This study was done to evaluate the hepatoprotective effects of methanolic extract of Chenopodium album leaves on paracetamol-induced hepatotoxicity in albino rats. The hepatoprotective effect was evaluated on the basis of liver function parameters viz. Serum glutamic oxaloacetic transaminase (SGOT), Serum gluta...
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ALTERATIONS IN LIPID PROFILE PARAMETERS OF ALBINO RAT AFTER INTOXICATION OF MERCURY SELENIDE NANOPARTICLES
Nanoparticles are of great scientific interest, in fact, a bridge between bulk materials and atomic or molecular structures. The main characteristic of nanoparticles is their extreme smaller size, which falls in the transitional zone between molecules and the corresponding bulk materials. Lipids and fatty acids are a family of molecules classified within the lipid macronutrient class. The present ...
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A VALIDATED STABILITY-INDICATING RP-HPLC METHOD FOR DETERMINATION OF ESMOLOL HYDROCHLORIDE AND ITS RELATED IMPURITIES
Esmolol Hydrochloride belongs to the class II anti-arrhythmic drugs. Due to composite compositions and low reproducibility, challenges are still warranted for the systematic method development for related substances and identification of its acid degradation products. Development, validation and characterization of RP-HPLC stability-indicating method for the quantitative analysis of two impurities...
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A REVIEW ON PRECLINICAL PHARMACEUTICAL RESEARCH: PRINCIPAL AND COMMON ROUTES OF ADMINISTRATION IN SMALL RODENTS
Preclinical drug or pharmaceutical research in mouse and rat species is inevitable in the scientific investigations of a chemical substance or lead entity. The administration routes are the experimental study design, and regulatory requirements may influence the study of humans' intended therapeutic/clinical route. Specific route selection in the investigation of test substances must be profoundly...
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IN-VITRO EVALUATION OF BIOACTIVE COMPOUNDS FROM FIVE DIFFERENT MEDICINAL PLANTS
The forest of India is the principal repository of a large number of medicinal and aromatic plants; they are the richest source of bioactive compounds, which are largely collected as raw materials for the manufacture of drugs and perfumery products. The present study deals with five different medicinal plants viz., Polyalthia longifolia, Anonna muricata, Elephendopus scaber, Senna alata, and Hypti...
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STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF INOTUZUMAB OZOGAMICIN IN BULK DRUG AND INJECTION DOSAGE FORM
A simple, rapid, accurate, precise, and reproducible stability indicating RP-HPLC method for the estimation of Inotuzumab Ozogamicin in bulk and injection dosage form was developed and validated as per ICH guidelines. The separation was done using BDS C18 150 × 4.6 mm, 5 µ column. The mobile phase (Water and Acetonitrile 55:45% v/v) was pumped at 1.0 ml/min, and effluent was detected at 240 nm u...
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SYNTHESIS, CHARACTERIZATION AND IN-VITRO ANTICANCER SCREENING OF VITIS VINIFERA SEED ETHANOLIC EXTRACT LOADED CHITOSAN NANOPARTICLES IN H-29 COLON CANCER CELL LINE
Nanotechnology can be applied to deliver and protect antioxidants in order to control the oxidative stress phenomena in several chronic pathologies. Chitosan (CS) and its carboxymethyl derivatives are smart biopolymers that are non-toxic, biocompatible, and biodegradable, and, hence, suitable for various biomedical applications, such as drug delivery gene therapy and tissue engineering. Vitis vini...
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ESTABLISHMENT OF QUALITY STANDARDS FOR SHYONAK: AN IMPORTANT INGREDIENT OF THE DASHMOOLA GROUP OF DRUGS
Shyonak is botanically equated to Oroxylum indicum (L.) Kurz. of family Bignoniaceae. It is extensively used in the Indian system of medicine as an important ingredient of ‘Dashmoola and also one of the important constituents of a reputed Ayurvedic formulation ‘Chyavanprash’. The drug consists of root bark of Oroxylum indicum (L.) Kurz. Ayurvedic Pharmacopoeia of India (API) advocates that t...
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A NEW SERIES OF CHALCONES INCORPORATED WITH PYRIDINE MOIETY AS POTENTIAL ANTI-BACTERIAL AGENTS
A new series of chalcones have been designed and synthesized, which are incorporated with pyridine moiety chalcones possess heterocyclic rings like pyridine, pyrazole, indole, etc. These heterocycles are cyclic compounds in which one or more atoms of the ring are hetero atoms: O, N, S, P, etc. These are important components in many of the pharmaceuticals and therapeutic drugs. These are present in...
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ANTIBACTERIAL ACTIVITY FROM BARK EXTRACTS OF PTEROSPERMUM ACERIFOLIUM (L.) WILLD.
Although there are many studies on antimicrobial activities of different plants, there is no report on antibacterial activity of Pterospermum acerifolium (Sterculiaceae). Therefore, a microbiological study was conducted to detect antibacterial activity of P. acerifolium. Successive ethanolic extract of bark of P. acerifolium were fractionated with hexane, butanol, methanol and water. In vitro anti...
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