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GREEN SYNTHESIS OF SILVER NANOPARTICLES USING SAUROPUS ANDROGYNOUS LEAF EXTRACT WITH POTENTIAL BIOLOGICAL PROPERTIES
Nanoparticles are being constantly exploited by the scientific community due to their versatile properties and applications. However, the synthesis of metallic nanoparticles achieved through conventional physical and chemical techniques is quite expensive and a labor-intensive process with serious consequences like instability of nanoparticles and toxic byproducts. Hence, green synthesis utilizing...
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EVALUATION OF ANTI-ALZHEIMER’S ACTIVITY OF ALCOHOLIC EXTRACT OF HYLOCEREUS UNDATUS FRUITS IN WISTAR ALBINO RATS
Alzheimer's is a degenerative brain disease associated with memory depletion and mild cognitive dysfunction, leading to dementia. Today's world attempts to treat various ailments have increased with medical advancements. There is still considerable research into medications capable of preventing or at least effectively altering the trajectory of AD. Medicinal plants play a major role in Alzheimer'...
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MECHANISM OF ACTION OF A MULTI-HERBAL EXTRACT BLEND (KARALLIEF EASY CLIMB) IN SUPPORTING JOINT HEALTH
Osteoarthritis (OA) commonly affects many joints in the human body, including the knee joints. The knee joint is made up of two parts - the patella-femoral (PF) and tibiofemoral (TF) compartment. Animal models for OA studies are well-established and serve as an important tool for understanding the impact of OA in humans. This study evaluates the anti-OA potential of a multi-herbal extract blend pr...
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EVALUATION OF WOUND HEALING ACTIVITY OF HYDROALCOHOLIC EXTRACT OF FICUS GLOMERATA ON WISTAR ALBINO RATS
Traditionally, Ficus glomerata is used for wound healing activity. Since no detailed scientific data are available regarding the wound-healing activity of F. glomerata, the present study was designed to explore the effect of hydro-alcoholic leaf extract of Ficus glomerata (HEFG) on experimentally induced excision and incision wound models in Wistar rats. The wound-healing efficacy of Hydroalcoho...
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DoE ASSISTED UV-VISIBLE SPECTROPHOTOMETRIC METHOD DEVELOPMENT FOR CRITICAL FACTOR ESTIMATION INVOLVED IN NORFLOXACIN DEGRADATION
Degradation studies are essential to determine the inference of degradation routes and stability of pharmaceuticals at different stress conditions. Norfloxacin is an extensively used antibiotics; hence, it is also commonly found in wastewater effluent. For proper risk assessment of norfloxacin and for better understanding of the factors involved in its environmental fate, different factors were st...
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PROTEIN PROFILING AND ISOLATION OF BIOACTIVE HYDROLYSATES WITH ANTIOXIDANT ACTIVITY FROM STEM CALLUS TISSUE OF TINOSPORA CORDIFOLIA (WILLD.) MIERS EXPOSED TO CYCLODEXTRIN
This study is aimed to evaluate the effects of different concentrations of cyclodextrin, an auxin stabilizing agent, on callus growth from the stem explants of Tinospora cordifolia and to assess the antioxidant properties of the bioactive hydrolysates of callus tissue using chymotrypsin, trypsin, pepsin, and papain. Cyclodextrin exerted a dose- and time-dependent effect on the callus growth. α-c...
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SHORT TERM (21 DAYS) TOXIC IMPLICATIONS OF PERMETHRIN ON REPRODUCTIVE TISSUES OF MALE SWISS ALBINO MICE
Permethrin, a member of one of the newest class of insecticides, the synthetic type-I pyrethroids, is very much in use nowadays. Due to its relatively low mammalian toxicity and high photostability, it has earned great popularity. Several reports suggest its endocrine disrupting activity, damaging effect on nervous system, its receptors, and other adverse effects. However, very limited information...
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SCREENING OF PHYTOCHEMICALS, GC-MS BASED PHYTOCONSTITUENTS PROFILING AND ANTIBACTERIAL EFFICIENCY OF LEAVES EXTRACTS OF ANISOMELES MALABARICA
The present study aimed to determine the phytochemical components of the leaf extracts of A. malabarica, antimicrobial, antioxidant activities and GC-MS analysis. The leaves extracts have folklore and traditional applications in India. The polar and non-polar solvents extracts such as methanol, ethyl acetate, chloroform, hexane and water were used for various phytochemical analysis proved the exis...
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QUALITY BY DESIGN APPROACH FOR THE FORMULATION OF DUAL RELEASE DRUG DELIVERY SYSTEM: A CHRONOMODULATED APPROACH
The focus of the current article is to prepare the chrono-modulated dual release formulation using various optimization techniques. The conventional formulations as the Controlled Release Drug Delivery System (CRDDS) are not effective in the chronomodulated formulation. The advancement in research and development in CRDDS leads to the formulation of chronomodulated formulations. Dual release table...
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GC-MS METABOLITE PROFILING OF BIOACTIVE COMPOUNDS IN LEAF, FRUIT AND SEED EXTRACTS OF SYZYZIUM CUMINI (L.)
The present study aimed to explore the primary metabolites present in leaf, fruit, and seed crude extracts of Syzygium cumini L by Gas chromatography - Mass spectrometry. The compounds in the leaf, seed, and fruit extracts resulted from the GC-MS analysis was relevant to the National Institute of Standards and Technology (NIST) library. The metabolite profiling of the extracts revealed the presenc...
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