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ASSESSMENT OF CAUSALITY, SEVERITY AND PREVENTABILITY OF ADVERSE DRUG REACTIONS OF CANCER CHEMOTHERAPY IN A TERTIARY CARE TEACHING HOSPITAL, GUJARAT, INDIA
Background: To evaluate the various adverse drug reactions with different cancer chemotherapy regimens, severity, causality assessment and preventability. Methods: This cross-sectional, observational study was carried out in the oncology department at a tertiary care teaching hospital over a period of one year. Data on Adverse Drug Reactions (ADRs) of anticancer drugs were collected of cancer pati...
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DESIGN, FORMULATION AND OPTIMIZATION OF RUTIN TRIHYDRATE EMULGEL BY RESPONSE SURFACE METHODOLOGY
Rutin trihydrate a herbal drug having abundant medicinal properties, mainly used for topical treatment of inflammation, presents a hindrance and reduced anti-inflammatory activity. It is BCS class II drug having low oral bioavailability, poor water solubility (0.125 g/L), and low stability of rutin in aqueous alkaline medium, restricting its application in use. So, it is successfully formulated as...
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ANTI-DIABETIC ACTIVITIES OF ISOLATED COMPOUND BETA-SITOSTEROL FROM THE ETHANOLIC EXTRACT OF STEM OF ANDROGRAPHIS ECHIOIDES
To study the anti-oxidant and anti-diabetic activities of isolated compound beta-sitosterol from the ethanolic extract of stem of Andrographis echioides under the in-vitro model. The isolation was done using column chromatography using gradient elution with different mobile phases. Structural elucidation was carried out on the basis of spectral analysis. Anti-oxidant activity was determined by 2,2...
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DEVELOPMENT AND VALIDATION OF UPLC METHOD FOR ESTIMATION OF % RELEASE OF SOME ANTI-HIV DRUGS IN FIXED DOSE COMBINATION
A simple, accurate and precise UPLC method was developed and validated for dissolution testing of Lamivudine, Tenofovir disoproxil fumarate and Efavirenz in tablet dosage form. The separation was achieved under optimized chromatographic condition on an Acquity UPLC BEH (50 mm × 2.1 mm, 1.7 μm) column with mobile phase consist of 20 mM potassium dihydrogen phosphate buffer pH 2.5: acetonitrile wi...
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SPECTRUM OF INFECTIONS AND ASSESSMENT OF ANTIBIOTIC USE IN MAINTENANCE HEMODIALYSIS PATIENTS
Indian literature relating to the spectrum of infections in maintenance hemodialysis patients has not been extensively published. The purpose of this study was to carry out surveillance of infections in this population and to determine the clinical patterns and outcomes of infections and also to assess the prescribed antibiotic therapy. This was a prospective observational study carried out in the...
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MOLECULAR DYNAMICS INVESTIGATION FOR THE IMPACT OF METAKAOLIN ON MECHANICAL PROPERTIES OF THE ORDINARY PORTLAND CEMENT
The incorporation of Ordinary Portland cement with additional cementing materials is one of the most efficient methods to improve its microscopic properties. The aim of this work is to investigate the effect of metakaolin on Portland cement performance by using theoretical methods. 14 Å tobermorite was used as an alternative familiar molecular structure in representing Ordinary Portland cement. A...
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ANTIBACTERIAL ACTIVITY, PHARMACOKINETICS AND MOLECULAR DOCKING OF PHYTOCHEMICALS FROM RICINUS COMMUNIS` LEAF EXTRACT
To evaluate the antibacterial activity, pharmacokinetics and molecular interaction of the compounds from Ricinus communis` leaf extract. Antibacterial activity was assessed by using the micro-dilution method. The chemical constituents of the methanolic leaf extract were assessed by using gas chromatography-mass spectrophotometry (GC-MS). The drug-like and toxicity properties of the phytocompounds ...
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COMPARITIVE REVIEW ON ANTI-ULCER ACTIVITY OF SOME MEDICINAL PLANT EXTRACTS
Peptic ulcer is an excavation of mucosa and may extend to the submucosal layer. The bacterium Helicobacter pylori is regarded as the most common cause of infection. Long-term use of NSAIDs (non-steroidal anti-inflammatory disease drugs) like Aspirin, Diclofenac, and Naproxen and stress were also regarded as causes of ulceration. Ancient technology of synthesizing and utilizing plant-based medicine...
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UNLOCKING THE ADAPTOGENIC POWER OF ROSEMARY (ROSMARINUS OFFICINALIS): A COMPREHENSIVE EXPLORATION OF ITS PHARMACOLOGICAL POTENTIAL FOR STRESS RESILIENCE AND HOLISTIC WELL-BEING
Rosmarinic acid, a key component of Rosemary (Rosmarinus officinalis), holds significant promise as an adaptogen in herbal medicine, offering a natural remedy to counteract stress's wide-ranging impacts on health. This abstract explores rosmarinic acid's pharmacological activities, emphasizing its modulation of the hypothalamic-pituitary-adrenal (HPA) axis, regulation of neurotransmitters, antioxi...
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MICROWAVE ASSISTED EXTRACTION OF BIOLOGICAL COMPONENTS OF CROCUS SATIVUS WITH DNA BARCODING TECHNOLOGY
Saffron is derived from the flower of Crocus sativus as a dried stigma. Kashmiri saffron is the most expensive herb and in sky-scraping demand by herbal and pharmaceutical industries due to which the illegal trade is prevailing in the industry to earn instant Profit. Detection of adulteration and comparison of genuine saffron vs. fake saffron is the crucial aspect which needs a scientific solution...
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